University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Linda D. Ferrell, MD

Linda D. Ferrell, MD

Professor, Department of Pathology, UCSF

Education

University of Kansas, Lawrence KS, B.A., 1974, Microbiology
University of Kansas, Lawrence KS, M.D., 1977, Medicine
University of Kansas, Lawrence KS, Resident, 1977-79, Pathology
Univ. California, San Francisco, CA, Chief Resident, 1980-81, Pathology


Professional Experience

  • 1988-94
    Associate Professor of Pathology and Surgery, University of California, San Francisco, CA
  • 1994-present
    Professor of Pathology, University of California, San Francisco, CA
  • 1999-present
    Vice Chair of Clinical Affairs, Director of Surgical Pathology

Honors & Awards

  • 1983
    Academic Senate Distinguished Teaching Award, UCSF
  • 1984
    American Roentgen Ray Executive Council Award
  • 1987
    Kaiser Award for Excellence in Teaching, UCSF
  • 1987
    Distinction in Teaching, Pathology Residents
  • 1989
    125th Anniversary Celebration Award for Exceptional Contribution, UCSF
  • 1991
    "Major Contribution to Teaching" award, 1993 Medical Student Class, UCSF
  • 1992
    MS IV Award for Teaching Excellence, UCSF
  • 1993
    MS IV Award for Teaching Excellence, UCSF
  • 1993
    Recognition Award, US and Canadian Academy of Pathology
  • 1994
    MS IV Award for Teaching Excellence, UCSF
  • 1994
    MS IV Award for Teaching Excellence, UCSF

Selected Publications

  1. Fels Elliott DR, Tavakol M, Lucas CH, Sheahon K, Kakar S, Hameed B, Ferrell LD, Gill RM. Clinicopathological features and outcomes of parenchymal rejection in liver transplant biopsies. Histopathology. 2020 May; 76(6):822-831.
    View on PubMed
  2. Wen KW, Rabinovitch PS, Wang D, Mattis AN, Ferrell LD, Choi WT. Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions. Virchows Arch. 2020 Apr 15.
    View on PubMed
  3. Sala M, Gonzales D, Leste-Lasserre T, Dugot-Senant N, Paradis V, Di Tommaso S, Dupuy JW, Pitard V, Dourthe C, Sciarra A, Sempoux C, Ferrell LD, Clouston AD, Miller G, Yeh MM, Thung S, Gouw ASH, Quaglia A, Han J, Huan J, Fan C, Crawford J, Nakanuma Y, Harada K, le Bail B, Castain C, Frulio N, Trillaud H, Possenti L, Blanc JF, Chiche L, Laurent C, Balabaud C, Bioulac-Sage P, Raymond AA, Saltel F. ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice. Hepatol Commun. 2020 Jun; 4(6):809-824.
    View on PubMed
  4. Putra J, Ferrell LD, Gouw ASH, Paradis V, Rishi A, Sempoux C, Balabaud C, Thung SN, Bioulac-Sage P. Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon. Mod Pathol. 2020 04; 33(4):665-675.
    View on PubMed
  5. Joseph NM, Umetsu SE, Shafizadeh N, Ferrell L, Kakar S. Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum. Mod Pathol. 2019 11; 32(11):1627-1636.
    View on PubMed
  6. Balitzer D, Joseph NM, Ferrell L, Shafizadeh N, Jain D, Zhang X, Yeh M, di Tommaso L, Kakar S. Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma. Mod Pathol. 2019 10; 32(10):1486-1494.
    View on PubMed
  7. Joseph NM, Tsokos CG, Umetsu SE, Shain AH, Kelley RK, Onodera C, Bowman S, Talevich E, Ferrell LD, Kakar S, Krings G. Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma. J Pathol. 2019 06; 248(2):164-178.
    View on PubMed
  8. Guido M, Alves VAF, Balabaud C, Bathal PS, Bioulac-Sage P, Colombari R, Crawford JM, Dhillon AP, Ferrell LD, Gill RM, Hytiroglou P, Nakanuma Y, Paradis V, Quaglia A, Rautou PE, Theise ND, Thung S, Tsui WMS, Sempoux C, Snover D, van Leeuwen DJ. Histology of portal vascular changes associated with idiopathic non-cirrhotic portal hypertension: nomenclature and definition. Histopathology. 2019 Jan; 74(2):219-226.
    View on PubMed
  9. Joseph NM, Brunt EM, Marginean C, Nalbantoglu I, Snover DC, Thung SN, Yeh MM, Umetsu SE, Ferrell LD, Gill RM. Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. Am J Surg Pathol. 2018 09; 42(9):1201-1207.
    View on PubMed
  10. van Leeuwen DJ, Alves V, Balabaud C, Bhathal PS, Bioulac-Sage P, Colombari R, Crawford JM, Dhillon AP, Ferrell L, Gill RM, Guido M, Hytiroglou P, Nakanuma Y, Paradis V, Rautou PE, Sempoux C, Snover DC, Theise ND, Thung SN, Tsui WMS, Quaglia A, Liver Pathology Study Group TI. Acute-on-chronic liver failure 2018: a need for (urgent) liver biopsy? Expert Rev Gastroenterol Hepatol. 2018 Jun; 12(6):565-573.
    View on PubMed
  11. Kakar S, Ferrell LD. Glutamine synthetase staining and CTTNB1 mutation in hepatocellular adenomas. Hepatology. 2017 12; 66(6):2092-2093.
    View on PubMed
  12. Graham RP, Yeh MM, Lam-Himlin D, Roberts LR, Terracciano L, Cruise MW, Greipp PT, Zreik RT, Jain D, Zaid N, Salaria SN, Jin L, Wang X, Rustin JG, Kerr SE, Sukov WR, Solomon DA, Kakar S, Waterhouse E, Gill RM, Ferrell L, Alves VA, Nart D, Yilmaz F, Roessler S, Longerich T, Schirmacher P, Torbenson MS. Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. Mod Pathol. 2018 01; 31(1):141-149.
    View on PubMed
  13. Tsai JH, Ferrell LD, Tan V, Yeh MM, Sarkar M, Gill RM. Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition. Mod Pathol. 2017 06; 30(6):834-842.
    View on PubMed
  14. Deniz K, Moreira RK, Yeh MM, Ferrell LD. Steatohepatitis-like Changes in Focal Nodular Hyperplasia, A Finding to Distinguish From Steatohepatitic Variant of Hepatocellular Carcinoma. Am J Surg Pathol. 2017 Feb; 41(2):277-281.
    View on PubMed
  15. Balitzer D, Shafizadeh N, Peters MG, Ferrell LD, Alshak N, Kakar S. Autoimmune hepatitis: review of histologic features included in the simplified criteria proposed by the international autoimmune hepatitis group and proposal for new histologic criteria. Mod Pathol. 2017 05; 30(5):773-783.
    View on PubMed
  16. Ehman EC, Umetsu SE, Ohliger MA, Fidelman N, Ferrell LD, Yeh BM, Yee J, Hope TA. Imaging prediction of residual hepatocellular carcinoma after locoregional therapy in patients undergoing liver transplantation or partial hepatectomy. Abdom Radiol (NY). 2016 11; 41(11):2161-2168.
    View on PubMed
  17. Cuervo H, Nielsen CM, Simonetto DA, Ferrell L, Shah VH, Wang RA. Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice. Hepatology. 2016 10; 64(4):1302-1316.
    View on PubMed
  18. Tsokos CG, Krings G, Yilmaz F, Ferrell LD, Gill RM. Proliferative index facilitates distinction between benign biliary lesions and intrahepatic cholangiocarcinoma. Hum Pathol. 2016 11; 57:61-67.
    View on PubMed
  19. Ehman EC, Behr SC, Umetsu SE, Fidelman N, Yeh BM, Ferrell LD, Hope TA. Rate of observation and inter-observer agreement for LI-RADS major features at CT and MRI in 184 pathology proven hepatocellular carcinomas. Abdom Radiol (NY). 2016 05; 41(5):963-9.
    View on PubMed
  20. Quaglia A, Alves VA, Balabaud C, Bhathal PS, Bioulac-Sage P, Crawford JM, Dhillon AP, Ferrell L, Guido M, Hytiroglou P, Nakanuma Y, Paradis V, Snover DC, Theise ND, Thung SN, Tsui WM, van Leeuwen DJ. Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation. Histopathology. 2016 Jun; 68(7):953-67.
    View on PubMed

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