Lily Jan, PhD
Professor of Physiology and Biochemistry, UCSF
Jack and De Loris Lange Endowed Chair of Physiology and Biophysics, UCSF
Cancer Center Program Memberships
Non-alignedResearch Summary
Taken together with our previous studies of the KCNK9 potassium channel upregulation in breast cancer (Mu et al., 2003, Cancer Cell 3, 297-302; Pei et al., 2003, PNAS 100, 7803-7807) and the EAG2 potassium channel upregulation in multiple subgroups of medulloblastoma (MB) that facilitates MB cell proliferation and migration (Huang et al., 2012, Genes & Development 26, 1780-1796; Huang et al., 2015, Nature Neuroscience 18, 1236-1246), our recent study of the TMEM16A calcium activated chloride channel upregulation in pancreatic cancer that is associated with the ligand-dependent EGF receptor signaling pathway and poor prognosis (Crottes et al., 2019, PNAS 116, 13026-13035) and our on-going studies of ion channels that are up- or down-regulated in various cancers support the notion that different types of cancer may involve different ion channels for their rapid proliferation, extensive migration and invasion.Education
National Taiwan University, Taipei, Taiwan, B.Sc., 06/1968, Physics
California Institute of Technology, Pasadena, CA, M.Sc., 06/1970, Physics
California Institute of Technology, Pasadena, CA, Ph.D., 06/1974, Biophysics & Physics
California Institute of Technology, Pasadena, CA, Postdoc, 06/1977, Neuroscience
Harvard Medical School, Boston, MA, Postdoc, 06/1979, Neuroscience
Honors & Awards
- 1996-present
Member, National Academy of Sciences - 1998-present
Member, Academia Sinica - 2006
NIMH MERIT Award - 2007-present
Member, American Academy of Arts and Sciences - 2007
Outstanding Mentorship Award form the Postdoctoral Scholar’s Association of UCSF - 2009
Ralph W. Gerard Prize, Society for Neuroscience - 2010
Edward M. Scolnick Prize in Neuroscience - 2010
Grass Lecture at Society for Neuroscience Annual Meeting - 2011
Wiley Prize in Biomedical Research - 2012
Gruber Prize in Neuroscience
Selected Publications
- Petkovic M, Oses-Prieto J, Burlingame A, Jan LY, Jan YN. TMEM16K is an interorganelle regulator of endosomal sorting. Nat Commun. 2020 07 03; 11(1):3298.
View on PubMed - He M, Wu B, Ye W, Le DD, Sinclair AW, Padovano V, Chen Y, Li KX, Sit R, Tan M, Caplan MJ, Neff N, Jan YN, Darmanis S, Jan LY. Chloride channels regulate differentiation and barrier functions of the mammalian airway. Elife. 2020 Apr 14; 9.
View on PubMed - Jin P, Jan LY, Jan YN. Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms. Annu Rev Neurosci. 2020 07 08; 43:207-229.
View on PubMed - Piggott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN. Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors. Genes Dev. 2019 12 01; 33(23-24):1739-1750.
View on PubMed - Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019 09 04; 8.
View on PubMed - Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 30; 28(5):1385.
View on PubMed - Ye W, Han TW, He M, Jan YN, Jan LY. Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Elife. 2019 07 18; 8.
View on PubMed - Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY. TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice. J Neurosci. 2019 09 04; 39(36):7102-7117.
View on PubMed - Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 Jul 17; 103(2):349.
View on PubMed - Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 07 09; 28(2):567-579.e4.
View on PubMed - Crottès D, Jan LY. The multifaceted role of TMEM16A in cancer. Cell Calcium. 2019 09; 82:102050.
View on PubMed - Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13026-13035.
View on PubMed - Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 07 17; 103(2):309-322.e7.
View on PubMed - Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5126-5134.
View on PubMed - Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019 04 17; 102(2):373-389.e6.
View on PubMed - Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318.
View on PubMed - Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT. Far away from the lamppost. PLoS Biol. 2018 12; 16(12):e3000067.
View on PubMed - Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY. Activation of orexin system facilitates anesthesia emergence and pain control. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10740-E10747.
View on PubMed - Jan LY, Jan YN. Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 06 04; 150(6):773-775.
View on PubMed - DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 03 01; 32(5-6):402-414.
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