Morris Herzstein Endowed Chair in Biology and Physiology, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
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elizabeth.blackburn@ucsf.edu
Box 2200, UCSF; San Francisco, CA 94143-2200 |
additional websites: |
| EDUCATION | |
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University of Melbourne, Melbourne, Australia, B.Sc., 1970, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1970-1971 |
Graduate Research Student, Master of Science Degree course, Department of Biochemistry, University of Melbourne, Australia |
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1971-1974 |
Graduate Research Student Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Cambridge, England (advisor: F. Sanger) |
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1975-1977 |
Postdoctoral Fellow, Department of Biology, Yale University, New Haven, Connecticut |
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1/78-6/78 |
Postdoctoral Fellow, Department of Biochemistry, UCSF, San Francisco, California |
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1978-1983 |
Assistant Professor, Department of Molecular Biology, University of California, Berkeley |
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1983-1986 |
Associate Professor, Department of Molecular Biology, University of California, Berkeley |
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1986-1990 |
Professor, Department of Molecular Biology, University of California, Berkeley |
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1993-1999 |
Chair, Department of Microbiology and Immunology, University of California, San Francisco |
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1990-present |
Professor, Departments of Biochemistry and Biophysics, and Microbiology and Immunology, , University of California, San Francisco |
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1996-present |
Member, Breast Oncology Program (1996) and Genitourinary Oncology Program (1999), UCSF Helen Diller Family Comprehensive Cancer Center |
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2001-present |
Scientific Advisory Board, Division of Basic Science, Fred Hutchinson Cancer Research Center |
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2003-present |
Scientific Advisory Board, Huntsman Cancer Institute, University of Utah, Salt Lake City |
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2003-present |
Member, National Advisory Council on Aging, National Institute of Aging, NIH |
| HONORS & AWARDS | |
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Elections and Selected Recent Honors |
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1990 |
National Academy of Science Award in Molecular Biology |
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1991 |
Honorary Doctorate of Science, Yale University |
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1992 |
Elected, Fellow of the Royal Society of London |
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1993 |
Elected, Foreign Associate, National Academy of Sciences |
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1996-present |
Member, Breast Oncology Program (1996) and Genitourinary Oncology Program (1999), UCSF Helen Diller Family Comprehensive Cancer Center |
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1998 |
Elected, President, American Society for Cell Biology (ASCB) |
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1998 |
Gairdner Foundation Award |
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1998 |
Australia Prize |
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1998 |
le Grand Prix Charles-Leopold Mayer |
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1999 |
Passano Award |
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1999 |
Rosenstiel Award |
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1999 |
California Scientist of the Year Award |
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1999 |
Harvey Prize |
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1999 |
AAMC Baxter Award |
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1999 |
Novartis-Drew Award for Biomedical Science |
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1999 |
Keio University Medical Science Fund Prize |
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2000 |
The Feodor Lynen Award |
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2000 |
AACR-G.H.A. Clowes Memorial Award |
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2000 |
The Dickson Prize in Medicine |
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2000 |
The Steven and Michele Kirsch Foundation Investigator Fellowship |
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2000 |
Elected, Institute of Medicine |
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2000 |
American Cancer Society Medal of Honor |
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2000 |
Elected, Fellow of the American Association for the Advancement of Science |
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2001 |
AACR-Pezcoller Foundation Award for Cancer Research |
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2001 |
Memorial Sloan-Kettering Cancer Center Katharine Berkan Judd Award Lectureship |
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2001 |
GM Cancer Research Foundation Sloan Award |
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2001 |
E.B. Wilson Award, American Society for Cell Biology |
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2001-present |
Scientific Advisory Board, Division of Basic Science, Fred Hutchinson Cancer Research Center |
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2003 |
City of Medicine Award |
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2003 |
26th Annual Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research |
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2003 |
Indiana University School of Medicine Steven C. Beering Award |
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2003 |
The Robert J. and Claire Pasarow Foundation Cancer Award |
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2003-present |
Scientific Advisory Board, Huntsman Cancer Institute, University of Utah, Salt Lake City |
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2003-present |
Member, National Advisory Council on Aging, National Institute of Aging, NIH |
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2004 |
Honorary Doctoral Degree, University of Pennsylvania |
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2004 |
Honorary Doctor of Science Degree, Bard College |
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2004 |
Honorary Doctorate Degree, Brandeis University |
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2004 |
Honorary Doctorate Degree, University of Chicago |
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2004 |
Dr. A.H. Heineken Prize for Medicine |
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2004 |
American Society for Cell Biology Public Service Award |
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2005 |
Kirk A. Landon-AACR Prize for Basic Cancer Research |
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2005 |
Benjamin Franklin Medal in Life Science |
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2005 |
New York Academy of Medicine Medal |
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2006 |
National Cancer Institute Alfred G. Knudson Award |
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2006 |
Fifth Annual Wiley Prize in Biomedical Sciences |
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2006 |
Honorary Doctorate of Science Degree, Harvard University |
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2006 |
Albert Lasker Award for Basic Medical Research |
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2006 |
the Peter Gruber Foundation Genetics Prize |
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2006 |
the Meyenburg Prize for Cancer Research |
| SELECTED PUBLICATIONS | |
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(Selected) |
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Greider, C.W. and E.H. Blackburn (1989). A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331Ð337. | |
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Shippen-Lentz, D. and EH Blackburn (1990). Functional evidence for an RNA template in telomerase. Science 247: 546-52. | |
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Yu, G-L., J.D. Bradley, L.D. Attardi and E.H. Blackburn (1990). In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126-132. | |
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Romero D. and EH Blackburn (1991) A conserved secondary structure for telomerase RNA Cell 67:343-53. | |
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Yu, G-L. and E.H. Blackburn (1991). Developmentally programmed chromosome healing by telomerase in Tetrahymena. Cell 67: 823-32. | |
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Bhattacharyya, A. and E.H. Blackburn (1994). Architecture of telomerase RNA. EMBO J. 13: 5721-5731. | |
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McEachern, M.J. and E.H. Blackburn (1995). Runaway telomere elongation caused by telomerase RNA mutations. Nature 376: 403-409. | |
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Gilley, D., M.S. Lee and E.H. Blackburn (1995). Altering specific telomerase RNA template residues affects active site function. Genes Dev. 9: 2214-26. | |
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Krauskopf, A. and E.H. Blackburn (1996). Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354-357. | |
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Kirk, K.E., B.P. Harmon, I.K. Reichardt, J.W. Sedat and E.H. Blackburn (1997). Block in anaphase chromosome separation caused by a telomerase template mutation. Science 275:1478-1481. | |
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Prescott, J. and E.H. Blackburn (1997). Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790-2800. | |
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Zhu, J., H. Wang, J.M. Bishop, and E.H. Blackburn (1999). Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA. 96: 3723-3728. | |
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Smith, C.D. and E.H. Blackburn. (1999) Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. J. Cell Biol. 145: 203-214. | |
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Tzfati, Y., T.B. Fulton, J. Roy, and E.H. Blackburn (2000). Template boundary in a yeast telomerase specified by RNA structure. Science. 288: 863-7. | |
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Blackburn, E.H. (2000). Telomere states and cell fates. Nature 408: 53-56. | |
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Kim, M.M., Rivera, M.A., Botchkina, I.L., Shalaby, R., Thor, A.D., and Blackburn, E.H. (2001). A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. PNAS 98: 7982. | |
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Blackburn, E.H. (2001) Switching and signaling at the telomere. Cell 106: 661-673. | |
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Chan, S., Chang, J., Prescott, J. and Blackburn, E.H. (2001). Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Current Biology 11: 1240-1250. | |
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Nautiyal, S., J. DeRisi, and E.H. Blackburn. (2002). Genome-wide gene-expression profile of a telomerase deletion mutant of S. cerevisiae. Proc. Natl. Acad Sci. U.S.A. 99:9316-9321. | |
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Comolli, L.R., I. Smirnov, L. Xu, E.H. Blackburn and T.L. James. (2002) A molecular switch underlies a human telomerase disease. Proc. Natl. Acad Sci. U.S.A. 99: 16998-17003. | |
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Ly, H., Xu, L., Rivera, M., Parslow, T. and Blackburn, E. (2003). A role for a novel `trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev 17: 1078-1083. | |
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Chan, S. W.-L and Blackburn, E.H. (2003) Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Molec Cell 11: 1379-1387. | |
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Tzfati, Y., Knight, Z., Roy, J. and E.H. Blackburn. (2003) A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev 17:1779-1788. | |
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Kim, M.M, L. Xu and E. H. Blackburn. (2003) Catalytically normal human telomerase mutants with allele-specific biological properties. Exper Cell Res 288: 277-287. | |
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Li, S. et al. (2004) Rapid inhibition of cancer cell growth induced by lentiviral expression of mutant-template telomerase RNA constructs and anti-telomerase siRNA. Cancer Res 64: 4833-4840. | |
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Lin, J., D.L. Smith and E.H. Blackburn. (2004) Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Molec. Biol. Cell 15: 1623-1634. | |
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Lin, J. and E.H. Blackburn. (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev. 18: 387-396. | |
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Lin, J., H. Ly, A. Hussain, M. Abraham, S. Pearl, T.G. Parslow, Y. Tzfati and E.H. Blackburn (2004). A universal telomerase RNA core structure includes structure motifs required for binding the telomerase reverse transcriptase protein. Proc. Natl. Acad. Sci. USA 101:14713-8. | |
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Nosrati, M. et al. (2004) Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin Cancer Res. 10:4983-4990. | |
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Levy, D.L. and E.H. Blackburn. (2004) Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Mol. Cell. Biol. 24: 10857-10867. | |
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Epel, E.S., E.H. Blackburn, J. Lin, F. Dhabar, N. Adler, J. Morrow, and R. Cawthon. (2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA. 101: 17312-15. | |
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Rivera, M.A. and E.H. Blackburn (2004). Processive utilization of the human telomerase template: Lack of a requirement for template switching. J Biol Chem 279: 53770-53781. | |
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Xu, L. and E.H. Blackburn (2004). Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol 167: 819-830. | |
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Li, S. et al. (2005) Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J. Biol. Chem. 280:23709-23717. | |
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Ly, H. et al. (2005) Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita Blood 106: 1246-1252. | |
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Epel, E.S., J. Lin, F.H. Wilhelm, O.M. Wolkowitz, R. Cawthon, N. Adler, C. Dolbier, W.B. Mendes, and E.H. Blackburn. (2006) Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31: 277-287. | |
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Goldkorn, A. and E.H. Blackburn. (2006) Assembly of mutant template telomerase RNA into catalytically active telomerase ribonucleoprotein at the telomere is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Research 66 (11): 5763-71. | |
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Bagheri S., Nosrati M., Li S., Fong S., Torabian S., Rangel J., Moore D.H., Feerman S., Laposa R.R., Baehner F.L., Sagebiel R.W., Cleaver J.E., Haqq C., Debs R.J. Blackburn E.H. and Kashani-Sabet M. (2006) Genes and pathways downstream of telomerase in melanoma metastasis. Proc. Natl. Acad. Sci. USA 103: 11306-11311. |
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11/21/06 |
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