Louis K. Diamond, MD, Chair in Hematology, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
|
YW.Kan@ucsf.edu Box 0793, UCSF; San Francisco, CA 94143-0793 |
additional websites: |
| EDUCATION | |
|
University of Hong Kong, Hong Kong, M.B.B.S., 1958, Medicine
|
|
| PROFESSIONAL EXPERIENCE | |
|
1970-1972 |
Assistant Professor of Pediatrics, Harvard Medical School, Boston, MA |
|
1972-1977 |
Assoc. Professor, Depts of Medicine & Laboratory Medicine, Univ of California, San Francisco, CA (UCSF) |
|
1977-present |
Professor, Depts. of Medicine & Laboratory Medicine, UCSF |
|
1983-present |
Louis K. Diamond Professor of Hematology, Dept. of Medicine, UCSF |
|
1984-present |
Chief, Division of Molecular Medicine and Diagnostics, Dept. of Laboratory Medicine, UCSF |
|
1990-1994 |
1990-1994 Director (part-time), Institute of Molecular Biology, Hong Kong |
| HONORS & AWARDS | |
|
1979 |
Dameshek Award, American Society of Hematology |
|
1980 |
Stratton Award, International Society of Hematology |
|
1980 |
George Thorn Award, Howard Hughes Medical Institute |
|
1984 |
Gairdner Foundation International Award, Canada |
|
1984 |
Allan Award, American Society of Human Genetics |
|
1984 |
Lita Annenberg Hazen Award for Excellence in Clinical Research |
|
1985 |
NIH Career Development Award |
|
1987 |
Waterford Award |
|
1988 |
American College of Physicians Award |
|
1989 |
Sanremo International Award for Genetic Research, Italy |
|
1989 |
Warren Alpert Foundation Prize |
|
1991 |
Albert Lasker Clinical Medical Research Award |
|
1992 |
Christopher Columbus Discovery Award in Biomedical Research |
|
1993 |
City of Medicine Award |
|
1995 |
Helmut Horten Research Award (Switzerland) |
|
2004 |
Shaw Foundation Prize (Hong Kong) |
|
HONORS |
M.D. Honoris Causa, University of Cagliari, Sardenia; DSC. Honoris Causa: University of Hong Kong, Chinese University of Hong Kong, Open University of Hong Kong. Honorary Professor: University of Hong Kong; Peking Union Medical College, Beijing; Zhejiang University, Hangzhou; Jia Tong University, Xi'an; First Military Medical University, Guanzhou; Fourth Medical Military University, Xi'an, China. |
| SELECTED PUBLICATIONS | |
|
Cheung MC, Goldberg J and Kan YW. Prenatal Diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood. Nature Genetics 14:264-268, 1996. | |
|
Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TSB and Kan YW. Targeted disruption of the ubiquitous CNC b-ZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. Embo 17:1779-1787, 1998. | |
|
Zhang L, Wang D, Fischer H, Fan P-D, Widdicombe JH, Kan YW and Dong JY. Efficient expression of CFTR function with AAV vectors that carry shortened CFTR genes. Proc Natl Acad Sci 95:10158-10163, 1998. | |
|
Kwong M, Kan YW, and Chan JY. The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents. Journal of Biological Chemistry 274, #52:37491-37498, 1999. | |
|
Kan YW, Goldberg JD, Cheung M-C. Fetal cells in maternal circulation to diagnose hemoglobinopathies and thalassemia. Diagnosis and Treatment of the Unborn Child by Maria I. New, 129-132, 1999. | |
|
Chan K, and Kan YW. Nrf2 is essential protection against acute pulmonary injury in mice. Proc Natl Acad Sci 96:12731-12736, 1999. | |
|
Su H, Lu R, Kan YW. Adeno-Associated Viral Vector (AAV) Mediated Vascular Endothelial Growth Factor (VEGF) Gene Transfer Induces Formation in Ischemic Heart. Proc Natl Acad Sci 97:13801-13806, 2000. | |
|
Mentzer WC, Kan YW. Sickle Cell Disease and Thalassemia. JAMA 285:640-642, 2001. | |
|
Chan K, Han XD, Kan YW. An Important Function of Nrf2 in Combating Oxidative Stress: Detoxification of Acetaminophen. Proc Natl Acad Sci 98:4611-4616, 2001. | |
|
Huie MA, Cheung M-C, Muench MO, Becerril B, Kan YW, and Marks JD: Antibodies to Human Fetal Erythroid Cells From a Non-immune Phage Antibody Library. Proc Natl Acad Sci 98:2682-2687, 2001. | |
|
Baklircioglu ME, Lin C-S, Fan P, Sievert K-D, Kan YW, and Lue TF. The effect of Adeno-associated virus on mediated brain derived neurotrophic factor in an animal model of neurogenic impotence. J Urology, 165:2103-2109, 2001. | |
|
Su H, Arakawa-Hoyt J and Kan YW: Adeno-associated viral vector-mediated hypoxia response element -regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci 99:9480-5. 2002. | |
|
Chang DS, Su H, Tang GL Brevetti LS, Sarkar R, Wang R, Kan YW, Messina LM. Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Mol Ther 7: 44-51, 2003. | |
|
Roger RS, Graziottin TM, Lin CS, Kan YW, Lue TF. Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. Int J Impot Res. 15:26-37, 2003. | |
|
Lee JM, Calkins MJ, Chan K, Kan YW, Johnson JA. Identification of the NF-E2-related factoe-2-dependent gene conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 278:12029-38, 2003. | |
|
Ma Q, Kinneer K, Bi Y, Chan JY, Kan YW. Induction of murine NAD(P)H:quinine oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2: cross-interaction between AhR (aryl hydrocarbon receptor) and Nfr2 signal transduction. Biochem J 377:205-213, 2004. | |
|
T Lee JM, Chan K, Kan YW, Johnson JA. Targeted disruption of Nrf2 causes regenerative immune mediated hemolytic anemia. Proc Natl Acad Sci U S A. Jun 29;101(26):9751-6, 2004. | |
|
Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc Natl Acad Sci U S A. Nov 16;101(46):16280-5 2004. | |
|
Calkins MJ, Jakel RJ, Johnson DA, Chan K, Kan YW, Johnson JA. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc Natl Acad Sci U S A. Jan 4;102(1):244 2005. Epub 2004 Dec 20. | |
|
Feng D and Kan YW. The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes. Proc Natl Acad Sci USA 102(28): 9896-900, 2005. | |
|
Chang JC, Ye L and Kan YW. Correction of the sickle cell mutation in embryonic stem cells. Proc Natl Acad Sci USA 103(4):1036-1040, 2006 | |
|
Xu X, Roberts JR, Apopa PL, Kan YW, and Ma Q. Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Molec Cell Biol 26(3):940-54, 2006. | |
|
Shen F, Shu H, Liu W, Kan YW, Young WL and Yang GY. Recombinant adeno-associated viral vector encoding human VEGF165 induce neomicrovessel formation in the adult mouse brain. Front Biosci 11:3190-8, 2006. |
|
|
1/30/07 |
|
