University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Sharanjot Saini, PhD

Sharanjot Saini, PhD

Assistant Adjunct Professor, Department of Urology, UCSF

Cancer Center Program Memberships

Prostate Cancer

Research Summary

My research program is primarily focused on delineating the molecular mechanisms driving progression, recurrence and metastasis of prostate cancer with an objective of identifying novel molecular targets for better diagnostic and therapeutic strategies against advanced disease. Current research interests include understanding the role of microRNAs in tumor progression and metastasis and understanding microRNA-mediated control of prostate cancer stem cells and tumor recurrence. Other focus areas are characterizing the role of extracellular vesicles (EVs) in advanced prostate cancer, delineating EV-mediated molecular mechanisms underlying resistance to androgen pathway inhibitors (APIs) in castration-resistant prostate cancer (CRPC) and developing non-invasive EV-based biomarkers for predicting prostate cancer aggressiveness and response to APIs. Further, we are addressing the underlying mechanisms of resistance for men with metastatic CRPC to APIs by defining the miRNA- mediated signaling pathways associated with progression of CRPC to androgen-independent neuroendocrine states.

Education

Panjab University, Chandigarh, India, BS, 1997, Biochemistry
Panjab University, Chandigarh, India, MS, 1999, Biochemistry
Institute of Microbial Technology and Jawaharlal Nehru University, New Delhi, India, PhD, 2005, Biotechnology, Molecular Biology
University of Massachusetts Medical School, Worcester, Massachusetts, Postdoctoral, 2005, Molecular Biology
University of California, San Francisco/Northern California Institute of Research and Education, Postdoctoral, 2007, Molecular Biology, Cancer Biology


Professional Experience

  • 2010-2014
    Assistant Research Scientist, Department of Urology, NCIRE, San Francisco VA Medical Center
  • 2014-present
    Research Scientist/Principal Investigator, Department of Urology, NCIRE and San Francisco VA Medical Center
  • 2012-present
    Assistant Adjunct Professor, Department of Urology, UCSF

Honors & Awards

  • 2014
    Invited speaker at 4th World Congress on Cancer Science & Therapy, Chicago, USA
  • 2015
    Outstanding abstract selected for oral presentation at Annual Prostate Cancer Program Research Retreat, University of California San Francisco, CA
  • 2015
    Invited speaker at Veterans Affairs Medical Center, San Francisco, CA

Selected Publications