Allan Balmain, PhD, FRSE

Co-Leader, Cancer Genetics Program, and Director, Genome Analysis Core Facility, UCSF Helen Diller Family Comprehensive Cancer Center
Barbara Bass Bakar Distinguished Professorship in Cancer Genetics, UCSF

abalmain@cc.ucsf.edu

Phone: (415) 514-0229 (asst); (415) 502-4192 (office); (415) 502-6791 (lab)
Box 0128, UCSF
San Francisco, CA 94143-0128

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Education

University of Glasgow, BSc, 1966, Hons. Chemistry
University of Glasgow, Ph.D., 1969, Organic Chemistry
University of Strasbourg, France, Postdoc, 1969-71
German Cancer Research Centre, Heidelberg, West Germany, Postdoc, 1971-72
 

Professional Experience

• 1972-1976
  Tenured member of staff, German Cancer Research Centre, Heidelberg, Germany
• 1976-1982
  Staff Scientist, Beatson Institute for Cancer Research, Glasgow
• 1982-1994
  Group Leader, Beatson Institute for Cancer Research, Glasgow
• 1987-1994
  CRC Special Appointment, Beatson Institute for Cancer Research, Glasgow
• 1994-1996
  Director of Laboratory Research and Professor of Molecular Oncology, Dept. of Medical Oncology, University of Glasgow, Jerry Turner Fellow of the Cancer Research Campaign
• 1996-1998
  Vice President, Research, Onyx Pharmaceuticals, Richmond, CA
• 1999-2001
  Professor of Cancer Genetics, Cancer Research Institute and Departments of Biochemistry and Biophysics, UCSF
• 2001-present
  Barbara Bass Bakar Endowed Chair in Cancer Genetics, UCSF

Honors & Awards

• Royal Society European Programme Fellowship
• Alexander Von Humboldt-Stiftung Fellowship
• 1995
  Elected Fellow of the Royal Society of Edinburgh
• 1999
  Elected to UICC (International Union Against Cancer) Roll of Honor
• 2000
  Tom Connors Prize and lecture
• 2007
  John B. Little Award, Harvard School of Public Health
• 2011
  American Skin Association Achievement Award

Selected Publications

1. Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun. 2013 Apr 16; 4:1701.
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2. Wong CE, Yu JS, Quigley DA, To MD, Jen KY, Huang PY, Del Rosario R, Balmain A. Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression. Genes Dev. 2013 Mar 15; 27(6):670-82.
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3. Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH. Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes. Clin Cancer Res. 2013 Mar 15; 19(6):1353-62.
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4. Kang HC, Wakabayashi Y, Jen KY, Mao JH, Zoumpourlis V, Del Rosario R, Balmain A. Ptch1 Overexpression Drives Skin Carcinogenesis and Developmental Defects in K14Ptch(FVB) Mice. J Invest Dermatol. 2012 Dec 6.
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5. Kwon YW, Kim IJ, Wu D, Lu J, Stock WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012 Jun; 10(6):834-44.
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6. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility. PLoS One. 2012; 7(2):e31301.
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7. Jen KY, Song IY, Banta KL, Wu D, Mao JH, Balmain A. Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas. Blood. 2012 Jan 19; 119(3):805-9.
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8. To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A. Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Mol Cancer Res. 2011 Oct; 9(10):1339-45.
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9. Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, DelRosario R, Huang EJ, Balmain A. Hipk2 cooperates with p53 to suppress ?-ray radiation-induced mouse thymic lymphoma. Oncogene. 2012 Mar 1; 31(9):1176-80.
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10. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 1; 25(13):1426-38.
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11. Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011; 12(1):R5.
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12. Pelorosso FG, Balmain A. C/EBPd: friend or foe? a novel role for C/EBPd in metastasis. EMBO J. 2010 Dec 15; 29(24):4063-5.
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13. Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17268-73.
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14. Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A. Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol. 2010 Aug 10; 28(23):3770-8.
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15. Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA. Guidelines for the welfare and use of animals in cancer research. Br J Cancer. 2010 May 25; 102(11):1555-77.
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16. Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, Balmain A, Saura CA. Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene. 2010 May 20; 29(20):2950-61.
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17. Li Z, Zhang Q, Mao JH, Weise A, Mrasek K, Fan X, Zhang X, Liehr T, Lu KH, Balmain A, Cai WW. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Oncogene. 2010 May 6; 29(18):2659-71.
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18. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24.
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19. Quigley D, Balmain A. Systems genetics analysis of cancer susceptibility: from mouse models to humans. Nat Rev Genet. 2009 Sep; 10(9):651-7.
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20. Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S. A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell. 2009 Apr 3; 137(1):87-98.
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