abalmain@cc.ucsf.edu
(415) 514-0229 (asst); (415) 502-4192 (office)
(415) 502-6791 (lab); (415) 502-6779 (fax)

Box 0875, UCSF; San Francisco, CA 94143-0875

additional websites:

Balmain Lab Website

University of Glasgow, BSc, 1966, Hons. Chemistry
University of Glasgow, Ph.D., 1969, Organic Chemistry
University of Strasbourg, France, Postdoc, 1969-71
German Cancer Research Centre, Heidelberg, West Germany, Postdoc, 1971-72

A detailed research statement on this site includes additional references to recent articles and reviews.

Selected References (from >180)

Nagase, H.; Mao, J.H.; and Balmain, A. (1999) A subset of skin tumor modifier loci determines survival time of tumor-bearing mice, Proc Natl Acad Sci U S A. Dec; 96(26):15032-7

Petritsch, C.; Beug, H.; Balmain, A. and Oft, M. (2000) TGFβ inhibits p70S6 kinase via protein phosphatase 2A to induce growth arrest. Genes and Development, Dec; 14(24):3093-101

Nagase, H., Mao, J., deKoning, John, Minami, T., Balmain, A., (2001) Epistatic Interactions between Skin Tumor Modifier Loci in Interspecific (spretus/musculus) Backcross Mice. Cancer Research, Advances in Brief, February; 61(4), 1305-8

Balmain, A., (2001) Cancer Genetics: from Boveri and Mendel to Microarrays. Nature Reviews Cancer, 1(1):77-82

Derynck, R., Akhurst, R., Balmain, A., (2001) TGF-β signaling in tumor suppression and cancer progression. Nature Genetics 29(2):117-129

Hann, B., Balmain, A., (2001) Building �evalidated�f mouse models of human cancer. Current Opinion in Cell Biology, 13(6):778-784

Balmain, A., (2002) Cancer as a Complex Genetic Trait: Tumor Susceptibility in Humans and Mouse Models, Cell, 108(2):145-152.

Cai, W., Mao, J., Chow, C., Damani, S., Balmain, A., and Bradley, (2002) A. Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays, Nature Biotechnology, 20(4): 393-396

Balmain, A., (2002) New-age tumor suppressors, Nature 417(6886): 235-237

Oft, M., Akhurst, R., Balmain, A., (2002) Metastasis is driven by sequential elevation of H-ras and Smad2 levels, Nature Cell Biology, 4(7): 487-494

Psichari E., Balmain A., Plows, D., Zoumpourlis, V., Pintzas, A., (2002) High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling, J Biol Chem, 277(33): 29490-29495

Balmain, A., Gray, J., and Ponder, B.A. (2003) The genetics and genomics of cancer. Nature Genetics, 33: 238-244

Perez-Losada, J., and Balmain, A. (2003) Stem cell hierarchy in skin cancer. Nature Cancer Reviews, 3(6): 434-43 .

Mao, J.-H. and Balmain, A. (2003) Genomic approaches to identification of tumor susceptibility genes using mouse models. Curr. Op.Genet.Develop., 13(1): 14-19

Mao, J-H., Wu, D., Perez-Losada, J., Nagase, H., DelRosario, R., and Balmain, A., (2003) Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene, 22(52): 8379-85

Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A., (2003) Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet. 34(4):403-12

Mao JH, Wu D, Perez-Losada J, Nagase H, DelRosario R, Balmain A. Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene. 2003 Nov 20;22(52):8379-85.

Balmain A, Akhurst RJ Cancer: dangerous liaisons. Nature. 2004 Mar 18;428(6980):271-2

Girardi M, Oppenheim D, Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma. J Invest Dermatol. 2004 Mar;122(3):699-706

Ewart-Toland A, Chan JM, Yuan J, Balmain A, Ma J A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer. Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):759-64

Ewart-Toland A, Balmain A The genetics of cancer susceptibility: from mouse to man Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:26-30

Mao JH, To MD, Perez-Losada J, Wu D, Del Rosario R, Balmain A. Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Dev. 2004 Aug 1;18(15):1800-5

Li J, Jiang T, Mao JH, Balmain A, Peterson L, Harris C, Rao PH, Havlak P, Gibbs R, Cai WW. Genomic segmental polymorphisms in inbred mouse strains. Nat Genet. 2004 Sep;36(9):952-4. Epub 2004 Aug 22

Jian-Hua Mao, Jesus Perez-losada, Di Wu, Reyno DelRosario, Tsunematsu R, Nakayama KI, Ken Brown, Sheila Bryson, and Allan Balmain. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 2004 Dec 9;432(7018):775-9.

Dai Q, Cai QY, Shu XO, Ewart-Toland A, Wen WQ, Balmain A, Gao YT, Zheng W. Synergistic Effects of STK15 Gene Polymorphisms and Endogenous Estrogen Exposure in the Risk of Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2065-70

Snijders AM, Nowak NJ, Huey B, Fridlyand J, Law S, Conroy J, Tokuyasu T, Demir K, Chiu R, Mao JH, Jain AN, Jones SJ, Balmain A, Pinkel D, Albertson DG. Mapping segmental and sequence variations among laboratory mice using BAC array CGH Genome Res. 15: 302-311 (2005).

Perez-losada J, Wu D, DelRosario R, Balmain A and Mao JH. p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. Oncogene. 2005 Jun 20; [Epub ahead of print].

Ewart-Toland A, Dai Q, Gao YT, Nagase H, Dunlop MG, Farrington SM, Barnetson RA, Anton-Culver H, Peel d, Ziogas A, Lin D, Miao X, Sun T, Ostrander EA, Stanford JL, Langlois M, Chan JM, Yuan J, Harris C, Bowman E, Clayman GL, Lippman SM, Lee JJ, Zheng W, Balmain A. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of Multiple cancer types. Carcinogenesis. 2005 Aug;26(8):1368-73. Epub 2005 Mar 31.

Perez-Losada J, Mao JH, Balmain A, Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res. 2005 Aug 1;65(15):6488-92.

To, M., Perez-Losada, J., Mao, J-H., and Balmain, A. Crosstalk between Pten and Ras pathways in epithelial carcinogenesis. Cell Cycle, 2005 Sep;4(9):1185-8.

Mao JH, Li J, Jiang T, Li Q, Wu D, Perez-Losada J, DelRosario R, Peterson L, Balmain A, Cai WW. Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene. 2005 Nov 24;24(53):7924-34.

Lacher MD, Tiirikainen MI, Saunier EF, Christian C, Anders M, Oft M, Balmain A, Akhurst RJ, Korn WM. Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition. Cancer Res. 2006 Feb 1;66(3):1648-57.

Balmain, A. and Montell, DJ. Oncogenes and cell proliferation: Shifting paradigms in the understanding and treatment of cancer. Curr.Op.Genet.Develop. 2006, 16, 1-3.

Mao J-H , Elise F. Saunier, John P. de Koning, Margaret M. McKinnon, Mamie Nakijama Higgins, Kathy Nicklas, Hai-Tao Yang, Allan Balmain and Rosemary J. Akhurst. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8125-30.

To MD , Perez-Losada J , Mao J-H , Hsu J , Jacks T, Balmain A. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in KrasLA2 mice. Nat Genet. 2006 Aug;38(8):926-30.

12/7/06