Benjamin Braun, MD, PhD


Associate Professor in Residence, Department of Pediatrics, UC, San Francisco
Director, Laboratory for Cell Analysis Core, UCSF Helen Diller Family Comprehensive Cancer Center

Phone: (415) 353-2584 (appts)
Box 0106, UCSF
San Francisco, CA 94143-0106

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Additional Websites


Princeton University, A.B., 1990, Molecular Biology
University of California, Los Angeles, Ph.D., 1998, Molecular Biology
University of California, Los Angeles, M.D., 1998, Medicine
University of California, San Francisco, Resident, 1998-2000, Pediatrics
University of California, San Francisco, Fellow, 2000-2003, Hematology/Oncology

Professional Experience

  • 1992-1996
    Graduate Student, Laboratory of Christopher Denny, M.D., University of California, Los Angeles (Project: mechanism of oncogenesis by the Ewing sarcoma fusion protein EWS-FLI)
  • 1998-2000
    Resident, Department of Pediatrics, University of California, San Francisco
  • 2000-2003
    Clinical Fellow, Hematology/Oncology, University of California, San Francisco
  • 2001-present
    Post-doctoral researcher, Laboratory of Kevin Shannon, M.D., University of California, San Francisco (Project: myeloid proliferation and neoplasia initiated by mutant Kras)
  • 2004-2005
    Instructor, Department of Pediatrics, University of California, San Francisco
  • 2005-2007
    Adjunct Assistant Professor, Department of Pediatrics, University of California, San Francisco
  • 2007-2013
    Assistant Professor in Residence, Department of Pediatrics, University of California, San Francisco
  • 2013-present
    Associate Professor in Residence, Department of Pediatrics, University of California, San Francisco

Honors & Awards

  • 1990
    Cum Laude, Princeton University
  • 1990
    Phi Beta Kappa
  • 1990
    Medical Scientist Training Program Fellowship, University of California, Los Angeles
  • 2000-2003
    Campini Fellowship, University of California, San Francisco
  • 2004
    David G. Nathan Award, Society for Pediatric Research
  • 2004
    Melvin Grumbach Pediatric Research Award, UCSF
  • 2005
    Basic Research Scholar American Society of Hematology
  • 2010
    Fellows' Leadership and Advocacy Group Faculty
    Leadership Award, Department of Pediatrics, UCSF

Selected Publications

  1. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PLC-? and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras. Sci Signal. 2013; 6(304):ra105.
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  2. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013 Jan 2; 123(1):335-9.
    View on PubMed
  3. Braun BS. KIT's ship comes in. Blood. 2012 Sep 27; 120(13):2541-2.
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  4. Ward AF, Braun BS, Shannon KM. Targeting oncogenic Ras signaling in hematologic malignancies. Blood. 2012 Oct 25; 120(17):3397-406.
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  5. Lyubynska N, Gorman MF, Lauchle JO, Hong WX, Akutagawa JK, Shannon K, Braun BS. A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice. Sci Transl Med. 2011 Mar 30; 3(76):76ra27.
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  6. Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood. 2011 Apr 21; 117(16):4253-61.
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  7. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32.
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  8. Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010 Sep; 42(9):794-800.
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  9. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11.
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  10. Braun BS, Shannon K. The SPS affair: a complex tale of illicit proliferation. Cancer Cell. 2009 Aug 4; 16(2):87-8.
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  11. Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell. 2009 Apr 7; 15(4):341-52.
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  12. Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009 Mar 17; 7(3):e59.
    View on PubMed
  13. Braun BS, Lessnick SL. Pediatric malignancies: update on sarcomas and leukemia development in children. Curr Opin Genet Dev. 2009 Feb; 19(1):92-6.
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  14. Braun BS, Shannon K. Targeting Ras in myeloid leukemias. Clin Cancer Res. 2008 Apr 15; 14(8):2249-52.
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  15. Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. 2007 May 1; 109(9):3945-52.
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  16. Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 2006 Sep 15; 108(6):2041-4.
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  17. Lauchle JO, Braun BS, Loh ML, Shannon K. Inherited predispositions and hyperactive Ras in myeloid leukemogenesis. Pediatr Blood Cancer. 2006 May 1; 46(5):579-85.
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  18. Zhang IH, Zane LT, Braun BS, Maize J, Zoger S, Loh ML. Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol. 2006 Feb; 54(2 Suppl):S22-7.
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  19. Braun BS, Shannon K. The sum is greater than the FGFR1 partner. Cancer Cell. 2004 Mar; 5(3):203-4.
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  20. Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004 Jun 1; 103(11):4243-50.
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