University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Lewis L. Lanier, PhD

Lewis L. Lanier, PhD

American Cancer Society Professor and Chair, Department of Microbiology and Immunology, UCSF
Leader, Cancer Immunology Program, UCSF Helen Diller Family Comprehensive Cancer Center
J. Michael Bishop, MD, Distinguished Professor in Microbiology and Immunology, UCSF

Cancer Center Program Memberships

Cancer Immunology

Research Summary

I have studied natural killer (NK) cells in humans and mice since 1981. My lab has identified many of the activating and inhibitory NK receptors, their ligands, and signaling pathways and defined their role in innate and adaptive immune responses to pathogens and cancer.

Education

Virginia Polytechnic Institute & State U., Blacksburg, VA, B.S. (honors), 1975, Microbiology
Univ. North Carolina - Chapel Hill, NC, Ph.D., 1978, Immunology
Univ. North Carolina - Chapel Hill, NC, Postdoc, 1978-79, Immunology
Univ. New Mexico Med Sch, Albuquerque, NM, Postdoc, 1979-81, Immunology

Honors & Awards

  • 1971
    Virginia Polytechnic Institute and State University Freshman Science Scholarship
  • 1978-1979
    National Research Service Award Fellowship, University of North Carolina School of Medicine at Chapel Hill Cancer Research Center
  • 1979-1981
    Damon Runyon - Walter Winchell Cancer Fund Postdoctoral Fellowship
  • 2001
    American Association of Immunologists Distinguished Service Award
  • 2002
    William B Coley Award for Distinguished Research in Basic and Tumor Immunology, Cancer Research Institute, New York
  • 2003
    American Cancer Society Research Professorship
  • 2005
    American Society for Histocompatibility and Immunogenetics Rose Payne Award
  • 2006
    NIH Merit Grant Award
  • 2010
    Member, National Academy of Sciences
  • 2011
    Member, National Academy of Arts and Sciences
  • 2011
    Fellow, American Academy of Microbiology
  • 2013
    J. Michael Bishop Distinguished Professor of Microbiology and Immunology
  • 2017
    American Association of Immunologists Excellence in Mentoring Award

Selected Publications

  1. Aguilar OA, Tanaka M, Balaji GR, Berry R, Rossjohn J, Lanier LL, Carlyle JR. Tetramer Immunization and Selection Followed by CELLISA Screening to Generate Monoclonal Antibodies against the Mouse Cytomegalovirus m12 Immunoevasin. J Immunol. 2020 Aug 19.
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  2. Su Y, Chen D, Lausted C, Yuan D, Choi J, Dai C, Voillet V, Scherler K, Troisch P, Duvvuri VR, Baloni P, Qin G, Smith B, Kornilov S, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Jones L, Zhou Y, Roper R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Michael ZA, Magis A, Wei W, Price ND, Huang S, Subramanian N, Wang K, Hadlock J, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg P, Gottardo R, Davis MM, Goldman JD, Heath JR. Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories. bioRxiv. 2020 Jul 31.
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  3. Guerra N, Lanier LL. Editorial: Emerging Concepts on the NKG2D Receptor-Ligand Axis in Health and Diseases. Front Immunol. 2020; 11:562.
    View on PubMed
  4. Dogra P, Rancan C, Ma W, Toth M, Senda T, Carpenter DJ, Kubota M, Matsumoto R, Thapa P, Szabo PA, Li Poon MM, Li J, Arakawa-Hoyt J, Shen Y, Fong L, Lanier LL, Farber DL. Tissue Determinants of Human NK Cell Development, Function, and Residence. Cell. 2020 02 20; 180(4):749-763.e13.
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  5. Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST. Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 10; 20(10):1299-1310.
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  6. Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH. A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer. Cytometry A. 2019 09; 95(9):1019-1030.
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  7. McKechnie JL, Beltrán D, Pitti A, Saenz L, Araúz AB, Vergara R, Harris E, Lanier LL, Blish CA, López-Vergès S. HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response. Front Cell Infect Microbiol. 2019; 9:268.
    View on PubMed
  8. Lanier LL. Plastic fantastic innate lymphoid cells. J Exp Med. 2019 08 05; 216(8):1726-1727.
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  9. Lam VC, Folkersen L, Aguilar OA, Lanier LL. KLF12 Regulates Mouse NK Cell Proliferation. J Immunol. 2019 08 15; 203(4):981-989.
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  10. Feng Y, Daley-Bauer LP, Roback L, Guo H, Koehler HS, Potempa M, Lanier LL, Mocarski ES. Caspase-8 restricts antiviral CD8 T cell hyperaccumulation. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15170-15177.
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  11. Feng Y, Daley-Bauer LP, Roback L, Potempa M, Lanier LL, Mocarski ES. Caspase-8 restricts natural killer cell accumulation during MCMV Infection. Med Microbiol Immunol. 2019 Aug; 208(3-4):543-554.
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  12. Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 06; 105(6):1305-1317.
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  13. Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR. NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients. Transplantation. 2019 03; 103(3):493-501.
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  14. Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S. Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2019 03; 37(3):252-258.
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  15. Balaji GR, Aguilar OA, Tanaka M, Shingu-Vazquez MA, Fu Z, Gully BS, Lanier LL, Carlyle JR, Rossjohn J, Berry R. Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition. Nat Commun. 2018 11 05; 9(1):4623.
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  16. Calabrese DR, Lanier LL, Greenland JR. Natural killer cells in lung transplantation. Thorax. 2019 04; 74(4):397-404.
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  17. Sun JC, Lanier LL. Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer. Cold Spring Harb Perspect Biol. 2018 10 01; 10(10).
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  18. Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL. Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria. Sci Immunol. 2018 08 31; 3(26).
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  19. Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med. 2018 07; 24(7):1005-1014.
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  20. Nabekura T, Chen Z, Schroeder C, Park T, Vivier E, Lanier LL, Liu D. Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection. J Immunol. 2018 05 15; 200(10):3420-3428.
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