University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Ophir D. Klein, MD, PhD

Ophir D. Klein, MD, PhD

Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF
Larry L. Hillblom Distinguished Professorship in Craniofacial Anomalies, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

I am a developmental biologist as well as a pediatrician and clinical geneticist, and I am interested in translating an understanding of developmental mechanisms into advances for regenerative medicine. After completing the MD/PhD degrees and a pediatric residency, I trained in Medical Genetics. As a physician scientist, I treat patients with various syndromes, including those that predispose patients to cancer. As the Chief of the Division of Genetics at UCSF and Chair of the Division of Craniofacial Anomalies at UCSF, I take a strong interest in integrating clinical and research activities. Work in my research group centers on organ development and regeneration, with a major focus on understanding the processes underlying stem cell-based renewal and on integrating evolutionary and developmental approaches.

Education

University of California, Berkeley, B.A., 1993, Spanish
Yale University, New Haven, CT, Ph.D., 1999, Genetics
Yale University, New Haven, CT, M.D., 2000
Yale-New Haven Hospital, New Haven, CT, 2000-2003, Pediatrics
University of California, San Francisco, 2003-2007, Clinical Genetics


Professional Experience

  • 2007-2011
    Assistant Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2009-present
    Director, UCSF Program in Craniofacial and Mesenchymal Biology
  • 2011-2015
    Associate Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2013-present
    Chair, Division of Craniofacial Anomalies
  • 2013-present
    Medical Director, Craniofacial Anomalies Clinic
  • 2014-2016
    Chair, Division of Orthodontics
  • 2015-present
    Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2016-present
    Chief, Division of Genetics

Honors & Awards

  • 1989-1993
    Chancellor's Scholarship, University of California, Berkeley
  • 1993-2000
    NIH Medical Scientist Training Program
  • 1999
    Dean's Distinguished Thesis Commendation, Yale University Graduate School
  • 2004
    Fellow, American Academy of Pediatrics
  • 2004-2007
    Fellow, Pediatric Scientist Development Program, NICHD/NIH
  • 2005
    David W. Smith Trainee Research Award, Western Society for Pediatric Research
  • 2005
    Fellow (Basic) Research Award, Society for Pediatric Research
  • 2005
    American Academy of Pediatrics Young Investigator Research Grant
  • 2008
    Fellow, American College of Medical Genetics
  • 2008-2010
    Culpeper Scholar
  • 2008
    United States Bone and Joint Decade Young Investigator
  • 2008-2013
    California Institute of Regenerative Medicine New Faculty Award
  • 2008
    Elected to Society for Pediatric Research
  • 2009-2011
    March of Dimes Basil O'Connor Award
  • 2009
    Elected to Western Society for Pediatric Research
  • 2009
    ASBMR Harold M. Frost Young Investigator Award

Selected Publications

  1. Blutt SE, Klein OD, Donowitz M, Shroyer NF, Guha C, Estes MK. Use of organoids to study regenerative responses to intestinal damage. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 07.
    View on PubMed
  2. Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 Sep; 21(9):1102-1112.
    View on PubMed
  3. Marangoni P, Charles C, Ahn Y, Seidel K, Jheon A, Ganss B, Krumlauf R, Viriot L, Klein OD. Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar. JBMR Plus. 2019 Aug; 3(8):e10205.
    View on PubMed
  4. Ko J, Pomerantz JH, Perry H, Shieh JT, Slavotinek AM, Oberoi S, Klein OD. Case Report of Floating-Harbor Syndrome With Bilateral Cleft Lip. Cleft Palate Craniofac J. 2019 Jun 27; 1055665619858257.
    View on PubMed
  5. El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development. Int J Mol Sci. 2019 May 08; 20(9).
    View on PubMed
  6. Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting. Am J Med Genet A. 2019 May; 179(5):864-869.
    View on PubMed
  7. Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S. Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration. EMBO J. 2019 Feb 15; 38(4).
    View on PubMed
  8. Wang TC, Martin MG, Kuo CJ, Klein OD, Niland J. Introduction to themed series on intestinal stem cells and the NIDDK Intestinal Stem Cell Consortium. Am J Physiol Gastrointest Liver Physiol. 2019 Feb 01; 316(2):G247-G250.
    View on PubMed
  9. Zwick RK, Ohlstein B, Klein OD. Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 01; 316(3):G313-G322.
    View on PubMed
  10. Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 2019 Jan 15; 38(2).
    View on PubMed
  11. Jones KB, Furukawa S, Marangoni P, Ma H, Pinkard H, D'Urso R, Zilionis R, Klein AM, Klein OD. Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells. Cell Stem Cell. 2019 01 03; 24(1):183-192.e8.
    View on PubMed
  12. Prochazkova M, Prochazka J, Marangoni P, Klein OD. Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development. Front Genet. 2018; 9:542.
    View on PubMed
  13. May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein OD, Knox SM. Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage. Development. 2018 11 05; 145(21).
    View on PubMed
  14. Calamari ZT, Hu JK, Klein OD. Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function. Bioessays. 2018 12; 40(12):e1800140.
    View on PubMed
  15. Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature. 2018 11; 563(7732):514-521.
    View on PubMed
  16. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055.
    View on PubMed
  17. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 10; 562(7727):E22.
    View on PubMed
  18. Weichselbaum L, Klein OD. The intestinal epithelial response to damage. Sci China Life Sci. 2018 Oct; 61(10):1205-1211.
    View on PubMed
  19. Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, Pogontke C, Carmona RM, Salvador JM, Perez-Pomares JM, Klein OD, Prósper F, Jimenez-Borreguero LJ, Bernad A. Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2160-2173.
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  20. Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genom Med. 2018; 3:21.
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