Assistant Professor, Department of Radiology, UCSF
Education
Valparaiso University, Valparaiso, IN, B.S., 1980, Biology and Chemistry
University of Illinois, Champaign-Urbana, IL, Ph.D., 1984, Biochemistry
John Hopkins University, Baltimore, MD, M.D., 1989, Medicine
University of Minnesota, Minneapolis, MN, Residency, 1992, Internal Medicine
University of California, San Francisco, Fellow, 1996, Hematology-Oncology
Professional Experience
- 1980-84
Biochemical studies on the regulation of plasminogen activation by fibrin and lysine-binding sites, University of Illinois, Biochemistry Department. Advisor: Walter Mangel, Ph.D.- As Graduate Student
- 1984-85
Studies on the distribution of ubiquitin, a regulator of intracellular proteolysis, in biological systems, St. Jude Children's Research hospital, Memphis, TN. Advisor: Victor Fried, Ph.D. -- as Post-Doc
- 1985-86
Summer research project on evaluation of small molecule serine protease inhibitor in cell culture system, Children's Hospital, university of Southern California, Los Angeles, CA Advisor: Walter Laug, M.D. -- as Medical Student
- 1987
Research elective studying inhibition of tumor angiogensis by the antibiotic minocycline, Johns Hopkins Hospital, Brain Tumor Lab, Baltimore MD. Advisor: Henry Brem, M.D. -- as Medical Student
- 1988
Research elective investigating serum of patients with Thrombotic Thrombocytopenic Purpura (TTP) for potential anti-endothelial cell auto-antibodies, Johns Hopkins Hospital, Hematology Division, Baltimore, MD. Advisor: William Bell M.D. -- As Medical Student
- 1990
Research honors rotation studying the effect of HSB on Plasminogen Activator Inhibitor -- 1 (PAI-1) expression by endothelal Cells, University of Minnesota, Hematology Division, Dept. of Medicine, Minneapolis, MN. Advisor: Greg Vercellotti, M.D. -- As Medical Resident
- 1992-96
Isolation and characterization of genomic fragments of the murine beta3 integrin gene for purposes of homologous recombination, Hematology-Oncology Division, Univ. of Calif., San Francisco. Advisor: Marc Shuman, M.D. -- As Hematology-Oncology Fellow
- 1996-98
Characterization of integrins in basal cells of prostatic epithelium; Targeting of recombinant proteins to platelet granules via Dodecapeptide sequence, Hem.-Onc. Div., UCSF. Advisor: Marc Shuman, M.D. -- As Visiting Post-Doc
- 1998-2000
Clinical Instructor, Urological Oncology Program, UCSF/Mt. Zion Cancer Center, San Francisco, CA.
Assistant Clinical Professor appointment pending.
Establishment of TRAMP transgenic mouse colony and protease expression analysis in conjunction with the Protease Project Group at UCSF.
Selected Publications
- Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive (13)C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2012 Dec 20.
View on PubMed - Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-(13)C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2012 Oct 26.
View on PubMed - von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized (13)C metabolic imaging at 14.1 T. Magn Reson Imaging. 2013 Feb; 31(2):163-70.
View on PubMed - Hu S, Yoshihara HA, Bok R, Zhou J, Zhu M, Kurhanewicz J, Vigneron DB. Use of hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. Magn Reson Imaging. 2012 Dec; 30(10):1367-72.
View on PubMed - von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB. Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1658-62.
View on PubMed - Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson. 2012 Apr; 217:41-7.
View on PubMed - Costello LC, Franklin RB, Zou J, Feng P, Bok R, Swanson MG, Kurhanewicz J. Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model. Cancer Biol Ther. 2011 Dec 15; 12(12):1078-84.
View on PubMed - von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. Magn Reson Imaging. 2012 Apr; 30(3):305-11.
View on PubMed - Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11.
View on PubMed - Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40.
View on PubMed - Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 6; 14(1):131-42.
View on PubMed - Park I, Bok R, Ozawa T, Phillips JJ, James CD, Vigneron DB, Ronen SM, Nelson SJ. Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging. 2011 Jun; 33(6):1284-90.
View on PubMed - von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011 Aug; 211(2):109-13.
View on PubMed - von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7.
View on PubMed - Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7.
View on PubMed - Hurd RE, Yen YF, Mayer D, Chen A, Wilson D, Kohler S, Bok R, Vigneron D, Kurhanewicz J, Tropp J, Spielman D, Pfefferbaum A. Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med. 2010 May; 63(5):1137-43.
View on PubMed - Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7.
View on PubMed - Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB. Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91.
View on PubMed - Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21.
View on PubMed - Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ. Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44.
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