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Boris C. Bastian, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
bastian_boris

Professor of Dermatology and Pathology, University of California, San Francisco
Gerson and Barbara Bass Bakar Distinguished Professorship, UCSF

BastianB@derm.ucsf.edu

Phone: (415) 502-0267 (voice)
Box 3118 , UCSF
San Francisco, CA 94143-3118

View on UCSF Profiles


Education

Humboldt-Gymnasium, Solingen, Germany, Baccalaureate, 1980
University of Munich, Germany, M.D., 1988, Medicine
University of Munich, Germany, Dr. med., 1989, Laboratory Medicine
University of Wurzburg, Germany, Residency, 1994, Dermatology
University of California, San Francisco, Postdoctoral, 1999, Cancer Genetics


Professional Experience

  • 1986-1989
    Dissertation 'Development and Characterization of an enzymatic assay for human pancreatic phospholipase A2'
  • 1988-89
    Fellowship, Dept. of Hematology, Ludwig-Maximilian-University, Munich, Germany
  • 1989-1994
    Residency, Dermatology, Dept. of Dermatology, University of Würzburg, Germany
  • 1993
    German board certification for Dermatology
  • 1995
    German board certification Allergy and Immunology
  • 1994-1997
    Attending Physician, Dept. of Dermatology, University of Würzburg, Germany
  • 1995-1997
    Director of the Dermatopathology Section, Dept. of Dermatology, University of Würzburg, Germany
  • 1997-1999
    Postdoctoral Fellowship, Cancer Genetics Group, Cancer Center at UCSF
  • 1999-2002
    Assistant Clinical Professor, Dept. of Dermatology and Pathology, UCSF
  • 2002-2004
    Assistant Professor in Residence, Department of Dermatology and Assistant Clinical Professor, Department of Pathology, UCSF
  • 7/2004-2008
    Associate Professor in Residence, Department of Dermatology and Associate Clinical Professor, Department of Pathology, UCSF
  • 7/2008
    Professor in Residence, Department of Dermatology and Clinical Professor, Department of Pathology, UCSF
  • 9/2008
    Leader, Cutaneous Oncology Program, UCSF
  • 4/2010-8/11
    Chairman, Department of Pathology, and Member, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
  • 9/2011-present
    Professor of Dermatology and Pathology, University of California, San Francisco

Honors & Awards

  • 1995
    Graduate Stipend of the Novartis Foundation for Therapeutic Research
  • 1997
    Habilitandenstipendium of the German Research Society (Deutsche Forschungsgemeinschaft)
  • 2000
    American Melanoma Foundation Research Award
  • 2001
    American Skin Association Research Scientist Development Award
  • 2005
    Hermann Pinkus Lectureship and Award, American Society of Dermatopathology
  • 2006
    Stewart Trust Award
  • 2007
    Melanoma Research Foundation Individual Investigator Award
  • 2008
    Abby S. and Howard P. Milstein Innovation Award for Skin Cancer Research, American Skin Association
  • 2011-2013
    President, Society of Melanoma Research
  • 2011
    German National Academy of Science (Leopoldina)

Selected Publications

  1. Yeh I, Mully TW, Wiesner T, Vemula SS, Mirza SA, Sparatta AJ, McCalmont TH, Bastian BC, LeBoit PE. Ambiguous melanocytic tumors with loss of 3p21. Am J Surg Pathol. 2014 Aug; 38(8):1088-95.
    View on PubMed
  2. North JP, Garrido MC, Kolaitis NA, Leboit PE, McCalmont TH, Bastian BC. Fluorescence in situ hybridization as an ancillary tool in the diagnosis of ambiguous melanocytic neoplasms: a review of 804 cases. Am J Surg Pathol. 2014 Jun; 38(6):824-31.
    View on PubMed
  3. Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL. Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP. Cancer Cell. 2014 Jun 16; 25(6):822-30.
    View on PubMed
  4. Menzel M, Meckbach D, Weide B, Toussaint NC, Schilbach K, Noor S, Eigentler T, Ikenberg K, Busch C, Quintanilla-Martinez L, Kohlhofer U, Göke A, Göke F, Handgretinger R, Ottmann C, Bastian BC, Garbe C, Röcken M, Perner S, Kohlbacher O, Bauer J. In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival. Pigment Cell Melanoma Res. 2014 Jul; 27(4):671-3.
    View on PubMed
  5. Bastian BC. The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu Rev Pathol. 2014 Jan 24; 9:239-71.
    View on PubMed
  6. Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian BC. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun. 2014 Jan 20; 5:3116.
    View on PubMed
  7. North JP, Vemula SS, Bastian BC. Chromosomal copy number analysis in melanoma diagnostics. Methods Mol Biol. 2014; 1102:199-226.
    View on PubMed
  8. Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res. 2014 Jan; 27(1):37-47.
    View on PubMed
  9. Chen X, Wu Q, Tan L, Porter D, Jager MJ, Emery C, Bastian BC. Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene. 2014 Sep 25; 33(39):4724-34.
    View on PubMed
  10. Botton T, Yeh I, Nelson T, Vemula SS, Sparatta A, Garrido MC, Allegra M, Rocchi S, Bahadoran P, McCalmont TH, LeBoit PE, Burton EA, Bollag G, Ballotti R, Bastian BC. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment Cell Melanoma Res. 2013 Nov; 26(6):845-51.
    View on PubMed
  11. Bastian BC, Esteve-Puig R. Targeting activated KIT signaling for melanoma therapy. J Clin Oncol. 2013 Sep 10; 31(26):3288-90.
    View on PubMed
  12. Lyons J, Bastian BC, McCormick F. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13845-50.
    View on PubMed
  13. Cronin JC, Watkins-Chow DE, Incao A, Hasskamp JH, Schönewolf N, Aoude LG, Hayward NK, Bastian BC, Dummer R, Loftus SK, Pavan WJ. SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Res. 2013 Sep 15; 73(18):5709-18.
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  14. Fleming JL, Dworkin AM, Allain DC, Fernandez S, Wei L, Peters SB, Iwenofu OH, Ridd K, Bastian BC, Toland AE. Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma. Int J Cancer. 2014 Jan 1; 134(1):244-8.
    View on PubMed
  15. Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SE, Krause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian BC, Vogt T, Herlyn M. Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell. 2013 Jun 10; 23(6):811-25.
    View on PubMed
  16. Yeh I, von Deimling A, Bastian BC. Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia. J Natl Cancer Inst. 2013 Jun 19; 105(12):917-9.
    View on PubMed
  17. Suri P, Bull N, Worthington A, Gunawaran P, Reeves G, Bastian B, Collins N. Audit of the aetiology and prevalence of pulmonary hypertension in a tertiary hospital setting. Intern Med J. 2013 Mar; 43(3):323-7.
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  18. Wiesner T, Murali R, Fried I, Cerroni L, Busam K, Kutzner H, Bastian BC. A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression. Am J Surg Pathol. 2012 Jun; 36(6):818-30.
    View on PubMed
  19. Murali R, Wiesner T, Rosenblum MK, Bastian BC. GNAQ and GNA11 mutations in melanocytomas of the central nervous system. Acta Neuropathol. 2012 Mar; 123(3):457-9.
    View on PubMed
  20. Griewank KG, Yu X, Khalili J, Sozen MM, Stempke-Hale K, Bernatchez C, Wardell S, Bastian BC, Woodman SE. Genetic and molecular characterization of uveal melanoma cell lines. Pigment Cell Melanoma Res. 2012 Mar; 25(2):182-7.
    View on PubMed

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