Adjunct Assistant Professor, Department of Pediatrics (Hematology/Oncology), UCSF
Additional Websites
Education
Princeton University, A.B., 1990, Molecular Biology
University of California, Los Angeles, Ph.D., 1998, Molecular Biology
University of California, Los Angeles, M.D., 1998, Medicine
University of California, San Francisco, Resident, 1998-2000, Pediatrics
University of California, San Francisco, Fellow, 2000-2003, Hematology/Oncology
Professional Experience
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1992-1996
Graduate Student, Laboratory of Christopher Denny, M.D., University of California, Los Angeles (Project: mechanism of oncogenesis by the Ewing sarcoma fusion protein EWS-FLI)
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1998-2000
Resident, Department of Pediatrics, University of California, San Francisco
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2000-2003
Clinical Fellow, Hematology/Oncology, University of California, San Francisco
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2001-present
Post-doctoral researcher, Laboratory of Kevin Shannon, M.D., University of California, San Francisco (Project: myeloid proliferation and neoplasia initiated by mutant Kras)
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2004-2005
Adjunct Instructor, Department of Pediatrics, University of California, San Francisco
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2005-present
Adjunct Assistant Professor, Department of Pediatrics, University of California, San Francisco
Honors & Awards
- 1990
Cum Laude, Princeton University - 1990
Phi Beta Kappa - 1990
Medical Scientist Training Program Fellowship, University of California, Los Angeles - 2000-2003
Campini Fellowship, University of California, San Francisco - 2004
David G. Nathan Award, Society for Pediatric Research - 2004
Melvin Grumbach Pediatric Research Award, UCSF
Selected Publications
- Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013 Jan 2; 123(1):335-9.
View on PubMed - Braun BS. KIT's ship comes in. Blood. 2012 Sep 27; 120(13):2541-2.
View on PubMed - Ward AF, Braun BS, Shannon KM. Targeting oncogenic Ras signaling in hematologic malignancies. Blood. 2012 Oct 25; 120(17):3397-406.
View on PubMed - Lyubynska N, Gorman MF, Lauchle JO, Hong WX, Akutagawa JK, Shannon K, Braun BS. A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice. Sci Transl Med. 2011 Mar 30; 3(76):76ra27.
View on PubMed - Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood. 2011 Apr 21; 117(16):4253-61.
View on PubMed - Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32.
View on PubMed - Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010 Sep; 42(9):794-800.
View on PubMed - Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11.
View on PubMed - Braun BS, Shannon K. The SPS affair: a complex tale of illicit proliferation. Cancer Cell. 2009 Aug 4; 16(2):87-8.
View on PubMed - Santaguida M, Schepers K, King B, Sabnis AJ, Forsberg EC, Attema JL, Braun BS, Passegué E. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell. 2009 Apr 7; 15(4):341-52.
View on PubMed - Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009 Mar 17; 7(3):e59.
View on PubMed - Braun BS, Lessnick SL. Pediatric malignancies: update on sarcomas and leukemia development in children. Curr Opin Genet Dev. 2009 Feb; 19(1):92-6.
View on PubMed - Braun BS, Shannon K. Targeting Ras in myeloid leukemias. Clin Cancer Res. 2008 Apr 15; 14(8):2249-52.
View on PubMed - Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. 2007 May 1; 109(9):3945-52.
View on PubMed - Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 2006 Sep 15; 108(6):2041-4.
View on PubMed - Lauchle JO, Braun BS, Loh ML, Shannon K. Inherited predispositions and hyperactive Ras in myeloid leukemogenesis. Pediatr Blood Cancer. 2006 May 1; 46(5):579-85.
View on PubMed - Zhang IH, Zane LT, Braun BS, Maize J, Zoger S, Loh ML. Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol. 2006 Feb; 54(2 Suppl):S22-7.
View on PubMed - Braun BS, Shannon K. The sum is greater than the FGFR1 partner. Cancer Cell. 2004 Mar; 5(3):203-4.
View on PubMed - Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004 Jun 1; 103(11):4243-50.
View on PubMed - Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):597-602.
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