University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Neal L. Benowitz, MD

Neal L. Benowitz, MD

Professor, Departments of Medicine, Biopharmaceutical Sciences, Psychiatry, and Clinical Pharmacy, UCSF

Cancer Center Program Memberships

Tobacco Control

Research Summary

I am Professor of Medicine and Bioengineering & Therapeutic Sciences and Chief of the Division of Clinical Pharmacology at San Francisco General Hospital. With over 500 publications, I am a leading authority on the human pharmacology of nicotine and nicotine addiction. My laboratory also is a leading site for biomarker assessment of tobacco toxicant exposure. I am former president of the Society for Research on Nicotine and Tobacco (SRNT), and the recipient of the Ove Ferno SRNT Award for Clinical Research on Nicotine and Tobacco. I have been a contributing author or editor to six US Surgeon General's Reports on tobacco including the 2010 Surgeon General's Report—How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease.

Education

Rennselaer Polytechnic Institute, Troy, NY
University of Rochester School of Medicine, Rochester, NY, MD, 1969, Medicine
Bronx Municipal Hospital Center, Bronx, New York, Intern and Resident, Internal Medicine, 1969-1971
Fellow in Clinical Pharmacology, Department of Medicine, University of California San Francisco, 1971-1972
 


Professional Experience

  • 1973-1972
    Clinical Instructor, Department of Medicine, University of California San Francisco
  • 1975-1972
    Director, Drug Detoxification Unit, San Francisco General Hospital, San Francisco, California
  • 1974-present
    Member of Staff, Medical Service, San Francisco General Hospital, San Francisco, California
  • 1979-present
    Associate Medical Director, San Francisco Bay Area Regional Poison Center, San Francisco, CA
  • 1974-1982
    Asst. Professor, Depts of Medicine and Psychiatry, University of Calif-ornia San Francisco, San Francisco, CA
  • 1981-1982
    Assoc. Professor, Depts of Medicine and Psychiatry, University of California San Francisco, San Francisco, CA
  • 1987-present
    Professor, Departments of Medicine, Psychiatry and Pharmacy, University of California San Francisco, San Francisco, California
  • 1983-present
    Chief, Division Clinical Pharmacology and Experimental Therapeutics, University of California San Francisco
  • 1994-2010
    Vice Chair, Department of Biopharmaceutical Sciences, University of California, San Francisco
  • 2004-present
    Professor of Medicine, Biopharmaceutical Sciences, Psychiatry and Clinical Pharmacy, University of California, San Francisco

Honors & Awards

  • Oscar B. Hunter Award
  • Ove Ferno Award
  • 2002
  • UCSF Annual Distinguished Clinical Research Lecturer
  • Rawls Palmer Award for Progress in Medicine
  • Alton Ochsner Award Relating Smoking and Health
  • 1994-2002
  • NIDA Merit Award
  • American Board of Internal Medicine (Diplomate, 1968)
  • American Board of Medical Toxicology
  • American Board of Clinical Pharmacology
  • American Federation for Clinical Research (President 1996 to 1997)
  • American Society for Clinical Inves-tigation
  • American Society of Clinical Pharma-cology and Therapeutics
  • American Society for Pharmacology and Experimental Therapeutics
  • Association of American Physicians
  • Society for Research on Nicotine and Tobacco (President, 1996-1997)

Selected Publications

  1. Song MA, Benowitz NL, Berman M, Brasky TM, Cummings KM, Hatsukami DK, Marian C, O'Connor R, Rees VW, Woroszylo C, Shields PG. Cigarette Filter Ventilation and its Relationship to Increasing Rates of Lung Adenocarcinoma. J Natl Cancer Inst. 2017 Dec 01; 109(12).
    View on PubMed
  2. Havel CM, Benowitz NL, Jacob P, St Helen G. An Electronic Cigarette Vaping Machine for the Characterization of Aerosol Delivery and Composition. Nicotine Tob Res. 2017 Oct 01; 19(10):1224-1231.
    View on PubMed
  3. Chenoweth MJ, Ware JJ, Zhu AZX, Cole CB, Cox LS, Nollen N, Ahluwalia JS, Benowitz NL, Schnoll RA, Hawk LW, Cinciripini PM, George TP, Lerman C, Knight J, Tyndale RF. Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences. Addiction. 2017 Sep 16.
    View on PubMed
  4. Nollen NL, Mayo MS, Clark L, Cox LS, Khariwala SS, Pulvers K, Benowitz NL, Ahluwalia JS. Tobacco toxicant exposure in cigarette smokers who use or do not use other tobacco products. Drug Alcohol Depend. 2017 Oct 01; 179:330-336.
    View on PubMed
  5. Benowitz NL. Comprehensive Nicotine Regulation to End the Combustible Tobacco Epidemic. Ann Intern Med. 2017 Aug 15.
    View on PubMed
  6. Logue JM, Sleiman M, Montesinos VN, Russell ML, Litter MI, Benowitz NL, Gundel LA, Destaillats H. Emissions from Electronic Cigarettes: Assessing Vapers' Intake of Toxic Compounds, Secondhand Exposures, and the Associated Health Impacts. Environ Sci Technol. 2017 Aug 15; 51(16):9271-9279.
    View on PubMed
  7. Kassem NOF, Kassem NO, Liles S, Jackson SR, Chatfield DA, Jacob P, Benowitz NL, Hovell MF. Urinary NNAL in hookah smokers and non-smokers after attending a hookah social event in a hookah lounge or a private home. Regul Toxicol Pharmacol. 2017 Oct; 89:74-82.
    View on PubMed
  8. Peng AR, Morales M, Wileyto EP, Hawk LW, Cinciripini P, George TP, Benowitz NL, Nollen NL, Lerman C, Tyndale RF, Schnoll R. Measures and predictors of varenicline adherence in the treatment of nicotine dependence. Addict Behav. 2017 Dec; 75:122-129.
    View on PubMed
  9. St Helen G, Dempsey DA, Havel CM, Jacob P, Benowitz NL. Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes. Drug Alcohol Depend. 2017 Sep 01; 178:391-398.
    View on PubMed
  10. Gubner NR, Guydish J, Humfleet GL, Benowitz NL, Hall SM. Nicotine biomarkers and rate of nicotine metabolism among cigarette smokers taking buprenorphine for opioid dependency. Drug Alcohol Depend. 2017 Sep 01; 178:267-270.
    View on PubMed
  11. Schick SF, Blount BC, Jacob P, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A. Biomarkers of exposure to new and emerging tobacco delivery products. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L425-L452.
    View on PubMed
  12. Fix BV, O'Connor RJ, Benowitz N, Heckman BW, Cummings KM, Fong GT, Thrasher JF. Nicotine metabolite ratio (NMR) prospectively predicts smoking relapse: Longitudinal findings from ITC Surveys in five countries. Nicotine Tob Res. 2017 Apr 06.
    View on PubMed
  13. Taghavi T, St Helen G, Benowitz NL, Tyndale RF. Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans. Pharmacogenet Genomics. 2017 Apr; 27(4):143-154.
    View on PubMed
  14. Weinstein JR, Asteria-Peñaloza R, Diaz-Artiga A, Davila G, Hammond SK, Ryde IT, Meyer JN, Benowitz N, Thompson LM. Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds among recently pregnant rural Guatemalan women cooking and heating with solid fuels. Int J Hyg Environ Health. 2017 Jun; 220(4):726-735.
    View on PubMed
  15. Hang B, Snijders AM, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob P, Benowitz N, Destaillats H, Gundel LA, Mao JH. Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice. Sci Rep. 2017 Feb 03; 7:41915.
    View on PubMed
  16. Benowitz NL, Jain S, Dempsey DA, Nardone N, St Helen G, Jacob P. Urine Cotinine Screening Detect Nearly Ubiquitous Tobacco Smoke Exposure in Urban Adolescents. Nicotine Tob Res. 2016 Dec 28.
    View on PubMed
  17. Jacob P, Benowitz NL, Destaillats H, Gundel L, Hang B, Martins-Green M, Matt GE, Quintana PJ, Samet JM, Schick SF, Talbot P, Aquilina NJ, Hovell MF, Mao JH, Whitehead TP. Thirdhand Smoke: New Evidence, Challenges, and Future Directions. Chem Res Toxicol. 2017 01 17; 30(1):270-294.
    View on PubMed
  18. Pulvers K, Emami AS, Nollen NL, Romero DR, Strong DR, Benowitz NL, Ahluwalia JS. Tobacco Consumption and Toxicant Exposure of Cigarette Smokers Using Electronic Cigarettes. Nicotine Tob Res. 2016 Dec 21.
    View on PubMed
  19. Vo KT, Horng H, Smollin CG, Benowitz NL. Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. J Emerg Med. 2017 May; 52(5):680-683.
    View on PubMed
  20. Rupprecht LE, Koopmeiners JS, Dermody SS, Oliver JA, al'Absi M, Benowitz NL, Denlinger-Apte R, Drobes DJ, Hatsukami D, McClernon FJ, Pacek LR, Smith TT, Sved AF, Tidey J, Vandrey R, Donny EC. Reducing nicotine exposure results in weight gain in smokers randomised to very low nicotine content cigarettes. Tob Control. 2017 Mar; 26(e1):e43-e48.
    View on PubMed

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