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Daniel D. Bikle, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
bikle_daniel

Professor, Departments of Medicine and Dermatology, UCSF

daniel.bikle@ucsf.edu

Phone: (415) 221-4810, ext. 3338; (415) 750-2089 (voice)
VAMC 111N, San Francisco, CA 94142

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Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

Professional Experience

  • 1974-1972
    Research Internist & Staff Endocrinologist, Letterman Army Institute of Research, San Francisco, CA
  • 1979-1982
    Assistant Professor of Medicine, University of California, San Francisco, CA
  • 1979-present
    Co-director, Special Diagnostic & Treatment Unit, Veterans Affairs Medical Center, San Francisco, CA
  • 1986-1992
    Associate Professor of Medicine, University of California, San Francisco, CA
  • 1991-present
    Professor of Medicine, University of California, San Francisco, CA
  • 1993-present
    Professor of Dermatology, University of California, San Francisco, CA

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Bikle DD, Jiang Y. The protective role of vitamin d signaling in non-melanoma skin cancer. Cancers (Basel). 2013; 5(4):1426-38.
    View on PubMed
  2. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Endocrinology. 2013 Nov; 154(11):3957-60.
    View on PubMed
  3. Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. Vitamin D3 Effects on Lipids Differ in Statin and Non-Statin-Treated Humans: Superiority of Free 25-OH D Levels in Detecting Relationships. J Clin Endocrinol Metab. 2013 Nov; 98(11):4400-9.
    View on PubMed
  4. Norman AW, Bikle D, Bouillon R. Fifteenth vitamin D workshop. J Steroid Biochem Mol Biol. 2013 Jul; 136:1-2.
    View on PubMed
  5. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42.
    View on PubMed
  6. Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. Peroxisome proliferation-activated receptor d agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry. 2013 Jun 18; 52(24):4193-203.
    View on PubMed
  7. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58.
    View on PubMed
  8. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100.
    View on PubMed
  9. Tu CL, Bikle DD. Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):415-27.
    View on PubMed
  10. Tahimic CG, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol (Lausanne). 2013; 4:6.
    View on PubMed
  11. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 2013 Feb; 22(2):113-8.
    View on PubMed
  12. Bikle DD. Protective actions of vitamin D in UVB induced skin cancer. Photochem Photobiol Sci. 2012 Dec; 11(12):1808-16.
    View on PubMed
  13. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part I. J Am Acad Dermatol. 2012 Nov; 67(5):803.e1-12, quiz 815-6.
    View on PubMed
  14. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part II. J Am Acad Dermatol. 2012 Nov; 67(5):817.e1-11; quiz 827-8.
    View on PubMed
  15. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Am J Physiol Endocrinol Metab. 2012 Dec 1; 303(11):E1354-62.
    View on PubMed
  16. Bikle DD, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A. Protective role of vitamin D signaling in skin cancer formation. J Steroid Biochem Mol Biol. 2013 Jul; 136:271-9.
    View on PubMed
  17. Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD. 1a,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the ß-catenin pathway. J Steroid Biochem Mol Biol. 2013 Jul; 136:229-32.
    View on PubMed
  18. Bikle DD, Wang Y. Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone. Curr Mol Pharmacol. 2012 Jun; 5(2):135-42.
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  19. Bikle DD. Vitamin D and bone. Curr Osteoporos Rep. 2012 Jun; 10(2):151-9.
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  20. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-9.
    View on PubMed

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