Elizabeth H. Blackburn, PhD

University of Melbourne, Melbourne, Australia, B.Sc., 1970, Biochemistry
University of Melbourne, Melbourne, Australia, M.Sc., 1972, Biochemistry
University of Cambridge, England, Ph.D., 1975, Molecular Biology
Yale University, New Haven, Connecticut, Postdoc., 1975-1977, Molecular and Cellular Biology

• 1970-1971
  Graduate Research Student, Master of Science Degree course Department of Biochemistry, University of Melbourne, Australia
• 1971-1974
  Graduate Research Student, Division of Protein and Nucleic Acid Chemistry MRC Laboratory of Molecular Biology, Cambridge, England (Advisor: F. Sanger)
• 1975-1977
  Postdoctoral Fellow, Department of Biology, Yale University
• 1978 Postdoctoral Fellow, Department of Biochemistry, University of California, San Francisco
• 1978-1983
  Assistant Professor, Department of Molecular Biology, University of California, Berkeley
• 1983-1986
  Associate Professor, Department of Molecular Biology, University of California, Berkeley
• 1986-1990
  Professor, Department of Molecular Biology, University of California, Berkeley
• 1993-1999
  Chair, Department of Microbiology Immunology, University of California, San Francisco
• 1990-present
  Professor, Departments of Biochemistry and Biophysics, and Microbiology and Immunology, University of California, San Francisco
• 1996-present
  Member, Breast Oncology Program (1996) and Genitourinary Oncology Program (1999), UCSF Comprehensive Cancer Center
• 2001-present
  Scientific Advisory Board, Division of Basic Science, Fred Hutchinson Cancer Research Center
• 2003-present
  Scientific Advisory Board, Huntsman Cancer Institute, University of Utah, Salt Lake City
• 2003-2007
  Member, National Advisory Council on Aging, National Institute of Aging, NIH
• 2008-present
  Member, National Academies of Sciences Committee on Science, Technology and the Law.

• Selected honors and awards since 2000. For complete list, see Blackburn Lab website.
• 2000
  American Association for Cancer Research-G.H.A. Clowes Memorial Award
• 2000
  Elected, Institute of Medicine
• 2000
  American Cancer Society Medal of Honor
• 2000
  Elected, Fellow of the American Association for the Advancement of Science
• 2001
  AACR-Pezcoller Foundation International Award for Cancer Research
• 2001
  General Motors Cancer Research Foundation Alfred P. Sloan Award
• 2003
  26th Annual Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research
• 2005
  Kirk A. Landon-American Association for Cancer Research Prize for Basic Cancer Research
• 2005
  Benjamin Franklin Medal in Life Science
• 2005
  New York Academy of Medicine Medal
• 2006
  National Cancer Institute Alfred G. Knudson Award
• 2006
  Fifth annual Wiley Prize in Biomedical Sciences
• 2006
  Albert Lasker Award for Basic Medical Research
• 2006
  The 25th Meyenburg Prize
• 2006
  Elected, American Philosophical Society
• 2007
  Elected, Australian Academy of Science
• 2007
  TIME 100 Most Influential People in the World
• 2008
  L’Oreal UNESCO For Women In Science Award
• 2008
  Weizmann Women & Science Award: Weizmann Institute of Science
• 2009
  Nobel Prize in Physiology or Medicine

• Nautiyal, S., J. DeRisi, and E.H. Blackburn. (2002). Genome-wide gene-expression profile of a telomerase deletion mutant of S. cerevisiae. Proc. Natl. Acad Sci. U.S.A. 99:9316-9321.
• Li, S., J.E. Rosenberg, A.A. Donjacour, I.L. Botchkina, Y.-K. Hom, G.R. Cunha and E.H. Blackburn. Rapid inhibition of cancer cell growth induced by lentiviral expression of mutant-template telomerase RNA constructs and anti-telomerase siRNA. Cancer Res 64: 4833-4840 (2004).
• Nosrati, M. S. Li, S. Bagheri, D. Ginzinger, E.H. Blackburn, R.J. Debs, and M. Kashani-Sabet. Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Clin Cancer Res. 10:4983-4990 (2004).
• Kim, M.M, L. Xu and E. H. Blackburn. Catalytically normal human telomerase mutants with allele-specific biological properties. Exper Cell Res 288: 277-287. (2003).
• Chan, S. and E.H. Blackburn. Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Molecular Cell 11:1379-1387 (2003).
• Li, S., J. Crothers, C.M. Haqq and E.H. Blackburn. Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J. Biol. Chem. 280:23709-23717 (2005).
• Bagheri S., Nosrati M., Li S., Fong S., Torabian S., Rangel J., Moore, D.H., Feerman S., Laposa R.R., Baehner F.L., Sagebiel R.W., Cleaver J.E., Haqq C., Debs R.J. Blackburn E.H. and Kashani-Sabet M. Genes and pathways downstream of telomerase in melanoma metastasis. Proc. Natl. Acad. Sci. USA 103: 11306-11311. (2006). PMCID: PMC1544082
• Goldkorn, A. and E.H. Blackburn. Assembly of mutant template telomerase RNA into catalytically active telomerase ribonucleoprotein at the telomere is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Research 66 (11):5763-71 (2006).
• Wang, XY, Kam, Z, Carlton, PM, Xu, L, Sedat, JW and E.H. Blackburn. Rapid Telomere Motions in Live Human Cells Analyzed by Highly Time-Resolved Microscopy. Epigenetics Chromatin 1 (1):4 (2008). Epub 2008 October 27. PMCID: PMC2585561
• Stohr and BA Blackburn EH. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 2008 Jul 1;68(13):5309-17. (2008). PMCID: PMC2553270
• Xu, L, Blackburn, EH. Human Cancer Cells Harbor T-Stumps, a Prominent Novel Class of Extremely Short Telomeres. Molecular Cell 28 (2):315-27 (2007). PMCID: PMC2081152
• Makovets, S and EH Blackburn. DNA damage signaling prevents deleterious telomere addition at DNA breaks. Nature Cell Biol. 11(11):1383-1386. (2009). PMCID: PMC2806817.
• Stohr, B, Xu, L and Blackburn EH. The Terminal Telomeric DNA Sequence Determines the Mechanism of Dysfunctional Telomere Fusion. Molecular Cell. Jul 30;39(2):307-14. (2010) PMCID: PMC2920734.
• Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S and E Blackburn. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: Insights for epidemiology of telomere maintenance. J Immunol Methods. 2010 Jan 31; 352(1-2):71-80. [Epub 2009 Oct 21].
• Williams, T L, Levy, D L, Maki-Yonekura, S, Yonekura, K and EH Blackburn. Characterization of the yeast telomere nucleoprotein core: Rap1 binds independently to each recognition site. J Biol Chem. [EPub Sep 7 2010]. (2010) PMCID: PMC2975205