University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Mallar Bhattacharya, MD

Mallar Bhattacharya, MD

Assistant Professor, Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, UCSF

Cancer Center Program Memberships

Cancer Immunology

Research Summary

Dr. Bhattacharya attends at Moffitt Hospital ICU and directs a research laboratory at the Mission Bay Campus focused on the functions of lung macrophages. Ongoing studies are exploring the role of macrophage interactions with other cell types in lung disease models, including lung fibrosis and asthma.


  • Harvard University, Cambridge, MA, A.B., 06/1998, Biology and Psychology
  • Oxford University, Oxford, United Kingdom, M.Sc., 10/1999, Neuroscience
  • Harvard University, Boston, MA, M.D., 06/2004, Medicine
  • Johns Hopkins Hospital, Baltimore, MD, Residency, 06/2007, Internal Medicine
  • University of California, San Francisco, CA, Fellowship, 06/2010, Pulmonary and Critical Care

Professional Experience

  • 1998-1999
    Honorary Frank Knox Memorial Fellowship (awarded by Harvard University), Oxford, UK
  • 2002-2003
    Ruth L. Kirschstein Medical Student National Research Service Award Fellowship, Fred Hutchison Cancer Research Center, Seattle, WA
  • 2004-2007
    Residency in Internal Medicine, Johns Hopkins Hospital, Baltimore, MD
  • 2007-2010
    Fellowship, Pulmonary/Critical Care Medicine, UCSF
  • 2010-2012
    Instructor, Department of Medicine, Division of Pulmonary and Critical Care Medicine, UCSF
  • 2012-present
    Assistant Professor, Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, UCSF

Honors & Awards

  • 2008-2009
    Will Rogers Institute Fellowship
  • 2000
    American Neurological Association Summer Fellowship
  • 2000
    Pasteur Summer Research Fellowship for Medical Students
  • 1997
    Member, Phi Beta Kappa Society, Harvard College Chapter
  • 1994-1998
    New York State Robert C. Byrd Honors Scholarship
  • 1994-1998
    Dean's List, Harvard College
  • 1995, 97, 98
    John Harvard Scholarship
  • 1996
    Harvard College Scholarship

Selected Publications

  1. Looney AP, Bhattacharya M. Fibroblast Gap-closure Assay-Microscopy-based in vitro Assay Measuring the Migration of Murine Fibroblasts. Bio Protoc. 2019 Aug 20; 9(16).
    View on PubMed
  2. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019 02; 20(2):163-172.
    View on PubMed
  3. Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 11 02; 3(21).
    View on PubMed
  4. Bhattacharya M. Could a coffee a day keep the inflammasome away? Sci Transl Med. 2017 02 08; 9(376).
    View on PubMed
  5. Bhattacharya M. Mesenchymal metamorphosis. Sci Transl Med. 2016 12 21; 8(370):370ec202.
    View on PubMed
  6. Bhattacharya M, Kallet RH, Ware LB, Matthay MA. Negative-Pressure Pulmonary Edema. Chest. 2016 Oct; 150(4):927-933.
    View on PubMed
  7. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8.
    View on PubMed
  8. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin avß5. Crit Care Med. 2013 Feb; 41(2):546-53.
    View on PubMed
  9. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9.
    View on PubMed
  10. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. Absence of integrin avß3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):58-66.
    View on PubMed
  11. Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG. Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. J Cell Sci. 2004 Sep 01; 117(Pt 19):4481-94.
    View on PubMed

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