Thank you for your interest in GI clinical trials at UCSF.
Research studies conducted with cancer patients are called clinical trials. As a cancer patient, you may take part in a clinical trial.
Please see the links below for current open trials at UC San Francisco.
COLORECTAL
METASTATIC
CC#16452:
Phase I Study of TAS-102 (Lonsurf) and Radioembolization with 90Y Resin Microspheres for Chemo-refractory Colorectal Liver Metastases
Contact: Curt Johanson (415) 353-2310:
curt.johanson@ucsf.edu
CC# 159510:
A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10 in Advanced Solid Tumors and in Combination with FOLFIRI for Patients with Previously Treated Metastatic Colorectal Cancer
Contact: Brittany Bianchi (415) 885-3725:
Brittany.Bianchi@ucsf.edu
NEOADJUVANT RECTAL
Alliance N1048:
A Phase II/III Trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision
Contact: Samantha Maisel (415) 502-3310:
Samantha.Maisel@ucsf.edu
ANAL
AMC 092: A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons (NCT02437851).
SURVIVORSHIP
CC#154520 Lifestyle and Outcomes after Gastro-Intestinal Cancer: A Prospective Cohort Study (LOGIC)
Contact: Marissa Savoie (415) 353-7683
LOGICstudy@ucsf.edu
EARLY PHASE
CC#AMC095:
A phase 1 study of Ipilimumab and Nivolumab in Advanced HIV Associated Solid Tumors with an Expansion Cohort in HIV Associated Solid Tumors
Contact: Denisha Otis (415) 748-9513;
Denisha.Otis@ucsf.edu
CC# 149511:
A Phase 1, Open-Label, Dose-Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics and Clinical Effects of Orally Administered CB-5083 in Patients with Advanced Solid Tumors
CC# 15956: A Phase 1, Open-label, Dose Finding Study of CC-90002, a Monoclonal Antibody Directed against CD47, in Subjects with Advanced Solid and Hematologic Cancers
CC# 15958: Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCB054329 in Subjects with Advanced Malignancies
CC# 159510:
A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10 in Advanced Solid Tumors and in Combination with FOLFIRI for Patients with Previously Treated Metastatic Colorectal Cancer
Contact: Armand Harb (415) 353-7381
Armand.Harb@ucsf.edu
CC# 159516: A phase Ib, open-label study of alpelisib (BYL719) in combination with cisplatin in patients with HPV+ solid tumor malignancies
Contact: Armand Harb (415) 353-7381
Armand.Harb@ucsf.edu
CC# 159518:
A Phase I, First-Time-in-Human Study of MEDI9197, a TLR 7/8 Agonist, Administered Intratumorally in Subjects with a Solid Tumor Cancer
Contact: Nilson Wu (415) 353-4084
Nilson.Wu@ucsf.edu
CC# 159520:
A Platform Study Exploring the Safety, Tolerability, Effects on the Tumor Microenvironment and Efficacy of Pembrolizumab (MK-3475) + INCB Combinations in Advanced Solid Tumors
Contact: Claire Hooker (415) 885-3724
Claire.Hooker@ucsf.edu
CC# 159512:
A Phase 1 Open-Label First-in-Human Dose-Escalating Safety and Tolerability Study Evaluating Subcutaneous Administration of Andes-1537 for Injection in Patients With Advanced Unresectable Solid Tumors That Are Refractory to Standard Therapy or For Which No Standard Therapy Is Available
Contact: Emily Boyd (415) 514-6638
Emily.Boyd2@ucsf.edu
CC# 16954:
Phase 1/2 Study of CORT125134 in Combination with Nab-paclitaxel in Patients with Solid Tumors
CC#169518:
Phase I clinical trial of VX-970 in combination with the topoisomerase I inhibitor irinotecan in patients with advanced solid tumors
GASTRO ESOPHAGEAL
CC#159510: A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10 in Advanced Solid Tumors and in Combination with FOLFIRI for Patients with Previously Treated Metastatic Colorectal Cancer
CC# 16459: A Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo in Subjects with Resected Esophageal, or Gastroesophageal Junction Cancer
CC# 154525: A Randomized, Active-Controlled, Partially Blinded, Biomarker Select, Phase III Clinical Trial of Pembrolizumab as Monotherapy and in Combination with Cisplatin+5-Fluorouracil versus Placebo+Cisplatin+5-Fluorouracil as First-Line Treatment in Subjects with Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
Contact: Claire Greene (415) 514-6258: Claire.Greene@ucsf.edu
HEPATOCELLULAR AND BILIARY TRACT
CC# 13455:
A Phase 3, Randomized, Double-blind, Controlled Study of Cabozantinib (XL184) vs Placebo in Subjects with Hepatocellular Carcinoma Who Have Received Prior Sorafenib
Contact: Malori Mindo (415)502-6313:
Malori.Mindo@ucsf.edu
CC# 154514: A Phase II Study of Oral ENMD-2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma (FLC)
Contact: Samantha Maisel (415) 502-3310:
Samantha.Maisel@ucsf.edu
CC# 154523:
A Randomized, Multi-center Phase III Study of Nivolumab versus Sorafenib as First-Line Treatment in Patients with Advanced Hepatocellular Carcinoma
Contact: Kelly Bauer (415) 514-4633: Kelly.Bauer@ucsf.edu
CC# 154524:
A Phase II Trial of Pembrolizumab (MK-3475) with GM-CSF Induction in Advanced Biliary Cancers
Contact: Emily Mitchell (415) 476-5442: Emily.Mitchell@ucsf.edu
CC# 16451:
A Study of Safety, Tolerability, and Clinical Activity of MEDI4736 and Tremeliumumab Administered as Monotherapy and in Combination to Subjects with Unresectable Hepatocellular Carcinoma
Contact: Ari Alfaro (415) 353-7284: AlfaroA@cc.ucsf.edu
CC# 16456:
Phase II Study of Pembrolizumab (MK-3475) as Monotherapy in Subjects with Advanced Hepatocellular Carcinoma who Progressed on or Were Intolerant to First-Line Systemic Therapy
Contact: Kelly Bauer (415) 514-4633: Kelly.Bauer@ucsf.edu
CC#16457:
Protocol I3O-MC-JSBF Randomized, Double-Blind, Phase 2 Study of Ramucirumab or Merestinib or Placebo plus Cisplatin and Gemcitabine as First-Line Treatment in Patients with Advanced or Metastatic Biliary Tract Cancer
Contact: Malori Mindo (415) 502-6313: Malori.Mindo@ucsf.edu
CC#16458: A Multicenter Phase I/II Study of Enzalutamide With and Without Sorafenib in Advanced Hepatocellular Carcinoma Patients
Contact: Paige Steiding (415) 514-6314: Paige.Steiding@ucsf.edu
CC#15452: A Phase II Multicenter, Single Arm Study of Oral BGJ398 in Adult Patients with Advanced or Metastatic Cholangiocarcinoma with FGFR2 Gene Fusions or Other FGFR Genetic Alterations Who Failed or Are Intolerant to Platinum-based Chemotherapy
Contact: Maddy Griffith (415) 476-7974: Madeline.Griffith@ucsf.edu
CC# 164514: Phase I Dose-Escalating Study of Combining Tirapazamine and Transarterial Embolization in Hepatocellular Carincoma
Contact: Curt Johanson (415) 353-2310: Curt.Johanson@ucsf.edu
NEUROENDOCRINE TUMORS
CC#14453: Evaluation of Gallium-68 DOTA-TOC Imaging of Somatostatin Receptor Positive Malignancies
Contact: Thomas Hope:
Thomas.Hope@ucsf.edu
CC# 149511:
A Phase 1, Open-Label, Dose-Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics and Clinical Effects of Orally Administered CB-5083 in Patients with Advanced Solid Tumors
CC#16455: Expanded Access Protocol for Therapeutic Use of 177Lu-DOTA0-Tyr3-Octreotate in Patients with Inoperable, Somatostatin Receptor Positive, Midgut Carcinoid Tumors, Progressive Under Somatostatin Analogue Therapy
CC#144515: A Phase II Study of PEGPH20, Gemcitabine Plus Nab-Paclitaxel in Patients With Upfront or Borderline Resectable Pancreatic Cancer
Contact: Louis Wong (415) 514-8101: Louis.Wong@ucsf.edu
CC#144525: A Phase Ib/II Safety and Efficacy Trial of Ibrutinib Combined with Gemcitabine and Nab-Paclitaxel in Patients with Metastatic Pancreatic Adenocarcinoma
Contact: Maddy Griffith (415) 476-7974: Madeline.Griffith@ucsf.edu
CC#15459: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of MM-141 plus Nab-Paclitaxel and Gemcitabine versus Nab-Paclitaxel and Gemcitabine in Front-Line Metastatic Pancreatic Cancer (CARRIE)
Contact: Ari Alfaro (415) 353-7284: AlfaroA@cc.ucsf.edu
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**TO BE OPENED WITHIN 3 MONTHS**
CC#169517: A Phase I Dose Escalation Study, with Cohort Expansion, to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AbGn-107 Therapy in Patients with Chemo-refractory Locally Advanced, Recurrent, or Metastatic Gastric, Colorectal, or Pancreatic Cancer
CC#17451:
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled Study of AG-120 in Previously-treated Subjects with Nonresectable or Metastatic Cholangiocarcinoma with an IDH1 Mutation
Contact: Malori Mindo (415) 502-6313: Malori.Mindo@ucsf.edu
CC#17452:
An open label phase II study to evaluate the efficacy and safety of PDR001 in patients with advanced or metastatic non-functional neuroendocrine tumors of pancreatic, gastrointestinal (GI), or thoracic origin who have progressed on prior treatment
Contact: Bryant Chee (415) 353-7145:
Bryant.Chee@ucsf.edu
CC#164518:
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) in Combination with nab-Paclitaxel Plus Gemcitabine Compared with Placebo Plus nab-Paclitaxel and Gemcitabine in Subjects with Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma
Contact: Louis Wong (415) 514-8101
Louis.Wong@ucsf.edu
CC#17455
: Yttrium-90 DOTA-TOC Intra-arterial (IA) Peptide Receptor Radionuclide Therapy (PRRT) for Neuroendocrine Tumor
Contact: Bryant Chee (415) 353-7145:
Bryant.Chee@ucsf.edu
CC#16452:
A Dose-Finding Phase 1 Study of TAS-120 in Patients With Advanced Solid Tumors With or Without Fibroblast Growth Factor/Receptor (FGF/FGFR)-Related Abnormalities followed by a Phase 2 Study in Patients with Advanced Solid Tumors with FGF/FGFR-Related
Contact: Maddy Griffith (415) 476-7974:
Madeline.Griffith@ucsf.edu
For information on Phase 1 clinical trials not listed in this newsletter please contact:
Anne Reinert, NP (415) 415-353-9291: Anne.Reinert@ucsfmedctr.org
