Diane L. Barber, PhD

Diane L. Barber, PhD

Professor and Vice Chair, Department of Cell and Tissue Biology, UCSF


Phone: (415) 476-3764 (voice)
Box 0512, UCSF
San Francisco, CA 94143-0512

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Cancer Center Membership

Associate Member ยป Non-aligned


University of California, Davis, B.S., 1975, Biological Sciences
University of California, Davis, M.S., 1977, Physiology
University of California, Los Angeles, Ph.D., 1985, Anatomy

Professional Experience

  • 1977-1980
    Lecturer, Department of Biology, University of California, Los Angeles
  • 1980-1985
    Predoctoral Fellow, Department of Anatomy, University of California, Los Angeles
  • 1985-1987
    NIH Postdoctoral Fellow (NRSA), Department of Physiology, University of Massachusetts Medical Center, Worcester, MA
  • 1987-1991
    Assistant Professor, Department of Surgery/Section of Anatomy, Yale University
  • 1991-1995
    Assistant Professor, Departments of Stomatology and Surgery, UCSF
  • 1993-present
    Member, Biomedical Sciences Graduate Program, UCSF
  • 1995-2001
    Associate Professor, Departments of Stomatology and Surgery, UCSF
  • 2001-present
    Professor, Department of Cell and Tissue Biology (previously Stomatology), UCSF
  • 2005- present
    Vice Chair, Department of Cell and Tissue Biology, UCSF

Honors & Awards

  • 1985-87
    NIH Individual NRSA Postdoctoral Fellowship
  • 1986
    Joseph P. Healy Research Award, University of Massachusetts
  • 1995-2000
    Established Investigator, American Heart Association
  • 1998-present
    Editorial Board, American Journal of Physiology: Cell Physiology
  • 1998-1999
    American Heart Association, National Review Committee for Transport and Metabolism
  • 1998
    Innovation in Basic Sciences Award, UCSF
  • 2000-2002
    American Heart Association, Co-chair National Review Committee for Transport and Metabolism
  • 2001/2003
    Vice-chair/Chair, Gordon Conference on Molecular Pharmacology
  • 2001-2003
    Member, NIH CDF3 Study Section
  • 2003-present
    Editorial Board, Journal of Biological Chemistry
  • 2005
    Sandler Program Integrative Award

Selected Publications

  1. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature. 2015 Jul 2; 523(7558):111-4.
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  2. Increased H(+) efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife. 2015; 4.
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  3. Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation. J Cell Sci. 2015 Mar 15; 128(6):1083-9.
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  4. The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit. J Cell Biol. 2015 Jan 19; 208(2):161-70.
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  5. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52.
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  6. Ratiometric imaging of pH probes. Methods Cell Biol. 2014; 123:429-48.
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  7. pH sensing by FAK-His58 regulates focal adhesion remodeling. J Cell Biol. 2013 Sep 16; 202(6):849-59.
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  8. Electrostatics control actin filament nucleation and elongation kinetics. J Biol Chem. 2013 Apr 26; 288(17):12102-13.
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  9. Considering protonation as a posttranslational modification regulating protein structure and function. Annu Rev Biophys. 2013; 42:289-314.
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  10. Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium. J Biol Chem. 2013 Jan 25; 288(4):2464-74.
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  11. Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1). Biochem J. 2012 Sep 15; 446(3):427-35.
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  12. Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation. PLoS Comput Biol. 2011 Nov; 7(11):e1002226.
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  13. Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell. 2011 Dec; 22(24):4750-64.
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  14. Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer. 2011 Sep; 11(9):671-7.
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  15. A human MAP kinase interactome. Nat Methods. 2010 Oct; 7(10):801-5.
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  16. Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis. J Biol Chem. 2010 Nov 19; 285(47):36260-6.
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  17. Expression of actin-interacting protein 1 suppresses impaired chemotaxis of Dictyostelium cells lacking the Na+-H+ exchanger NHE1. Mol Biol Cell. 2010 Sep 15; 21(18):3162-70.
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  18. The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors. J Biol Chem. 2009 Sep 25; 284(39):26666-75.
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  19. Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation. Mol Biol Cell. 2009 Apr; 20(8):2327-36.
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  20. Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J Cell Biol. 2008 Dec 1; 183(5):865-79.
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