University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Joseph O. Humtsoe, PhD

Assistant Research, Dept. of Cell and Tissue Biology, UCSF

Cancer Center Program Memberships



Science College Kohima, Kohima, Nagaland, BS, 1993, Life sciences
North Eastern Hill University, Shillong, Meghalaya, MS, 1995, Biochemistry
North Eastern Hill University, Shillong, Meghalaya, PhD, 2000, Biochemistry
University of Houston, Texas, Postdoctoral Fellow, 2004, Cell and Molecular Biology

Professional Experience

  • 2004 - 2015
    Associate Specialist, UCSF
  • 2015 - present
    Assistant Research, UCSF

Honors & Awards

  • 1996
    Junior Research Fellowship, University Grants Commission, New Delhi, INDIA
  • 1998
    Senior Research Fellowship, University Grants Commission, New Delhi, INDIA
  • 1999
    Guest Scientist to Institute of Medicine, Research Center, Juelich, Germany
  • 2000
    "Dr. A. R. Gopal-Ayenger Best Poster Award" at the International Conference on Radiation Biology- RADIOBIOLOGY 2000, Regional Cancer Center, Trivandrum, India

Selected Publications

  • Humtsoe JO, Pham E, Louie RJ, Chan DA, Kramer RH. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene. 2015; PMID: 26073080
  • Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, et al. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Experimental cell research. 2012; 318(4):379-90. PMID: 22154512
  • Chatterjee I, Humtsoe JO, Kohler EE, Sorio C, Wary KK. Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and CYCLIN-D1 signaling. Molecular cancer. 2011; 10:51. PMID: 21569306 PMCID: PMC3112429
  • Humtsoe JO, Liu M, Malik AB, Wary KK. Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.Molecular and cellular biology. 2010; 30(7):1593-606. PMID: 20123964 PMCID: PMC2838065
  • Humtsoe JO, Kramer RH.Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene. 2010; 29(8):1214-26. NIHMSID: NIHMS152413 PMID: 19935697 PMCID: PMC2829113
  • Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, et al. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis.
    Molecular cancer research : MCR. 2010; 8(2):170-82. PMID: 20145039
  • Onishi A, Chen Q, Humtsoe JO, Kramer RH. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Experimental cell research. 2008; 314(2):377-86. NIHMSID: NIHMS36370 PMID: 17961551 PMCID: PMC2766263