Daniel D. Bikle, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Daniel D. Bikle, MD, PhD

Professor, Departments of Medicine and Dermatology, UCSF

daniel.bikle@ucsf.edu

Phone: (415) 221-4810, ext. 3338; (415) 750-2089 (voice)
VAMC 111N, San Francisco, CA 94142

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Cancer Center Membership

Associate Member » Breast Oncology

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry


Professional Experience

  • 1974-1972
    Research Internist & Staff Endocrinologist, Letterman Army Institute of Research, San Francisco, CA
  • 1979-1982
    Assistant Professor of Medicine, University of California, San Francisco, CA
  • 1979-present
    Co-director, Special Diagnostic & Treatment Unit, Veterans Affairs Medical Center, San Francisco, CA
  • 1986-1992
    Associate Professor of Medicine, University of California, San Francisco, CA
  • 1991-present
    Professor of Medicine, University of California, San Francisco, CA
  • 1993-present
    Professor of Dermatology, University of California, San Francisco, CA

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76.
    View on PubMed
  2. Bourguignon LY, Bikle D. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224.
    View on PubMed
  3. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6.
    View on PubMed
  4. Welsh J, Bikle DD, Lips P. Highlights from the 17th workshop on vitamin d, chicago, IL, june 17-21, 2014. J Steroid Biochem Mol Biol. 2015 Apr; 148:1-2.
    View on PubMed
  5. Bikle DD. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015 May; 93(5):349-54.
    View on PubMed
  6. Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015 Apr; 148:47-51.
    View on PubMed
  7. Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct; 74(4):787-98.
    View on PubMed
  8. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13.
    View on PubMed
  9. Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS One. 2014; 9(6):e99991.
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  10. Bikle DD, Mauro TM. Calcium, Orai1, and epidermal proliferation. J Invest Dermatol. 2014 Jun; 134(6):1506-8.
    View on PubMed
  11. Bikle D. Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:1-4.
    View on PubMed
  12. Jiang YJ, Bikle DD. LncRNA: a new player in 1a, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation. Exp Dermatol. 2014 Mar; 23(3):147-50.
    View on PubMed
  13. Hollis BW, Bikle DD. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014 Feb 27; 370(9):879-80.
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  14. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 Mar 20; 21(3):319-29.
    View on PubMed
  15. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab. 2014 May; 99(5):1631-7.
    View on PubMed
  16. Bikle DD. Vitamin D and cancer: the promise not yet fulfilled. Endocrine. 2014 May; 46(1):29-38.
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  17. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014; 810:282-302.
    View on PubMed
  18. Jiang YJ, Bikle DD. LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:87-90.
    View on PubMed
  19. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:156-8.
    View on PubMed
  20. Hu L, Bikle DD, Oda Y. Reciprocal role of vitamin D receptor on ß-catenin regulated keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:237-41.
    View on PubMed

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