Director, UCSF Helen Diller Family Comprehensive Cancer Center
David A. Wood Distinguished Professorship of Tumor Biology and Cancer Research
E. Dixon Heise Distinguished Professorship in Oncology
Associate Dean, UCSF School of Medicine
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS)
| CONTACT | |
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director@cc.ucsf.edu Box 0128, UCSF; San Francisco, CA 94143-0128 |
additional websites: |
| EDUCATION | |
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University of Birmingham, England, B.Sc., 1972, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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1975-78 |
Professor Seymour S. Cohen, State University of New York at Stony Brook (Post Doctoral Fellow) |
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1978-81 |
Dr. Alan Smith, Imperial Cancer Research Fund, London (Post Doctoral Fellow) |
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1981-90 |
Cetus Corporation (Director of Molecular Biology) |
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1990-91 |
Cetus Corporation (Vice President, Research) |
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1991-92 |
Chiron Corporation (Vice President, Research) |
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1992-96 |
Onyx Pharmaceuticals (Founder, Chief Scientific Officer) |
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1996-present |
Fellow of the Royal Society |
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1997-2009 |
University of California, San Francisco, Cancer Research Institute (Director) |
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1997-present |
University of California, San Francisco, Dept. of Microbiology & Immunology (Professor) |
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1997- |
University of California, San Francisco, Cancer Center, (Director, Associate Dean) |
| HONORS & AWARDS | |
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1996 |
Fellow of the Royal Society |
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2002 |
Bristol Myers Squibb Unrestricted Cancer Research Grant |
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2002 |
AACR - G.H.A. Clowes Memorial Award |
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2002 |
Novartis Drew Award in Biomedical Research |
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2003 |
University of Chicago, Cancer Research Center, Shubitz Award |
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2005 |
Institute of Medicine |
| SELECTED PUBLICATIONS | |
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(from 267 full-length publications) | |
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Stokoe D, McCormick F. Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. Embo J 1997;16:2384-96. | |
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F Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes A, McCormick F, Hawkins PT. Dual role of phosphatidylinositol 3,4,5-trisphosphate in the activation of protein kinase B. Science 1997;277:567-70. | |
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Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998;279:710-4. | |
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Tetsu O, McCormick F. β-catenin regulates cyclin D1 expression in colon carcinoma cells. Nature 1999; 398:422-6. | |
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Ries S, Brandts C, Chung A, Biederer C, Hann B, Lipner E, McCormick F, Korn M. Loss of p14ARF in tumor cells facilities replication of the adenovirus mutant dl1520 (ONYX-015). Nature Medicine 2000; 6:1128-33. | |
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Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF. Cell 2000; 03:321-30. | |
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McCormick F. Cancer Gene Therapy: Fringe or Cutting Edge. Nature Reviews Cancer 2001;1:130-41. | |
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Johnson L, Shen A, Boyle L, Kunich J, Pandey K, Lemmon M, Hermiston T, Giedlin M, McCormick F, Fattaey A. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell 2002;1:325-37. | |
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Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 2003;3:233-46. | |
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Anders M, Christian C, McMahon M, McCormick F, Korn, WM. Inhibition of the Raf/MEK/ERK pathway up regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer Res 2003; 63:2088-95. | |
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McCormick F. Cancer-specific viruses and the development of ONYX-015. Cancer Biol Ther 2003;2:S157 60. | |
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O'Shea C, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, Shen Y, Habets G, Ginzinger D, McCormick F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 2004;6:611-23. | |
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OfShea C, Klupsch K, Choi S, Bagus B, Soria C, Shen J, McCormick F, Stokoe D. Adenoviral proteins mimic nutrient/ growth signals to activate the mTOR pathway for viral replication. EMBO J 2005;24:1211 | |
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Reid TR, Freeman S, Post L, McCormick F, Sze DY. Effects of ONYX-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucoforin. Cancer Gene Ther 2005;12:673-81. | |
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OfShea C, Choi S, Bagus B, McCormick F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 2005;8:61 74. | |
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Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell 2005;8:111-8. | |
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Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA. Germline mutations in genes within the MAPK pathway cause radio-facio-cutaneous syndrome. Science 2006;311:1287-90. | |
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Rodriguez-Viciana P, McCormick F. Ras ubiquitination: coupling spatial sorting and signal transmission. Cancer Cell 2006;9:243-4. | |
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Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. A phosphate holoenzyme comprised of shoc2/sur8 and the catalytic subunit of pp1 functions as an M-Ras effector to to modulate Raf activity. Molecular Cell 2006;22:217-30. | |
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Lee SH, McCormick F. p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. EMBO J 2006;25:4008-19. | |
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Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006; 10:515-27. | |
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Okabe, H., Lee, S.H., Phucareon, J., Albertson, D.G., McCormick, F., Tetsu, O. 2006. A critical role for FBXW8 and MAPK in cylin D1 degradation and cancer cell proliferation. PLoS ONE 1: e128. | |
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Ding, V., Lin, L., Chiang, A., McCormick, F. 2007. Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. Journal of Molecular Medicine 85:1281-9. | |
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Iacovides, D.C., OfShea, C.C., Oses-Prieto, J., Burlingame, A., McCormick, F. 2007. Critical role for arginine methylation in adenovirus-infected cells. Journal of Virology 81:13209-17. | |
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Jiang, H., Gomez-Manzano, C., Aoki, H., Alonso, M.M., Kondo, S., McCormick, F., Xu, J., Kondo, Y., Bekele, B.N., Colman, H., Lang, F.F, Fueyo, J. 2007. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst 99:1410-4. | |
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Estep A.L., Palmer, C., McCormick, F., Rauen, K.A. 2008. Mutation analysis of BRAF, MEK1 and MEK2 in 15 Ovarian Cancer Cell Lines: Implications for Therapy. PLoS ONE 2:e1279. | |
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Senawong, T., Phuchareon, J., Ohara, O., McCormick, F., Rauen, K.A., Tetsu, O. 2008. Germline mutations of MEK in cardio-facio-cutaneous (CFC) syndrome are sensitive to MEK and RAF inhibition: Implications for therapeutic options. Hum Mol Genet 17: 419-30. | |
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Kitagawa, M., Lee, S.H., McCormick, F. 2008. Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Mol Cell 29:217-31. | |
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Weisenberger, D., Trinh, B., Campan, M., Sharma, S., Long, T., Ananthnarayan, S., Liang, G., Esteva, F., Hortobagyi, G., McCormick, F., Jones, P., Laird, P. 2008. DNA Methylation Analysis by Digital Bisulfite Genomic Sequencing and Digital MethyLight. NAR-00542-S-20008.R1. |
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5/1/09 |
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