University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Mark L. Rubinstein, MD

Professor, Department of Pediatrics (Adolescent Medicine), UCSF

Cancer Center Program Memberships

Tobacco Control

Research Summary

As an Adolescent Medicine physician and researcher, I have extensive experience working with adolescent smokers both in the clinical and research setting. Furthermore, as the PI on several NIH-funded adolescent nicotine addiction studies, I have expertise recruiting and following adolescent smokers over time. I am a member of the UCSF HDFCCC and have demonstrated a record of productive research projects in the area of adolescent smoking, including factors involved with the development of nicotine addiction such as nicotine metabolism, as well as the utilization of biomarkers to study adolescent nicotine exposure behaviors.
Given the rapid uptake of electronic nicotine delivery systems (ENDS) among teens, there is a critical need to understand the safety of these products in adolescents, including (1) how use contributes to toxicant exposure and (2) identification of possible biologic mediators of usage and dependence, such as the nicotine metabolic rate. The goal of my current research is to investigate the presence of toxicants and examine the influence of the rate of nicotine metabolism on ENDS use behaviors and nicotine dependence in adolescent ENDS-only users.


New York University, New York, B.F.A., 1990, Film and Television
Yale University School of Medicine, M.D., 1997, Medicine
Yale New Haven Hospital, New Haven, Residency, 2000, Internal Medicine
University of California, San Francisco, Fellowship, 2003, Adolescent Medicine

Professional Experience

  • 2003-present
    Professor, Dept. of Adolescent Medicine, University of California, San Francisco

Honors & Awards

  • 1986
    Scholars Program, New York University
  • 1990
    Founders Day Award, New York University
  • 2000-2003
    MCHB Postdoctoral Training Fellowship in Adolescent Health
  • 2002-2004
    Tobacco-Related Disease Research Program Fellowship

Selected Publications

  • Rubinstein, M., Yeager, C., Goodstein, C., Lewis, D. Juvenile Male Sexual Assaulters: A Follow-Up. American Journal of Psychiatry 1991; 150:262-265.
  • Rubinstein, M., Yeager, C., Goodstein, C., Lewis, D. Juvenile Male Sexual Assaulters (excerpt). Clinical Digest Series.1992.
  • Rubinstein, M., Yeager, C., Goodstein, C., Lewis, D. Juvenile Male Sexual Assaulters (excerpt). Brown University Child and Adolescent Behavior Letter, July 1993.
  • Rubinstein, M., Yeager, C., Goodstein, C., Lewis, D. Juvenile Male Sexual Assaulters (excerpt). Psychiatry Digest (Spanish) 1994; 1:12-13.
  • Rubinstein, M.L., Selwyn, P. High Prevalence of Insomnia in an Outpatient Population With HIV Infection. Journal of Aquired Immune Deficiency Syndromes and Human Retrovirology 1998; 19:260-265.
  • Rubinstein, M.L., Halpern-Felsher, B.L., Thompson, P., Millstein, S.G. Adolescents Discriminate Among Types Of Smokers And Related Risks. Journal of Adolescent Research. 2003.
  • Rubinstein, M.L., Halpern-Felsher, B.L., Irwin Jr., C.E. An Evaluation Of The Use The Transdermal Contraceptive Patch in Adolescents, Journal of Adolescent Health. 34(5):395-401, 2004.
  • Halpern-Felsher, B.L., Biehl, M., & Rubinstein, M.L. Perceived risks and benefits of smoking: Differences between adolescents with different smoking experiences and intentions, Preventative Medicine. 39 (3):559-567, 2004.
  • Halpern-Felsher, B.L., Rubinstein, M.L. Adolescents' Perceptions of The Risks Associated With Second Hand Smoke, Preventative Medicine. 41(1):16-22, 2005.