director@cc.ucsf.edu
(415) 502-1710 (voice)
(415) 502-1712 (fax)

Box 0128, UCSF; San Francisco, CA 94143-0128

additional websites:

McCormick Lab Website

University of Birmingham, England, B.Sc., 1972, Biochemistry
University of Cambridge, England, Ph.D., 1975, Biochemistry

(from 259 full-length publications)

McCormick F, Harlow E. Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol 1980;34:213-24.

McCormick F, Clark R, Harlow E, Tijan R. SV40 T antigen binds specifically to a cellular 53 k protein in vitro. Nature 1981;292:63-5.

Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature 1993;366:643-54.

Cook SJ, McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science 1993; 262:1069-72.

Qiu RG, Chen J, Kirn D, McCormick F, Symons M. A role for Rho in Ras transformation. Nature 1995; 374:457-9.

Bischoff JR, Kirn, DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A, McCormick F. An Adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996;274:373-6.

Heise C, Sampson-Johannes A, Williams A, McCormick F, Von Hoff DD, Kirn DH. ONYX-015-, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 1997;3:639-45.

Stokoe D, McCormick F. Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. Embo J 1997;16:2384-96.

Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes A, McCormick F, Hawkins PT. Dual role of phosphatidylinositol 3,4,5-trisphosphate in the activation of protein kinase B. Science 1997;277:567-70.

Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998;279:710- 4.

Tetsu O, McCormick F. -catenin regulates cyclin D1 expression in colon carcinoma cells. Nature 1999; 398:422-6.

Ries S, Brandts C, Chung A, Biederer C, Hann B, Lipner E, McCormick F, Korn M. Loss of p14ARF in tumor cells facilities replication of the adenovirus mutant dl1520 (ONYX-015). Nature Medicine 2000; 6:1128-33.

Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF. Cell 2000; 103:321-30.

McCormick F. Cancer Gene Therapy: Fringe or Cutting Edge. Nature Reviews Cancer 2001;1:130-41.

Johnson L, Shen A, Boyle L, Kunich J, Pandey K, Lemmon M, Hermiston T, Giedlin M, McCormick F, Fattaey A. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell 2002;1:325-37.

Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 2003;3:233-46.

Anders M, Christian C, McMahon M, McCormick F, Korn, WM. Inhibition of the Raf/MEK/ERK pathway up regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer Res 2003; 63:2088-95.

McCormick F. Cancer-specific viruses and the development of ONYX-015. Cancer Biol Ther 2003;2:S157 60.

O'Shea C, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, Shen Y, Habets G, Ginzinger D, McCormick F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 2004;6:611-23.

O'Shea C, Klupsch K, Choi S, Bagus B, Soria C, Shen J, McCormick F, Stokoe D. Adenoviral proteins mimic nutrient/ growth signals to activate the mTOR pathway for viral replication. EMBO J 2005;24:1211 21.

Reid TR, Freeman S, Post L, McCormick F, Sze DY. Effects of ONYX-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucoforin. Cancer Gene Ther 2005;12:673-81.

O'Shea C, Choi S, Bagus B, McCormick F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 2005;8:61 74.

Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell 2005;8:111-8.

Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA. Germline mutations in genes within the MAPK pathway cause radio-facio-cutaneous syndrome. Science 2006;311:1287-90.

Rodriguez-Viciana P, McCormick F. Ras ubiquitination: coupling spatial sorting and signal transmission. Cancer Cell 2006;9:243-4.

Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. A phosphate holoenzyme comprised of shoc2/sur8 and the catalytic subunit of pp1 functions as an M-Ras effector to to modulate Raf activity. Molecular Cell 2006;22:217-30.

Lee SH, McCormick F. p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. EMBO J 2006;25:4008-19.

Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006; 10:515-27.

6/5/08