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K. Mark Ansel, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Assistant Professor of Microbiology and
Immunology

Mark.Ansel@ucsf.edu

UCSF Box 0414
San Francisco, CA 94143-0414

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Education

Virginia Tech (Blacksburg, VA), B.S., 1992-1996, Biochemistry
University of California, San Francisco, Ph.D., 1996-2001, Biomedical Sciences
Immune Disease Institute, Harvard Medical School, 2001-2007, Immunology


Professional Experience

  • 2001 - 2005
    Postdoctoral Fellow, Immune Disease Institute (p.k.a. Center for Blood Research), Harvard Medical School, Boston, MA
  • 2005 - 2007
    Instructor, Department of Pediatrics, Children’s Hospital and Immune Disease Institute (p.k.a. Center for Blood Research), Harvard Medical School, Boston, MA
  • 2008 -
    Assistant Professor, Department of Microbiology and Immunology and Sandler Asthma Basic Research Center, University of California San Francisco

Honors & Awards

  • 1997 - 2001
    Howard Hughes Medical Institute Predoctoral Fellowship
  • 2001 - 2004
    Damon Runyon Cancer Research Fund Postdoctoral Fellowship
  • 2005 - 2007
    Leukemia and Lymphoma Society Special Fellow
  • 2006 - 2012
    Burroughs Wellcome Career Award in Biomedical Sciences
  • 2007
    International Cytokine Society Outstanding Postdoctoral Fellow
  • 2009 - 2012
    Dana Foundation Human Immunology Scholar
  • 2012
    American Association of Immunologists Young Investigator Travel Award
  • 2012 -
    Leukemia & Lymphoma Society Scholar

  • Selected Publications

    1. Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, Kim SJ, Zeng R, Dent A, Ansel KM, Diamond B, Hadeiba H, Butcher EC. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014 Jan; 15(1):98-108.
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    2. Baumjohann D, Ansel KM. MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol. 2013 Sep; 13(9):666-78.
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    3. Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8.
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    4. Bronevetsky Y, Ansel KM. Regulation of miRNA biogenesis and turnover in the immune system. Immunol Rev. 2013 May; 253(1):304-16.
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    5. Ansel KM. RNA regulation of the immune system. Immunol Rev. 2013 May; 253(1):5-11.
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    6. Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013 Mar 21; 38(3):596-605.
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    7. Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11; 210(2):417-32.
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    8. Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V. Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol. 2013 Jan; 20(1):73-81.
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    9. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74.
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    10. Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012 Jul 5; 120(1):130-42.
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    11. Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity. 2012 Feb 24; 36(2):175-87.
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    12. Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81.
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    13. Baumjohann D, Okada T, Ansel KM. Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol. 2011 Sep 1; 187(5):2089-92.
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    14. Sofi MH, Qiao Y, Ansel KM, Kubo M, Chang CH. Induction and maintenance of IL-4 expression are regulated differently by the 3' enhancer in CD4 T cells. J Immunol. 2011 Mar 1; 186(5):2792-9.
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    15. Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb; 6(2):e1000764.
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    16. Thomas MF, Ansel KM. Construction of small RNA cDNA libraries for deep sequencing. Methods Mol Biol. 2010; 667:93-111.
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    17. Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol. 2008 May; 15(5):523-30.
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    18. Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol. 2007 Oct 15; 179(8):5099-108.
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    19. Carvalho LD, Teixeira LK, Carrossini N, Caldeira AT, Ansel KM, Rao A, Viola JP. The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. Cell Cycle. 2007 Jul 15; 6(14):1789-95.
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    20. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27; 316(5824):604-8.
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