Professor, Departments of Medicine and Dermatology, UCSF
Education
Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry
Professional Experience
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1974-1972
Research Internist & Staff Endocrinologist, Letterman Army Institute of Research, San Francisco, CA
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1979-1982
Assistant Professor of Medicine, University of California, San Francisco, CA
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1979-present
Co-director, Special Diagnostic & Treatment Unit, Veterans Affairs Medical Center, San Francisco, CA
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1986-1992
Associate Professor of Medicine, University of California, San Francisco, CA
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1991-present
Professor of Medicine, University of California, San Francisco, CA
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1993-present
Professor of Dermatology, University of California, San Francisco, CA
Honors & Awards
- 1962
Harvard Honorary Scholarship - 1964, 1962
National Science Foundation Summer Fellowship - 1962
Henderson Memorial Prize in Biochemistry - 1962
Magna Cum Laude, Harvard University - 1962
Baldwin Lucke Memorial Prize - 1967-1962
Medical Scientist Fellowship - 1962
Alpha Omega Alpha, Honorary Medical Society - 1962
Horatio C Wood Prize in Pharmacology - 1962
Bordon Research Award in Medicine - 1962
Spencer Morris Prize - 1971, 1972
National Institutes of Health Special Postdoctoral Fellowship - 1982
Fellowship, American College of Physicians - 1982
American Society of Clinical Investigation - 1982
Western Association of Physicians - 1992
Association of American Physicians
Selected Publications
- Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca(2+) and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100.
View on PubMed - Tahimic CG, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol (Lausanne). 2013; 4:6.
View on PubMed - Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 2013 Feb; 22(2):113-8.
View on PubMed - Bikle DD. Protective actions of vitamin D in UVB induced skin cancer. Photochem Photobiol Sci. 2012 Nov 19; 11(12):1808-16.
View on PubMed - Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: Part II. J Am Acad Dermatol. 2012 Nov; 67(5):817.e1-817.e11.
View on PubMed - Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: Part I. J Am Acad Dermatol. 2012 Nov; 67(5):803.e1-803.e12.
View on PubMed - Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Am J Physiol Endocrinol Metab. 2012 Dec; 303(11):E1354-62.
View on PubMed - Bikle DD. Vitamin D and bone. Curr Osteoporos Rep. 2012 Jun; 10(2):151-9.
View on PubMed - Bikle DD, Wang Y. Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone. Curr Mol Pharmacol. 2012 Jun; 5(2):135-42.
View on PubMed - Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-9.
View on PubMed - Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66.
View on PubMed - Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun; 33(3):456-92.
View on PubMed - Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem. 2012 May 24; 55(10):4640-51.
View on PubMed - Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH. Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes. J Invest Dermatol. 2012 Aug; 132(8):2097-100.
View on PubMed - Bikle DD. Vitamin D and the skin: Physiology and pathophysiology. Rev Endocr Metab Disord. 2012 Mar; 13(1):3-19.
View on PubMed - Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95.
View on PubMed - Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle DD. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol. 2012 Apr; 132(4):1075-83.
View on PubMed - Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle DD. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J Bone Miner Res. 2011 Dec; 26(12):2948-58.
View on PubMed - Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47.
View on PubMed - Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. Negative cross-talk between calcium-sensing receptor and ß-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 6; 287(2):1158-67.
View on PubMed
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