Boris C. Bastian, MD, PhD

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Education

Humboldt-Gymnasium, Solingen, Germany, Baccalaureate, 1980
University of Munich, Germany, M.D., 1988, Medicine
University of Munich, Germany, Dr. med., 1989, Laboratory Medicine
University of Wurzburg, Germany, Residency, 1994, Dermatology
University of California, San Francisco, Postdoctoral, 1999, Cancer Genetics

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Professional Experience

• 1986-1989
  Dissertation 'Development and Characterization of an enzymatic assay for human pancreatic phospholipase A2'
• 1988-89
  Fellowship, Dept. of Hematology, Ludwig-Maximilian-University, Munich, Germany
• 1989-1994
  Residency, Dermatology, Dept. of Dermatology, University of Würzburg, Germany
• 1993
  German board certification for Dermatology
• 1995
  German board certification Allergy and Immunology
• 1994-1997
  Attending Physician, Dept. of Dermatology, University of Würzburg, Germany
• 1995-1997
  Director of the Dermatopathology Section, Dept. of Dermatology, University of Würzburg, Germany
• 1997-1999
  Postdoctoral Fellowship, Cancer Genetics Group, Cancer Center at UCSF
• 1999-2002
  Assistant Clinical Professor, Dept. of Dermatology and Pathology, UCSF
• 2002-2004
  Assistant Professor in Residence, Department of Dermatology and Assistant Clinical Professor, Department of Pathology, UCSF
• 7/2004-2008
  Associate Professor in Residence, Department of Dermatology and Associate Clinical Professor, Department of Pathology, UCSF
• 7/2008
  Professor in Residence, Department of Dermatology and Clinical Professor, Department of Pathology, UCSF
• 9/2008
  Leader, Cutaneous Oncology Program, UCSF
• 4/2010-8/11
  Chairman, Department of Pathology, and Member, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
• 9/2011-present
  Professor of Dermatology and Pathology, Gerson and Barbara Bakar Distinguished Professor of Cancer Biology, University of California, San Francisco

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Honors & Awards

• 1995
  Graduate Stipend of the Novartis Foundation for Therapeutic Research
• 1997
  Habilitandenstipendium of the German Research Society (Deutsche Forschungsgemeinschaft)
• 2000
  American Melanoma Foundation Research Award
• 2001
  American Skin Association Research Scientist Development Award
• 2005
  Hermann Pinkus Lectureship and Award, American Society of Dermatopathology
• 2006
  Stewart Trust Award
• 2007
  Melanoma Research Foundation Individual Investigator Award
• 2008
  Abby S. and Howard P. Milstein Innovation Award for Skin Cancer Research, American Skin Association
• 2011-2013
  President, Society of Melanoma Research
• 2011
  German National Academy of Science (Leopoldina)

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Selected Publications

1. Wiesner T, Murali R, Fried I, Cerroni L, Busam K, Kutzner H, Bastian BC. A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression. Am J Surg Pathol. 2012 Jun; 36(6):818-30.
   View on PubMed
2. Murali R, Wiesner T, Rosenblum MK, Bastian BC. GNAQ and GNA11 mutations in melanocytomas of the central nervous system. Acta Neuropathol. 2012 Mar; 123(3):457-9.
   View on PubMed
3. Griewank KG, Yu X, Khalili J, Sozen MM, Stempke-Hale K, Bernatchez C, Wardell S, Bastian BC, Woodman SE. Genetic and molecular characterization of uveal melanoma cell lines. Pigment Cell Melanoma Res. 2012 Mar; 25(2):182-7.
   View on PubMed
4. Minor DR, Kashani-Sabet M, Garrido M, O'Day SJ, Hamid O, Bastian BC. Sunitinib therapy for melanoma patients with KIT mutations. Clin Cancer Res. 2012 Mar 1; 18(5):1457-63.
   View on PubMed
5. McCalmont TH, Bastian BC. An unconventional deep penetrating melanocytic nevus with microscopic involvement of regional lymph nodes. J Cutan Pathol. 2012 Jan; 39(1):25-8.
   View on PubMed
6. Daud A, Bastian BC. Beyond BRAF in Melanoma. Curr Top Microbiol Immunol. 2012; 355:99-117.
   View on PubMed
7. Feito-Rodríguez M, de Lucas-Laguna R, Bastian BC, Leboit P, González-Beato MJ, López-Gutiérrez JC, Requena L, Pizarro A. Nodular lesions arising in a large congenital melanocytic naevus in a newborn with eruptive disseminated Spitz naevi. Br J Dermatol. 2011 Nov; 165(5):1138-42.
   View on PubMed
8. Jalas JR, Vemula S, Bezrookove V, Leboit PE, Simko JP, Bastian BC. Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma. Am J Surg Pathol. 2011 Sep; 35(9):1413-8.
   View on PubMed
9. Wiesner T, Obenauf AC, Murali R, Fried I, Griewank KG, Ulz P, Windpassinger C, Wackernagel W, Loy S, Wolf I, Viale A, Lash AE, Pirun M, Socci ND, Rütten A, Palmedo G, Abramson D, Offit K, Ott A, Becker JC, Cerroni L, Kutzner H, Bastian BC, Speicher MR. Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet. 2011 Oct; 43(10):1018-21.
   View on PubMed
10. Ahronowitz IZ, Daud AI, Leong SP, Shue EH, Bastian BC, McCalmont TH, Yu SS. An isolated Merkel cell carcinoma metastasis at a distant cutaneous site presenting as a second 'primary' tumor. J Cutan Pathol. 2011 Oct; 38(10):801-7.
    View on PubMed
11. Kumar SM, Zhang G, Bastian BC, Arcasoy MO, Karande P, Pushparajan A, Acs G, Xu X. Erythropoietin receptor contributes to melanoma cell survival in vivo. Oncogene. 2012 Mar 29; 31(13):1649-60.
    View on PubMed
12. Whiteman DC, Pavan WJ, Bastian BC. The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res. 2011 Oct; 24(5):879-97.
    View on PubMed
13. North JP, Vetto JT, Murali R, White KP, White CR, Bastian BC. Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma. Am J Surg Pathol. 2011 Aug; 35(8):1146-50.
    View on PubMed
14. Carvajal RD, Antonescu CR, Wolchok JD, Chapman PB, Roman RA, Teitcher J, Panageas KS, Busam KJ, Chmielowski B, Lutzky J, Pavlick AC, Fusco A, Cane L, Takebe N, Vemula S, Bouvier N, Bastian BC, Schwartz GK. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011 Jun 8; 305(22):2327-34.
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15. McCalmont TH, Vemula S, Sands P, Bastian BC. Molecular-microscopical correlation in dermatopathology. J Cutan Pathol. 2011 Apr; 38(4):324-6, 323.
    View on PubMed
16. Bauer J, Büttner P, Murali R, Okamoto I, Kolaitis NA, Landi MT, Scolyer RA, Bastian BC. BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site. Pigment Cell Melanoma Res. 2011 Apr; 24(2):345-51.
    View on PubMed
17. Broekaert SM, Roy R, Okamoto I, van den Oord J, Bauer J, Garbe C, Barnhill RL, Busam KJ, Cochran AJ, Cook MG, Elder DE, McCarthy SW, Mihm MC, Schadendorf D, Scolyer RA, Spatz A, Bastian BC. Genetic and morphologic features for melanoma classification. Pigment Cell Melanoma Res. 2010 Dec; 23(6):763-70.
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18. Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC. Mutations in GNA11 in uveal melanoma. N Engl J Med. 2010 Dec 2; 363(23):2191-9.
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19. Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian BC, Attardi LD. Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet. 2010 Oct; 6(10):e1001168.
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20. Dworkin AM, Ridd K, Bautista D, Allain DC, Iwenofu OH, Roy R, Bastian BC, Toland AE. Germline variation controls the architecture of somatic alterations in tumors. PLoS Genet. 2010 Sep; 6(9).
    View on PubMed

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