University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Chiung-Yu Huang, PhD

Chiung-Yu Huang, PhD

Professor, Dept. of Epidemiology and Biostatistics, UCSF

Cancer Center Program Memberships

Hematopoietic Malignancies

Research Summary

Dr. Chiung-Yu Huang is Professor of Biostatistics at the Department of Epidemiology and Biostatistics and an elected Fellow of the American Statistical Association (ASA). She is a Member of the UCSF Helen Diller Family Comprehensive Cancer Center and an Adjunct Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center. She is recognized for her novel methodology research in survival analysis, competing risks analysis, recurrent event analysis, outcome-dependent sampling, and design and evaluation of vaccine efficacy trials. Dr. Huang’s recent methodology contributions include (1) methods for combining information from external large databases, such as disease registries, to improve efficiency in the analysis of relatively small-scale studies that collect more detailed patient-level information. The importance of such methods has been recognized as we have now entered the big bata era; (2) methods to better model, estimate, and predict the risk of recurrent events to identify individuals who are at a high risk of experiencing recurrent events, allowing one to target these individuals for more intensive monitoring and treatment; (3) statistical methods for analyzing vaccine trials with active or passive surveillance by incorporating information about infecting pathogens collected at the time of infection; (4) efficient statistical methods for survival data collected in prevalent cohort studies. (5) benefit-risk assessment tools for evaluating treatment risks and benefit in cancer patients with end-stage disease; (6) statistical methods that can properly account for informative clinic visits in the analysis of electronic health records.

In addition to statistical method research, Dr. Huang has a rich experience in collaborative research across a wide range of areas, including influenza, malaria, transplant, and cancer studies. During her service as a Mathematical Statistician at NIAID, NIH (2004-2013), she worked closely with both extramural and intramural NIH scientists on the design, conduct, monitoring, analysis, and presentation of preclinical and clinical studies. She served as a statistician to the NIAID Influenza Research Collaboration (NIRC) and the Mexican Emerging Infectious Disease Clinical Research Network (La Red), and was a statistical reviewer to the Infectious Disease Clinical Research Program (IDCRP) and several intramural laboratories within NIAID. She has received numerous awards for her collaborative research, including the prestigious NIAID Merit Award. Prior to joining UCSF, she was an Associate Professor at the Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center (2013-2017), where she served as the lead statistician to the Breast and Ovarian Cancer Program. She also worked closely with the Transplant and Oncology Infectious Diseases Programs in modeling and characterizing morbidities attributable to infections occurring after solid organ transplants (SOT) and hematopoietic stem cell transplants (HSCT). Since joining UCSF in 2017, she has been serving as the lead statistician to the Hematopoietic Malignancies Program at UCSF Helen Diller Family Comprehensive Cancer Center and is the primary statistician to the University of California Hematologic Malignancies Consortium (UCHMC).

Education

National Tsing-Hua University, Hsinchu, Taiwan, B.S., 07/1994, Mathematics
National Tsing-Hua University, Hsinchu, Taiwan, M.S., 07/1996, Mathematics
Johns Hopkins University, Baltimore, Maryland, Ph.D., 05/2002, Biostatistics


Professional Experience

  • 2002-2004
    Assistant Professor, Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN 2004-2013 Mathematical Statistician, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD
  • 2013-2017
    Associate Professor, Division of Oncology Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
  • 2014-2017
    Associate Professor, Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
  • 2017-present
    Professor, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA

Honors & Awards

  • 1991
    Invited Contestant, Asian Pacific Mathematics Olympiad (APMO)
  • 1991
    College admission for gifted students under Taiwan’s Special Education Act
  • 1991-1995
    Four-Year College Scholarship for Gifted Students in Mathematics and Sciences, Taiwanese Ministry of Education
  • 1992, 1993, 1994
    President’s Academic Awards (3 times), National Tsing-Hua University
  • 1994
    Graduated first in class from the Department of Mathematics, National Tsing-Hua University, Taiwan (completed a bachelor's degree in three years and admitted into graduate school without entrance exam)
  • 1997-2002
    Five-year departmental scholarship, Department of Biostatistics, Johns Hopkins University
  • 2002
    Margaret Merrell Award for Excellence in Research, Department of Biostatistics, Johns Hopkins University
  • 2004
    NIH Travel Award, ENAR Young Investigators Meeting
  • 2003-2005
    Grant-in-Aid of Research, Artistry, and Scholarship, University of Minnesota
  • 2005
    Performance Award for special achievement, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, NIH
  • 2005, 2006, 2007, 2008, 2010, 2011
    Special Act or Service Award, National Institute of Allergy and Infectious Diseases, NIH
  • 2007
    NIAID Merit Award, National Institute of Allergy and Infectious Diseases, NIH

Selected Publications

  1. Generalized scale-change models for recurrent event processes under informative censoring. Statistica Sinica. 2019.
    View on PubMed
  2. Lee CH, Huang CY, DeFor TE, Brunstein CG, Weisdorf DJ, Luo X. Semiparametric regression model for recurrent bacterial infections after umbilical cord blood transplantation. Statistica Sinica. 2019.
    View on PubMed
  3. Connolly RM, Huang CY, Stearns V, Wahl RL. Reply to E. Hindié et al. J Clin Oncol. 2019 Jun 28; JCO1901078.
    View on PubMed
  4. Chiou S, Huang CY, Xu G, Yan J. Semiparametric regression analysis of panel count data: a practical review. International Statistical Review. 2019; 1(87):24-43.
    View on PubMed
  5. Connolly RM, Leal JP, Solnes L, Huang CY, Carpenter A, Gaffney K, Abramson V, Carey LA, Liu MC, Rimawi M, Specht J, Storniolo AM, Valero V, Vaklavas C, Krop IE, Winer EP, Camp M, Miller RS, Wolff AC, Cimino-Mathews A, Park BH, Wahl RL, Stearns V. TBCRC026: Phase II Trial Correlating Standardized Uptake Value With Pathologic Complete Response to Pertuzumab and Trastuzumab in Breast Cancer. J Clin Oncol. 2019 Mar 20; 37(9):714-722.
    View on PubMed
  6. Nawas MT, Andreadis C, Martin TG, Wolf JL, Ai WZ, Kaplan LD, Mannis GN, Logan AC, Damon LE, Huang CY, Olin RL. Limitation in Patient-Reported Function Is Associated with Inferior Survival in Older Adults Undergoing Autologous Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2019 Jun; 25(6):1218-1224.
    View on PubMed
  7. Lanzkron S, Little J, Field J, Shows JR, Wang H, Seufert R, Brooks J, Varadhan R, Haywood C, Saheed M, Huang CY, Griffin B, Frymark S, Piehet A, Robertson D, Proudford M, Kincaid A, Green C, Burgess L, Wallace M, Segal J. Increased acute care utilization in a prospective cohort of adults with sickle cell disease. Blood Adv. 2018 Sep 25; 2(18):2412-2417.
    View on PubMed
  8. Sun Y, Qin J, Huang CY. Missing information principle: a unified approach for general truncated and/or censored survival data problems. Statistical Science. 2018; 33:261-276.
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  9. Jose JJM, Brahmadathan KN, Abraham VJ, Huang CY, Morens D, Hoe NP, Follmann DA, Krause RM. Streptococcal group A, C and G pharyngitis in school children: a prospective cohort study in Southern India. Epidemiol Infect. 2018 05; 146(7):848-853.
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  10. Chiou SH, Xu G, Yan J, Huang CY. Semiparametric estimation of the accelerated mean model with panel count data under informative examination times. Biometrics. 2018 09; 74(3):944-953.
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  11. Follmann D, Huang CY. Sieve analysis using the number of infecting pathogens. Biometrics. 2018 09; 74(3):1023-1033.
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  12. Lyu T, Luo X, Xu G, Huang CY. Induced smoothing for rank-based regression with recurrent gap time data. Stat Med. 2018 Mar 30; 37(7):1086-1100.
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  13. Lee CH, Huang CY, Xu G, Luo X. Semiparametric regression analysis for alternating recurrent event data. Stat Med. 2018 Mar 15; 37(6):996-1008.
    View on PubMed
  14. Murphy AG, Foley K, Rucki AA, Xia T, Jaffee EM, Huang CY, Zheng L. Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer. Oncotarget. 2017 Dec 05; 8(63):106405-106414.
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  15. Xu G, Sit T, Wang L, Huang CY. Estimation and Inference of Quantile Regression for Survival Data Under Biased Sampling. J Am Stat Assoc. 2017; 112(520):1571-1586.
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  16. Shrestha B, Sun Y, Faisal F, Kim V, Soares K, Blair A, Herman JM, Narang A, Dholakia AS, Rosati L, Hacker-Prietz A, Chen L, Laheru DA, De Jesus-Acosta A, Le DT, Donehower R, Azad N, Diaz LA, Murphy A, Lee V, Fishman EK, Hruban RH, Liang T, Cameron JL, Makary M, Weiss MJ, Ahuja N, He J, Wolfgang CL, Huang CY, Zheng L. Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer. Cancer Med. 2017 Jul; 6(7):1552-1562.
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  17. Sengupta S, Nagalingam A, Muniraj N, Bonner MY, Mistriotis P, Afthinos A, Kuppusamy P, Lanoue D, Cho S, Korangath P, Shriver M, Begum A, Merino VF, Huang CY, Arbiser JL, Matsui W, Gyorffy B, Konstantopoulos K, Sukumar S, Marignani PA, Saxena NK, Sharma D. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. Oncogene. 2017 10 12; 36(41):5709-5721.
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  18. Xu G, Chiou SH, Huang CY, Wang MC, Yan J. Joint scale-change models for recurrent events and failure time. J Am Stat Assoc. 2017; 112(518):794-805.
    View on PubMed
  19. Sun Y, Huang CY, Wang MC. Nonparametric Benefit-Risk Assessment Using Marker Process in the Presence of a Terminal Event. J Am Stat Assoc. 2017; 112(518):826-836.
    View on PubMed
  20. Huang CY, Qin J, Tsai HT. Efficient Estimation of the Cox Model With Auxiliary Subgroup Survival Information. J Am Stat Assoc. 2016; 111(514):787-799.
    View on PubMed

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