Lily Jan, PhD
Professor of Physiology and Biochemistry, UCSF
Jack and De Loris Lange Endowed Chair of Physiology and Biophysics, UCSF
Cancer Center Program Memberships
Non-alignedResearch Summary
In collaboration with our UCSF colleagues including Sabine Mueller, Marc Shuman, Bill Weiss and David Rowitch, our recent study revealed that EAG2 is upregulated in multiple subgroups of medulloblastoma (MB) and the activity of this potassium channel is crucial for MB growth and metastasis, MB cell proliferation (Huang et al., 2012, Genes & Development 26, 1780-1796) and migration (Huang et al., 2015, Nature Neuroscience 18, 1236-1246). Taken together with our previous collaborative studies of KCNK9 that is upregulated in breast cancer (Mu et al., 2003, Cancer Cell 3, 297-302; Pei et al., 2003 PNAS 100, 7803-7807) and our on-going study of the involvement of another ion channel in pancreatic cancer, these studies support the notion that different types of cancer may upregulate different potassium channels and/or other ion channels in order to undergo rapid proliferation, extensive migration and invasion.Education
National Taiwan University, Taipei, Taiwan, B.Sc., 06/1968, Physics
California Institute of Technology, Pasadena, CA, M.Sc., 06/1970, Physics
California Institute of Technology, Pasadena, CA, Ph.D., 06/1974, Biophysics & Physics
California Institute of Technology, Pasadena, CA, Postdoc, 06/1977, Neuroscience
Harvard Medical School, Boston, MA, Postdoc, 06/1979, Neuroscience
Professional Experience
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1979–1983
Assistant Professor of Physiology, University of California, San Francisco -
1983–1985
Associate Professor of Physiology and Biochemistry, University of California, San Francisco -
1985–present
Professor of Physiology and Biochemistry, University of California, San Francisco
Honors & Awards
- 1977-1982
Established Investigator of the American Heart Association - 1977-1979
Alfred P. Sloan Research Fellowship - 1983-1986
Klingenstein Fellowship Award - 1988
W. Alden Spencer Award and Lecture, Columbia University - 1988-2001
NINDS Javits Neuroscience Investigator Award - 1995
Faculty Lecturer at University of California, San Francisco - 1996-present
Member, National Academy of Sciences - 1998–present
Member, Academia Sinica - 1998
Harvey Lecture - 1999
Stephen W. Kuffler Lecture, Harvard Medical School - 2004
K.S. Cole Award, Biophysical Society - 2004
NIH Margaret Pittman Lecture - 2006
Distinguished Alumni Award, California Institute of Technology - 2006
NIMH MERIT Award - 2006
Society of Chinese Bioscientists in America (SCBA) Presidential Award - 2007-present
Member, American Academy of Arts and Sciences - 2007
Outstanding Mentorship Award form the Postdoctoral Scholar’s Association of UCSF - 2009
Ralph W. Gerard Prize, Society for Neuroscience - 2010
Edward M. Scolnick Prize in Neuroscience - 2010
Grass Lecture at Society for Neuroscience Annual Meeting - 2011
Wiley Prize in Biomedical Research - 2012
Gruber Prize in Neuroscience
Selected Publications
- Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019 Sep 04; 8.
View on PubMed - Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 30; 28(5):1385.
View on PubMed - Ye W, Han TW, He M, Jan YN, Jan LY. Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Elife. 2019 07 18; 8.
View on PubMed - Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY. TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice. J Neurosci. 2019 Sep 04; 39(36):7102-7117.
View on PubMed - Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 Jul 17; 103(2):349.
View on PubMed - Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 09; 28(2):567-579.e4.
View on PubMed - Crottès D, Jan LY. The multifaceted role of TMEM16A in cancer. Cell Calcium. 2019 Sep; 82:102050.
View on PubMed - Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26):13026-13035.
View on PubMed - Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 07 17; 103(2):309-322.e7.
View on PubMed - Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5126-5134.
View on PubMed - Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019 Apr 17; 102(2):373-389.e6.
View on PubMed - Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318.
View on PubMed - Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT. Far away from the lamppost. PLoS Biol. 2018 12; 16(12):e3000067.
View on PubMed - Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY. Activation of orexin system facilitates anesthesia emergence and pain control. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10740-E10747.
View on PubMed - Jan LY, Jan YN. Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 06 04; 150(6):773-775.
View on PubMed - DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 03 01; 32(5-6):402-414.
View on PubMed - Jan YN, Jan LY. Force-activated ion channels in close-up. Nature. 2018 02 22; 554(7693):469-470.
View on PubMed - Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 03 07; 97(5):1063-1077.e4.
View on PubMed - Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1667-E1674.
View on PubMed - Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429.
View on PubMed