K. Mark Ansel, PhD

K. Mark Ansel, PhD

Associate Professor of Microbiology & Immunology, UCSF


Phone: (415) 476-5368
UCSF Box 0997
San Francisco, CA 94143-0414

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Cancer Center Membership

Program Member » Cancer, Immunity, and Microenvironment

Research Summary

I am an Associate Professor in the UCSF Department of Microbiology & Immunology, and a Leukemia and Lymphoma Society Scholar. My laboratory in the Sandler Asthma Basic Research Center at the UCSF Parnassus campus studies the molecular basis of immune cell programming, with a particular focus on post-transcriptional regulation of gene expression in T cells. My laboratory is part of the Sandler Asthma Basic Research Center (SABRe), an investigative unit dedicated to basic discovery in asthma research. The SABRe Center’s advanced technology cores and connections with clinical research centers create an advantageous environment for marrying basic discoveries and technological innovation in RNA biology with translational approaches to apply fundamental research to advance the prevention and treatment of human disease. Our connections with other HDFCCC investigators have led to synergistic collaborations and joint funding to investigate miRNA homeostasis and function in cancer and immunity.


Virginia Tech (Blacksburg, VA), B.S., 1992-1996, Biochemistry
University of California, San Francisco, Ph.D., 1996-2001, Biomedical Sciences
Immune Disease Institute, Harvard Medical School, 2001-2007, Immunology

Professional Experience

  • 2001 - 2005
    Postdoctoral Fellow, Immune Disease Institute (p.k.a. Center for Blood Research), Harvard Medical School, Boston, MA
  • 2005 - 2007
    Instructor, Department of Pediatrics, Children’s Hospital and Immune Disease Institute (p.k.a. Center for Blood Research), Harvard Medical School, Boston, MA
  • 2008 - 2013
    Assistant Professor, Department of Microbiology & Immunology and Sandler Asthma Basic Research Center, UCSF
  • 2013 - present
    Associate Professor in residence, Department of Microbiology & Immunology and Sandler Asthma Basic Research Center, UCSF
  • 2013 – present
    Associate Director, Biomedical Sciences Graduate Program, University of California San Francisco

Honors & Awards

  • 1997 - 2001
    Howard Hughes Medical Institute Predoctoral Fellowship
  • 2001 - 2004
    Damon Runyon Cancer Research Fund Postdoctoral Fellowship
  • 2005 - 2007
    Leukemia and Lymphoma Society Special Fellow
  • 2006 - 2012
    Burroughs Wellcome Career Award in Biomedical Sciences
  • 2007
    International Cytokine Society Outstanding Postdoctoral Fellow
  • 2009 - 2012
    Dana Foundation Human Immunology Scholar
  • 2012
    American Association of Immunologists Young Investigator Travel Award
  • 2012 -
    Leukemia & Lymphoma Society Scholar

Selected Publications

  1. Simpson LJ, Ansel KM. MicroRNA regulation of lymphocyte tolerance and autoimmunity. J Clin Invest. 2015 Jun 1; 125(6):2242-9.
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  2. Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Mark Ansel K, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Mar 9; 27(3):409-25.
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  3. Warth SC, Hoefig KP, Hiekel A, Schallenberg S, Jovanovic K, Klein L, Kretschmer K, Ansel KM, Heissmeyer V. Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation. EMBO J. 2015 May 5; 34(9):1195-213.
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  4. Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. The transcription factor NFAT promotes exhaustion of activated CD8(+) T cells. Immunity. 2015 Feb 17; 42(2):265-78.
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  5. Baumjohann D, Ansel KM. Tracking early T follicular helper cell differentiation in vivo. Methods Mol Biol. 2015; 1291:27-38.
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  6. Sperling AI, Ansel KM. Editorial overview: Allergy and hypersensitivity. Curr Opin Immunol. 2014 Dec; 31:ix-xi.
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  7. Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70.
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  8. Seumois G, Chavez L, Gerasimova A, Lienhard M, Omran N, Kalinke L, Vedanayagam M, Ganesan AP, Chawla A, Djukanovic R, Ansel KM, Peters B, Rao A, Vijayanand P. Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nat Immunol. 2014 Aug; 15(8):777-88.
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  9. Thomas MF, L'Etoile ND, Ansel KM. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways. Trends Genet. 2014 Jul; 30(7):298-307.
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  10. Baumjohann D, Ansel KM. MicroRNA regulation of the germinal center response. Curr Opin Immunol. 2014 Jun; 28:6-11.
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  11. Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, Kim SJ, Zeng R, Dent A, Ansel KM, Diamond B, Hadeiba H, Butcher EC. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014 Jan; 15(1):98-108.
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  12. Baumjohann D, Ansel KM. MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol. 2013 Sep; 13(9):666-78.
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  13. Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8.
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  14. Ansel KM. RNA regulation of the immune system. Immunol Rev. 2013 May; 253(1):5-11.
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  15. Bronevetsky Y, Ansel KM. Regulation of miRNA biogenesis and turnover in the immune system. Immunol Rev. 2013 May; 253(1):304-16.
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  16. Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013 Mar 21; 38(3):596-605.
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  17. Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11; 210(2):417-32.
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  18. Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V. Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol. 2013 Jan; 20(1):73-81.
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  19. Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM. An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol. 2012 Nov 30; 1(2):70-89.
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  20. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74.
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