Professor and Chair, Biopharmaceutical Sciences and Professor of Pharmaceutical Chemistry and Molecular & Cellular Pharmacology, UCSF
| CONTACT | |
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kmg@itsa.ucsf.edu Box 0446, UCSF; San Francisco, CA 94143-0446 |
additional websites: |
| EDUCATION | |
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University of Houston, Houston, TX, B.S., 1973, Pharmacy
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| PROFESSIONAL EXPERIENCE | |
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1981-87 |
Assistant Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology |
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1987-91 |
Associate Professor of Pharmacy/ Pharmaceutical Chem. & Pharmacology |
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1992-present |
Professor of Biopharmaceutical Sciences, Pharmaceutical Chemistry, and Cellular & Molecular Pharmacology, UCSF |
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1998-present |
Chair of the Department of Biopharmaceutical Sciences |
| HONORS & AWARDS | |
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1973 |
Rho Chi, Honorary Pharmacy Fraternity |
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1983-84 |
Long Foundation Award for Excellence in Teaching, School of Pharmacy, UCSF |
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1984-85 |
UCSF Nominee, Recognition Award for Young Scholars, American Association of University Women |
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1985-86 |
Distinguished Teaching Award, UCSF, Academic Senate |
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1990 |
Leon Goldberg Young Investigator Award, American Society for Clinical Pharmacology and Therapeutics |
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1990-94 |
Member of Pharmacological Science Review Committee; National Institutes of Health (GM) |
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1990-94 |
Member of Generic Drugs Advisory Committee; Food and Drug Administration |
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1992 |
Recipient, Fogarty International Fellowship; National Institutes of Health |
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1993 |
Elected Fellow, American Association of Pharmaceutical Scientists |
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1994 |
UCSF, Dr. Martin Luther King, Jr. Award for the Advancement of Women and Minorities |
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1996-97 |
Vice President, American Society for Clinical Pharmacology and Therapeutics |
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1996-97 |
UCSF, Chancellor's Award for the Advancement of Women |
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1999 |
Recognition Award for Distinguished Achievement of Filipino at UCSF |
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1999 |
International Pharmaceutical Federation (FIP), Pharmaceutical Scientist of the Year |
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2001 |
Elected Fellow, American Association for the Advancement of Science |
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2001 |
Keynote Speaker: Gordon Conference on Drug Metabolism |
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2002 |
Honored Celebrating Women Faculty |
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2002 |
Distinguished Bill Abram's Lectureship |
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2002 |
Distinguished Gerhard Levy Lectureship |
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2002 |
Speaker: State Legislative Presentation 'The Impact of the Human Genome Pronect on Drug Development and Use: Tailoring Drugs to Individuals' |
| SELECTED PUBLICATIONS | |
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Screening a Large Reference Sample to Identify Very Low Frequency Sequence Variants: Comparisons Between Two Genes. C.E. Glatt, J.A. DeYoung, S. Delgado, S.K. Service, K.M. Giacomini, R.H. Edwards, N. Risch, N.B. Freimer Nature Genet. 27 435-438 (2001). |
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Functional Characteristics and Steroid Hormone-Mediated Regulation of an Organic Cation Transporter in Madin-Darby Canine Kidney Cells. Y. Shu, C.L. Bello, L.M. Mangravite, B. Feng,, K.M. Giacomini, J. Pharmacol Exp. Ther., 299(1) 392-398 (2001). |
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Polymorphisms in a Human Kidney Xenobiotic Tansporter, OCT2, Exhibit Altered Function. M.K. Leabman, C.C. Huang, M. Kawamoto, S.J. Johns, D. Stryke, T.E. Ferrin, J. DeYoung, T.Taylor, A.G. Clark, I. Herskowitz, K.M. Giacomini on behalf of the Phamacogenetics of Membrane Transporters Investigators. Pharmacogenetics 12:395-405 (2002). |
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Specificity of Human and Rat Orthologs of the Concentrative Nucleoside Transporters, SPNT. K.M. Gerstin, M.J. Dresser, K.M. Giacomini. Am. J. Physiol Renal 283:F344-9 (2002). |
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Role of Aromatic Transmembrane Residues of the Organic Anion Transporter, rOAT3. B. Feng,, Y. Shu, and K.M. Giacomini. Biochemistry 41:8941-7 (2002). |
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Interactions of n-Tetraalkylammonium Compounds and Biguanides with a Human Renal Organic Cation Transporter (hOCT2). M.J. Dresser, G. Xiao, M.K. Leabman, A.T. Gray, K.M. Giacomini. Pharm.Res. 19(8), 1243-46 (2002). |
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Snp Analysis and Presentation in the Pharmacogenetics of Membrane Transporters Project. D. Stryke, CC Huang, M. Kawamoto, SJ Johns, EJ Carlson, JA DeYoung, MK Leabman, I. Herskowitz, KM Giacomini, TE Ferrin. Pacific Symposium on Biocomputing 535-547 (2003). |
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Sorting of Rat SPNT in Renal Epithelium is Independent of N-Glycosylation. LM. Mangravite, K.M. Giacomini. Pharm. Res. 20:319-23 (2003). |
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Localization of Human Equilibrative Nucleoside Transporters, hENT1 and hENT2, in Renal Epithelial Cells. L.M. Mangravite, G. Xiao, and K.M. Giacomini. Am. J. Physiol Renal Physiol 284:F902-10 (2003) |
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Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints. M.K. Leabman, C.C. Huang, J. DeYoung, E.J. Carlson, T. Taylor, M. de la Cruz, S.J. Johns, D. Stryke, M. Kawamoto, T. J. Urban, D.L. Kroetz, T.E. Ferrin, A.G. Clark, N. Risch, I. Herskowtiz, K.M. Giacomini. Proc. Natl. Acad. Sci. 100:5896-901 (2003). |
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Evolutionary Conservation Predicts Function of Variants of the Human Organic Cation Transporter, OCT1. Y. Shu, M.K. Leabman, B. Feng, L.M. Mangravite, C.C. Huang, D. Stryke, M. Kawamoto, S.J. Johns, J. DeYoung, E. Carlson, T.E. Ferrin, I. Herskowitz, K.M. Giacomini. Proc. Natl. Acad. Sci. 100:5902-07 (2003). |
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Functional Characterization in Yeast of Genetic Variants in the Human Equilibrative Nucleoside Transporter, ENT1. D.H. Osato, C.C. Huang, M. Kawamoto, S.J. Johns, D. Stryke, J. Wang, T.E. Ferrin, I. Herskowitz, K.M. Giacomini. Pharmacogenetics 13:297-301(2003). |
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PharmGKB Update: I. Genetic Variants of the Organic Cation Transporter 2 (OCT2, SLC22A2). M.K. Leabman, C. Huang, D. Stryke, S. Johns, M. Kawamoto, T. Ferrin, J. DeYoung, T. Taylor, M. Cruz, I. Herskowitz, and K.M. Giacomini. Pharmacol Rev 55: 399, (2003). |
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Estimating the Contribution of Genes and Environment to Variation in Renal Drug Clearance. M.K. Leabman and K.M. Giacomini. Pharmacogenetics 13:581-584 (2003). |
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Nucleoside Transporters in the Disposition and Targeting of Nucleoside Analogs in the Kidney. L.M. Mangravite, I. Badagnani, and K.M. Giacomini, Europeon Journal of Pharmacology 479:269-281 (2003). |
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The Concentrative Nucleoside Transporter Family, SLC28. J.H. Gray, R. Owen, K.M. Giacomini, Eur J Physiol 447:728-734 (2004) |
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Functional and Genetic Diversity in the Concentrative Nucleoside Transporter, CNT1, in Human Populations. J.H. Gray, L.M. Mangravite, R.P. Owen, T.J. Urban, W. Chan, ElJ. Carlson, C.C. Huang, M. Kawamoto, S.J. Johns, D. Stryke, T.E. Ferrin, and K.M. Giacomini, Mol Pharmacol 65:512-519 (2004). |
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Haplotype Structure and Ethnic-Specific Allele Frequencies at the OCTN Locus: Implications for the Genetics of Crohn Disease. T.J. Urban, N. Risch, K.M. Giacomini, Inflammatory Bowel Diseases Journal (Accepted) 2004. |
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2/1/05 |
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