University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Claudia Petritsch, PhD

Claudia Petritsch, PhD

Associate Professor, Brain Tumor Research Center and Department of Neurological Surgery; and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF

Cancer Center Program Memberships

Neurologic Oncology


University of Vienna BioCenter, Vienna, MS, BA, 1985 -1991, Cell and Molecular Biology and Biochemistry
University of Vienna BioCenter, Vienna, PhD, 1991-1996, Cell & Molecular Biology
Institute of Molecular Pathology, Vienna, Postdoc, 1996-1997
University of California, San Francisco, Dept of Physiology, Postdoc, 1997-2002

Professional Experience

  • 2002-2003
    Postgraduate Researcher, Department of Physiology, University of California, San Francisco
  • 2003-2005
    Investigator, GeneCenter and Institute of Biochemistry at the University of Munich
  • 2005-2008
    Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco
  • 2008-present
    Assistant Professor, Brain Tumor Research Center and Department of Neurological Surgery, University of California, San Francisco

Honors & Awards

  • 1990
    Diploma Fellowship, Institute of Molecular Pathology
  • 1991-96
    PhD Fellowship, Institute for Molecular Pathology
  • 1993
    European Molecular Biology Organisation short-term fellowship
  • 1994
    Federation of European Biochemical Societies short-term fellowship
  • 1996
    European Molecular Biology Organisation long-term fellowship
  • 1999
    Human Frontiers Science Program Organization long-term fellowship
  • 2003
    PO 1 Research Grant; German Research Council (DFG) # SFB 413
  • 2004
    PO 1 Research Grant; German Research Council (DFG) # SFB 413
  • 2004-06
    Award for Outstanding Women in Life Sciences (University of Munich)
  • 2005-06
    Bavarian California Technology Award
  • 2006
    California Breast Cancer Research Program/CBRCP, IDEA Award, San Francisco, USA
  • 2007-2008
    National Brain Tumor Foundation, Oligodendroglioma Award, San Francisco, USA
  • 2007-2008
    Brain Tumor SPORE, Career Development Research Award, San Francisco, USA
  • 2010
    American Brain Tumor Association, Discovery Award, Des Plaines, USA

Selected Publications

  1. Mueller S, Jain P, Liang WS, Kilburn L, Kline C, Gupta N, Panditharatna E, Magge SN, Zhang B, Zhu Y, Crawford JR, Banerjee A, Nazemi K, Packer RJ, Petritsch CK, Truffaux N, Roos A, Nasser S, Phillips JJ, Solomon D, Molinaro A, Waanders AJ, Byron SA, Berens ME, Kuhn J, Nazarian J, Prados M, Resnick AC. A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium. Int J Cancer. 2019 Mar 12.
    View on PubMed
  2. Daynac M, Chouchane M, Collins HY, Murphy NE, Andor N, Niu J, Fancy SPJ, Stallcup WB, Petritsch CK. Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis. Nat Commun. 2018 08 21; 9(1):2862.
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  3. Robson JP, Wagner B, Glitzner E, Heppner FL, Steinkellner T, Khan D, Petritsch C, Pollak DD, Sitte HH, Sibilia M. Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain. FEBS J. 2018 09; 285(17):3175-3196.
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  4. Daynac M, Petritsch CK. Regulation of Asymmetric Cell Division in Mammalian Neural Stem and Cancer Precursor Cells. Results Probl Cell Differ. 2017; 61:375-399.
    View on PubMed
  5. Grossauer S, Koeck K, Murphy NE, Meyers ID, Daynac M, Truffaux N, Truong AY, Nicolaides TP, McMahon M, Berger MS, Phillips JJ, James CD, Petritsch CK. Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. Oncotarget. 2016 Nov 15; 7(46):75839-75853.
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  6. Olow A, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick AC, Waanders AJ, Stalpers LJ, Berger MS, Gupta N, James CD, Petritsch CK, Haas-Kogan DA. BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. Clin Cancer Res. 2016 Nov 01; 22(21):5312-5321.
    View on PubMed
  7. Andor N, Graham TA, Jansen M, Xia LC, Aktipis CA, Petritsch C, Ji HP, Maley CC. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med. 2016 Jan; 22(1):105-13.
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  8. Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK. Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells. Cancer Res. 2015 Dec 15; 75(24):5355-66.
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  9. Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015 Jan 21; 6:5990.
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  10. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6.
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  11. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23.
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  12. Lerner RG, Petritsch C. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nat Cell Biol. 2014 Mar; 16(3):212-4.
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    View on PubMed
  14. Andor N, Harness JV, Müller S, Mewes HW, Petritsch C. EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. 2014 Jan 01; 30(1):50-60.
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  15. Gómez-López S, Lerner RG, Petritsch C. Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci. 2014 Feb; 71(4):575-97.
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  16. Wade A, Robinson AE, Engler JR, Petritsch C, James CD, Phillips JJ. Proteoglycans and their roles in brain cancer. FEBS J. 2013 May; 280(10):2399-417.
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  17. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5.
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  18. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40.
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  19. Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96.
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  20. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82.
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