University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Millie Hughes-Fulford, PhD

Millie Hughes-Fulford, PhD

Professor, Department of Biochemistry and Biophysics, UCSF; and Director, Laboratory of Cell Growth, VAMC/UCSF

Cancer Center Program Memberships

Affiliate Member


Tarleton State University, Stephenville, TX, B.S., 1968, Chemistry and Biology
Texas Women's University, Denton, TX, Ph.D., 1972, Radiation Chemistry
Woods Hole, Post-Graduate Training, 1987, Summer Physiology courses; 1999, Microscopy course

Professional Experience

  • 1973-1985
    Research Chemist, VAMC San Francisco, CA
  • 1977-1984
    Adjunct Assistant Professor; Biochemistry, Department of Medicine; University of California, San Francisco; and San Francisco Extension Faculty, Biochemistry, UC Berkeley
  • 1984-1991
    Astronaut Scientist, Spacelab Life Sciences-l, JSC, Houston
  • 1984-1994
    Adjunct Associate Professor of Biochemistry, Dept. of Medicine, UCSF, San Francisco
  • 1995- 2001
    Deputy Associate Chief of Staff for Education VAMCSF
  • 1991-present
    Scientific Advisor to the Undersecretary of the Department of Veteran's Affairs
  • 1993-present
    Director, Hughes-Fulford Laboratory, VAMC/UCSF
  • 1993-2012
    Scientific Advisor to the UnderSecretary, Dept of Veteran's Affairs, Washington, DC
  • 1994-present
    Adjunct Professor in Medicine, Dept. of Medicine, UCSF, San Francisco
  • 1996-present
    Principal Medical Investigator NCIRE
  • 2001-present
    Principal Medical Investigator, VAMC/NCIRE

Honors & Awards

  • 1965
    National Science Foundation Summer Research Fellow (Undergraduate)
  • 1968-1971
    National Science Foundation Fellowship (Graduate)
  • 1971-1972
    American Association of University Women's Fellowship
  • 1984
    Presidential Award for Federal Employee for Western Region
  • 1995
    Woman of the Year Marin county
  • 1995
    Named International Zontian, 1995

Selected Publications

  1. Richard Boyle, Millie Hughes-Fulford. Space Biology (Cells to Amphibians). Encyclopedia of Bioastronautics. 2019 Jan 1; 1-10.
    View on PubMed
  2. Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). J Am Heart Assoc. 2015 Aug 21; 4(8):e002034.
    View on PubMed
  3. Hughes-Fulford M, Chang TT, Martinez EM, Li CF. Spaceflight alters expression of microRNA during T-cell activation. FASEB J. 2015 Dec; 29(12):4893-900.
    View on PubMed
  4. Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB J. 2015 Oct; 29(10):4122-32.
    View on PubMed
  5. Martinez EM, Yoshida MC, Candelario TL, Hughes-Fulford M. Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 15; 308(6):R480-8.
    View on PubMed
  6. Chang TT, Hughes-Fulford M. Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. Biomaterials. 2014 Feb; 35(7):2162-71.
    View on PubMed
  7. Grenon SM, Owens CD, Alley H, Chong K, Yen PK, Harris W, Hughes-Fulford M, Conte MS. n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial. Vasc Med. 2013 Oct; 18(5):263-74.
    View on PubMed
  8. Marlene Grenon, Christopher D. Owens, Hugh Alley, Karen Chong, Eric Vittinghoff, William Harris, Millie Hughes-Fulford, Joseph Rapp, Michael Conte. The Association Between Erythrocyte n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Content and Inflammation in Male Patients With Peripheral Artery Disease (PAD). Journal of Vascular Surgery. 2013 May 1; 57(5):10s-11s.
    View on PubMed
  9. S. Grenon, M. Jeanne, M.S. Conte, M. Hughes-Fulford. Effects of Mechanical Gravitational Unloading on Vascular Endothelial Cells Function. Journal of Surgical Research. 2013 Feb 1; 179(2):200.
    View on PubMed
  10. Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M. Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules. Sci Rep. 2013; 3:1494.
    View on PubMed
  11. Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M. Can I take a space flight? Considerations for doctors. BMJ. 2012 Dec 13; 345:e8124.
    View on PubMed
  12. Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol. 2012 Dec; 92(6):1133-45.
    View on PubMed
  13. Marlene Grenon, Jesus Aguado-Zunega, Michael S. Conte, Millie Hughes-Fulford. PS204. Mechanical (or “Gravitational”) Unloading Reduces Inflammatory and Cell Adhesion Molecule Gene Expression in Human Endothelial Cells. Journal of Vascular Surgery. 2012 Jun 1; 55(6):78s-79s.
    View on PubMed
  14. Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M. Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. J Surg Res. 2012 Sep; 177(1):e35-43.
    View on PubMed
  15. Grenon SM, Hughes-Fulford M, Rapp J, Conte MS. Polyunsaturated fatty acids and peripheral artery disease. Vasc Med. 2012 Feb; 17(1):51-63.
    View on PubMed
  16. S.M. Grenon, J. Aguado-Zuniga, M.S. Conte, M. Hughes-Fulford. The Effects of Polyunsaturated Fatty Acids on Monocyte-Endothelial Cell Interactions. Journal of Surgical Research. 2012 Feb 1; 172(2):269.
    View on PubMed
  17. Magbanua MJ, Roy R, Sosa EV, Weinberg V, Federman S, Mattie MD, Hughes-Fulford M, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM. Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PLoS One. 2011; 6(9):e24004.
    View on PubMed
  18. Hughes-Fulford M. To infinity ... and beyond! Human spaceflight and life science. FASEB J. 2011 Sep; 25(9):2858-64.
    View on PubMed
  19. Hughes-Fulford M, Li CF. The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. J Orthop Surg Res. 2011 Feb 09; 6:8.
    View on PubMed
  20. Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, Shinohara K, Federman S, Mattie M, Hughes-Fulford M, Haqq C, Carroll PR. Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. Cancer Causes Control. 2011 Jan; 22(1):141-50.
    View on PubMed

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