jayanta.debnath@ucsf.edu
(415) 476-1780 (voice)
(415) 514-3165 (fax)

Box 0511, UCSF; San Francisco, CA 94143-0511

Georgia Institute of Technology, Atlanta, Georgia, 1988-1992, Bachelor of Science in Chemistry, Highest Honors
Harvard Medical School, Boston, Massachusetts, 1992-1998, Doctor of Medicine, magna cum laude
National Cancer Institute, Bethesda, MD, NIH-HHMI Scholar, 1995-1997, Biochemistry
Resident, Anatomic Pathology, Department of Pathology, Brigham and Women's Hospital, 1998-2000
Clinical Fellow, Department of Pathology, Brigham and Women's Hospital, 2000-2003
Postdoctoral Fellow, Department of Cell Biology, Harvard Medical School, 2000-2005

J. Debnath, Husain, P.A., and May, S.W. (1992). Activation of an Adrenergic Pro-Drug Through Sequential Stereoselective Action of Tandem Target Enzymes. Biochem. Biophys. Res. Comm. 239: 33-39.

P.A. Husain, Debnath, J., and May, S.W. (1993). HPLC-Based Method for the Determination of Absolute Configuration of -Chiral Amines. Anal. Chem. 65: 1456-1461.

R.A. Van Etten, Debnath, J., Casasnovas, J.M., and Zhou, H. (1995). Introduction of a Loss-of-function Point Mutation From the SH3 Region of the Caenorhabditis elegans sem 5 Gene Activates the Transforming Ability of c-abl in vivo and Abolishes Binding of Proline Rich Ligands in vitro. Oncogene. 10: 1977-1988.

J. Debnath, Chamorro, M., Czar, M., Schaeffer, E., Lenardo, M., Varmus, H., and Schwartzberg, P. (1999). rlk/txk Encodes Two Forms Of A Novel Cysteine-String Kinase Involved in T Cell Signaling. Mol. Cell. Biol. 19: 1498-1507.

E. Schaeffer*, Debnath, J.*, Yap, G., McVicar, D., Sher, A., Liao, C., Littman, D., Varmus, H., Lenardo, M., and Schwartzberg, P. (1999). Requirement for Tec kinases Rlk and Itk in T Cell Signaling And Immunity. Science. 284: 638-641. *co-first authors.

E. Schaeffer, Broussard, C., Debnath, J., Anderson, S., McVicar, D., and Schwartzberg, P (2000). Tec family kinases modulate thresholds for thymocyte development and selection. J. Exp. Med. 192: 987-1000.

M. Chamorro, Czar, M., Debnath, J., Cheng, G., Lenardo, M., Varmus, H, and Schwartzberg, P. (2001). Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunology: 2: 3.

M. Czar, Debnath, J., Schaeffer, E., Lewis, C., and Schwartzberg, P. (2001). Biochemical and Genetic Analyses of the Tec kinases Itk and Rlk/Txk. Biochem Soc. Trans. 29: 863-867.

J. Debnath, Mills, K., Collins, N., Reginato, M., Muthuswamy, S., and Brugge, J. (2002). The Role Of Apoptosis In Creating and Maintaining Luminal Space Within Normal and Oncogene-Expressing Mammary Acini. Cell. 111: 29-40.

M. Reginato, Mills, K., Paulus, J., Debnath, J., Muthuswamy, S. and Brugge, J. (2003). Integrins and EGFR Coordinately Regulate the Pro-apoptotic Protein Bim to Prevent Anoikis. Nat. Cell Biol. 5: 733-40.

J. Debnath, Walker, S. and Brugge, J. (2003). Akt Activation Disrupts Mammary Acinar Architecture and Enhances Proliferation In An mTOR Dependent Manner. J. Cell Biol. 163: 315-326.

J. Debnath, Muthuswamy, S., and Brugge, J. (2003). Morphogenesis and Oncogenesis of MCF-10A Mammary Epithelial Acini Grown In Three-Dimensional Basement Membrane Cultures. Methods. 30: 256-268.

K. Mills, Reginato, M., Debnath, J., Queenan, B., and Brugge, J. (2004). TRAIL Is Required For Induction of Autophagy During Lumen Formation In Vitro. Proc. Nat. Acad. Sci. 101:3438-43.

C. Wrobel, Debnath, J., Lin, E., Beausoliel, S., Roussel, M., and Brugge, J. (2004). Autocrine CSF-1R Activation Promotes Src-Dependent Disruption of Mammary Epithelial Architecture. J. Cell Biol. 165: 263-273.

J. Debnath, Baehrecke, E., and Kroemer, G. (2005). Does Autophagy Contribute to Cell Death? Autophagy.1(2): e10-18.

J. Debnath and Brugge, J. (2005). Modeling Glandular Epithelial Cancers in Three Dimensional Cultures. Nat. Rev. Cancer. 5: 675-688.

J. Debnath and Fung, C. (2006). The Dual Roles of Autophagy in Cell Death and Survival. In Deretic, V. (Ed.): Autophagy In Immunity and Infection. Weinheim, Germany: Wiley-VCH. Pp. 105-121.

12/07/06