David B. Donner, PhD

Queens College, New York, NY, B.A., 1966, Chemistry
Rensselaer Polytechnic Institute, New York, NY, Ph.D., 1972, Chemistry
Cornell University, Ithaca, NY, post-doc, 1972-1973, Biochemistry

• 2005-present
  Professor in Residence, Department of Surgery, University of California, San Francisco, CA
• 10/2004-
  Member, Editorial Advisory Board, The Biochemical Journal
• 2004
  Member Cellular and Molecular Pathology Study Section, NIH
• 1997-2005
  Professor, Microbiology & Immunology, Indiana Univ. School of Medicine (IUSM)
• 1993-
  Member, Indiana University Cancer Center (IUSM)
• 1992-
  Member, Walther Oncology Center (IUSM)
• 1992-1997
  Professor, Dept. Physiology & Biophysics (IUSM)
• 1986-1990
  Editor, Endocrinology (journal)
• 1983-1992
  Associate Member, Memorial Sloan-Kettering Cancer Center (MSKCC), NY, NY Associate Professor, Dept. Cell Biology & Genetics, Cornell Univ. Graduate School of Medical Sciences (CUMC), NY, NY
• 1983-1990
  Graduate Program Director, Cell Biol. & Genetics, CUMC.
• 1978-1983
  Assistant Member, MSKCC, Assistant Professor, Dept. Biochemistry, CUMC
• l973-1978
  Research Associate, MSKCC and Instructor, Dept. Biochemistry, CUMC

  Honors & Awards

  • 7/82 to 6/87
    NIH Career Development Award
  • 1/82 to 6/82
    American Cancer Society Faculty Research Award
  • 1984
    Louise & Alston Boyer Young Investigator Award for Laboratory Research
  • 1978-79
    American Diabetes Association Research and Development Award
  • 1962-1966
    NY State Regents Scholarship
  • 1962-1966
    NY State Scholar Incentive Award

  Selected Publications

  • Guo, D. and Donner, D.B. Tumor necrosis factor promotes phosphorylation and binding of RS-1 to phosphatidyinositol 3-kinase in 3T3-L1 adipocytes. J. Biol. Chem. 271:615-618, 1996.
  • Marino, M., Dunbar, J.D., Wu, L.W, Ngaiza, J.R., Han, H. M., Guo, D., Matsushita, M., Nairn,A., Zhang, Y., Kolesnick, R., Jaffe, E. & Donner, D.B. Inhibition of TNF signal transduction in endothelial cells by dimethylaminopurine. J. Biol. Chem. 271:28624-28629, 1996.
  • Warren, R.S., Yuan, H., Matli, M.R., Ferrara, N., and Donner, D.B. Induction of vascular endothelial cell growth factor by insulin-like growth factor 1 in colorectal carcinoma. J. Biol. Chem. 271:29483-29488, 1996.
  • Dunbar, J.D., Song, H.Y., Guo, D., Wu, L.W. and Donner, D.B. Two-hybrid cloning of a gene encoding TRAP2 a protein that interacts with the intracellular domain of the type 1 TNF receptor. Identity with subunit 2 of the 26S protease. J. Immunol. 158:4252-4259, 1997.
  • Guo, D., Dunbar, J.D., Chuan, H.Y., Pfeffer, L.M. and Donner, D.B. Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J. Immunol. 160:2742-2750, 1998.
  • Vig, E., Green, M., Liu, Y., Donner, D.B., Mukaida, N., Goebl, M. G. and Harrington, M.A. Modulation of tumor necrosis factor and interleukin-1 dependent NF-B activity by mPLK/IRAK. J. Biol.Chem. 274:13077-13084, 1999.
  • Ozes, O., Mayo, L.D., Gustin, J.A., Pfeffer, S., Pfeffer, L.M. and Donner, D.B. NF- B activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85, 1999.
  • Pazdernik, N.J., Donner, D.B., Goebl, M.G. and Harrington, M.A. Mouse receptor interacting protein 3 (mRIP3) does not contain a caspase recruiting domain or a death domain, but induces apoptosis and activates NF- B. Mol. Cell. Biol. 19:6500-6508, 1999.
  • Felts, S.A., Own, B. A.L., Nguyen, P.M., Trepel, J., Donner, D.B., and Toft, D.O. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J. Biol. Chem. 275:3305-3312, 2000.
  • Wu, L.W., Mayo, L.D., Dunbar, J.D., Kessler, K.M., Baerwald, M.R., Jaffe, E.A., Wang, D., Warren, R.S., and Donner, D.B. Utilization of distinct signaling pathways by receptors for VEGF and other mitogens in the induction of endothelial cell proliferation. J. Biol. Chem. 275:5096-5103, 2000.
  • Wu, L.W., Mayo, L., Ozes, O., Jaffe, E.A., Warren, R.S., & Donner, D.B. VRAP is an adaptor protein that binds the cytoplasmic domain of KDR, a receptor for vascular endothelial cell growth factor. J. Biol. Chem. 275: 6059-6062, 2000.
  • Guo, D., Wu, L-W., Dunbar, J.D., Mayo, L.D., Gustin, J., Jaffe, E.A., Warren, R.S. and Donner, D.B. Tumor necrosis factor inhibits activation of KDR and VEGF-induced endothelial cell proliferation. J. Biol. Chem. 275:11216-11221, 2000.
  • Wang, D., Donner, D.B. and Warren, R.S. Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the VEGF receptor mRNAs by VEGF. J. Biol. Chem. 275:15905-15911, 2000.
  • Ozes, O.N., Akca, H., Mayo, L.D., Gustin, J.A., Maehama, T., Dixon, J.E. and Donner, D.B. A PI 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes TNF inhibition of signaling through IRS-1. Proc. Natl. Acad. Sci. USA. 98:4640-4645, 2001.
  • Yang, C.H., Murti, A., Pfeffer, S.R., Kim, J.G., Donner, D.B. and Pfeffer, L.M. IFN / promotes cell survival by activating NF- B through phosphatidyinositol 3-kinase and Akt. J. Biol. Chem. 276:13756-13761, 2001.
  • Gustin, J.A., Maehama, T., Dixon, J.E., and Donner, D.B. The PTEN tumor suppressor protein inhibits TNF induced NF- B activity. J. Biol.Chem. 276:27740-27744, 2001.
  • Mayo, L.D., Kessler, K.M., Pincheira, R., Warren, R.S. and Donner, D.B. Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase. J. Biol. Chem. 276:25184-25189, 2001.
  • Mayo, L.D. and Donner, D.B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 98:11598-11603, 2001.
  • Wang, D., Lehman, R.E., Donner, D.B., Matli, M.R., Warren, R.S., & Welton, M.L. Expression and endocytosis of VEGF and its receptors in human colonic vascular endothelial cells. Amer. J. Physiol. G1088-G1096, 2002.
  • Mayo, L.D. and Donner, D.B. The PTEN, Mdm2. p53 tumor suppressor-oncoprotein network. Trends in Biochemical Sciences 27: 462-467, 2002.
  • Su, J.D., Mayo, L.D., Donner, D.B., and Durden, D.L. PTEN and PI 3-kinase inhibitors up-regulate p53 and block tumor induced angiogenesis; evidence for an effect on the tumor and endothelial compartment. Cancer Res. 63:3585-3592, 2003.
  • Gustin, J.A., Pincheira, R., Mayo, L.D., Ozes, O.N., Kessler, K.M., Baerwald, M.R. and Donner, D.B. Tumor necrosis factor activates CRE binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. Amer. J. Physiol., Cell. Physiol. 286: C547-C555, 2004.
  • Gustin, J.A., Ozes, O. N., Akca, H., Pincheira, R., Mayo, L., Li, Q., Rivera Guzman, H., Korgaonkar, C.K., and Donner, D.B. Cell type specific expression of the I B kinases determines the significance of PI 3-kinase/Akt signaling to NF- B activation. J. Biol. Chem. 279:1615-1620, 2004.
  • Toussaint-Smith, E., Donner, D.B. and Roman, A. Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytesis is sufficient to alter expression of angiogenic factors. Oncogene 23L2988-2995, 2004.
  • Ozes, O.N., Gustin, J.A., Mayo, L.D., Pincheira, R., and Donner, D.B., Tumor necrosis factor/receptor signaling through the Akt kinase. In Proinflammatory signaling mechanisms in the pulmonary circulation. Humana Press, NJ, 2005.
  • Mayo, L.D., Seo, Y.R., Jackson, M.W., Smith, M.L., Rivera Guzman, J., Korgaonkar, C.K., and Donner, D.B. Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. J Biol Chem. 280:25953-9, 2005.
  • Matei, D., Emerson, R.E., Lai, Y., Baldrige, L.A., Rao, J., Yiannoutsos, C., and Donner, D.B. Autocrine activation of the PDGFR promotes the progression of ovarian cancer. Oncogene, 2005 in press.
  • Gustin, J.A., Korgaonkar, C., Pincheira, R., Li, Q., and Donner, D.B. Akt induces basal and induced processing of NF- B2 (p100) to p52. J. Biol. Chem. 2005 in press.
  • Schmidt, N.W., Mayo, L.D., Donner, D.B., and Kaplan, M.H. p53 regulates Btk-dependent B cell proliferation but no differentiation. J Leuk Biol. 2005 in press
  • Srirangam, A., Mitra, R., Wang, M., Gorski, J.C., Badve, S., Baldridge, L.A., Hamilton, J., Kishimoto, H., Hawes, J., Li, L., Orschell, C.M., Srour, E.F., Blum, J.S., Donner, D., Sledge, G.W., Nakshatri, H., and Potter, D.A. Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. J. Clin. Oncol. 12:1883-1896, 2006
  • Jackson, M.W., Patt, L.E., LaRusch. G.A., Donner, D.B., Stark, G.G., and Mayo, L.D. Hdm2 nuclear export, regulated by IGF-1/MAPK/p90Rsk signaling, mediates the transformation of human cells. J. Biol. Chem. 281: 16814-16820, 2006.
  • Srirangam, A., Mitra, R., Wang, M., Gorski, J.C., Badve, S., Baldridge, L.A., Hamilton, J., Kishimoto, H., Hawes, J., Li, L., Orschell, C.M., Srour, E.F., Blum, J.S., Donner, D., Sledge, G.W., Nakshatri, H., and Potter, D.A. Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. J. Clin. Oncol. 12:1883-1896, 2006
  • Jackson, M.W., Patt, L.E., LaRusch. G.A., Donner, D.B., Stark, G.G., and Mayo, L.D. Hdm2 nuclear export, regulated by IGF-1/MAPK/p90Rsk signaling, mediates the transformation of human cells. J. Biol. Chem. 281: 16814-16820, 2006.

  Updated: December 20, 2011