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Allan Balmain, PhD, FRSE

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
balmain_allan

Co-Leader, Cancer Genetics Program, and Director, Genome Analysis Core Facility, UCSF Helen Diller Family Comprehensive Cancer Center
Barbara Bass Bakar Distinguished Professorship in Cancer Genetics, UCSF

abalmain@cc.ucsf.edu

Phone: (415) 514-0229 (asst); (415) 502-4192 (office); (415) 502-6791 (lab)
Box 0128, UCSF
San Francisco, CA 94143-0128

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Education

University of Glasgow, BSc, 1966, Hons. Chemistry
University of Glasgow, Ph.D., 1969, Organic Chemistry
University of Strasbourg, France, Postdoc, 1969-71
German Cancer Research Centre, Heidelberg, West Germany, Postdoc, 1971-72
 


Professional Experience

  • 1972-1976
    Tenured member of staff, German Cancer Research Centre, Heidelberg, Germany
  • 1976-1982
    Staff Scientist, Beatson Institute for Cancer Research, Glasgow
  • 1982-1994
    Group Leader, Beatson Institute for Cancer Research, Glasgow
  • 1987-1994
    CRC Special Appointment, Beatson Institute for Cancer Research, Glasgow
  • 1994-1996
    Director of Laboratory Research and Professor of Molecular Oncology, Dept. of Medical Oncology, University of Glasgow, Jerry Turner Fellow of the Cancer Research Campaign
  • 1996-1998
    Vice President, Research, Onyx Pharmaceuticals, Richmond, CA
  • 1999-2001
    Professor of Cancer Genetics, Cancer Research Institute and Departments of Biochemistry and Biophysics, UCSF
  • 2001-present
    Barbara Bass Bakar Endowed Chair in Cancer Genetics, UCSF

Honors & Awards

  • Royal Society European Programme Fellowship
  • Alexander Von Humboldt-Stiftung Fellowship
  • 1995
    Elected Fellow of the Royal Society of Edinburgh
  • 1999
    Elected to UICC (International Union Against Cancer) Roll of Honor
  • 2000
    Tom Connors Prize and lecture
  • 2007
    John B. Little Award, Harvard School of Public Health
  • 2011
    American Skin Association Achievement Award

Selected Publications

  1. Balmain A, Yuspa SH. Milestones in skin carcinogenesis: the biology of multistage carcinogenesis. J Invest Dermatol. 2014; 134(e1):E2-7.
    View on PubMed
  2. Huang PY, Balmain A. Modeling cutaneous squamous carcinoma development in the mouse. Cold Spring Harb Perspect Med. 2014 Sep; 4(9):a013623.
    View on PubMed
  3. Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2078-92.
    View on PubMed
  4. Sjölund J, Pelorosso FG, Quigley DA, DelRosario R, Balmain A. Identification of Hipk2 as an essential regulator of white fat development. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7373-8.
    View on PubMed
  5. Quigley DA, Fiorito E, Nord S, Van Loo P, Alnæs GG, Fleischer T, Tost J, Moen Vollan HK, Tramm T, Overgaard J, Bukholm IR, Hurtado A, Balmain A, Børresen-Dale AL, Kristensen V. The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors. Mol Oncol. 2014 Mar; 8(2):273-84.
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  6. Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA. Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19537-42.
    View on PubMed
  7. Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol. 2013 Nov; 132(5):1121-9.
    View on PubMed
  8. Wong CE, Yu JS, Quigley DA, To MD, Jen KY, Huang PY, Del Rosario R, Balmain A. Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression. Genes Dev. 2013 Mar 15; 27(6):670-82.
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  9. Kang HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A. Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology. J Invest Dermatol. 2013 Jul; 133(7):1907-10.
    View on PubMed
  10. Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH. Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes. Clin Cancer Res. 2013 Mar 15; 19(6):1353-62.
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  11. Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun. 2013; 4:1701.
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  12. Kang HC, Wakabayashi Y, Jen KY, Mao JH, Zoumpourlis V, Del Rosario R, Balmain A. Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice. J Invest Dermatol. 2013 May; 133(5):1311-20.
    View on PubMed
  13. To MD, Rosario RD, Westcott PM, Banta KL, Balmain A. Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis. Oncogene. 2013 Aug 22; 32(34):4028-33.
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  14. Kwon YW, Kim IJ, Wu D, Lu J, Stock WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012 Jun; 10(6):834-44.
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  15. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility. PLoS One. 2012; 7(2):e31301.
    View on PubMed
  16. Jen KY, Song IY, Banta KL, Wu D, Mao JH, Balmain A. Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas. Blood. 2012 Jan 19; 119(3):805-9.
    View on PubMed
  17. To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A. Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Mol Cancer Res. 2011 Oct; 9(10):1339-45.
    View on PubMed
  18. Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, DelRosario R, Huang EJ, Balmain A. Hipk2 cooperates with p53 to suppress ?-ray radiation-induced mouse thymic lymphoma. Oncogene. 2012 Mar 1; 31(9):1176-80.
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  19. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1; 25(13):1426-38.
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  20. Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011; 12(1):R5.
    View on PubMed

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