Robert Blelloch, MD, PhD

Robert Blelloch, MD, PhD

Associate Professor, Department of Urology, UCSF
Peter R. Carroll, MD, Endowed Chair, UCSF

Phone: (415) 476-2838 (voice)
Box 0525, UCSF

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Cancer Center Membership

Program Member ยป Prostate Cancer


Duke University, Durham, North Carolina, B.S., 5/1989, Zoology
Duke University, Durham, North Carolina, M.A.T., 5/1990, Biology
University of Wisconsin, Madison, Wisconsin, Ph.D., 5/1999, Cell & Molec Biology
University of Wisconsin, Madison, Wisconsin, M.D., 5/2001, Medicine

Professional Experience

  • 7/01 - 7/02
    Resident, Pathology, Brigham and Women's Hospital
  • 3/03 - 7/02
    Chief Resident, Pathology, Brigham and Women's Hospital
  • 7/04 - 7/02
    Clinical Fellow, Harvard Medical School Joint Program of Transfusion Medicine
  • 8/02 - 12/02
    Post-Doctoral Fellow, Whitehead Institute of Biomedical Research
  • 12/05 - 7/10
    Assistant Professor, Institute for Regenerative Medicine and Comprehensive Cancer Center, Departments of Urology and Pathology, University of California, San Francisco
  • 7/10 - present
    Associate Professor, UCSF
  • 7/10 - present
    Chair, UCSF Biomedical Sciences Graduate Program Admissions Committee

Honors & Awards

  • 2000-2001
    Rath Wisconsin Distinguished Graduate Fellow
  • 2001
    GATE Pharmaceuticals Outstanding Medical Student Award
  • 2001
    Alpha Omega Alpha (Medical Student Honor Society)
  • 2001
    University of Wisconsin-Madison Commencement Student Speaker
  • 2004
    Paul E. Strandjord Young Investigator Award with Distinction
  • 2006-
    Peter Carroll Endowed Chair
  • 2007-2011
    Pew Scholar
  • 2009
    Kavli Fellow (National Academy of Sciences
  • 2011
    International Society of Stem Cell Research Outstanding Young Investigator Award.

Selected Publications

  1. Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT. Biogenesis, delivery, and function of extracellular RNA. J Extracell Vesicles. 2015; 4:27494.
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  2. Belair CD, Paikari A, Moltzahn F, Shenoy A, Yau C, Dall'Era M, Simko J, Benz C, Blelloch R. DGCR8 is essential for tumor progression following PTEN loss in the prostate. EMBO Rep. 2015 Sep; 16(9):1219-32.
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  3. Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA, Blelloch R. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015 Jul 22.
    View on PubMed
  4. Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M. Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. EMBO J. 2015 Jul 2; 34(13):1759-72.
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  5. Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A. CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation. Stem Cell Reports. 2015 Mar 10; 4(3):374-89.
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  6. Shenoy A, Danial M, Blelloch RH. Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis. EMBO J. 2015 May 5; 34(9):1180-94.
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  7. Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong MW. Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage. Osteoarthritis Cartilage. 2015 Jul; 23(7):1214-20.
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  8. Guo WT, Wang XW, Yan YL, Li YP, Yin X, Zhang Q, Melton C, Shenoy A, Reyes NA, Oakes SA, Blelloch R, Wang Y. Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells. Cell Death Differ. 2015 Jul; 22(7):1158-69.
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  9. Ye J, Blelloch R. Regulation of pluripotency by RNA binding proteins. Cell Stem Cell. 2014 Sep 4; 15(3):271-80.
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  10. Shenoy A, Blelloch RH. Regulation of microRNA function in somatic stem cell proliferation and differentiation. Nat Rev Mol Cell Biol. 2014 Sep; 15(9):565-76.
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  11. Wang SY, Shiboski S, Belair CD, Cooperberg MR, Simko JP, Stoppler H, Cowan J, Carroll PR, Blelloch R. miR-19, miR-345, miR-519c-5p serum levels predict adverse pathology in prostate cancer patients eligible for active surveillance. PLoS One. 2014; 9(6):e98597.
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  12. Parchem RJ, Ye J, Judson RL, LaRussa MF, Krishnakumar R, Blelloch A, Oldham MC, Blelloch R. Two miRNA clusters reveal alternative paths in late-stage reprogramming. Cell Stem Cell. 2014 May 1; 14(5):617-31.
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  13. Judson RL, Greve TS, Parchem RJ, Blelloch R. MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol. 2013 Oct; 20(10):1227-35.
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  14. Krishnakumar R, Blelloch RH. Epigenetics of cellular reprogramming. Curr Opin Genet Dev. 2013 Oct; 23(5):548-55.
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  15. Greve TS, Judson RL, Blelloch R. microRNA control of mouse and human pluripotent stem cell behavior. Annu Rev Cell Dev Biol. 2013; 29:213-39.
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  16. Wang Y, Melton C, Li YP, Shenoy A, Zhang XX, Subramanyam D, Blelloch R. miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms. Cell Rep. 2013 Jul 11; 4(1):99-109.
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  17. Jeker LT, Zhou X, Blelloch R, Bluestone JA. DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. PLoS One. 2013; 8(5):e66282.
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  18. Blelloch R, Gutkind JS. Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. Curr Opin Cell Biol. 2013 Apr; 25(2):149-51.
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  19. Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7.
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  20. Cook MS, Blelloch R. Small RNAs in germline development. Curr Top Dev Biol. 2013; 102:159-205.
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