Boris C. Bastian, MD, PhD

Humboldt-Gymnasium, Solingen, Germany, Baccalaureate, 1980
University of Munich, Germany, M.D., 1988, Medicine
University of Munich, Germany, Dr. med., 1989, Laboratory Medicine
University of Wurzburg, Germany, Residency, 1994, Dermatology
University of California, San Francisco, Postdoctoral, 1999, Cancer Genetics

• 1986-1989
  Dissertation 'Development and Characterization of an enzymatic assay for human pancreatic phospholipase A2'
• 1988-89
  Fellowship, Dept. of Hematology, Ludwig-Maximilian-University, Munich, Germany
• 1989-1994
  Residency, Dermatology, Dept. of Dermatology, University of Würzburg, Germany
• 1993
  German board certification for Dermatology
• 1995
  German board certification Allergy and Immunology
• 1994-1997
  Attending Physician, Dept. of Dermatology, University of Würzburg, Germany
• 1995-1997
  Director of the Dermatopathology Section, Dept. of Dermatology, University of Würzburg, Germany
• 1997-1999
  Postdoctoral Fellowship, Cancer Genetics Group, Cancer Center at UCSF
• 1999-2002
  Assistant Clinical Professor, Dept. of Dermatology and Pathology, UCSF
• 2002-2004
  Assistant Professor in Residence, Department of Dermatology and Assistant Clinical Professor, Department of Pathology, UCSF
• 7/2004-2008
  Associate Professor in Residence, Department of Dermatology and Associate Clinical Professor, Department of Pathology, UCSF
• 7/2008
  Professor in Residence, Department of Dermatology and Clinical Professor, Department of Pathology, UCSF
• 9/2008
  Leader, Cutaneous Oncology Program, UCSF
• 4/2010-8/11
  Chairman, Department of Pathology, and Member, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
• 9/2011-present
  Professor of Dermatology and Pathology, Gerson and Barbara Bakar Distinguished Professor of Cancer Biology, University of California, San Francisco

• 1995
  Graduate Stipend of the Novartis Foundation for Therapeutic Research
• 1997
  Habilitandenstipendium of the German Research Society (Deutsche Forschungsgemeinschaft)
• 2000
  American Melanoma Foundation Research Award
• 2001
  American Skin Association Research Scientist Development Award
• 2005
  Hermann Pinkus Lectureship and Award, American Society of Dermatopathology
• 2006
  Stewart Trust Award
• 2007
  Melanoma Research Foundation Individual Investigator Award
• 2008
  Abby S. and Howard P. Milstein Innovation Award for Skin Cancer Research, American Skin Association
• 2011-2013
  President, Society of Melanoma Research
• 2011
  German National Academy of Science (Leopoldina)

• Bastian BC, LeBoit PE, Hamm H, Bröcker EB, Pinkel D. Chromosomal Gains and Losses in Primary Cutaneous Melanomas Detected by Comparative Genomic Hybridization. Cancer Res. 1998;58:2170-2175. PMID 10766187.
• Bastian BC , Kashani-Sabet M, Hamm H, Godfrey T, Moore II DH, Bröcker EB, LeBoit PE, Pinkel D.
• Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells. Cancer Res. 2000;60: 1968-73. PMID 10766187.
• Bastian BC, LeBoit, P. E., and Pinkel, D. Mutations and copy number increases of HRAS in Spitz nevi with distinctive histopathologic features, Am. J. Pathol. 2000;157: 967-972. PMCID PMC1885704.
• Sauter, E.R., Yeo U.C., von Stemm, A., Weizhu, Z., Litwin, S., Tichansky, S., Nesbit, M., Pinkel, D., Herlyn, M., and Bastian BC Cyclin D1 is a Candidate Oncogene in Cutaneous Melanoma. Cancer Res. 2002 Jun 1;62(11):3200-6. PMID 12036934.
• Bastian BC, Olshen A, LeBoit PE, Pinkel D: Classification of melanocytic tumors by DNA copy number changes. Am J Pathol 2003;163, 1765-1770. PMCID PMC1892437.
• Maldonado JL, Fridlyand J, Patel H, Jain AN, Busam K, Kageshita T, Ono T, Albertson D, Pinkel D, Bastian BC: Determinants of BRAF mutations in primary melanoma. J Natl Cancer Inst 2003 Dec 17;95(24):1878-90. PMID 14679157.
• Maize Jr., JC, McCalmont TH, Carlson JA, Busam KJ, Kutzner H, Bastian BC. Genomic Analysis of Blue Nevi and Related Dermal Melanocytic Proliferations Am J Surg Pathol. 2005 Sep;29(9):1214-1220. PMID 16096412.
• Curtin JA, Fridlyand J, Kageshita T, Patel H, Busam K, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, Pinkel D, Bastian BC. Distinct Sets of Genetic Alterations in Melanoma. N Engl J Med. 2005 17;353(20):2135-47. PMID 16291983.
• Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P, Calista D, Pinkel D, Kanetsky PA, Bastian BC. MC1R Germline Variants Confer Risk for BRAF-Mutant Melanoma. Science 2006;313(5786):512-2.
• Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P, Calista D, Kanetsky PA, Pinkel D, Bastian BC, ‚ÄúMC1R Germline Variants Confer Risk for BRAF-Mutant Melanoma,‚Äù Science 313, no. 5786 (2006): 512-
• Curtin, J. A., Busam, K., Pinkel, D., and Bastian BC. Somatic Activation of KIT in Distinct Subtypes of Melanoma. J Clin Oncol, 2006 Sep 10; 24(26):4340-6. Epub 2006 Aug 14. PMID 16908931.
• Denoyelle C*, Abou-Rjaily G*, Bezrookove V*, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol. 2006;8(10):1053-63. Epub 2006 Sep 10. PMID 16964246.
• Viros A, Fridlyand J, Bauer J, Lasithiotakis K, Garbe C, Pinkel D, Bastian BC, Improving Melanoma Classification by Integrating Genetic and Morphologic Features. PLOS Medicine. 2008;5(6):e120. PMCID PMC2408611.
• Van Raamsdonk, CD, Bezrookove V, Green G, Bauer J, Gaugler L, O‚ O'Brien JM, Simpson EM, Barsh GE, Bastian BC. Frequent somatic mutations of GNAQ in uveal melanoma and blue nevi. Nature. 2009 Jan 29;457(7229):599-602. Epub 2008 Dec 10. PMCID PMC2696133.
• Gerami P, Jewell SS, Morrison LE, Blondin B, Schulz J, Ruffalo T, Matushek P, Legator M, Jacobson K, Dalton SR, Charzan S, Kolaitis NA, Guitart J, Lertsbarapa T, Boone S, LeBoit PE, Bastian BC. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am. J. Surg. Pathol 2009 Aug;33(8):1146-1156. PMID 19561450.
• Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel, Werner, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dogalev I, Khanin R, Busam K, Speicher MR, O'Brien JM, Bastian BC. Mutations in GNA11 in Uveal Melanoma. N Engl J Med 2010; Dec 2;363(23):2191-9. PMID 21083380
• Wiesner T, Obenauf AC, Murali R, Fried I, Griewank KG, Ulz P, Windpassinger C, Wackernagel W, Loy S, Wolf I, Viale A, Lash AE, Pirun M, Socci ND, Rütten A, Palmedo G, Abramson D, Offit K, Ott A, Becker JC, Cerroni L, Kutzner H, Bastian BC*, Speicher MR*. Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet, August 2011, published online ahead of print
• *co-corresponding and co--last authors