Discovery of VH domains that allosterically inhibit ENPP1. Read more about Discovery of VH domains that allosterically inhibit ENPP1.
Polarized focal adhesion kinase activity within a focal adhesion during cell migration. Read more about Polarized focal adhesion kinase activity within a focal adhesion during cell migration.
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Read more about Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability. Read more about Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
Reversible lysine-targeted probes reveal residence time-based kinase selectivity. Read more about Reversible lysine-targeted probes reveal residence time-based kinase selectivity.
KRAS is vulnerable to reversible switch-II pocket engagement in cells. Read more about KRAS is vulnerable to reversible switch-II pocket engagement in cells.
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Read more about ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Read more about Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
Deep mutational scanning reveals the structural basis for α-synuclein activity. Read more about Deep mutational scanning reveals the structural basis for α-synuclein activity.
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Read more about Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
