Research Summary

Dr. Rosenthal is the Director of Pediatric Hepatology, Medical Director of the Pediatric Liver Transplant Program and a Professor of Pediatrics and Surgery at the University of California, San Francisco (UCSF). He is board certified in Pediatrics and Pediatric Gastroenterology and has a Certificate of Added Qualification in Transplant Hepatology. Dr. Rosenthal completed his medical training at Downstate Medical Center and the Albert Einstein Medical Center in New York. He then completed a fellowship in pediatric gastroenterology at UCSF. He joined the UCSF faculty in 1995 after serving as Professor of Pediatrics at University of California, Los Angeles (UCLA).

Dr. Rosenthal is a prolific author and a recipient of a number of professional honors and awards and is committed to clinical service, research and education. He has published numerous research articles on hepatitis. Currently, Dr. Rosenthal is pursuing research on the pharmaceutical treatment of hepatitis B and C, genetics and immunology of biliary disease, use of bioartificial liver support utilizing porcine hepatocytes for patients with fulminant liver failure, as well as researching the quality of life following liver transplantation in children.

Dr. Rosenthal’s professional services to the public include television, newspaper and radio interviews on various topics such as hepatitis A, B, and C, and liver transplants for local, national and international audiences. He is consultant to organizations such as the American Liver Foundation, Parents of Kids with Infectious Disease, the Centers for Disease Control and Prevention (CDC), and the National Institute of Health (NIH)

Research Funding

  • April 15, 2020 - March 31, 2025 - Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01AI141308
  • September 15, 2002 - May 31, 2024 - Childhood Liver Disease Research Network (ChiLDReN) - UCSF (CC) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01DK062500
  • June 22, 2018 - May 31, 2023 - Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipeline , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI139179

Education

02/2021 - Diversity, Equity, and Inclusion Champion Training, University of California
M.D., 1975 - School of Medicine, SUNY Brooklyn

Honors & Awards

  • Murray Davidson Award, American Academy of Pediatrics, 2013
  • Chancellor's Award for Public Service, UCSF, 2002

Selected Publications

  1. Schwarzenberg SJ, King WC, Ling SC, Murray KF, Mogul D, Rosenthal P, Rodriguez-Baez N, Teckman J, Schwarz KB, Hepatitis B Research Network (HBRN). Change in Health-related Quality of Life in Youth with Chronic Hepatitis B Living in North America:A 5-year Cohort Study. J Pediatr Gastroenterol Nutr. 2023 Sep 27.  View on PubMed
  2. Conrad MD, Asua V, Garg S, Giesbrecht D, Niaré K, Smith S, Namuganga JF, Katairo T, Legac J, Crudale RM, Tumwebaze PK, Nsobya SL, Cooper RA, Kamya MR, Dorsey G, Bailey JA, Rosenthal PJ. Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda. N Engl J Med. 2023 Aug 24; 389(8):722-732.  View on PubMed
  3. Roh ME, Zongo I, Haro A, Huang L, Somé AF, Yerbanga RS, Conrad MD, Wallender E, Legac J, Aweeka F, Ouédraogo JB, Rosenthal PJ. Seasonal malaria chemoprevention drug levels and drug resistance markers in children with or without malaria in Burkina Faso: a case control study. J Infect Dis. 2023 May 23.  View on PubMed
  4. Rosenthal PJ. Proteasome inhibitors: The next generation of antimalarial drugs? Cell Chem Biol. 2023 05 18; 30(5):413-415.  View on PubMed
  5. Squires JE, Miethke AG, Valencia CA, Hawthorne K, Henn L, Van Hove JLK, Squires RH, Bove K, Horslen S, Kohli R, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL, Rosenthal P, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children. Hepatol Commun. 2023 06 01; 7(6).  View on PubMed
  6. Ghany MG, Belle SH, Kleiner DE, Smith C, Kelley SS, Rosenthal P, Fontana RJ, Hepatitis B Research Network. Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study. Hepatol Commun. 2023 06 01; 7(6).  View on PubMed
  7. Blank BR, Gut J, Rosenthal PJ, Renslo AR. Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials. ACS Med Chem Lett. 2023 Apr 13; 14(4):493-498.  View on PubMed
  8. Wojcicki JM, Gill RM, Wilson L, Lin J, Rosenthal P. Shorter leukocyte telomere length protects against NAFLD progression in children. Sci Rep. 2023 04 03; 13(1):5446.  View on PubMed
  9. Harpavat S, Hawthorne K, Setchell KDR, Rivas MN, Henn L, Beil CA, Karpen SJ, Ng VL, Alonso EM, Bezerra JA, Guthery SL, Horslen S, Loomes KM, McKiernan P, Magee JC, Merion RM, Molleston JP, Rosenthal P, Thompson RJ, Wang KS, Sokol RJ, Shneider BL, for Childhood Liver Disease Research Network (ChiLDReN). Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy. Hepatology. 2023 03 01; 77(3):862-873.  View on PubMed
  10. Gonzalez-Peralta RP, Wirth S, Squires RH, Mutschler F, Lang T, Pawlowska M, Sluzewski W, Majda-Stanislawska E, Fischler B, Balistreri WF, Jonas MM, Blondet N, Rosenthal P, Alkhouri N, Romero R, Grandhi A, Castronuovo P, Caro L, Du L, Rosenbloom DIS, Haber BA. Elbasvir/grazoprevir in children aged 3-18 years with chronic HCV genotype 1 or 4 infection: a pharmacokinetic modeling study. Hepatol Commun. 2023 03 01; 7(3):e0031.  View on PubMed
  11. Miloh T, Goldstein A, Howard R, Mogul DB, Marden JR, Anderson A, Gaburo K, Kirson N, Rosenthal P. Costs of pediatric liver transplantation among commercially insured and Medicaid-insured patients with cholestasis in the US. Liver Transpl. 2023 07 01; 29(7):735-744.  View on PubMed
  12. Nachega JB, Nsanzimana S, Rawat A, Wilson LA, Rosenthal PJ, Siedner MJ, Varma JK, Kilmarx PH, Mutesa L, Tanner M, Binagwaho A, Forrest J, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Ntoumi F, Zumla A, de Oliveira T, Mills EJ. Advancing detection and response capacities for emerging and re-emerging pathogens in Africa. Lancet Infect Dis. 2023 05; 23(5):e185-e189.  View on PubMed
  13. Nachega JB, Sam-Agudu NA, Machekano RN, Rosenthal PJ, Schell S, de Waard L, Bekker A, Gachuno OW, Kinuthia J, Mwongeli N, Budhram S, Vannevel V, Somapillay P, Prozesky HW, Taljaard J, Parker A, Agyare E, Opoku AB, Makarfi AU, Abdullahi AM, Adirieje C, Ishoso DK, Pipo MT, Tshilanda MB, Bongo-Pasi Nswe C, Ditekemena J, Sigwadhi LN, Nyasulu PS, Hermans MP, Sekikubo M, Musoke P, Nsereko C, Agbeno EK, Yeboah MY, Umar LW, Ntakwinja M, Mukwege DM, Birindwa EK, Mushamuka SZ, Smith ER, Mills EJ, Otshudiema JO, Mbala-Kingebeni P, Tamfum JM, Zumla A, Tsegaye A, Mteta A, Sewankambo NK, Suleman F, Adejumo P, Anderson JR, Noormahomed EV, Deckelbaum RJ, Stringer JSA, Mukalay A, Taha TE, Fowler MG, Wasserheit JN, Masekela R, Mellors JW, Siedner MJ, Myer L, Kengne AP, Yotebieng M, Mofenson LM, Langenegger E, AFREhealth Research Collaboration on COVID-19 and Pregnancy. Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Pregnancy in Sub-Saharan Africa: A 6-Country Retrospective Cohort Analysis. Clin Infect Dis. 2022 11 30; 75(11):1950-1961.  View on PubMed
  14. Felzen A, van Wessel DBE, Gonzales E, Thompson RJ, Jankowska I, Shneider BL, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipinski P, Czubkowski P, Rock N, Shagrani M, Broering D, Nicastro E, Kelly D, Nebbia G, Arnell H, Fischler B, Hulscher JBF, Serranti D, Arikan C, Polat E, Debray D, Lacaille F, Goncalves C, Hierro L, Muñoz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezsofi A, Calvo PL, Grabhorn E, Hartleif S, van der Woerd WJ, Kamath BM, Wang JS, Li L, Durmaz Ö, Kerkar N, Jørgensen MH, Fischer R, Jimenez-Rivera C, Alam S, Cananzi M, Laverdure N, Ferreira CT, Guerrero FO, Wang H, Sency V, Kim KM, Chen HL, de Carvalho E, Fabre A, Bernabeu JQ, Zellos A, Alonso EM, Sokol RJ, Suchy FJ, Loomes KM, McKiernan PJ, Rosenthal P, Turmelle Y, Horslen S, Schwarz K, Bezerra JA, Wang K, Hansen BE, Verkade HJ, NAtural course and Prognosis of PFIC and Effect of biliary Diversion (NAPPED) Consortium. Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in bile salt export pump deficiency. JHEP Rep. 2023 Feb; 5(2):100626.  View on PubMed
  15. Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S, Squires R, Sindhi R, Venkat V, Bukauskas K, McKiernan P, Haberstroh L, Squires J, Rosenthal P, Bull L, Curry J, Langlois C, Kim G, Teckman J, Kociela V, Nagy R, Patel S, Cerkoski J, Molleston JP, Bozic M, Subbarao G, Klipsch A, Sawyers C, Cummings O, Horslen SP, Murray K, Hsu E, Cooper K, Young M, Finn L, Kamath BM, Ng V, Quammie C, Putra J, Sharma D, Parmar A, Guthery S, Jensen K, Rutherford A, Lowichik A, Book L, Meyers R, Hall T, Wang KS, Michail S, Thomas D, Goodhue C, Kohli R, Wang L, Soufi N, Thomas D, Karpen S, Gupta N, Romero R, Vos MB, Tory R, Berauer JP, Abramowsky C, McFall J, Shneider BL, Harpavat S, Hertel P, Leung D, Tessier M, Schady D, Cavallo L, Olvera D, Banks C, Tsai C, Thompson R, Doo E, Hoofnagle J, Sherker A, Torrance R, Hall S, Magee J, Merion R, Spino C, Ye W, Childhood Liver Disease Research Network. Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease. Hepatology. 2023 02 01; 77(2):530-545.  View on PubMed
  16. Nachega JB, Sam-Agudu NA, Siedner MJ, Rosenthal PJ, Mellors JW, Zumla A, Hermans MP, Ntakwinja MB, Mukwege DM, Langenegger E, Mofenson LM, African Forum for Research and Education in Health (AFREhealth) Research Collaboration on COVID-19 a. Prioritizing Pregnant Women for Coronavirus Disease 2019 Vaccination in African Countries. Clin Infect Dis. 2022 Oct 12; 75(8):1462-1466.  View on PubMed
  17. Ebel NH, Goldstein A, Howard R, Mogul DB, Marden JR, Anderson A, Gaburo K, Kirson N, Rosenthal P. Health Care Resource Utilization by Patients with Alagille Syndrome. J Pediatr. 2023 02; 253:144-151.e1.  View on PubMed
  18. Hughes E, Wallender E, Kajubi R, Jagannathan P, Ochieng T, Kakuru A, Kamya MR, Clark TD, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM. Piperaquine-Induced QTc Prolongation Decreases With Repeated Monthly Dihydroartemisinin-Piperaquine Dosing in Pregnant Ugandan Women. Clin Infect Dis. 2022 08 31; 75(3):406-415.  View on PubMed
  19. Rosenthal P. Advances in Pediatric Liver Diseases. Clin Liver Dis. 2022 08; 26(3):xiii.  View on PubMed
  20. Shneider BL, Spino CA, Kamath BM, Magee JC, Ignacio RV, Huang S, Horslen SP, Molleston JP, Miethke AG, Kohli R, Leung DH, Jensen MK, Loomes KM, Karpen SJ, Mack C, Rosenthal P, Squires RH, Baker A, Rajwal S, Kelly D, Sokol RJ, Thompson RJ, for ChiLDReN and UK IMAGO/IMAGINE Investigators. Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome. Hepatol Commun. 2022 08; 6(8):1922-1933.  View on PubMed

Go to UCSF Profiles, powered by CTSI