George H. Caughey, MD


Professor, Department of Medicine, UCSF; Chief of Pulmonary and Critical Care Medicine, San Francisco VA Medical Center
Julius and Lilian Nadel Endowed Chair, UCSF

Phone: (415) 221-4810 x2385 (voice)
Mail Box 111-D, Veterans Affairs Medical Center, San Francisco, CA 94121

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Arizona State University, BS, 1975, Chemistry
Stanford University School of Medicine, MD, 1979, Medicine
Pennsylvania Hospital, 1982, Internal Medicine
University of California, San Francisco, 1986, Pulmonary Medicine

Professional Experience

  • 1988-92
    Assistant Professor, Dept. of Medicine, UCSF
  • 1988-98
    Associate Staff, Cardiovascular Research Institute, UCSF
  • 1992-98
    Associate Professor, Dept. of Medicine, UCSF
  • 1992-present
    Molecular Medicine Program Faculty, UCSF
  • 1995-present
    Editorial Board, American Journal of Respiratory Cell and Molecular Biology
  • 1996-present
    Member of UCSF Graduate Program in Biomedical Sciences
  • 1998-present
    Professor, Dept. of Medicine, UCSF
  • 1999-present
    Associate Director, UCSF Adult Cystic Fibrosis Program
  • 1999-present
    Investigator, Cardiovascular Research Institute, UCSF
  • 2002-present
    Editorial Boards: FASEB Journal and Journal of Childrens Health
  • 2002-present
    Member, UCSF Cancer Center and Center for Neurobiology of Digestive Disease
  • 2004-present
    Editorial Board, Current Respiratory Medicine Reviews
  • 2004-present
    Chief of Pulmonary and Critical Care Medicine, San Francisco VA Medical Center

Honors & Awards

  • 1974
    American Chemical Society Outstanding Undergraduate Award, ASU
  • 1975
    Phi Beta Kappa and Merck Award in Chemistry, ASU
  • 1986
    NIH Clinical Investigator Award
  • 1992
    American Lung Association Career Investigator Award
  • 1992
    Elected to American Society for Clinical Investigation
  • 2000
    Elected to American Association of Physicians
  • 2004
    Recipient of Julius and Lillian Endowed Chair of Medicine

Selected Publications

  1. Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH. Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Respir Res. 2014; 15(1):95.
    View on PubMed
  2. Sutherland RE, Barry SS, Olsen JS, Salantes DB, Caughey GH, Wolters PJ. Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):818-23.
    View on PubMed
  3. Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH. Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection. Am J Transplant. 2014 Apr; 14(4):831-40.
    View on PubMed
  4. Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald DM, Caughey GH. Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Am J Respir Cell Mol Biol. 2013 Sep; 49(3):437-44.
    View on PubMed
  5. Chau JY, Tiffany CM, Nimishakavi S, Lawrence JA, Pakpour N, Mooney JP, Lokken KL, Caughey GH, Tsolis RM, Luckhart S. Malaria-associated L-arginine deficiency induces mast cell-associated disruption to intestinal barrier defenses against nontyphoidal Salmonella bacteremia. Infect Immun. 2013 Oct; 81(10):3515-26.
    View on PubMed
  6. Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem. 2013 Apr 12; 288(15):10588-98.
    View on PubMed
  7. Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN. Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):417-23.
    View on PubMed
  8. Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH. Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L97-106.
    View on PubMed
  9. Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb 1; 122(2):748-58.
    View on PubMed
  10. Sutherland RE, Xu X, Kim SS, Seeley EJ, Caughey GH, Wolters PJ. Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice. PLoS One. 2011; 6(11):e27564.
    View on PubMed
  11. Xu X, Zhang H, Song Y, Lynch SV, Lowell CA, Wiener-Kronish JP, Caughey GH. Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol. 2012 Feb; 91(2):275-84.
    View on PubMed
  12. Caughey GH. Mast cell proteases as protective and inflammatory mediators. Adv Exp Med Biol. 2011; 716:212-34.
    View on PubMed
  13. Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH. How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. J Immunol. 2010 Nov 1; 185(9):5360-8.
    View on PubMed
  14. Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol. 2010 May; 125(5):1046-1053.e8.
    View on PubMed
  15. Trivedi NN, Caughey GH. Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol. 2010 Mar; 42(3):257-67.
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  16. Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. J Allergy Clin Immunol. 2009 Nov; 124(5):1099-105.e1-4.
    View on PubMed
  17. Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV. Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med. 2009 Aug 1; 180(3):203-10.
    View on PubMed
  18. Raymond WW, Su S, Makarova A, Wilson TM, Carter MC, Metcalfe DD, Caughey GH. Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity. J Immunol. 2009 May 1; 182(9):5770-7.
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  19. Caughey GH, Beauchamp J, Schlatter D, Raymond WW, Trivedi NN, Banner D, Mauser H, Fingerle J. Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem. 2008 May 16; 283(20):13943-51.
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  20. Trivedi NN, Raymond WW, Caughey GH. Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution. J Allergy Clin Immunol. 2008 May; 121(5):1262-8.
    View on PubMed

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