University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jonathan Weissman, PhD

Jonathan Weissman, PhD

Professor, Dept. of Cellular Molecular Pharmacology, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Education

Harvard College, A.B., 06/1988, Physics
Massachusetts Institute of Technology, Ph.D., 05/1993, Physics


Professional Experience

  • 1993-1996
    Postdoctoral Fellow, Structural/Biochemical Studies of GroEL, Yale University 
  • 1996-2000
    Assistant Professor, Departments of Cellular & Molecular Pharmacology, and Biochemistry & Biophysics, UCSF
  • 2000-2003
    Associate Professor, Departments of Cellular & Molecular Pharmacology, and Biochemistry & Biophysics, UCSF 
  • 2000-present
    Investigator, Howard Hughes Medical Institute, San Francisco, CA
  • 2003-present
    Professor, Department of Cellular & Molecular Pharmacology, UCSF
  • 2010-present
    Vice-chair of Department of Cellular and Molecular Pharmacology, UCSF
  • 2014-present
    Co-Director of Innovative Genomics Initiative of Berkeley and UCSF
  • 2016-present
    Presidents Advisory Committee of the Chan-Zuckerberg Biohub

Honors & Awards

  • 1988
    Summa cum laude in Physics, Harvard University
  • 1988
    NSF Pre-doctoral Fellowship
  • 1996
    David and Lucile Packard Fellowship
  • 1997
    Searle Scholars Program Fellowship
  • 2004
    Protein Society’s Irving Sigal Young Investigator’s Award
  • 2008
    Raymond & Beverly Sackler International Prize in Biophysics
  • 2009
    Member National Academy of Sciences USA
  • 2009
    David Perlman Award Lecturer of the ACS
  • 2009
    Fellow American Academy of Microbiology
  • 2013
    Marshall Nirenberg Lecturer, National Institutes of Health
  • 2013
    Bashour Distinguished Lecturer, University of Texas Southwestern Medical Center
  • 2014
    Max Planck Distinguished Seminar, Max Planck Institute (MPI) for Developmental Biology
  • 2014
    Cedars-Sinai Medical Center Research Day 2014 Lecturer, Academic Senate Faculty Research Lecturer in Basic Science, UCSF
  • 2015
    National Academy of Sciences Award for Scientific Discovery
  • 2015
    12th Annual Albert L. Lehninger Lecturer, Johns Hopkins University
  • 2015
    Keith R. Porter Lecture Award, American Society for Cell Biology
  • 2016
    Frank H. Westheimer Prize Lecture, Harvard University

Selected Publications

  1. Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J. New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. J Cell Biol. 2019 Sep 05.
    View on PubMed
  2. Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS. Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. Science. 2019 Aug 08.
    View on PubMed
  3. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626.
    View on PubMed
  4. Santos DA, Shi L, Tu BP, Weissman JS. Cycloheximide can distort measurements of mRNA levels and translation efficiency. Nucleic Acids Res. 2019 Jun 04; 47(10):4974-4985.
    View on PubMed
  5. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Ceapins block the unfolded protein response sensor ATF6a by inducing a neomorphic inter-organelle tether. Elife. 2019 May 31; 8.
    View on PubMed
  6. Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR. Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2019 Jun 04; 116(23):11291-11298.
    View on PubMed
  7. Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS. Molecular recording of mammalian embryogenesis. Nature. 2019 06; 570(7759):77-82.
    View on PubMed
  8. Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD. Cellular response to small molecules that selectively stall protein synthesis by the ribosome. PLoS Genet. 2019 03; 15(3):e1008057.
    View on PubMed
  9. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 Apr 04; 74(1):32-44.e8.
    View on PubMed
  10. Ingolia NT, Hussmann JA, Weissman JS. Ribosome Profiling: Global Views of Translation. Cold Spring Harb Perspect Biol. 2018 Jul 23.
    View on PubMed
  11. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. Mapping the Genetic Landscape of Human Cells. Cell. 2018 Aug 09; 174(4):953-967.e22.
    View on PubMed
  12. Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers L, Gestwicki JE. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem. 2018 Jul 26; 61(14):6163-6177.
    View on PubMed
  13. Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. 2018 07; 559(7714):405-409.
    View on PubMed
  14. Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. Elife. 2018 07 09; 7.
    View on PubMed
  15. Guenther UP, Weinberg DE, Zubradt MM, Tedeschi FA, Stawicki BN, Zagore LL, Brar GA, Licatalosi DD, Bartel DP, Weissman JS, Jankowsky E. The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. Nature. 2018 07; 559(7712):130-134.
    View on PubMed
  16. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife. 2018 05 29; 7.
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  17. Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH. Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology. 2018 08; 68(2):663-676.
    View on PubMed
  18. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife. 2018 05 10; 7.
    View on PubMed
  19. Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018 05 31; 173(6):1398-1412.e22.
    View on PubMed
  20. Zhang Y, Burkhardt DH, Rouskin S, Li GW, Weissman JS, Gross CA. A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation. Mol Cell. 2018 04 19; 70(2):274-286.e7.
    View on PubMed

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