University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jonathan Weissman, PhD

Jonathan Weissman, PhD

Professor, Dept. of Cellular Molecular Pharmacology, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Education

Harvard College, A.B., 06/1988, Physics
Massachusetts Institute of Technology, Ph.D., 05/1993, Physics


Professional Experience

  • 1993-1996
    Postdoctoral Fellow, Structural/Biochemical Studies of GroEL, Yale University 
  • 1996-2000
    Assistant Professor, Departments of Cellular & Molecular Pharmacology, and Biochemistry & Biophysics, UCSF
  • 2000-2003
    Associate Professor, Departments of Cellular & Molecular Pharmacology, and Biochemistry & Biophysics, UCSF 
  • 2000-present
    Investigator, Howard Hughes Medical Institute, San Francisco, CA
  • 2003-present
    Professor, Department of Cellular & Molecular Pharmacology, UCSF
  • 2010-present
    Vice-chair of Department of Cellular and Molecular Pharmacology, UCSF
  • 2014-present
    Co-Director of Innovative Genomics Initiative of Berkeley and UCSF
  • 2016-present
    Presidents Advisory Committee of the Chan-Zuckerberg Biohub

Honors & Awards

  • 1988
    Summa cum laude in Physics, Harvard University
  • 1988
    NSF Pre-doctoral Fellowship
  • 1996
    David and Lucile Packard Fellowship
  • 1997
    Searle Scholars Program Fellowship
  • 2004
    Protein Society’s Irving Sigal Young Investigator’s Award
  • 2008
    Raymond & Beverly Sackler International Prize in Biophysics
  • 2009
    Member National Academy of Sciences USA
  • 2009
    David Perlman Award Lecturer of the ACS
  • 2009
    Fellow American Academy of Microbiology
  • 2013
    Marshall Nirenberg Lecturer, National Institutes of Health
  • 2013
    Bashour Distinguished Lecturer, University of Texas Southwestern Medical Center
  • 2014
    Max Planck Distinguished Seminar, Max Planck Institute (MPI) for Developmental Biology
  • 2014
    Cedars-Sinai Medical Center Research Day 2014 Lecturer, Academic Senate Faculty Research Lecturer in Basic Science, UCSF
  • 2015
    National Academy of Sciences Award for Scientific Discovery
  • 2015
    12th Annual Albert L. Lehninger Lecturer, Johns Hopkins University
  • 2015
    Keith R. Porter Lecture Award, American Society for Cell Biology
  • 2016
    Frank H. Westheimer Prize Lecture, Harvard University

Selected Publications

  1. Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS. Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs. Nat Biotechnol. 2020 Jan 13.
    View on PubMed
  2. Monahan Vargas EJ, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y. The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Genes Dev. 2020 Jan 09.
    View on PubMed
  3. Wynn-Jones W, Koehlmoos TP, Tompkins C, Navathe A, Lipsitz S, Kwon NK, Learn PA, Madsen C, Schoenfeld A, Weissman JS. Variation in expenditure for common, high cost surgical procedures in a working age population: implications for reimbursement reform. BMC Health Serv Res. 2019 Nov 21; 19(1):877.
    View on PubMed
  4. Ngo AM, Shurtleff MJ, Popova KD, Kulsuptrakul J, Weissman JS, Puschnik AS. The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins. Elife. 2019 09 13; 8.
    View on PubMed
  5. Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J. New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. J Cell Biol. 2019 Nov 04; 218(11):3861-3879.
    View on PubMed
  6. Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS. Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. Science. 2019 08 23; 365(6455):786-793.
    View on PubMed
  7. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626.
    View on PubMed
  8. Santos DA, Shi L, Tu BP, Weissman JS. Cycloheximide can distort measurements of mRNA levels and translation efficiency. Nucleic Acids Res. 2019 06 04; 47(10):4974-4985.
    View on PubMed
  9. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Ceapins block the unfolded protein response sensor ATF6a by inducing a neomorphic inter-organelle tether. Elife. 2019 05 31; 8.
    View on PubMed
  10. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2019 Jun 04; 116(23):11291-11298.
    View on PubMed
  11. Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS. Molecular recording of mammalian embryogenesis. Nature. 2019 06; 570(7759):77-82.
    View on PubMed
  12. Ingolia NT, Hussmann JA, Weissman JS. Ribosome Profiling: Global Views of Translation. Cold Spring Harb Perspect Biol. 2019 May 01; 11(5).
    View on PubMed
  13. Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD. Cellular response to small molecules that selectively stall protein synthesis by the ribosome. PLoS Genet. 2019 03; 15(3):e1008057.
    View on PubMed
  14. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8.
    View on PubMed
  15. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22.
    View on PubMed
  16. Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem. 2018 Jul 26; 61(14):6163-6177.
    View on PubMed
  17. Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. 2018 07; 559(7714):405-409.
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  18. Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. Elife. 2018 07 09; 7.
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  19. Guenther UP, Weinberg DE, Zubradt MM, Tedeschi FA, Stawicki BN, Zagore LL, Brar GA, Licatalosi DD, Bartel DP, Weissman JS, Jankowsky E. The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. Nature. 2018 07; 559(7712):130-134.
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  20. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife. 2018 05 29; 7.
    View on PubMed

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