Richard M. Locksley, MD

Harvard College, Cambridge, MA, B.A., 1970, Biochemistry
Univ. of Rochester, Rochester, NY, M.D., 1976, Medicine
Univ. of California, San Francisco, CA, 1976-80, Resident, Chief Resident
Univ. Wash. School of Medicine, Seattle, WA, 1980-83, Infectious Diseases

• 1986-2003
  Chief, Division of Infectious Diseases, UCSF Medical Center, San Francisco, CA
• 1988-93
  Member and Chair (1991-93), Tropical Medicine and Parasitology Study Section, NIH
• 1991-94
  Co-Director, Immunology Section, Biology of Parasitism Course, Woods Hole, MA
• 1994-99
  Chair, Parasitology Pathogenesis Committee, WHO, Geneva
• 1995-05
  Council, Chair (1998), Midwinter Conference of Immunologists, Asilomar
• 1995-01
  Faculty, Assoc. of American Immunology Annual Course, Advanced Immunology
• 1997-present
  Investigator, Howard Hughes Medical Institute, UCSF
• 1998-01
  Member, Chair (2000-01), US-Japan Immunology Board, NIH
• 2002-05
  Council, NIAID, National Institutes of Health
• 2003-present
  Director, Strategic Asthma Basic Research Center, UCSF

• American Society for Clinical Investigation, 1991
• Burroughs Wellcome Fund Scholar in Molecular Parasitology, 1992-97
• Fellow, Infectious Diseases Society of American, 1992
• Association of American Physicians, 1994
• Bailey K Ashford Medal, American Society Tropical Medicine and Hygiene, 1994
• Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2001-05
• Distinguished Service Award, American Association of Immunologists, 2003
• Inspirational Teacher Award, UCSF class of 2006
• Sandler Distinguished Professorship, 2003
• American Academy of Arts & Sciences, 2005
• R37 MERIT Award, NIAID/NIH, 2006

• Reiner SL, ZE Wang, F Hatam, P Scott, RM Locksley. 1993. Th1 and Th2 cell antigen receptors in experimental leishmaniasis. Science 259:1457-60.
• Bix M, Locksley RM. 1998. Independent and epigenetic regulation of the interleukin 4 alleles in CD4+ T cells. Science 281:1352-4.
• Grogan JL, M Mohrs, B Harmon, DA Lacy, JW Sedat, RM Locksley. 2001. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14:205-15.
• Mohrs M, CM Blankespoor, ZE Wang, GG Loots, V Afzal, H Hadeiba, K Shinkai, EM Rubin, RM Locksley. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nature Immunol. 2:842-7, 2001.
• Mohrs M, K Shinkai, K Mohrs, RM Locksley. Analysis of type 2 immunity in vivo with a biscistronic IL-4 reporter. Immunity 15:303-11, 2001.
• Shinkai K, M Mohrs, RM Locksley. 2002. Helper T cells regulate type 2 immunity in vivo. Nature 420:825-9.
• Voehringer D, K Shinkai, RM Locksley. 2004. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20:267-77.
• Mohrs K, AE Wakil, N Killeen, RM Locksley, M Mohrs. 2005. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity 23:419-29. (PMCID: PMC2826320)
• Scheu S, DB Stetson, RL Reinhardt, JH Leber, M Mohrs, RM Locksley. 2006. Activation of the integrated stress response during T helper cell differentiation. Nature Immunol 7:644-51. (PMCID: PMC2629269)
• Voehringer D, TA Reese, X Huang, K Shinkai, RM Locksley. 2006. Type 2 immunity is controlled by IL-4/IL- 13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med 203:1435-46. (PMCID: PMC2118302)
• Reese TA, H-E Liang, AM Tager, AD Luster, N van Rooijen, D Voehringer, RM Locksley. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447:92-6. (PMCID: PMC2527589)
• Kang S-J, H-E Liang, B Reizis, RM Locksley. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29:819-33. (PMCID: PMC2858430)
• Barbalat R, L Lau, RM Locksley, GM Barton. 2009. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nature Immunol 10:1200-7 (PMCID: PMC2821672).
• Voehringer D, D Wu, H-E Liang, RM Locksley. 2009. Efficient generation of long-distance conditional Alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol 9:69 (PMCID: PMC2724507)
• Reinhardt RL, H-E Liang, RM Locksley. 2009. Cytokine-secreting follicular T cells shape the antibody repertoire. Nature Immunol 10:385-93. (PMCID: PMC2714053)
• Locksley RM. 2010. Asthma and allergic inflammation. Cell 140:777-83.
• Price AE, H-E Liang, BM Sullivan, RL Reinhardt, CJ Eisley DJ Erle, RM Locksley. 2010. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci USA 107:11489-94. (PMCID: pending)
• Ricardo-Gonzalez RR, A Red Eagle, JI Odegaard, H Jouihna, CR Morel, JE Heredia, L Mukundan, D Wu, RM Locksley, A Chawla. 2010. IL-4/Stat6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci USA 107:22617-22 (PMCID: PMC3012500).
• Wu D, AB Molofsky, H-E Liang, RR Ricardo-Gonzalez, HA Jouihan, JK Bando, A Chawla, RM Locksley. 2011. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332:243-7.
• Sullivan BM, H-E Liang, JK Bando, D Wu, LE Cheng, JK McKerrow, CDC Allen, RM Locksley. 2011. Genetic analysis of basophil function in vivo. Nature Immunol (in press).