D. Montgomery Bissell, MD

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Education

Harvard College, Cambridge, MA, A.B., 1962, English
Harvard Medical School, Boston, MA, M.D., 1967, Medicine
Harvard Medical Service, Boston City Hospital, Residency training, 1967-70, Int. Medicine
University of California, San Francisco, Research training, 1970-73, Liver Biology

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Professional Experience

• 1973-1982
  Assistant Professor of Medicine, UCSF
• 1977-1992
  Director, Liver Center Laboratory, San Francisco General Hospital
• 1980-1982
  Associate Professor of Medicine, UCSF
• 1986-present
  Professor of Medicine, UCSF
• 1973-present
  Attending Physician. UCSF and San Francisco General Hospital
• 1997-present
  Director, Division of Gastroenterology, UCSF
• 1998-present
  Director, UCSF Liver Center

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Honors & Awards

• 1992
  Election to the American Society for Clinical Investigation
• 1982
  Election to the Intl. Assn. for the Study of Liver Diseases
• 1982
  Election to the Association of American Physicians
• 1992
  Council, American Association for the Study of Liver Diseases
• 1992
  President, American Association for the Study of Liver Diseases
• 1998-2002
  NIDDK Advisory Council
• 1997-2002
  Editor, HEPATOLOGY
• 1995-2002
  Principal investigator, Merit award R37DK31192
  
• 2002
  Distinguished achievement award, American Association for the Study of Liver Diseases

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Selected Publications

• (selected from over 100)
• Pitas RE, Boyles J, Mahley RW, Bissell DM. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol 100~103-117, 1985.
• Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: The principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82:8681-8685, 1985.
• Bissell DM. Stamatoglou SC, Nermut MV, Hughes RC. Interactions of rat hepatocytes with type IV collagen, fibronectin and laminin matrices. Distinct matrix-controlled modes of attachment and spreading. Eur J Cell Biol 40,72-78, 1986.
• Bissell DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. J Clin Invest 79: 801-812, 1987.
• Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 94: 1053-1062, 1988.
• Maher JJ, Bissell DM, Friedman SL. Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derived from lipocytes within the monolayer. J Clin Invest 82:450-59, 1988.
• Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 264:10756-B2, 1989.
• Arthur MJP, Friedman SL. Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest 84: 1076-85, 1989.
• Bissell DM, Caron JM, Babiss, LE, Friedman JM. Transcriptional regulation of the albumin gene in cultured rat hepatocytes: role of basement membrane matrix. Mol Biol Med 7:187-197, 1990.
• Hultcrantz RH, Bissell DM, Roll, FJ. Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol. J Clin Invest 87:45-49, 1992
  
• McGuire RF, Bissell DM, Boyles J, Roll FJ. Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver. Hepatology 15:989-997, 1992.
• Jarnagin WR, Debs RJ, Wang S-S, Bissell DM. Cationic lipid-mediated transfection of liver cells in primary culture. Nucl Acid Res 20;4205-4211, 1992.
• Maher JJ, Bissell DM. Cell-matrix interactions in liver. Seminars in Cell Biology 4:189-201, 1993.
• Housset C, Rockey DC, Bissell DM. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin-1. Proc Natl Acad Sci USA, 90:9266-9270, 1993.
• Jarnagin WR, Rockey DC, Koteliansky VE, Bissell DM. Expression of variant fibronectin in wound-healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol 127:2037-2048, 1994.
• Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of TGF in rat liver regeneration, autocrine regulation of hepatocyte proliferation by TGF-2. J Clin Invest 96:447-455, 1995.
• Racine-Samson L, Rockey DC, Bissell DM. The role of 11 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. J Biol Chem 1997;272:30911-17.
• Wang Y-J, Wang S-S, Bickel M, Guenzler V, Gerl M, Bissell DM. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury. Differential effects in males and females. Amer J Pathol 1998;152:279-287.
• McDonagh AF, Bissell DM. Porphyria and porphyrinology - the past fifteen years. Semin Liver Dis 1998;18:3-15.
• George J, Roulot D, Koteliansky VE, Bissell DM. In vivo inhibition of rat stellate cell activation by soluble TGF type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci USA 1999;96:12719-24.
• Bissell DM, Roulot D, George J. Transforming growth factor and the liver. Hepatology 2001;34:859-867.
• Alonso CR, George J, Pesce CG, Bissell DM, Kornblihtt AR. Fibronectin transcription in liver cells: promoter occupation and function in sinusoidal endothelial cells and hepatocytes. Biochem Biophys Res Commun 2002;295:1077-84.
• Bissell, DM. Assessing fibrosis without a liver biopsy: are we there yet? Gastroenterology 2004; in press.
• Chang ML, Chen JC, Alonso CR, Kornblihtt AR, Bissell DM. Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver. Proc Natl Acad Sci USA 2004; in press.
• Kikuchi S, Griffin CT, Wang SS, Bissell DM. Role of cd44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and cd44v6. J Biol Chem 2005;280:15398-404.
• Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baestcher M, Wang B, Bissell DM, Burkly LC. Tweak induces liver progenitor cell proliferation. J Clin Invest 2005;115:2330-40.