Research Funding

  • August 10, 2017 - July 31, 2022 - The Cancer Target Discovery and Development Network at UCSF, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA217882
  • September 30, 2013 - May 31, 2018 - Harnessing CRISPR for Targeted and Inducible Epigenomic Reprogramming, Principal Investigator. Sponsor: NIH/NIDA, Sponsor Award ID: R01DA036858
  • May 1, 2012 - April 30, 2017 - Bay Area Cancer Target Discovery and Development Network, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA168370
  • May 1, 2012 - April 30, 2017 - Human Gene Knockdowns that May Extend Lifespan, Principal Investigator. Sponsor: NIH/NIA, Sponsor Award ID: R01AG041826

Education

Harvard College, A.B., 06/1988, Physics
Massachusetts Institute of Technology, Ph.D., 05/1993, Physics

Honors & Awards

  • 1988
    Summa cum laude in Physics, Harvard University
  • 1988
    NSF Pre-doctoral Fellowship
  • 1996
    David and Lucile Packard Fellowship
  • 1997
    Searle Scholars Program Fellowship
  • 2004
    Protein Society’s Irving Sigal Young Investigator’s Award
  • 2008
    Raymond & Beverly Sackler International Prize in Biophysics
  • 2009
    Member National Academy of Sciences USA
  • 2009
    David Perlman Award Lecturer of the ACS
  • 2009
    Fellow American Academy of Microbiology
  • 2013
    Marshall Nirenberg Lecturer, National Institutes of Health
  • 2013
    Bashour Distinguished Lecturer, University of Texas Southwestern Medical Center
  • 2014
    Max Planck Distinguished Seminar, Max Planck Institute (MPI) for Developmental Biology
  • 2014
    Cedars-Sinai Medical Center Research Day 2014 Lecturer, Academic Senate Faculty Research Lecturer in Basic Science, UCSF
  • 2015
    National Academy of Sciences Award for Scientific Discovery
  • 2015
    12th Annual Albert L. Lehninger Lecturer, Johns Hopkins University
  • 2015
    Keith R. Porter Lecture Award, American Society for Cell Biology
  • 2016
    Frank H. Westheimer Prize Lecture, Harvard University

Selected Publications

  1. Yan X, Stuurman N, Ribeiro SA, Tanenbaum ME, Horlbeck MA, Liem CR, Jost M, Weissman JS, Vale RD High-content imaging-based pooled CRISPR screens in mammalian cells.  View on PubMed
  2. Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, Bivona TG, Weissman JS Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.  View on PubMed
  3. Tian R, Samelson AJ, Rezelj VV, Chen M, Ramadoss GN, Guo X, Kain AM, Tran QD, Lim SA, Lui I, Nunez J, Rockwood SJ, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin B, Vignuzzi M, Kampmann M BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2.  View on PubMed
  4. Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation.  View on PubMed
  5. Liu SJ, Horlbeck MA, Weissman JS, Lim DA Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.  View on PubMed
  6. Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.  View on PubMed
  7. Hawkins JS, Silvis MR, Koo BM, Peters JM, Osadnik H, Jost M, Hearne CC, Weissman JS, Todor H, Gross CA Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.  View on PubMed
  8. Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.  View on PubMed
  9. Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.  View on PubMed
  10. Zou K, Rouskin S, Dervishi K, McCormick MA, Sasikumar A, Deng C, Chen Z, Kaeberlein M, Brem RB, Polymenis M, Kennedy BK, Weissman JS, Zheng J, Ouyang Q, Li H Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.  View on PubMed
  11. Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.  View on PubMed
  12. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.  View on PubMed
  13. O'Loughlin S, Capece MC, Klimova M, Wills NM, Coakley A, Samatova E, O'Connor PBF, Loughran G, Weissman JS, Baranov PV, Rodnina MV, Puglisi JD, Atkins JF Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5' mRNA Stem-Loop and Enhanced Drop-off.  View on PubMed
  14. Jones MG, Khodaverdian A, Quinn JJ, Chan MM, Hussmann JA, Wang R, Xu C, Weissman JS, Yosef N Inference of single-cell phylogenies from lineage tracing data using Cassiopeia.  View on PubMed
  15. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.  View on PubMed
  16. Replogle JM, Norman TM, Xu A, Hussmann JA, Chen J, Cogan JZ, Meer EJ, Terry JM, Riordan DP, Srinivas N, Fiddes IT, Arthur JG, Alvarado LJ, Pfeiffer KA, Mikkelsen TS, Weissman JS, Adamson B Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing.  View on PubMed
  17. Chen J, Brunner AD, Cogan JZ, Nuñez JK, Fields AP, Adamson B, Itzhak DN, Li JY, Mann M, Leonetti MD, Weissman JS Pervasive functional translation of noncanonical human open reading frames.  View on PubMed
  18. Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.  View on PubMed
  19. Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.  View on PubMed
  20. Vargas EJM, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration.  View on PubMed

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