ucsf banner
Helen Diller Family Compr Cancer Ctr
JAY A. LEVY, MD

Professor in Residence, Medicine; and Research Associate, Cancer Research Institute, UCSF

CONTACT

jalevy@itsa.ucsf.edu
(415) 476-4071 (voice)
(415) 476-8365 (fax)

Box 1270, UCSF; San Francisco, CA 94143-1270

additional websites:

Levy Lab Website

EDUCATION

Wesleyan University, Middletown, CT, BA, 1960, Biology
Universite de Paris, France, 1961, Regeneration
Columbia University, New York, MD, 1965, Medicine and Virology

PROFESSIONAL EXPERIENCE

1965-1966

Intern in Medicine, Hospital of the University of Pennsylvania

1966-1967

First year resident in Medicine, Hospital of the University of Pennsylvania

1967-1970

Staff Associate,National Cancer Institute, NIH, Bethesda, MD

1970-1971

Second year resident, University of California, San Francisco (UCSF)

1971-1972

Visiting Scientist, Hopital St. Louis (Prof. M. Boiron), Paris; Hopital Paul-Brousse (Dr. G. Mathe), ICIG, Paris

1972-1977

Assistant Professor of Medicine, Research Associate, Cancer Research Institute, University of California San Francisco

1978-1979

Visiting Scientist, Weizmann Institute, Rehovot, Israel (Prof. N. Haran-Ghera); Pasteur Institute, Paris (Prof. F. Jacob)

1978-1985

Associate Professor of Medicine, and Microbiology and Immunology, University of California San Francisco

1985-present

Professor, Dept of Med., Div of Hem/Onc and Research Assoc, Cancer Research Institute, UCSF
SELECTED PUBLICATIONS

(selected from over 400)

Levy JA, Hoffman AD, Kramer SM, Landis JA, Shimabukuro JM, Oshiro LS. Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science 225: 840-842, 1984.

Levy JA, Mitra G, Mozen MM. Recovery and inactivation of infectious retroviruses added to factor VIII concentrates. Lancet ii: 722-723, 1984.

Luciw PA, Potter SJ, Steimer K, Dina D, Levy JA. Molecular cloning of AIDS-associated retrovirus. Nature 312: 760-763, 1984.

Levy JA, Shimabukuro J, McHugh T, Casavant C, Stites D, Oshiro L. AIDS-associated retroviruses (ARV) can productively infect other cells besides human T helper cells. Virology 147: 441-448, 1985.

Sanchez-Pescador R, Power MD, Levy JA, et al. Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science 227: 484-492, 1985.

Hoffman AD, Banapour B, Levy JA. Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions. Virology 147: 326-335, 1985.

Levy JA, Cheng-Mayer C, Dina D, et. al. Replication of AIDS-associated retrovirus (ARV-2) in human and animal fibroblast cells transfected with a molecular clone of the virus. Science 232: 998-1001, 1986.

*Walker CM, Moody DJ, Stites DP, Levy JA. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234: 1563-1566, 1986.

*Cheng-Mayer C, Seto D, Tateno M, Levy JA: Biologic features of HIV that correlate with virulence in the host. Science 240: 80-82, 1988.

Nelson JA, Wiley CA, Levy JA, et. al. Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms. Lancet i: 259-262, 1988.

Evans LA, Moreau J, Odehouri K, Legg H, Barboza A, Cheng-Mayer C, Levy JA. Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression. Science 240: 1522-1525, 1988.

Homsy J, Meyer M, Tateno M, Clarkson S, Levy JA. The Fc and not the CD4 receptor mediates antibody enhancement of HIV infection in human cells. Science 244: 1357-1360, 1989.'

Walker CM, Levy JA. A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 66: 628-630, 1989.

Walker CM, Erickson AL. Hsueh FC, Levy JA. Inhibition of HIV replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism. J Virol, 65:5921-5927, 1991.

Mackewicz CE, Ortega HW, Levy JA. CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual. J Clin Invest 87: 1462-1466, 1991.

Levy JA. Pathogenesis of HIV infection. Microbiol Rev, 57:183-289, 1993.

Landay AL, Mackewicz C, Levy JA. An activated CD8+ T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status. Clin Immunol Immunopathol, 69:106-116, 1993.

*Mackewicz CE, Lee F, Ortega H, Levy JA. The anti-HIV activity in CD8+ cell culture fluids is not associated with other known cytokines. Cell Immunol 153:329-343, 1994.

Mackewicz CE, Yang LC, Lifson JD, Levy JA. Noncytolytic CD8+ cell anti-HIV responses and neutralizing antibody titers in primary HIV infection. Lancet 344:1671-1673, 1994.

Mackewicz CE, DJ Blackbourn and JA Levy. CD8+ lymphocytes from HIV-1 seropositive individuals block HIV replication in CD4+ lymphocytes by inhibiting HIV RNA synthesis. PNAS. 92: 2308-2312, 1995.

Barker E, Mackewicz CE, Levy JA. Effects of Th1 and Th2 cytokines on CD8+ cell anti-HIV response: implications for long-term survival. PNAS, 92:11135-11139, 1995.

Blackbourn DJ, CE Mackewicz, JA Levy, et. al. Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals. PNAS, 93: 13125-13130, 1996.

*Levy JA, Mackewicz C, Barker E. Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells. Immunol Today, 17:217-224, 1996.

Mackewicz CE, Barker E, Greco G, Reyes-Teran G, Levy JA. Do b-chemokines have clinical relevance in HIV infection? J Clin Invest 100:921-930, 1997.

Barker E, Bossart KN, Levy JA. Primary CD8+ cells from HIV-infected individuals can suppress productive infection of macrophages independent of b-chemokines. PNAS, 95:1725-1729, 1998.

Mackewicz CE, Garovoy MR, Levy JA. HLA compatibility requirements for CD8+ cell ив T-cell-mediated suppression of human immunodeficiency virus replication. J Virol 72: 10165-10170, 1998.

Stranford SA, Skurnick J, Louria D, Osmond D, Chang S, Sninsky J, Ferrari G, Weinhold K, Lindquist, Levy JA. Lack of infection in HIV-exposed individuals is associated with a strong CD8+ cell noncytotoxic anti-HIV response. PNAS 96:1030-35, 1999.

Mackewicz CE, Patterson, BK, Lee SA, Levy, JA. CD8+ cell non-cytotoxic anti-human immunodeficiency virus response inhibits expression of viral RNA but not reverse transcription or provirus integration. J. Gen Virol 81: 1261-64, 2000.

Stranford SA, Levy JA et. al. Reduction in CD8+ cell noncytotoxic anti-HIV activity in subjects receiving HAART therapy during primary infection. PNAS. 98:597-602, 2001.

Mackewicz CE, Wang B, Metkar S, Richey M, Froelich C, Levy JA. Lack of CD8+ cell anti-HIV factor in CD8+ cell granules. Blood, 102:180-183, 2003.

Locher CP, Witt SA, Herdier BG, Abbey NW, Tenner-Racz K, Racz P, Kiviat NB, Murthy KK, Brasky K, Leland M, Levy JA. Increased viral replication and virulence after serial passage of human immunodeficiency virus type-2 in baboons. J Virol. 77: 77-88, 2003.

Locher CP, Fujimura S, Murthy K, Brasky K, Leland M, Levy JA. Expression patterns of phenotypic markers on lymphocytes from human immunodeficiency virus type 2-infected baboons. AIDS Res Hum Retrovir. 19: 31-40, 2003

*Mackewicz CE, Craik CS, Levy JA. The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors. Proc Natl Acad Sci (USA), 100, 3433-3438, 2003.

Diaz L, Stone M, Mackewicz CE, Levy JA. Differential gene expression in CD8+ cells exhibiting non-cytotoxic anti-HIV activity. Virology. 311: 400-405, 2003.

Mackewicz C, Yuan J, Tran P, Diaz L, Mack E, Selsted M, Levy JA. _-Defensins can have anti-HIV activity but are not CD8+ cell anti-HIV factors. AIDS, 17: F23-F32. 2003.

Locher CP, Witt SA, Ashlock BM, Polacino P, Hu SH, Shbioski S, Schmidt AM, Agy MB, Anderson DM, Staprans SI, zur Megede J, and Levy, JA. Human Immunodeficiency Virus type 2 DNA vaccine provides partial protection from acute baboon infection. Vaccine. In press, 2004.

9/15/04

This site will look much better in a browser that supports web standards, but it is accessible to any browser or Internet device. Please upgrade your browser.