Elizabeth H. Blackburn, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Elizabeth H. Blackburn, PhD

Professor, Departments of Biochemistry/Biophysics and Microbiology/Immunology, UCSF
Morris Herzstein Endowed Chair in Biology and Physiology, UCSF

elizabeth.blackburn@ucsf.edu

Phone: (415) 476-4912 (office); (415) 476-2824 (asst)
Box 2200, UCSF
San Francisco, CA 94143-2202

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Additional Websites


Education

University of Melbourne, Melbourne, Australia, B.Sc., 1970, Biochemistry
University of Melbourne, Melbourne, Australia, M.Sc., 1972, Biochemistry
University of Cambridge, England, Ph.D., 1975, Molecular Biology
Yale University, New Haven, Connecticut, Postdoc., 1975-1977, Molecular and Cellular Biology


Professional Experience

  • 1970-1971
    Graduate Research Student, Master of Science Degree course Department of Biochemistry, University of Melbourne, Australia
  • 1971-1974
    Graduate Research Student, Division of Protein and Nucleic Acid Chemistry MRC Laboratory of Molecular Biology, Cambridge, England (Advisor: F. Sanger)
  • 1975-1977
    Postdoctoral Fellow, Department of Biology, Yale University
  • 1978 Postdoctoral Fellow, Department of Biochemistry, University of California, San Francisco
  • 1978-1983
    Assistant Professor, Department of Molecular Biology, University of California, Berkeley
  • 1983-1986
    Associate Professor, Department of Molecular Biology, University of California, Berkeley
  • 1986-1990
    Professor, Department of Molecular Biology, University of California, Berkeley
  • 1993-1999
    Chair, Department of Microbiology Immunology, University of California, San Francisco
  • 1990-present
    Professor, Departments of Biochemistry and Biophysics, and Microbiology and Immunology, University of California, San Francisco
  • 1996-present
    Member, Breast Oncology Program (1996) and Genitourinary Oncology Program (1999), UCSF Comprehensive Cancer Center
  • 2001-present
    Scientific Advisory Board, Division of Basic Science, Fred Hutchinson Cancer Research Center
  • 2003-present
    Scientific Advisory Board, Huntsman Cancer Institute, University of Utah, Salt Lake City
  • 2003-2007
    Member, National Advisory Council on Aging, National Institute of Aging, NIH
  • 2008-present
    Member, National Academies of Sciences Committee on Science, Technology and the Law.

Honors & Awards

  • Selected honors and awards since 2000. For complete list, see Blackburn Lab website.
  • 2000
    American Association for Cancer Research-G.H.A. Clowes Memorial Award
  • 2000
    Elected, Institute of Medicine
  • 2000
    American Cancer Society Medal of Honor
  • 2000
    Elected, Fellow of the American Association for the Advancement of Science
  • 2001
    AACR-Pezcoller Foundation International Award for Cancer Research
  • 2001
    General Motors Cancer Research Foundation Alfred P. Sloan Award
  • 2003
    26th Annual Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research
  • 2005
    Kirk A. Landon-American Association for Cancer Research Prize for Basic Cancer Research
  • 2005
    Benjamin Franklin Medal in Life Science
  • 2005
    New York Academy of Medicine Medal
  • 2006
    National Cancer Institute Alfred G. Knudson Award
  • 2006
    Fifth annual Wiley Prize in Biomedical Sciences
  • 2006
    Albert Lasker Award for Basic Medical Research
  • 2006
    The 25th Meyenburg Prize
  • 2006
    Elected, American Philosophical Society
  • 2007
    Elected, Australian Academy of Science
  • 2007
    TIME 100 Most Influential People in the World
  • 2008
    L’Oreal UNESCO For Women In Science Award
  • 2008
    Weizmann Women & Science Award: Weizmann Institute of Science
  • 2009
    Nobel Prize in Physiology or Medicine

Selected Publications

  1. Xie Z, Jay KA, Smith DL, Zhang Y, Liu Z, Zheng J, Tian R, Li H, Blackburn EH. Early telomerase inactivation accelerates aging independently of telomere length. Cell. 2015 Feb 26; 160(5):928-39.
    View on PubMed
  2. Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S. PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression. Psychiatry Res. 2015 Jan 19.
    View on PubMed
  3. Entringer S, Epel ES, Lin J, Blackburn EH, Buss C, Simhan HN, Wadhwa PD. Maternal estriol concentrations in early gestation predict infant telomere length. J Clin Endocrinol Metab. 2015 Jan; 100(1):267-73.
    View on PubMed
  4. Fraser JA, Worrall EG, Lin Y, Landre V, Pettersson S, Blackburn E, Walkinshaw M, Muller P, Vojtesek B, Ball K, Hupp TR. Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis. J Mol Biol. 2015 Apr 24; 427(8):1728-47.
    View on PubMed
  5. Zota AR, Needham BL, Blackburn EH, Lin J, Park SK, Rehkopf DH, Epel ES. Associations of cadmium and lead exposure with leukocyte telomere length: findings from national health and nutrition examination survey, 1999-2002. Am J Epidemiol. 2015 Jan 15; 181(2):127-36.
    View on PubMed
  6. Roberts JD, Dewland TA, Longoria J, Fitzpatrick AL, Ziv E, Hu D, Lin J, Glidden DV, Psaty BM, Burchard EG, Blackburn EH, Olgin JE, Heckbert SR, Marcus GM. Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1026-32.
    View on PubMed
  7. Leung CW, Laraia BA, Needham BL, Rehkopf DH, Adler NE, Lin J, Blackburn EH, Epel ES. Soda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the national health and nutrition examination surveys. Am J Public Health. 2014 Dec; 104(12):2425-31.
    View on PubMed
  8. Gazzaniga FS, Blackburn EH. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. Blood. 2014 Dec 11; 124(25):3675-84.
    View on PubMed
  9. Needham BL, Mezuk B, Bareis N, Lin J, Blackburn EH, Epel ES. Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey. Mol Psychiatry. 2015 Apr; 20(4):520-8.
    View on PubMed
  10. Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM. Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults. J Affect Disord. 2014 Dec 1; 169:86-90.
    View on PubMed
  11. Puterman E, Lin J, Krauss J, Blackburn EH, Epel ES. Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. Mol Psychiatry. 2015 Apr; 20(4):529-35.
    View on PubMed
  12. Jacobs EG, Epel ES, Lin J, Blackburn EH, Rasgon NL. Relationship between leukocyte telomere length, telomerase activity, and hippocampal volume in early aging. JAMA Neurol. 2014 Jul 1; 71(7):921-3.
    View on PubMed
  13. Chen S, Yeh F, Lin J, Matsuguchi T, Blackburn E, Lee ET, Howard BV, Zhao J. Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study. Aging (Albany NY). 2014 May; 6(5):380-9.
    View on PubMed
  14. Chen S, Lin J, Matsuguchi T, Blackburn E, Yeh F, Best LG, Devereux RB, Lee ET, Howard BV, Roman MJ, Zhao J. Short leukocyte telomere length predicts incidence and progression of carotid atherosclerosis in American Indians: the Strong Heart Family Study. Aging (Albany NY). 2014 May; 6(5):414-27.
    View on PubMed
  15. Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD, Blackburn EH, Steptoe A. Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4519-24.
    View on PubMed
  16. Zhao J, Zhu Y, Uppal K, Tran VT, Yu T, Lin J, Matsuguchi T, Blackburn E, Jones D, Lee ET, Howard BV. Metabolic profiles of biological aging in American Indians: the Strong Heart Family Study. Aging (Albany NY). 2014 Mar; 6(3):176-86.
    View on PubMed
  17. Rehkopf DH, Dow WH, Rosero-Bixby L, Lin J, Epel ES, Blackburn EH. Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population-based observational study. Am J Hum Biol. 2014 May-Jun; 26(3):367-75.
    View on PubMed
  18. Chae DH, Nuru-Jeter AM, Adler NE, Brody GH, Lin J, Blackburn EH, Epel ES. Discrimination, racial bias, and telomere length in African-American men. Am J Prev Med. 2014 Feb; 46(2):103-11.
    View on PubMed
  19. Buss J, Havel PJ, Epel E, Lin J, Blackburn E, Daubenmier J. Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite. 2014 May; 76:84-94.
    View on PubMed
  20. Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. 2013 Dec 19; 155(7):1479-91.
    View on PubMed

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