Daniel D. Bikle, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Daniel D. Bikle, MD, PhD

Professor, Departments of Medicine and Dermatology, UCSF

daniel.bikle@ucsf.edu

Phone: (415) 221-4810, ext. 3338; (415) 750-2089 (voice)
VAMC 111N, San Francisco, CA 94142

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Cancer Center Membership

Associate Member » Breast Oncology

Education

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry


Professional Experience

  • 1974-1972
    Research Internist & Staff Endocrinologist, Letterman Army Institute of Research, San Francisco, CA
  • 1979-1982
    Assistant Professor of Medicine, University of California, San Francisco, CA
  • 1979-present
    Co-director, Special Diagnostic & Treatment Unit, Veterans Affairs Medical Center, San Francisco, CA
  • 1986-1992
    Associate Professor of Medicine, University of California, San Francisco, CA
  • 1991-present
    Professor of Medicine, University of California, San Francisco, CA
  • 1993-present
    Professor of Dermatology, University of California, San Francisco, CA

Honors & Awards

  • 1962
    Harvard Honorary Scholarship
  • 1964, 1962
    National Science Foundation Summer Fellowship
  • 1962
    Henderson Memorial Prize in Biochemistry
  • 1962
    Magna Cum Laude, Harvard University
  • 1962
    Baldwin Lucke Memorial Prize
  • 1967-1962
    Medical Scientist Fellowship
  • 1962
    Alpha Omega Alpha, Honorary Medical Society
  • 1962
    Horatio C Wood Prize in Pharmacology
  • 1962
    Bordon Research Award in Medicine
  • 1962
    Spencer Morris Prize
  • 1971, 1972
    National Institutes of Health Special Postdoctoral Fellowship
  • 1982
    Fellowship, American College of Physicians
  • 1982
    American Society of Clinical Investigation
  • 1982
    Western Association of Physicians
  • 1992
    Association of American Physicians

Selected Publications

  1. Bikle DD. The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven. Endocrinology. 2016 May; 157(5):1717-8.
    View on PubMed
  2. Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. J Biol Chem. 2016 Apr 8; 291(15):8140-9.
    View on PubMed
  3. Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem. 2016 Feb 15; 109:238-46.
    View on PubMed
  4. Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72.
    View on PubMed
  5. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88.
    View on PubMed
  6. Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov; 35(11):6001-7.
    View on PubMed
  7. Bikle DD. Pregnane X receptor expression in skin: the good and the bad. Exp Dermatol. 2015 Nov; 24(11):829-30.
    View on PubMed
  8. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84.
    View on PubMed
  9. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Aug 8.
    View on PubMed
  10. Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD. IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. J Bone Miner Res. 2015 Dec; 30(12):2239-48.
    View on PubMed
  11. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6.
    View on PubMed
  12. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76.
    View on PubMed
  13. Bourguignon LY, Bikle D. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224.
    View on PubMed
  14. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6.
    View on PubMed
  15. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300.
    View on PubMed
  16. Welsh J, Bikle DD, Lips P. Highlights from the 17th workshop on vitamin d, chicago, IL, june 17-21, 2014. J Steroid Biochem Mol Biol. 2015 Apr; 148:1-2.
    View on PubMed
  17. Bikle DD. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015 May; 93(5):349-54.
    View on PubMed
  18. Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015 Apr; 148:47-51.
    View on PubMed
  19. Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct; 74(4):787-98.
    View on PubMed
  20. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13.
    View on PubMed

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