bastian@cc.ucsf.edu
(415) 476-5132
(415) 476-8218 (fax)

Box 0808, UCSF; San Francisco, CA 94143-0808

1972-1980, Humboldt-Gymnasium, Solingen
1981-1982, Chemistry, University of Cologne
1982-1988, Medicine, Ludwig-Maximilian-University of Munich

Bastian, B., Sellert C, Seekamp A, Römisch J, Pàques EP, Bröcker EB. The inhibition of human skin phospholipase A by 'lipocortins' is an indirect effect of substrate/lipocortin interaction. J. Invest. Dermatol. 101:359-363 (1993)

Drepper H, Köhler CO, Bastian, B. et al. Benefit of Elective Lymph Node Dissection in Subgroups of Melanoma Patients. Results of a Multicenter Study of 3616 Patients. Cancer 72:741-749 (1993)

Dummer W, Blaheta HJ, Bastian, B., Schenk T, Bröcker EB, Remy W. Preoperative characterization of pigmented skin lesions by epiluminescence and high-frequency ultrasound. Arch. Dermatol. 131:279-285 (1995).

Dummer W, Bastian, B., Ernst N, Schänzle C, Schwaaf A, Bröcker EB. Interleukin-10 production in malignant melanoma: Preferential detection of IL-10-secreting tumor cells in metastatic lesions. Int. J. Cancer 66: 607-610 (1996)

Spatz A, Ruiter D, Hardmeier T, Renard N, Weschler J, Bailly C, Avril MF, Kwee F, Bastian, B., Hill C, Prade M. Melanoma in childhood: an EORTC multicenter study. Int. J. Cancer 78:317-324 (1996)

Bastian, B., LeBoit PE, Hamm H, Bröcker EB, Pinkel D Chromosomal Gains and Losses in Primary Cutaneous Melanomas Detected by Comparative Genomic Hybridization. Cancer Res. 58:2170-2175 (1998)

Wesselmann, U., Becker, L. R., Brocker, E. B., LeBoit, P. E., and Bastian, B. Eosinophilic globules in spitz nevi: no evidence for apoptosis, Am J Dermatopathol. 20: 551-4 (1998).

Bastian, B. , Wesselmann U, Pinkel D, LeBoit PE. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J. Invest. Dermatol.113: 1065-9 (1999)

Bastian, B. , Kashani-Sabet M, Hamm H, Godfrey T, Moore II DH, Bröcker EB, LeBoit PE, Pinkel D. Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells. Cancer Res. 60: 1968-73 (2000)

Bastian, B., LeBoit, P. E., and Pinkel, D. Mutations and copy number increases of HRAS in Spitz nevi with distinctive histopathologic features, Am. J. Pathol. 157: 967-972 (2000).

Bardeesy, N., Bastian, B., Hezel, A., D., P., DePinho, R., and Chin, L. Dual inactivation of RB and P53 pathways in RAS-induced melanomas, Mol Cell Biol, 21, 2144-2153. (2001)

Polsky, D., Bastian, B.C., Hazan, C., Melzer, K., Pack, J., Houghton, Jr. A., K. Busam, K., Cordon-Cardo, C., and Osman, I. HDM2 Protein Overexpression, but not Gene Amplification, is Related to Tumorigenesis of Cutaneous Melanoma. Cancer Res 61, 7642-6, 2001

You M.J., Castrillon D.H., Bastian B.C., O'Hagan R.C., Bosenberg M.W., Parsons R., Chin L., and DePinho R.A. Genetic Analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1455-60.

Harvell J.D., Bastian B.C., LeBoit P.E. Persistent and recurrent Spitz nevi: a histopathologic, immunohistochemical and molecular pathologic study of 22 cases. Am J Surg Pathol. 2002 May;26(5):654-61.

Sauter, E.R., Yeo U.C., von Stemm, A., Weizhu, Z., Litwin, S., Tichansky, S., Nesbit, M., Pinkel, D., Herlyn, M., and Bastian, B.C. Cyclin D1 is a Candidate Oncogene in Cutaneous Melanoma. Cancer Res. 2002 Jun 1;62(11):3200-6.

Bastian B.C., Xiong J., Frieden I.J., Williams M.L., Busam K., Pinkel D., LeBoit P.E. Genetic changes in atypical nodular proliferations arising in congenital melanocytic nevi. Am J Pathol. 2002 Oct;161(4):1163-9.

Bastian BC: Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer. Oncogene. 2003 19;22(20):3081-6.

Bastian BC, Olshen A, LeBoit PE, Pinkel D: Classification of melanocytic tumors by DNA copy number changes. Am J Pathol 2003 163, 1765-1770.

Maldonado JL, Fridlyand J, Patel H, Jain AN, Busam K, Kageshita T, Ono T, Albertson D, Pinkel D, Bastian BC: Determinants of BRAF mutations in primary melanoma. J Natl Cancer Inst 2003 95, 1878-1890.

Maldonado, J. L., Fridlyand, J., Timmerman, L., and Bastian, B. C. (2004). Mechanisms of Cell Cycle Arrest in Spitz Nevi With Constitutive Activation of the MAP-Kinase Pathway. Am J Pathol 164, 1783-1787.

Hantschke M, Bastian BC, LeBoit PE. Consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and Spitz nevus. Am J Surg Pathol. 2004 Dec;28(12):1621-5

Maize Jr., JC, McCalmont TH, Carlson JA, Busam KJ, Kutzner H, Bastian BC. Genomic Analysis of Blue Nevi and Related Dermal Melanocytic Proliferations Am J Surg Pathol. 2005 Sep;29(9):1214-1220.

Curtin JA, Fridlyand J, Kageshita T, Patel H, Busam K, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, Pinkel D, Bastian BC. Distinct Sets of Genetic Alterations in Melanoma. N Engl J Med. 2005 17;353(20):2135-47

Curtin, J. A., Stark, M. S., Pinkel, D., Hayward, N. K., and Bastian, B. C. PI3-Kinase Subunits Are Infrequent Somatic Targets in Melanoma. J Invest Dermatol, 2006 Apr 13.

Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P, Calista D, Kanetsky PA, Pinkel D, Bastian BC. MC1R germline variants confer risk for BRAF-mutant melanoma. Science. 2006 Jul 28;313(5786):521-2. Epub 2006 Jun 29.

Bauer, J., Curtin, J. A., Pinkel, D., and Bastian, B. C. Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J Invest Dermatol, 2006 Aug 3.

Curtin, J. A., Busam, K., Pinkel, D., and Bastian, B. C. Somatic Activation of KIT in Distinct Subtypes of Melanoma. J Clin Oncol, 2006 Aug 14

Denoyelle C*, Abou-Rjaily G*, Bezrookove V*, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol. 2006 Sept 10

Dumaz, N., Martin, J., Ogilvie, L., Hedley, D., Curtin, J.A, Bastian, B.C., Springer, C., Marais R. Protein kinase A suppresses the oncogenic potential of C-RAF in human melanocytes. Cancer Res. 2006 Oct 1;66(19):9483-91.

Curtin, J. A., Pinkel, D., and Bastian, B. C. Absence of PDGFRA Mutations in Primary Melanoma. J Invest Dermatol. 2007 Aug 30;

Delmas V, Beermann F, Martinozzi S, Carreira S, Ackermann J, Kumasaka M, Denat L, Goodall J, Luciani F, Viros A, Demirkan N, Bastian BC, Goding CR, Larue L. beta-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev. 2007 Nov 15;21(22):2923-35

North JP, Kageshita T, Pinkel D, Leboit PE, Bastian BC. Distribution and Significance of Occult Intraepidermal Tumor Cells Surrounding Primary Melanoma. J Invest Dermatol. 2008 Mar 6;

Fargnoli MC, Pike K, Pfeiffer RM, Tsang S, Rozenblum E, Munroe DJ, Golubeva Y, Calista D, Seidenari S, Massi D, Carli P, Bauer J, Elder DE, Bastian BC, Peris K, Landi MT. MC1R Variants Increase Risk of Melanomas Harboring BRAF Mutations. J Invest Dermatol. 2008 Mar 27

Viros A, Fridlyand J, Bauer J, Lasithiotakis K, Garbe C, Pinkel D, Bastian BC, Improving Melanoma Classification by Integrating Genetic and Morphologic Features. PLOS Medicine, ;5:e120.

Lutzky J, Bauer J, Bastian BC. Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res. 2008 May 29.

Kim RD, Curtin JA, Bastian BC. Lack of somatic alterations of MC1R in primary melanoma. Pigment Cell Melanoma Res 2008.

Bastian BC, Pinkel D. Expanding the genetic spectrum of pigmentation. Pigment Cell Melanoma Res 2008.

Ridd K, Yu S, Bastian BC. The Presence of Polyomavirus in Non-Melanoma Skin Cancer in Organ Transplant Recipients Is Rare. J Invest Dermatol 2008.

Freedberg DE, Rigas SH, Russak J, et al. Frequent p16-independent inactivation of p14ARF in human melanoma. J Natl Cancer Inst 2008;100:784-95.

Muchemwa FC, Ma D, Inoue Y, et al. Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma. Br J Dermatol 2008;158:411-3.

Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O/'Brien JM, Simpson EM, Barsh GS, Bastian BC. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi Nature. 2008 Dec 10; Available from: http://dx.doi.org/10.1038/nature07586

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