Boris C. Bastian, MD, PhD

Boris C. Bastian, MD, PhD

Professor of Dermatology and Pathology, University of California, San Francisco
Gerson and Barbara Bass Bakar Distinguished Professor in Cancer Research, UCSF

Phone: (415) 502-0267 (voice)
Box 3118 , UCSF
San Francisco, CA 94143-3118

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Cancer Center Membership

Program Member » Cancer Genetics


Humboldt-Gymnasium, Solingen, Germany, Baccalaureate, 1980
University of Munich, Germany, M.D., 1988, Medicine
University of Munich, Germany, Dr. med., 1989, Laboratory Medicine
University of Wurzburg, Germany, Residency, 1994, Dermatology
University of California, San Francisco, Postdoctoral, 1999, Cancer Genetics

Professional Experience

  • 1986-1989
    Dissertation 'Development and Characterization of an enzymatic assay for human pancreatic phospholipase A2'
  • 1988-89
    Fellowship, Dept. of Hematology, Ludwig-Maximilian-University, Munich, Germany
  • 1989-1994
    Residency, Dermatology, Dept. of Dermatology, University of Würzburg, Germany
  • 1993
    German board certification for Dermatology
  • 1995
    German board certification Allergy and Immunology
  • 1994-1997
    Attending Physician, Dept. of Dermatology, University of Würzburg, Germany
  • 1995-1997
    Director of the Dermatopathology Section, Dept. of Dermatology, University of Würzburg, Germany
  • 1997-1999
    Postdoctoral Fellowship, Cancer Genetics Group, Cancer Center at UCSF
  • 1999-2002
    Assistant Clinical Professor, Dept. of Dermatology and Pathology, UCSF
  • 2002-2004
    Assistant Professor in Residence, Department of Dermatology and Assistant Clinical Professor, Department of Pathology, UCSF
  • 7/2004-2008
    Associate Professor in Residence, Department of Dermatology and Associate Clinical Professor, Department of Pathology, UCSF
  • 7/2008
    Professor in Residence, Department of Dermatology and Clinical Professor, Department of Pathology, UCSF
  • 9/2008
    Leader, Cutaneous Oncology Program, UCSF
  • 4/2010-8/11
    Chairman, Department of Pathology, and Member, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
  • 9/2011-present
    Professor of Dermatology and Pathology, University of California, San Francisco

Honors & Awards

  • 1995
    Graduate Stipend of the Novartis Foundation for Therapeutic Research
  • 1997
    Habilitandenstipendium of the German Research Society (Deutsche Forschungsgemeinschaft)
  • 2000
    American Melanoma Foundation Research Award
  • 2001
    American Skin Association Research Scientist Development Award
  • 2005
    Hermann Pinkus Lectureship and Award, American Society of Dermatopathology
  • 2006
    Stewart Trust Award
  • 2007
    Melanoma Research Foundation Individual Investigator Award
  • 2008
    Abby S. and Howard P. Milstein Innovation Award for Skin Cancer Research, American Skin Association
  • 2011-2013
    President, Society of Melanoma Research
  • 2011
    German National Academy of Science (Leopoldina)

Selected Publications

  1. Conde-Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, Viros A, Gesbert F, Delmas V, Rambow F, Bastian BC, Campbell AD, Colombo S, Puig I, Bellacosa A, Sansom O, Marais R, Van Kempen LC, Larue L. A caveolin-dependent and PI3K/AKT-independent role of PTEN in ß-catenin transcriptional activity. Nat Commun. 2015; 6:8093.
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  2. Sanborn JZ, Chung J, Purdom E, Wang NJ, Kakavand H, Wilmott JS, Butler T, Thompson JF, Mann GJ, Haydu LE, Saw RP, Busam KJ, Lo RS, Collisson EA, Hur JS, Spellman PT, Cleaver JE, Gray JW, Huh N, Murali R, Scolyer RA, Bastian BC, Cho RJ. Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination. Proc Natl Acad Sci U S A. 2015 Sep 1; 112(35):10995-1000.
    View on PubMed
  3. Menzies AM, Yeh I, Botton T, Bastian BC, Scolyer RA, Long GV. Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion. Pigment Cell Melanoma Res. 2015 Sep; 28(5):607-10.
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  4. Machan S, Molina-Ruiz AM, Fernández-Aceñero MJ, Encabo B, LeBoit P, Bastian BC, Requena L. Metastatic Melanoma in Association With a Giant Congenital Melanocytic Nevus in an Adult: Controversial CGH Findings. Am J Dermatopathol. 2015 Jun; 37(6):487-94.
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  5. Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015; 6:7174.
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  6. Yeh I, de la Fouchardiere A, Pissaloux D, Mully TW, Garrido MC, Vemula SS, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC. Clinical, Histopathologic, and Genomic Features of Spitz Tumors With ALK Fusions. Am J Surg Pathol. 2015 May; 39(5):581-91.
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  7. Algazi AP, Cha E, Ortiz-Urda SM, McCalmont T, Bastian BC, Hwang J, Pampaloni MH, Behr S, Chong K, Cortez B, Quiroz A, Coakley F, Liu S, Daud AI. The combination of axitinib followed by paclitaxel/carboplatin yields extended survival in advanced BRAF wild-type melanoma: results of a clinical/correlative prospective phase II clinical trial. Br J Cancer. 2015 Apr 14; 112(8):1326-31.
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  8. Carvajal RD, Lawrence DP, Weber JS, Gajewski TF, Gonzalez R, Lutzky J, O'Day SJ, Hamid O, Wolchok JD, Chapman PB, Sullivan RJ, Teitcher JB, Ramaiya N, Giobbie-Hurder A, Antonescu CR, Heinrich MC, Bastian BC, Corless CL, Fletcher JA, Hodi FS. Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition. Clin Cancer Res. 2015 May 15; 21(10):2289-96.
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  9. Botton T, Yeh I, Bastian BC. Melanoma BRAF Fusions-Letter. Clin Cancer Res. 2014 Dec 15; 20(24):6631.
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  10. Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB. Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nat Commun. 2014; 5:5442.
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  11. Esteve-Puig R, Gil R, González-Sánchez E, Bech-Serra JJ, Grueso J, Hernández-Losa J, Moliné T, Canals F, Ferrer B, Cortés J, Bastian B, Ramón Y Cajal S, Martín-Caballero J, Flores JM, Vivancos A, García-Patos V, Recio JÁ. A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PLoS Genet. 2014 Oct; 10(10):e1004721.
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  12. Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian BC, Gutkind JS, Bowcock AM, Streicher HZ, Patel PM, Sato T, Sossman JA, Sznol M, Welch J, Thurin M, Selig S, Flaherty KT, Carvajal RD. Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res. 2015 Mar; 28(2):135-47.
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  13. Yeh I, Mully TW, Wiesner T, Vemula SS, Mirza SA, Sparatta AJ, McCalmont TH, Bastian BC, LeBoit PE. Ambiguous melanocytic tumors with loss of 3p21. Am J Surg Pathol. 2014 Aug; 38(8):1088-95.
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  14. North JP, Garrido MC, Kolaitis NA, LeBoit PE, McCalmont TH, Bastian BC. Fluorescence in situ hybridization as an ancillary tool in the diagnosis of ambiguous melanocytic neoplasms: a review of 804 cases. Am J Surg Pathol. 2014 Jun; 38(6):824-31.
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  15. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30.
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  16. Menzel M, Meckbach D, Weide B, Toussaint NC, Schilbach K, Noor S, Eigentler T, Ikenberg K, Busch C, Quintanilla-Martinez L, Kohlhofer U, Göke A, Göke F, Handgretinger R, Ottmann C, Bastian BC, Garbe C, Röcken M, Perner S, Kohlbacher O, Bauer J. In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival. Pigment Cell Melanoma Res. 2014 Jul; 27(4):671-3.
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  17. North JP, Vemula SS, Bastian BC. Chromosomal copy number analysis in melanoma diagnostics. Methods Mol Biol. 2014; 1102:199-226.
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  18. Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian BC. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun. 2014; 5:3116.
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  19. Bastian BC. The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu Rev Pathol. 2014; 9:239-71.
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  20. Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res. 2014 Jan; 27(1):37-47.
    View on PubMed

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