Associate Professor, Pathology, UCSF
Member, Immunology Graduate Program, UCSF
| CONTACT | |
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matthew.krummel@ucsf.edu Box 0511, UCSF; San Francisco, CA 94143-0511 |
additional websites: |
| EDUCATION | |
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University of Illinois at Champaign-Urbana, B.S.+B.S., 1985-1989, Biology and Chemistry
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| PROFESSIONAL EXPERIENCE | |
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Summer 1987 |
Summer Undergraduate Research Fellow. University of Texas Health Science Center at Dallas |
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Summer 1988 |
Stagiare (Technician) Institut Pasteur, Paris, Unite de Genie Micro-Biologique |
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Aug 1989-May 1995 |
Graduate Student, University of California at Berkeley, Department of Molecular and Cell Biology |
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June 1995-May 1996 |
Postdoctoral Fellow, University of California at Berkeley |
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Aug 1996-Sept 1997 |
Postdoctoral Fellow, Walter and Eliza Hall Institute of Medical Research, Melbourne Australia |
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Nov 1997-August 2001 |
Postdoctoral Fellow, Beckman Institute, Stanford University, Stanford, CA |
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August 2001-2006 |
Assistant Professor, Department of Pathology, University of California at San Francisco |
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July 2006-present |
Associate Professor, Department of Pathology, University of California at San Francisco |
| HONORS & AWARDS | |
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1986 |
University of Illinois: James Scholar |
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1996-1997 |
Postdoctoral Fellowship, Juvenile Diabetes Foundation International |
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1997-2000 |
NRSA Postdoctoral Fellowship, National Institutes of Health |
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2004-2007 |
Investigator Award, Cancer Research Institute |
| SELECTED PUBLICATIONS | |
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Krummel, M.F. and Allison, J.P. 1995. CD28 and CTLA-4 deliver opposing signals which regulate the response of T cells to stimulation. J. Exp Med. 182, 459-465. | |
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Krummel, M.F., Sullivan, T.J. and Allison, J.P. 1995. Superantigen responses and costimulation: CD28 and CTLA-4 have opposing effects on T cell expansion In Vitro and In Vivo. Int.Immunol. 8, 101-105. | |
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Allison, J.P. and Krummel, M.F. 1995. The yin and yang of T cell costimulation. Science. 270,932-933. | |
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Krummel, M.F. and Allison, J.P. 1996. CTLA-4 Engagement Inhibits IL-2 Accumulation and Cell Cycle Progression Upon Activation of Resting T cells. J Exp Med 183, 2533-2540. | |
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Leach, D.R., Krummel, M.F. and Allison, J.P. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 271, 1734-1736. | |
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Chambers, C.A., Krummel, M.F., Boitel, B., Hurwitz, A., Sullivan, T.J., Fournier, S., Cassell, D., Brunner, M. and Allison, J.P.1996. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunological Reviews. 153, 27-46. | |
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Allison, J., Stephens, L., Kay, T.W., Kurts, C., Heath, W.R., Miller, J.F. and Krummel, M.F. The threshhold for autoimmune T cell killing is influenced by B7.1. European Journal of Immunology. 28,949-960. | |
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Krummel, M.F., Heath, W.R. and Allison, J. 1999.Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: Amplification of the lytic potential by B7. J.Immunol.163, 2999-3006. | |
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Krummel, M.F., Sjaastad,M.D., Wlfing,C., and Davis, M.M. 2000. Differential clustering of CD4 and CD3 during T cell recognition. Science. 289, 1349-1352. | |
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Krummel, M.F.and Davis, M.M. 2002 Dynamics of the Immunological Synapse: Finding, Establishing and Solidifying a Connection. Curr. Op. Immunol. 14:66-74. | |
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Richie, L.I., P.J.R. Ebert, Wu, L.C., Krummel, M.F., Owen, J.J.T., and Davis, M.M. 2002 Imaging synapse formation during thymocyte selection: inability of CD3to form a stable central accumulation during negative selection. Immunity. 16:595-606. | |
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Moss,W.C., Irvine,D.C, Davis,M.M., and Krummel, M.F. 2002. Quantifying Signaling-Induced Reorientation of Cell Membrane and TCRs During Immunological Synapse Formation. PNAS. 99 15024-15029. | |
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Richie Ehrlich,L.I., Ebert, P.J.R. Krummel, M.F., Weiss,A. and Davis, M.M. 2002. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 17 809-822. | |
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Andres,P.G., Howland,K.C., Dresnek,D. Edmondson, S., Abbas,A.K., and Krummel, M.F. 2004. CD28 signals in the immature immunological synapse. J Immunol 172, 5880-6 | |
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Jacobelli, J. Chmura, S.A., Buxton,D.B., Davis , M.M. and Krummel, M. F. 2004. A single class II myosin modulates T cell motility and stopping, but not synapse assembly. Nature Immunology 5, 531 - 538 | |
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Jacobelli, J., Andres, P.G., Boisvert, J., and Krummel, M.F. 2004. New Views of the Immunological Synapse: Variations in Assembly and Function. Curr Opin Immunol 16, 345-52 | |
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Boisvert, J., Edmondson, S. and Krummel, M.F. 2004. Immunological Synapse Formation Licenses CD40-CD40L Accumulations at T-APC Contact Sites. J. Immunol. 173, 3647-3652. | |
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Tooley,A.J., Jacobelli, J., Moldovan, M-C., Douglas, A., and Krummel, M.F. 2005. T cell Synapse Assembly: Proteins, Motors and the Underlying Cell Biology. Seminars in Immunology, 17, 65-75. | |
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Okada, T. Miller, M.J., Parker, I., Krummel, M.F., OĠGarra,A. Cahalan,M.D., Cyster, J.G. 2005. Antigen-engaged B cells undergo directional migration to the T cell zone and form motile conjugates with helper T cells. PLOS Biology 3 1-13. | |
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Friedman, R.S., Jacobelli, J., Krummel, M.F. 2005. Mechanisms of T cell Motility and Arrest: Deciphering the Relationship between Intra- and Extracellular determinants. Seminars in Immunology, 17, 387-99. | |
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Tang, Q., Adams, J.Y., Tooley, A.J., Bi, M., Serra, P., Santamaria, P., Krummel, M.F.* and Bluestone, J.A.* (*co-last authors) 2006. Visualizing regulatory T cell control of autoimmune response in NOD diabetic mice. Nature Immunology, 7, 83-92 | |
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Moldovan MC, Sabbagh L, Breton G, Sekaly RP*and Krummel MF*. (*co-last authors) 2006. Triggering of T cell activation via CD4 dimers. J Immunol. 176(9):5438-45. | |
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Tang, Q and Krummel M.F. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Jun 8 (Epub ahead of print) | |
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Friedman, R.S. Jacobelli, J, and Krummel, M.F. 2006. Surface-bound Chemokines Capture and Prime T cells For Synapse Formation. Nature Immunology 7, 1101-8. | |
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Krummel MF and Macara I. 2006. T cell Polarity PARtita: maintenance and modulation of directionality in T lymphocytes Nature Immunology. 7, 1143-49. |
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2/1/07 |
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