University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jeffrey Earl Gotts, MD, PhD

Jeffrey Earl Gotts, MD, PhD

Assistant Professor, Department of Medicine, UCSF

Cancer Center Program Memberships

Tobacco Control

Research Summary

My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.


University of Texas at Austin, B.A., 06/1997, Plan II Honors Program
University of California, Los Angeles, M.D., Ph.D., 06/2006, Medicine, Neuroscience
University of California, San Francisco, Residency, 06/2009, Internal Medicine
University of California, San Francisco, Fellowship, 06/2013, Pulmonary/Crit Care

Professional Experience

  • 2006 - 2007
    Internship, Internal Medicine, UCSF
  • 2007 - 2009
    Residency, Internal Medicine, UCSF
  • 2009 - 2010
    Clinical Instructor, Hospital Medicine, UCSF
  • 2010 - 2013
    Fellowship, Pulmonary and Critical Care, UCSF
  • 2014 - present
    Assistant Clinical Professor, Critical Care Medicine, UCSF

Honors & Awards

  • 2003
    UCLA Kavan Award for Neuroscience Research
  • 2005
  • 2006
    ACP Student Internist Award
  • 2009
    UCSF Internal Medicine Residency Professionalism Award
  • 2011
    UCSF Outstanding Pulmonary Fellow Award

Selected Publications

  1. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 Apr; 7(4):e14.
    View on PubMed
  2. Gotts JE. High-power vaping injures the human lung. Am J Physiol Lung Cell Mol Physiol. 2019 May 01; 316(5):L703-L704.
    View on PubMed
  3. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019 Feb; 7(2):154-162.
    View on PubMed
  4. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 11; 27(Suppl 1):s20-s25.
    View on PubMed
  5. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. Possible hepatotoxicity of IQOS. Tob Control. 2018 11; 27(Suppl 1):s39-s40.
    View on PubMed
  6. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 01; 315(1):L25-L40.
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  7. Gotts JE, Matthay MA. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 02 01; 197(3):280-281.
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  8. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L966-L967.
    View on PubMed
  9. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039.
    View on PubMed
  10. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914.
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  11. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L193-L206.
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  12. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501.
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  13. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 10; 55(4):613-615.
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  14. Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016 05 23; 353:i1585.
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  15. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5.
    View on PubMed
  16. Gotts JE, Matthay MA. Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):797-809.
    View on PubMed
  17. Gotts JE, Abbott J, Matthay MA. Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 01; 307(5):L395-406.
    View on PubMed
  18. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22.
    View on PubMed
  19. Gotts JE, Matthay MA. Treating ARDS: new hope for a tough problem. Lancet Respir Med. 2014 Feb; 2(2):84-5.
    View on PubMed
  20. Gotts JE, Matthay MA. Cell therapy for lung disease: a step forward. Chest. 2013 Jun; 143(6):1525-1527.
    View on PubMed

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