University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Sarah T. Arron, MD, PhD

Sarah T. Arron, MD, PhD

Assistant Professor, Department of Dermatology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

My research focuses on the pathogenesis of cutaneous squamous cell carcinoma. As a Mohs Micrographic surgeon in the department of Dermatology, I lead the High Risk Skin Cancer Program, a practice devoted to the care of patients at risk for skin cancer due to solid organ transplant and other iatrogenic immunosuppression, HIV infection, and genetic conditions predisposing to cutaneous malignancy.

A primary research question for our group is whether human papillomavirus (HPV) is an etiologic agent in cutaneous squamous cell carcinoma (SCC) in immunosuppressed patients and in the general population. Cutaneous SCC is the second most common type of skin cancer, with an estimated incidence of over 200,000 cases per year in the United States and a 65-fold increased risk in immunosuppressed organ transplant recipients over the general population. A related question is whether HPV carriage on the skin at baseline is a predictor for the development of SCC after solid organ transplant.

To address these questions, we must first be able to accurately and definitively identify HPV infection in the skin. Previous attempts to link cutaneous SCC with HPV infection have yielded contradictory results, primarily due to differences in viral detection techniques. Our laboratory is working to develop new technologies for the detection and genotyping of HPV. Over 90 fully sequenced human papillomaviruses and numerous fragment candidates have been identified. This creates a complex combination of sequence conservation and diversity within the family that has frustrated previous attempts at a unified genotyping strategy. Our group combines bioinformatics, microarray technology, and deep sequencing in order to overcome obstacles to accurate genotyping.

New techniques for HPV genotyping will also lend themselves to questions beyond the realm of dermatology. We have set up collaborations with groups in other departments at UCSF to implement our assays in studies on the role of HPV in the pathogenesis of head and neck SCC and anogenital SCC. We anticipate that this technology will lead to larger multidisciplinary studies on HPV in the future.

The second aspect of my research focuses on risk factors for cutaneous squamous cell carcinoma in organ transplant recipients. Through the UCSF Mechanisms of Skin Cancer Cohort, we are working to determine both phenotypic and genetic risk factors for the development of skin cancer in this high risk population. We are actively recruiting patients to our database and banking tissue for future studies.

The UCSF High Risk Skin Cancer Program is involved in a variety of collaborative translational research efforts. In addition, the program is structured to serve as an investigational site for pharmaceutical trials. As Director of this rapidly developing unit, I am committed to implementing research that improves the care of our patients.

Education

Harvard College, A.B., 06/96, Biology
Weill Medical College of Cornell University, M.D., 06/03,
The Rockefeller University, Ph.D., 06/02, Biomedical Sciences
Santa Clara Valley Medical Center, Intern, 06/04, Medicine- Transitional
University of California, San Francisco School of Medicine, Resident, 06/08, Dermatology
University of California, San Francisco School of Medicine, Fellow, 06/08, Molecular Medicine
University of California, San Francisco School of Medicine, Fellow, 06/07, Procedural Dermatology
University of California, San Francisco School of Medicine, Postdoctoral Fellow, 06/10, Viral Metagenomics
University of California, San Francisco School of Medicine, M.A.S., 06/12, Clinical Research
 


Professional Experience

  • 2008-2009
    University of California, San Francisco School of Medicine, Assistant Clinical Professor, Dermatology
  • 2009-present
    University of California, San Francisco School of Medicine, Assistant Professor in Residence, Dermatology
  • 2012-present
    San Francisco Veterans Administration Medical Center, Chief, Mohs Micrographic Surgery, Dermatology

Honors & Awards


  • 2009
    Academic Dermatology Leadership ProgramAmerican Academy of Dermatology

Selected Publications

  1. Yuan JT, Tello TL, Hultman C, Barker CA, Arron ST, Yom SS. Medical marijuana for the treatment of vismodegib-related muscle spasm. JAAD Case Rep. 2017 Sep; 3(5):438-440.
    View on PubMed
  2. Bhutani T, Abrouk M, Sima CS, Sadetsky N, Hou J, Caro I, Chren MM, Arron ST. Risk of cutaneous squamous cell carcinoma after treatment of basal cell carcinoma with vismodegib. J Am Acad Dermatol. 2017 Oct; 77(4):713-718.
    View on PubMed
  3. Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R. Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation. Stem Cells. 2017 Aug; 35(8):2001-2007.
    View on PubMed
  4. Ahn RS, Taravati K, Lai K, Lee KM, Nititham J, Gupta R, Chang DS, Arron ST, Rosenblum M, Liao W. Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. Sci Rep. 2017 May 02; 7(1):1343.
    View on PubMed
  5. Wei L, Allain DC, Bernhardt MN, Gillespie JL, Peters SB, Iwenofu OH, Nelson HH, Arron ST, Toland AE. Variants at the OCA2/HERC2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs. Br J Dermatol. 2017 Apr 29.
    View on PubMed
  6. Yanik EL, Pfeiffer RM, Freedman DM, Weinstock MA, Cahoon EK, Arron ST, Chaloux M, Connolly MK, Nagarajan P, Engels EA. Spectrum of Immune-Related Conditions Associated with Risk of Keratinocyte Cancers among Elderly Adults in the United States. Cancer Epidemiol Biomarkers Prev. 2017 Jul; 26(7):998-1007.
    View on PubMed
  7. Hibler BP, Saylor DK, Chin-Hong P, Arron ST. Antimicrobial Prophylaxis for Full-Face Laser Resurfacing in Transplant Recipients. Dermatol Surg. 2017 Apr; 43(4):599-604.
    View on PubMed
  8. Stuart SE, Schoen P, Jin C, Parvataneni R, Arron S, Linos E, Boscardin WJ, Chren MM. Tumor recurrence of keratinocyte carcinomas judged appropriate for Mohs micrographic surgery using Appropriate Use Criteria. J Am Acad Dermatol. 2017 Jun; 76(6):1131-1138.e1.
    View on PubMed
  9. Yuan JT, Chang TW, Yu SS, Arron ST. Mental Artery Occlusion From Poly-L-Lactic Acid Injection at the Lateral Chin. Dermatol Surg. 2017 Mar 14.
    View on PubMed
  10. Garrett GL, Blanc PD, Boscardin J, Lloyd AA, Ahmed RL, Anthony T, Bibee K, Breithaupt A, Cannon J, Chen A, Cheng JY, Chiesa-Fuxench Z, Colegio OR, Curiel-Lewandrowski C, Del Guzzo CA, Disse M, Dowd M, Eilers R, Ortiz AE, Morris C, Golden SK, Graves MS, Griffin JR, Hopkins RS, Huang CC, Bae GH, Jambusaria A, Jennings TA, Jiang SI, Karia PS, Khetarpal S, Kim C, Klintmalm G, Konicke K, Koyfman SA, Lam C, Lee P, Leitenberger JJ, Loh T, Lowenstein S, Madankumar R, Moreau JF, Nijhawan RI, Ochoa S, Olasz EB, Otchere E, Otley C, Oulton J, Patel PH, Patel VA, Prabhu AV, Pugliano-Mauro M, Schmults CD, Schram S, Shih AF, Shin T, Soon S, Soriano T, Srivastava D, Stein JA, Sternhell-Blackwell K, Taylor S, Vidimos A, Wu P, Zajdel N, Zelac D, Arron ST. Incidence of and Risk Factors for Skin Cancer in Organ Transplant Recipients in the United States. JAMA Dermatol. 2017 Mar 01; 153(3):296-303.
    View on PubMed
  11. Dizon MP, Linos E, Arron ST, Hills NK, Chren MM. Comparing the Quality of Ambulatory Surgical Care for Skin Cancer in a Veterans Affairs Clinic and a Fee-For-Service Practice Using Clinical and Patient-Reported Measures. PLoS One. 2017; 12(1):e0171253.
    View on PubMed
  12. Mansh M, Ing L, Dimon M, Celli A, Mauro TM, Arron ST. Voriconazole exposure regulates distinct cell-cycle and terminal differentiation pathways in primary human keratinocytes. Br J Dermatol. 2017 Mar; 176(3):816-820.
    View on PubMed
  13. Dizon M, Linos E, Arron ST, Abuabara K, Ruiz de Luzuriaga AM, Jin C, Boscardin WJ, Chren MM. Comparisons of patients' satisfaction should take expectations into account. Br J Dermatol. 2017 Jan; 176(1):252-254.
    View on PubMed
  14. Chang AL, Lewis KD, Arron ST, Migden MR, Solomon JA, Yoo S, Day BM, McKenna EF, Sekulic A. Safety and efficacy of vismodegib in patients aged =65 years with advanced basal cell carcinoma. Oncotarget. 2016 11 15; 7(46):76118-76124.
    View on PubMed
  15. Ahn R, Gupta R, Lai K, Chopra N, Arron ST, Liao W. Network analysis of psoriasis reveals biological pathways and roles for coding and long non-coding RNAs. BMC Genomics. 2016 Oct 28; 17(1):841.
    View on PubMed
  16. Faden DL, Arron ST, Heaton CM, DeRisi J, South AP, Wang SJ. Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers. J Otolaryngol Head Neck Surg. 2016 Sep 17; 45(1):47.
    View on PubMed
  17. Chang AL, Arron ST, Migden MR, Solomon JA, Yoo S, Day BM, McKenna EF, Sekulic A. Safety and efficacy of vismodegib in patients with basal cell carcinoma nevus syndrome: pooled analysis of two trials. Orphanet J Rare Dis. 2016 Sep 01; 11(1):120.
    View on PubMed
  18. Asgari MM, Toland AE, Arron ST. IRF4 Polymorphism Is Associated with Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients: A Pigment-Independent Phenomenon. J Invest Dermatol. 2017 Jan; 137(1):251-253.
    View on PubMed
  19. Reid-Bayliss KS, Arron ST, Loeb LA, Bezrookove V, Cleaver JE. Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency. Proc Natl Acad Sci U S A. 2016 Sep 06; 113(36):10151-6.
    View on PubMed
  20. Chow M, Lai K, Ahn R, Gupta R, Arron S, Liao W. Effect of Adalimumab on Gene Expression Profiles of Psoriatic Skin and Blood. J Drugs Dermatol. 2016 Aug 01; 15(8):988-94.
    View on PubMed

Go to UCSF Profiles, powered by CTSI