Allan Balmain, PhD, FRSE

University of Glasgow, BSc, 1966, Hons. Chemistry
University of Glasgow, Ph.D., 1969, Organic Chemistry
University of Strasbourg, France, Postdoc, 1969-71
German Cancer Research Centre, Heidelberg, West Germany, Postdoc, 1971-72

• 1972-1976
  Tenured member of staff, German Cancer Research Centre, Heidelberg, Germany
• 1976-1982
  Staff Scientist, Beatson Institute for Cancer Research, Glasgow
• 1982-1994
  Group Leader, Beatson Institute for Cancer Research, Glasgow
• 1987-1994
  CRC Special Appointment, Beatson Institute for Cancer Research, Glasgow
• 1994-1996
  Director of Laboratory Research and Professor of Molecular Oncology, Dept. of Medical Oncology, University of Glasgow, Jerry Turner Fellow of the Cancer Research Campaign
• 1996-1998
  Vice President, Research, Onyx Pharmaceuticals, Richmond, CA
• 1999-2001
  Professor of Cancer Genetics, Cancer Research Institute and Departments of Biochemistry and Biophysics, UCSF
• 2001-present
  Barbara Bass Bakar Endowed Chair in Cancer Genetics, UCSF

• Royal Society European Programme Fellowship
• Alexander Von Humboldt-Stiftung Fellowship
• 1995
  Elected Fellow of the Royal Society of Edinburgh
• 1999
  Elected to UICC (International Union Against Cancer) Roll of Honor
• 2000
  Tom Connors Prize and lecture
• 2007
  John B. Little Award, Harvard School of Public Health
• 2011
  American Skin Association Achievement Award

• A detailed research statement on this site includes additional references to recent articles and reviews. Selected References (from >180)
• Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A., (2003) Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet. 34(4):403-12. PMID: 12881723
• Balmain A, Akhurst RJ Cancer: dangerous liaisons. Nature. 2004;428(6980):271-2. PMID: 15029181
• Li J, Jiang T, Mao JH, Balmain A, Peterson L, Harris C, Rao PH, Havlak P, Gibbs R, Cai WW. Genomic segmental polymorphisms in inbred mouse strains. Nat Genet. 2004;36(9):952-4. Epub 2004 Aug 22. PMCID: 15322544
• Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature. 2004;432(7018):775-9. PMID: 15592418
• Snijders AM, Nowak NJ, Huey B, Fridlyand J, Law S, Conroy J, Tokuyasu T, Demir K, Chiu R, Mao JH, Jain AN, Jones SJ, Balmain A, Pinkel D, Albertson DG. Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res. 2005;15(2):302-11. PMCID: PMC546532
• Mao JH, Saunier EF, de Koning JP, McKinnon MM, Higgins MN, Nicklas K, Yang HT, Balmain A, Akhurst RJ. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A. 2006;103(21):8125-30. PMCID: PMC1472440
• To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2(LA2) mice. Nat Genet. 2006 38 926-30. PMID: 16823377
• Mao JH, Wu D, Perez-Losada J, Jiang T, Li Q, Neve RM, Gray JW, Cai WW, and Balmain A. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007).11 (2) 161-73. PMID: 16823377
• Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature. 2007; 445(7129):761-5. PMID: 17230190
• Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, Huang EJ. HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13040-5. Epub 2007 Jul 31. PMCID: PMC1936219
• To MD, Wong CE, Karnezis AN, Del Rosario R, Di Lauro R, Balmain A. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet. 2008 Oct;40(10):1240-4. PMCID: PMC2654781
• Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science. 2008 Sep 12;321(5895):1499-502. PMCID: PMC2849753
• Quigley DA, To MD, Pérez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, Balmain A. Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature. 2009 458. 505-8. PMID 19136944
• Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S. A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell. 2009 Apr 3;137(1):87-98. PMID: 19345189
• Quigley DA, Balmain A. Systems Genetics Analysis of cancer susceptibility:from mouse models to humans. Nat Rev Genet 2009 Sep;10(9):651-7. Epub 2009 Jul 28. PMID: 19636343
• Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A., J Clin Oncol. Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. 2010 Aug 10;28(23):3770-8. Epub 2010 Jul 12. PMID: 20625127
• Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17268-73. Epub 2010 Sep 20. PMID: 20855625
• Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Perez-Losada J, Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011 Jan 18;12(1):R5. PMID: 21244661
• Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1:25(13);1426-38. PMID: 21724834