Daniel D. Bikle, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Daniel D. Bikle, MD, PhD

Professor, Departments of Medicine and Dermatology, UCSF

daniel.bikle@ucsf.edu

Phone: (415) 221-4810, ext. 3338; (415) 750-2089 (voice)
VAMC 111N, San Francisco, CA 94142

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Cancer Center Membership

Associate Member » Breast Oncology

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry


Professional Experience

  • 1974-1972
    Research Internist & Staff Endocrinologist, Letterman Army Institute of Research, San Francisco, CA
  • 1979-1982
    Assistant Professor of Medicine, University of California, San Francisco, CA
  • 1979-present
    Co-director, Special Diagnostic & Treatment Unit, Veterans Affairs Medical Center, San Francisco, CA
  • 1986-1992
    Associate Professor of Medicine, University of California, San Francisco, CA
  • 1991-present
    Professor of Medicine, University of California, San Francisco, CA
  • 1993-present
    Professor of Dermatology, University of California, San Francisco, CA

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72.
    View on PubMed
  2. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88.
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  3. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov; 35(11):6001-7.
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  4. Pregnane X receptor expression in skin: the good and the bad. Exp Dermatol. 2015 Nov; 24(11):829-30.
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  5. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84.
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  6. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Aug 8.
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  7. IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. J Bone Miner Res. 2015 Dec; 30(12):2239-48.
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  8. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6.
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  9. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76.
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  10. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224.
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  11. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6.
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  12. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300.
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  13. Highlights from the 17th workshop on vitamin d, chicago, IL, june 17-21, 2014. J Steroid Biochem Mol Biol. 2015 Apr; 148:1-2.
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  14. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015 May; 93(5):349-54.
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  15. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015 Apr; 148:47-51.
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  16. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct; 74(4):787-98.
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  17. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13.
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  18. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS One. 2014; 9(6):e99991.
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  19. Calcium, Orai1, and epidermal proliferation. J Invest Dermatol. 2014 Jun; 134(6):1506-8.
    View on PubMed
  20. Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:1-4.
    View on PubMed

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