University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Neal L. Benowitz, MD

Neal L. Benowitz, MD

Professor, Departments of Medicine, Biopharmaceutical Sciences, Psychiatry, and Clinical Pharmacy, UCSF

Cancer Center Program Memberships

Tobacco Control

Research Summary

I am Professor of Medicine and Bioengineering & Therapeutic Sciences and Chief of the Division of Clinical Pharmacology at San Francisco General Hospital. With over 500 publications, I am a leading authority on the human pharmacology of nicotine and nicotine addiction. My laboratory also is a leading site for biomarker assessment of tobacco toxicant exposure. I am former president of the Society for Research on Nicotine and Tobacco (SRNT), and the recipient of the Ove Ferno SRNT Award for Clinical Research on Nicotine and Tobacco. I have been a contributing author or editor to six US Surgeon General's Reports on tobacco including the 2010 Surgeon General's Report—How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease.

Education

Rennselaer Polytechnic Institute, Troy, NY
University of Rochester School of Medicine, Rochester, NY, MD, 1969, Medicine
Bronx Municipal Hospital Center, Bronx, New York, Intern and Resident, Internal Medicine, 1969-1971
Fellow in Clinical Pharmacology, Department of Medicine, University of California San Francisco, 1971-1972
 


Professional Experience

  • 1973-1972
    Clinical Instructor, Department of Medicine, University of California San Francisco
  • 1975-1972
    Director, Drug Detoxification Unit, San Francisco General Hospital, San Francisco, California
  • 1974-present
    Member of Staff, Medical Service, San Francisco General Hospital, San Francisco, California
  • 1979-present
    Associate Medical Director, San Francisco Bay Area Regional Poison Center, San Francisco, CA
  • 1974-1982
    Asst. Professor, Depts of Medicine and Psychiatry, University of Calif-ornia San Francisco, San Francisco, CA
  • 1981-1982
    Assoc. Professor, Depts of Medicine and Psychiatry, University of California San Francisco, San Francisco, CA
  • 1987-present
    Professor, Departments of Medicine, Psychiatry and Pharmacy, University of California San Francisco, San Francisco, California
  • 1983-present
    Chief, Division Clinical Pharmacology and Experimental Therapeutics, University of California San Francisco
  • 1994-2010
    Vice Chair, Department of Biopharmaceutical Sciences, University of California, San Francisco
  • 2004-present
    Professor of Medicine, Biopharmaceutical Sciences, Psychiatry and Clinical Pharmacy, University of California, San Francisco

Honors & Awards

  • Oscar B. Hunter Award
  • Ove Ferno Award
  • 2002
  • UCSF Annual Distinguished Clinical Research Lecturer
  • Rawls Palmer Award for Progress in Medicine
  • Alton Ochsner Award Relating Smoking and Health
  • 1994-2002
  • NIDA Merit Award
  • American Board of Internal Medicine (Diplomate, 1968)
  • American Board of Medical Toxicology
  • American Board of Clinical Pharmacology
  • American Federation for Clinical Research (President 1996 to 1997)
  • American Society for Clinical Inves-tigation
  • American Society of Clinical Pharma-cology and Therapeutics
  • American Society for Pharmacology and Experimental Therapeutics
  • Association of American Physicians
  • Society for Research on Nicotine and Tobacco (President, 1996-1997)

Selected Publications

  1. Piper ME, Baker TB, Benowitz NL, Smith SS, Jorenby DE. E-cigarette Dependence Measures in Dual Users: Reliability and Relations with Dependence Criteria and E-Cigarette Cessation. Nicotine Tob Res. 2019 Mar 15.
    View on PubMed
  2. Benowitz NL, Helen GS, Nardone N, Cox LS, Jacob P. Urine Metabolites for Estimating Daily Intake of Nicotine from Cigarette Smoking. Nicotine Tob Res. 2019 Mar 10.
    View on PubMed
  3. Voos N, Kaiser L, Mahoney MC, Bradizza CM, Kozlowski LT, Benowitz NL, O'Connor RJ, Goniewicz ML. RANDOMIZED WITHIN-SUBJECT TRIAL TO EVALUATE SMOKERS' INITIAL PERCEPTIONS, SUBJECTIVE EFFECTS, AND NICOTINE DELIVERY ACROSS SIX VAPORIZED NICOTINE PRODUCTS. Addiction. 2019 Mar 09.
    View on PubMed
  4. Anthenelli RM, Gaffney M, Benowitz NL, West R, McRae T, Russ C, Lawrence D, St Aubin L, Krishen A, Evins AE. Predictors of Neuropsychiatric Adverse Events with Smoking Cessation Medications in the Randomized Controlled EAGLES Trial. J Gen Intern Med. 2019 Mar 07.
    View on PubMed
  5. Evins AE, Benowitz NL, West R, Russ C, McRae T, Lawrence D, Krishen A, St Aubin L, Maravic MC, Anthenelli RM. Neuropsychiatric Safety and Efficacy of Varenicline, Bupropion, and Nicotine Patch in Smokers With Psychotic, Anxiety, and Mood Disorders in the EAGLES Trial. J Clin Psychopharmacol. 2019 Mar/Apr; 39(2):108-116.
    View on PubMed
  6. El-Boraie A, Taghavi T, Chenoweth MJ, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Nollen NL, Benowitz NL, Tyndale RF. Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity. Addict Biol. 2019 Feb 27.
    View on PubMed
  7. Goodnough R, Nomura M, Badea A, Lynch KL, Benowitz NL, Tsutaoka B. Loperamide associated torsades de pointes, in the setting of complete heart block at marginally supratherapeutic dosing (20mg/day). Clin Toxicol (Phila). 2019 Feb 19; 1-2.
    View on PubMed
  8. Rezk-Hanna M, Mosenifar Z, Benowitz NL, Rader F, Rashid M, Davoren K, Moy NB, Doering L, Robbins W, Sarna L, Li N, Chang LC, Elashoff RM, Victor RG. High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults. Circulation. 2019 Feb 15.
    View on PubMed
  9. Nollen NL, Mayo MS, Cox LS, Benowitz NL, Tyndale RF, Ellerbeck EF, Scheuermann TS, Ahluwalia JS. Factors that Explain Differences in Abstinence between Black and White Smokers: A Prospective Intervention Study. J Natl Cancer Inst. 2019 Jan 18.
    View on PubMed
  10. Robinson JD, Li L, Chen M, Lerman C, Tyndale RF, Schnoll RA, Hawk LW, George TP, Benowitz NL, Cinciripini PM. Evaluating the temporal relationships between withdrawal symptoms and smoking relapse. Psychol Addict Behav. 2019 Jan 07.
    View on PubMed
  11. Chen M, Carmella SG, Sipe C, Jensen J, Luo X, Le CT, Murphy SE, Benowitz NL, McClernon FJ, Vandrey R, Allen SS, Denlinger-Apte R, Cinciripini PM, Strasser AA, al'Absi M, Robinson JD, Donny EC, Hatsukami D, Hecht SS. Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein. PLoS One. 2019; 14(1):e0210104.
    View on PubMed
  12. Benowitz NL. Managing Cannabis Use in Patients With Cardiovascular Disease. Can J Cardiol. 2019 Feb; 35(2):138-141.
    View on PubMed
  13. Khachatoorian C, Jacob P, Sen A, Zhu Y, Benowitz NL, Talbot P. Identification and quantification of electronic cigarette exhaled aerosol residue chemicals in field sites. Environ Res. 2018 Dec 16; 170:351-358.
    View on PubMed
  14. Barua RS, Rigotti NA, Benowitz NL, Cummings KM, Jazayeri MA, Morris PB, Ratchford EV, Sarna L, Stecker EC, Wiggins BS. 2018 ACC Expert Consensus Decision Pathway on Tobacco Cessation Treatment: A Report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2018 Dec 25; 72(25):3332-3365.
    View on PubMed
  15. Benowitz NL, Flanagan CA, Thomas TK, Koller KR, Wolfe AW, Renner CC, Hughes C, Decker PA, Hatsukami DK, Murphy NJ, Patten C. Urine 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol and cotinine in Alaska native postpartum women and neonates comparing smokers and smokeless tobacco users. Int J Circumpolar Health. 2018 12; 77(1):1528125.
    View on PubMed
  16. Wei J, Shufelt C, Oestreicher Stock E, Mills C, Dhawan S, Jacob R, Torbati T, Cook-Wiens G, Benowitz N, Jacob P, Ganz P, Bairey Merz CN, Redberg R. Vascular Aging is Accelerated in Flight Attendants with Occupational Secondhand Smoke Exposure. J Occup Environ Med. 2018 Nov 20.
    View on PubMed
  17. Liakoni E, Gugelmann H, Dempsey DA, Wiegand TJ, Havel C, Jacob P, Benowitz NL. Butanediol Conversion to Gamma-Hydroxybutyrate Markedly Reduced by the Alcohol Dehydrogenase Blocker Fomepizole. Clin Pharmacol Ther. 2018 Nov 19.
    View on PubMed
  18. Piper ME, Baker TB, Benowitz NL, Kobinsky K, Jorenby DE. Dual Users Compared to Smokers: Demographics, Dependence, and Biomarkers. Nicotine Tob Res. 2018 Oct 26.
    View on PubMed
  19. Patten CA, Koller KR, Flanagan CA, Hiratsuka VY, Hughes CA, Wolfe AW, Decker PA, Fruth K, Brockman TA, Korpela M, Gamez D, Bronars C, Murphy NJ, Hatsukami D, Benowitz NL, Thomas TK. Biomarker feedback intervention for smoking cessation among Alaska Native pregnant women: Randomized pilot study. Patient Educ Couns. 2018 Oct 12.
    View on PubMed
  20. Liakoni E, Edwards KC, St Helen G, Nardone N, Dempsey DA, Tyndale RF, Benowitz NL. Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence. Clin Pharmacol Ther. 2018 Sep 22.
    View on PubMed

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