Research Summary

Dr. Yabut's primary research interest is to elucidate the molecular mechanisms regulating neural stem cell behavior in stem cell niches of the developing and postnatal brain using rational mouse models. The ultimate goal of Dr. Yabut's research program is to advance our knowledge on how distinct and functional neural cell lineages are produced and facilitate the development of diagnostic and therapeutic tools to treat neurodevelopmental and neuro-oncological diseases.

Research Funding

  • September 1, 2016 - August 31, 2019 - The Role of Suppressor of Fused in Neural Stem Cells and its Implications in Tumorigenesis, Principal Investigator. Sponsor: NIH, Sponsor Award ID: K01CA201068
  • June 1, 2014 - March 31, 2016 - The Significance of Regulating Shh Signaling in Cortical Progenitor Specification, Principal Investigator. Sponsor: NIH, Sponsor Award ID: F32NS087719
  • September 1, 2016 - May 31, 2020 - The Role of Suppressor of Fused in Neural Stem Cells and its Implications in Tumorigenesis, Principal Investigator. Sponsor: NIH, Sponsor Award ID: K01CA201068
  • June 1, 2014 - March 31, 2016 - The Significance of Regulating Shh Signaling in Cortical Progenitor Specification, Principal Investigator. Sponsor: NIH, Sponsor Award ID: F32NS087719

Education

Rutgers University, Newark, NJ, BA, 2001, Biology
Baylor College of Medicine, Houston, TX, PhD, 2009, Developmental Biology
Rutgers University, Piscataway, NJ, 2010, Neurobiology
University of California San Francisco, 2016, Neurobiology

Honors & Awards

  • 2004 – 2009
    NIH NINDS Diversity Predoctoral Fellowship, Baylor College. of Medicine, Houston, TX
  • 2007
    Selected Speaker, Society for Neuroscience Conference, San Diego, CA
  • 2007
    Selected Speaker, Expert Workshop on the Biology of Chr. 21 Genes, Washington, DC
  • 2012 – 2014
    NIH NINDS Diversity Supplement Postdoctoral Fellowship, UCSF, San Francisco, CA
  • 2014 – 2016
    NIH NINDS National Research Service Award (F32), UCSF, San Francisco, CA
  • 2015 – 2017
    NIH NINDS Pediatric Research LRP Award, UCSF, San Francisco, CA
  • 2016
    American Brain Tumor Association Scholarship, Cold Spring Harbor Labs, NY
  • 2017 – 2019
    NIH NINDS Pediatric Research Renewal LRP Award, UCSF, San Francisco, CA
  • 2016 – 2020
    NIH NCI Research Scientist Development Award (K01), UCSF, San Francisco, CA
  • 2019 – 2021
    American Brain Tumor Association Collaboration Grant

Selected Publications

  1. Gomez HG, Noguchi H, Castillo JG, Aguilar D, Pleasure SJ, Yabut OR. Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism. Biol Open. 2019 Jun 06; 8(6).  View on PubMed
  2. Yabut OR, Pleasure SJ. Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development. Brain Plast. 2018 Aug 10; 3(2):119-128.  View on PubMed
  3. Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ. The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog. J Neurosci. 2018 06 06; 38(23):5237-5250.  View on PubMed
  4. Yabut OR, Pleasure SJ. The Crossroads of Neural Stem Cell Development and Tumorigenesis. Opera Med Physiol. 2016 Dec; 2(3-4):181-187.  View on PubMed
  5. Yabut OR, Ng HX, Fernandez G, Yoon K, Kuhn J, Pleasure SJ. Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors. J Dev Biol. 2016 Dec; 4(4).  View on PubMed
  6. Yabut OR, Fernandez G, Huynh T, Yoon K, Pleasure SJ. Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis. Cell Rep. 2015 Sep 29; 12(12):2021-34.  View on PubMed
  7. Yabut O, Pleasure SJ, Yoon K. A Notch above Sonic Hedgehog. Dev Cell. 2015 May 26; 33(4):371-2.  View on PubMed
  8. Yabut O, Pleasure SJ. The quintessence of quiescence. Neuron. 2014 May 07; 82(3):501-3.  View on PubMed
  9. Wong SS, Ritner C, Ramachandran S, Aurigui J, Pitt C, Chandra P, Ling VB, Yabut O, Bernstein HS. miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in human embryonic stem cells. PLoS One. 2012; 7(4):e36121.  View on PubMed
  10. Yabut O, Bernstein HS. The promise of human embryonic stem cells in aging-associated diseases. Aging (Albany NY). 2011 May; 3(5):494-508.  View on PubMed
  11. Zhang J, Li H, Yabut O, Fitzpatrick H, D'Arcangelo G, Herrup K. Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci. 2010 Apr 14; 30(15):5219-28.  View on PubMed
  12. Yabut O, Domogauer J, D'Arcangelo G. Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. J Neurosci. 2010 Mar 17; 30(11):4004-14.  View on PubMed
  13. Niu S, Yabut O, D'Arcangelo G. The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons. J Neurosci. 2008 Oct 08; 28(41):10339-48.  View on PubMed
  14. Yabut O, Renfro A, Niu S, Swann JW, Marín O, D'Arcangelo G. Abnormal laminar position and dendrite development of interneurons in the reeler forebrain. Brain Res. 2007 Apr 06; 1140:75-83.  View on PubMed

Go to UCSF Profiles, powered by CTSI