Marion and Herbert Sandler Distinguished Professorship in Asthma Research, UCSF
Member, Biomedical Sciences Graduate Program (BMS), Herbert Boyer Program in Biological Sciences (PIBS), and Immunology Graduate Program, UCSF
| CONTACT | |
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locksley@medicine.ucsf.edu Box 0654, UCSF; San Francisco, CA 94143-0654 |
| EDUCATION | |
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Harvard College, Cambridge, MA, B.A., 1970, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1986-2003 |
Chief, Division of Infectious Diseases, UCSF Medical Center, San Francisco, CA |
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1988-93 |
Member and Chair (1991-93), Tropical Medicine and Parasitology Study Section, NIH |
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1991-94 |
Co-Director, Immunology Section, Biology of Parasitism Course, Woods Hole, MA |
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1994-99 |
Chair, Parasitology Pathogenesis Committee, WHO, Geneva |
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1995-present |
Council, Chair (1998), Midwinter Conference of Immunologists, Asilomar |
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1995-2001 |
Faculty, Assoc. of American Immunology Annual Course, Advanced Immunology |
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1997-present |
Investigator, Howard Hughes Medical Institute, UCSF |
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1998-2001 |
Member, Chair (2000-2001), US-Japan Immunology Board, NIH |
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2003-present |
Director, Sandler Center for Basic Asthma Research |
| HONORS & AWARDS | |
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American Society for Clinical Investigation; American Association of Physicians | |
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1992-97 |
Burroughs Wellcome Fund Scholar in Molecular Parasitology |
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1994 |
Bailey K. Ashford Medal, American Society Tropical Medicine and Hygiene |
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2001- |
Ellison Medical Foundation Senior Scholar in Global Infectious Diseases |
| SELECTED PUBLICATIONS | |
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Reiner SL, ZE Wang, F Hatam, P Scott, RM Locksley. Th1 and Th2 cell antigen receptors in experimental leishmaniasis. Science 259:1457-60, 1993. | |
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Locksley RM, SL Reiner, F Hatam, DR Littman, N Killeen. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261:1448-51, 1993. | |
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Reiner SL, RM Locksley. The regulation of immunity to Leishmania major. Annu Rev Immunol 13:151 77, 1995. | |
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Mougneau E, F Altare, AE Wakil, S Zheng, T Coppola, ZE Wang, R Waldmann, RM Locksley, N Glaichenhaus. Expression cloning of a protective Leishmania antigen. Science 268:563-6, 1995. | |
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Fearon DT, RM Locksley. The instructive role of innate immunity in the acquired immune response. Science 272:50-4, 1996. | |
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Fowell DJ, J Magram, CW Turck, N Killeen, RM Locksley. Impaired Th2 subset development in the absence of CD4. Immunity 6:559-69, 1997. | |
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Bix M, Locksley RM. Independent and epigenetic regulation of the interleukin 4 alleles in CD4+ T cells. Science 281:1352-4, 1998. | |
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Grunig G, M Warnock, AE Wakil, R Venkayya, F Brombacher, DM Rennick, D Sheppard, M Mohrs, DD Donaldson, RM Locksley, DB Corry. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282:2261-3, 1998. | |
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Pingel S., P Launois, DJ Fowell, CW Turck, S Southwood, A Sette, N Glaichenhaus, JA Louis, RM Locksley. Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope. J Exp Med 189:1111-20, 1999. | |
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Fowell DJ, K Shinkai, XC Liao, AM Beebe, RL Coffman, DR Littman, RM Locksley. Impaired NFATc translocation and failure of Th2 development in itk-deficient CD4+ T cells. Immunity 11:399-409, 1999. | |
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Symula D, KA Frazer, Y Ueda, P Denefle, ME Stevens, ZE Wang, RM Locksley, EM Rubin. Functional screening of an asthma QTL in YAC transgenic mice. Nature Genetics 23:241-4, 1999. | |
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Shinkai K, RM Locksley. CD1, tuberculosis and the evolution of MHC molecules. J Exp Med 191:907-14, 2000. | |
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Lacy DA, ZE Wang, DJ Symula, CJ McArthur, EM Rubin, KA Frazer, RM Locksley. Faithful expression of the human 5q31 cytokine cluster in transgenic mice. J Immunol 164:4569-74, 2000. | |
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Loots GG, RM Locksley, CM Blankespoor, ZE Wang, W Miller, EM Rubin, KA Frazer. Identification of a coordinate regulator of interleukins 4, 13 and 5 by cross-species sequence comparsions. Science 288:136-40, 2000. | |
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Kelly BL, RM Locksley. Coordinate regulation of the IL-4, IL-13 and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J Immunol 165:2982-6, 2000. | |
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Grogan JL, M Mohrs, B Harmon, DA Lacy, JW Sedat, RM Locksley. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14:205-15, 2001. | |
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Locksley RM, N Killeen, MJ Lenardo. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487-501, 2001. | |
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Mohrs M, K Shinkai, K Mohrs, RM Locksley. Analysis of type 2 immunity in vivo with a biscistronic IL-4 reporter. Immunity 15:303-11, 2001. | |
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Mohrs M, C Blankespoor, Z Wang, G Loots, V Afzal, H Hadeiba, K Shinkai, EM Rubin, RM Locksley. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nature Immunol. 2:842-7, 2001. | |
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Davies SJ, JL Grogan, RB Blank, KC Lim, RM Locksley, JH McKerrow. Modulation of blood fluke development in the liver by unconventional hepatic CD4+ lymphocytes. Science 294:1358-61, 2001. | |
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Riese RJ, G-P Shi, J Villadangos, D Stetson, C Driessen, A-M Lennon-Dumenil, C-L Chu, Y Naumov, SM Behar, H Ploegh, RM Locksley, HA Chapman. Regulation of CD1 function and NK1.1+ T cell selection by cathepsin S. Immunity 15:909-919, 2001. | |
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Grogan JL, RM Locksley. T helper cell differentiation: on-again, off-again. Curr Opin Immunol 14:366-72. | |
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Baron JL, L Gardiner, S Nishimura, K Shinkai, RM Locksley, D Ganem. Activation of a nonclassical NK T cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 16:583-594, 2002. | |
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Stetson DB, M Mohrs, V Mallet-Designe, L Teyton, RM Locksley. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity 17:191-200, 2002. | |
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Shinkai K, M Mohrs, RM Locksley. Helper T cells regulate type-2 innate immunity in vivo. Nature 420:825-9, 2002. | |
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Bour-Jordan H, JL Grogan, Q Tang, JA Auger, RM Locksley, JA Bluestone. CTLA-4 abrogates the requirement for cytokine-induced signals in Th2 lineage commitment. Nature Immunol 4:182-8, 2003. | |
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Mohrs M, DA Lacy, RM Locksley. Stat signals release activated naive Th cells from an anergic checkpoint. J Immunol 170:1870-6, 2003. | |
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Stetson DB, M Mohrs, RL Reinhardt, JL Baron, ZE Wang, L Gapin, M Kronenberg, RM Locksley. 2003. Constitutive cytokine mRNAs mark NK and NK T cells poised for rapid effector responses. J Exp Med 198:1069-76. | |
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Kelly BL, DB Stetson, RM Locksley. 2003. Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med 198:1689-1698. | |
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Voehringer D, K Shinkai, RM Locksley. 2004. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20:267-277. | |
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Xu M, ZE Wang, RM Locksley. 2004. Innate immune responses in peptidoglycan recognition protein-L-deficient mice. Mol Cell Biol (in press). |
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10/15/04 |
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