University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Asmin Tulpule, MD, PhD

Asmin Tulpule, MD, PhD

Assistant Professor in Pediatric Hematology/Oncology, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Education

Princeton University, BA, 06/2002, Molecular Biology, Certificate in Biophysics
Harvard University, PhD, 07/2008, Biological and Biomedical Sciences
Harvard Medical School, MD, 06/2011
University of California, San Francisco, 06/2013, Pediatric Residency
University of California, San Francisco, 06/2017, Pediatric Hematology/Oncology Fellowship


Professional Experience

  • 2000-2002
    Undergraduate Senior Thesis Research in the laboratories of Dr. Michael Berry and Dr. Shirley Tilghman, Princeton University
  • 2009-2011
    Continuing research with Dr. George Daley, Boston Children’s Hospital, Boston, MA while concurrently enrolled in Harvard Medical School.
  • 2011-2013
    Pediatric Residency at University of California, San Francisco. Completed the American Board of Pediatrics Accelerated Research Pathway. Member of the Molecular Medicine Pathway.
  • 2013-2017
    University of California, San Francisco, Clinical Fellow in Pediatric Hematology/Oncology
  • 2017- present
    UCSF Physician-Scientist Scholar and Assistant Professor, Adjunct Series in Pediatric Hematology/Oncology, University of California, San Francisco

Honors & Awards

  • 1998
    Princeton University Department of Molecular Biology, Senior Thesis Speaker Award
  • 2011
    Harvard Medical School Award for Outstanding Performance and Accomplishment in Research
  • 2015
    NIH Pediatric Loan Repayment Program Recipient
  • 2016
    A.P Giannini Postdoctoral Fellowship Award
  • 2016
    Alex's Lemonade Stand Young Investigator Award
  • 2017
    UCSF Physician-Scientist Scholar Program
  • 2018
    St. Baldrick's Scholar Award

Selected Publications

  1. Kumar P, Gill RM, Phelps A, Tulpule A, Matthay K, Nicolaides T. SurveillanceScreening in Li-Fraumeni Syndrome: Raising Awareness of False Positives. Cureus. 2018 Apr 24;10(4):e2527. doi: 10.7759/cureus.2527. Review. PubMed PMID: 29946497;PubMed Central PMCID: PMC6017131.
  2. Okimoto RA, Breitenbuecher F, Olivas VR, Wu W, Gini B, Hofree M, Asthana S, Hrustanovic G, Flanagan J, Tulpule A, Blakely CM, Haringsma HJ, Simmons AD, Gowen K, Suh J, Miller VA, Ali S, Schuler M, Bivona TG. Inactivation of Capicua drives cancer metastasis. Nat Genet. 2017 Jan;49(1):87-96. doi: 10.1038/ng.3728. Epub 2016 Nov 21. PubMed PMID: 27869830; PubMed Central PMCID: PMC5195898.
  3. Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM,Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M,Aisner DL, Vaishnavi A, Ou SH, Collisson EA, Ichihara E, Mack PC, Lovly CM,Karachaliou N, Rosell R, Riess JW, Doebele RC, Bivona TG. RAS-MAPK dependenceunderlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. NatMed. 2015 Sep;21(9):1038-47. doi: 10.1038/nm.3930. Epub 2015 Aug 24. PubMed PMID:26301689; PubMed Central PMCID: PMC4734742.
  4. Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, Nakamura T, Schlaeger TM, Shimamura A, Daley GQ. Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction. Cell Stem Cell. 2013 Jun 6;12(6):727-36. doi:10.1016/j.stem.2013.04.002. Epub 2013 Apr 18. PubMed PMID: 23602541; PubMed Central PMCID: PMC3755012.
  5. Kelley JM, Tulpule A, Daley GQ. Proteolytic autodigestion: common tissue pathology in Shwachman-Diamond syndrome? Cell Cycle. 2013;12(22):3457-8. doi:10.4161/cc.26698. Epub 2013 Oct 8. PubMed PMID: 24107623; PubMed Central PMCID:PMC3906327.
  6. Tulpule A, Lensch MW, Miller JD, Austin K, D'Andrea A, Schlaeger TM, ShimamuraA, Daley GQ. Knockdown of Fanconi anemia genes in human embryonic stem cellsreveals early developmental defects in the hematopoietic lineage. Blood. 2010 Apr29;115(17):3453-62. doi: 10.1182/blood-2009-10-246694. Epub 2010 Jan 20. PubMedPMID: 20089964; PubMed Central PMCID: PMC2867260.
  7. Tulpule A, Daley GQ. Efficient gene knockdowns in human embryonic stem cellsusing lentiviral-based RNAi. Methods Mol Biol. 2009;482:35-42. doi:10.1007/978-1-59745-060-7_3. PubMed PMID: 19089348.
  8. Austin KM, Gupta ML Jr, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB,Mulligan RC, Daley G, Pellman D, Shimamura A. Mitotic spindle destabilization andgenomic instability in Shwachman-Diamond syndrome. J Clin Invest. 2008Apr;118(4):1511-8. doi: 10.1172/JCI33764. PubMed PMID: 18324336; PubMed CentralPMCID: PMC2263145.