YW.Kan@ucsf.edu
(415) 476-5841 (voice)
(415) 476-5841 (fax)

Box 0793, UCSF; San Francisco, CA 94143-0793

University of Hong Kong, Hong Kong, M.B.B.S., 1958, Medicine
University of Hong Kong, Hong Kong, D.Sc., 1980, Medicine

Cheung MC, Goldberg J and Kan YW. Prenatal Diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood. Nature Genetics 14:264-268, 1996.

Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TSB and Kan YW. Targeted disruption of the ubiquitous CNC b-ZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. Embo 17:1779-1787, 1998.

Zhang L, Wang D, Fischer H, Fan P-D, Widdicombe JH, Kan YW and Dong JY. Efficient expression of CFTR function with AAV vectors that carry shortened CFTR genes. Proc Natl Acad Sci 95:10158-10163, 1998.

Kwong M, Kan YW, and Chan JY. The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents. Journal of Biological Chemistry 274, #52:37491-37498, 1999.

Kan YW, Goldberg JD, Cheung M-C. Fetal cells in maternal circulation to diagnose hemoglobinopathies and thalassemia. Diagnosis and Treatment of the Unborn Child by Maria I. New, 129-132, 1999.

Chan K, and Kan YW. Nrf2 is essential protection against acute pulmonary injury in mice. Proc Natl Acad Sci 96:12731-12736, 1999.

Su H, Lu R, Kan YW. Adeno-Associated Viral Vector (AAV) Mediated Vascular Endothelial Growth Factor (VEGF) Gene Transfer Induces Formation in Ischemic Heart. Proc Natl Acad Sci 97:13801-13806, 2000.

Mentzer WC, Kan YW. Sickle Cell Disease and Thalassemia. JAMA 285:640-642, 2001.

Chan K, Han XD, Kan YW. An Important Function of Nrf2 in Combating Oxidative Stress: Detoxification of Acetaminophen. Proc Natl Acad Sci 98:4611-4616, 2001.

Huie MA, Cheung M-C, Muench MO, Becerril B, Kan YW, and Marks JD: Antibodies to Human Fetal Erythroid Cells From a Non-immune Phage Antibody Library. Proc Natl Acad Sci 98:2682-2687, 2001.

Baklircioglu ME, Lin C-S, Fan P, Sievert K-D, Kan YW, and Lue TF. The effect of Adeno-associated virus on mediated brain derived neurotrophic factor in an animal model of neurogenic impotence. J Urology, 165:2103-2109, 2001.

Su H, Arakawa-Hoyt J and Kan YW: Adeno-associated viral vector-mediated hypoxia response element -regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci 99:9480-5. 2002.

Chang DS, Su H, Tang GL Brevetti LS, Sarkar R, Wang R, Kan YW, Messina LM. Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Mol Ther 7: 44-51, 2003.

Roger RS, Graziottin TM, Lin CS, Kan YW, Lue TF. Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. Int J Impot Res. 15:26-37, 2003.

Lee JM, Calkins MJ, Chan K, Kan YW, Johnson JA. Identification of the NF-E2-related factoe-2-dependent gene conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 278:12029-38, 2003.

Ma Q, Kinneer K, Bi Y, Chan JY, Kan YW. Induction of murine NAD(P)H:quinine oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2: cross-interaction between AhR (aryl hydrocarbon receptor) and Nfr2 signal transduction. Biochem J 377:205-213, 2004.

T Lee JM, Chan K, Kan YW, Johnson JA. Targeted disruption of Nrf2 causes regenerative immune mediated hemolytic anemia. Proc Natl Acad Sci U S A. Jun 29;101(26):9751-6, 2004.

Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci U S A. Nov 16;101(46):16280-5 2004.

Calkins MJ, Jakel RJ, Johnson DA, Chan K, Kan YW, Johnson JA. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc Natl Acad Sci U S A. Jan 4;102(1):244 2005. Epub 2004 Dec 20.

Feng D and Kan YW. The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes. Proc Natl Acad Sci USA 102(28): 9896-900, 2005.

Chang JC, Ye L and Kan YW. Correction of the sickle cell mutation in embryonic stem cells. Proc Natl Acad Sci USA 103(4):1036-1040, 2006

Xu X, Roberts JR, Apopa PL, Kan YW, and Ma Q. Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Molec Cell Biol 26(3):940-54, 2006.

Shen F, Shu H, Liu W, Kan YW, Young WL and Yang GY. Recombinant adeno-associated viral vector encoding human VEGF165 induce neomicrovessel formation in the adult mouse brain. Front Biosci 11:3190-8, 2006.

1/30/07