University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Lily Jan, PhD

Lily Jan, PhD

Professor of Physiology and Biochemistry, UCSF
Jack and De Loris Lange Endowed Chair of Physiology and Biophysics, UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

In collaboration with our UCSF colleagues including Sabine Mueller, Marc Shuman, Bill Weiss and David Rowitch, our recent study revealed that EAG2 is upregulated in multiple subgroups of medulloblastoma (MB) and the activity of this potassium channel is crucial for MB growth and metastasis, MB cell proliferation (Huang et al., 2012, Genes & Development 26, 1780-1796) and migration (Huang et al., 2015, Nature Neuroscience 18, 1236-1246). Taken together with our previous collaborative studies of KCNK9 that is upregulated in breast cancer (Mu et al., 2003, Cancer Cell 3, 297-302; Pei et al., 2003 PNAS 100, 7803-7807) and our on-going study of the involvement of another ion channel in pancreatic cancer, these studies support the notion that different types of cancer may upregulate different potassium channels and/or other ion channels in order to undergo rapid proliferation, extensive migration and invasion.

Education

National Taiwan University, Taipei, Taiwan, B.Sc., 06/1968, Physics
California Institute of Technology, Pasadena, CA, M.Sc., 06/1970, Physics
California Institute of Technology, Pasadena, CA, Ph.D., 06/1974, Biophysics & Physics
California Institute of Technology, Pasadena, CA, Postdoc, 06/1977, Neuroscience
Harvard Medical School, Boston, MA, Postdoc, 06/1979, Neuroscience


Professional Experience

  • 1979–1983
    Assistant Professor of Physiology, University of California, San Francisco
  • 1983–1985
    Associate Professor of Physiology and Biochemistry, University of California, San Francisco
  • 1985–present
    Professor of Physiology and Biochemistry, University of California, San Francisco

Honors & Awards

  • 1977-1982
    Established Investigator of the American Heart Association
  • 1977-1979
    Alfred P. Sloan Research Fellowship
  • 1983-1986
    Klingenstein Fellowship Award
  • 1988
    W. Alden Spencer Award and Lecture, Columbia University
  • 1988-2001
    NINDS Javits Neuroscience Investigator Award
  • 1995
    Faculty Lecturer at University of California, San Francisco
  • 1996-present
    Member, National Academy of Sciences
  • 1998–present
    Member, Academia Sinica
  • 1998
    Harvey Lecture
  • 1999
    Stephen W. Kuffler Lecture, Harvard Medical School
  • 2004
    K.S. Cole Award, Biophysical Society
  • 2004
    NIH Margaret Pittman Lecture
  • 2006
    Distinguished Alumni Award, California Institute of Technology
  • 2006
    NIMH MERIT Award
  • 2006
    Society of Chinese Bioscientists in America (SCBA) Presidential Award
  • 2007-present
    Member, American Academy of Arts and Sciences
  • 2007
    Outstanding Mentorship Award form the Postdoctoral Scholar’s Association of UCSF
  • 2009
    Ralph W. Gerard Prize, Society for Neuroscience
  • 2010
    Edward M. Scolnick Prize in Neuroscience
  • 2010
    Grass Lecture at Society for Neuroscience Annual Meeting
  • 2011
    Wiley Prize in Biomedical Research
  • 2012
    Gruber Prize in Neuroscience

Selected Publications

  1. Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife. 2019 Sep 04; 8.
    View on PubMed
  2. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 30; 28(5):1385.
    View on PubMed
  3. Ye W, Han TW, He M, Jan YN, Jan LY. Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Elife. 2019 Jul 18; 8.
    View on PubMed
  4. Wang L, Simms J, Peters CJ, Fontaine MT, Li K, Gill TM, Nung Jan Y, Jan LY. TMEM16B calcium-activated chloride channels regulate action potential firing in lateral septum and aggression in male mice. J Neurosci. 2019 Jul 18.
    View on PubMed
  5. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 Jul 17; 103(2):349.
    View on PubMed
  6. Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y. Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep. 2019 Jul 09; 28(2):567-579.e4.
    View on PubMed
  7. Crottès D, Jan LY. The multifaceted role of TMEM16A in cancer. Cell Calcium. 2019 Jun 14; 82:102050.
    View on PubMed
  8. Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY. TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis. Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26):13026-13035.
    View on PubMed
  9. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 May 28.
    View on PubMed
  10. Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5126-5134.
    View on PubMed
  11. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019 Apr 17; 102(2):373-389.e6.
    View on PubMed
  12. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1309-1318.
    View on PubMed
  13. Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT. Far away from the lamppost. PLoS Biol. 2018 Dec; 16(12):e3000067.
    View on PubMed
  14. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY. Activation of orexin system facilitates anesthesia emergence and pain control. Proc Natl Acad Sci U S A. 2018 Nov 06; 115(45):E10740-E10747.
    View on PubMed
  15. Jan LY, Jan YN. Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 Jun 04; 150(6):773-775.
    View on PubMed
  16. DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 03 01; 32(5-6):402-414.
    View on PubMed
  17. Jan YN, Jan LY. Force-activated ion channels in close-up. Nature. 2018 02 22; 554(7693):469-470.
    View on PubMed
  18. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 Mar 07; 97(5):1063-1077.e4.
    View on PubMed
  19. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1667-E1674.
    View on PubMed
  20. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429.
    View on PubMed

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