University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Raymond Cho, MD, PhD

Raymond Cho, MD, PhD

Associate Professor of Dermatology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

Dr. Cho investigates the molecular basis of skin disease. He currently develops single-cell molecular fingerprints of unusual skin diseases to identify effective immunomodulatory therapies, in collaboration with the laboratory of Dr. Jeffrey Cheng.

Dr. Cho's group first reported NOTCH as the most commonly mutated gene in squamous cell cancers of the skin, SUFU loss-of-function as a basis for hereditary infundibulocystic basal cell cancer syndrome, and recurrent mutation of the ZNF750 tumor suppressor in sebaceous carcinoma. His lab also jointly identified APOBEC mutagenesis as the driver for cancer formation in recessive dystrophic epidermolysis bullosa, an inherited blistering disease.

Receiving both his MD and his PhD in Genetics from the Stanford University School of Medicine, Dr. Cho led the earliest demonstrations of transcriptional profiling, genetic screens, and SNV-based mapping on a whole-genome scale. He subsequently co-founded Ingenuity Systems, a privately funded genetic content and software concern later wholly acquired by Qiagen N.V.

Dr. Cho has been recognized with the American Academy of Dermatology Young Investigator Award and the Samsung Global Research Outreach Award. He was the Abby S. & Howard P. Milstein Research Scholar in Melanoma and received a Career Development Award from the Dermatology Foundation. He lectures at UCSF and at the Structure and Function of the Skin series in the American Academy of Dermatology's Annual Meeting. In his spare time, Dr. Cho teaches capoeira to golden retrievers.

Education

Brown University, Sc.B., Honors, 06/92, Biology
Stanford University Medical School, M.D., 06/05
Stanford University Department of Genetics, Ph.D., 06/03, Genetics


Professional Experience

  • 2016-Present
    Associate Professor, Dermatology, University of California, San Francisco 
  • 2009-2016
    Assistant Professor, Dermatology, University of California, San Francisco
  • 2006-2009
    Resident, Dermatology, University of California, San Francisco
  • 2005-2006
    Intern, Santa Clara Valley Medical Center
  • 2000-2003
    Vice President, Genomics, Ingenuity Systems, Inc.
  • 1998-2000
    Founder/Chief Biologist, Ingenuity Systems, Inc.

Honors & Awards

  • 1992
    Stanford Medical Scholar, Stanford University School of Medicine
  • 1993
    American Academy of Allergy, Asthma, and Immunology Research Award, Stanford University School of Medicine
  • 1994
    Howard Hughes Medical Student Fellowship, Stanford University School of Medicine
  • 1997
    1st place finish, Business Association of Stanford Engineering Students (BASES) Entrepreneurial Competition; founding business plan for Ingenuity Systems, Inc.
  • 2008
    Samsung Biotechnology Scholar-in-Residence
  • 2008
    Molecular Medicine Fellowship, Department of Dermatology, University of California, San Francisco
  • 2009
    Physician-Scientist Career Development Award, Dermatology Foundation
  • 2009
    Molecular Medicine Fellowship, Department of Dermatology, University of California, San Francisco
  • 2009
    Samsung Biotechnology Scholar-in-Residence
  • 2010
    Samsung Biotechnology Scholar-in-Residence
  • 2010
    Physician-Scientist Career Development Award, Dermatology Foundation
  • 2011
    Physician-Scientist Career Development Award, Dermatology Foundation
  • 2012
    Physician-Scientist Career Development Award, Dermatology Foundation
  • 2012
    American Skin Association Scholar Award, American Skin Association
  • 2012
    Young Investigator Award, American Academy of Dermatology
  • 2012
    K08 Training Award, NIH/NCI
  • 2013
    Samsung Global Research Outreach Award, Samsung Electronics, Inc.
  • 2014
    Samsung Global Research Outreach Award, Samsung Electronics, Inc.
  • 2015
    Sohana Research Scholar, Sohana Research Fund
  • 2016
    Epidermolysis Bullosa Research Partnership Award, Epidermolysis Bullosa Research Partnership
  • 2016
    Department of Translational Molecular Pathology Distinguished Speaker, M.D. Anderson
  • 2018
    American Academy of Dermatology Annual Meeting Structure and Function Speaker Series
  • 2019
    Society of Investigative Dermatology Annual Meeting Plenary Lecture
  • 2019
    World Congress of Dermatology Co-Chair Inherited Tumor Section

Selected Publications

  1. Heskett MB, Sanborn JZ, Boniface C, Goode B, Chapman J, Garg K, Rabban JT, Zaloudek C, Benz SC, Spellman PT, Solomon DA, Cho RJ. Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components. Mod Pathol. 2020 Jun; 33(6):1193-1206.
    View on PubMed
  2. Finnegan A, Cho RJ, Luu A, Harirchian P, Lee J, Cheng JB, Song JS. Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators. Front Genet. 2019; 10:775.
    View on PubMed
  3. North JP, Solomon DA, Golovato J, Bloomer M, Benz SC, Cho RJ. Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma. J Cutan Pathol. 2019 Oct; 46(10):736-741.
    View on PubMed
  4. Chiang A, Tan CZ, Kuonen F, Hodgkinson LM, Chiang F, Cho RJ, South AP, Tang JY, Chang ALS, Rieger KE, Oro AE, Sarin KY. Genetic Mutations Underlying Phenotypic Plasticity in Basosquamous Carcinoma. J Invest Dermatol. 2019 11; 139(11):2263-2271.e5.
    View on PubMed
  5. Harirchian P, Lee J, Hilz S, Sedgewick AJ, Perez White BE, Kesling MJ, Mully T, Golovato J, Gray M, Mauro TM, Purdom E, Kim EA, Sbitany H, Bhutani T, Vaske CJ, Benz SC, Cho RJ, Cheng JB. A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes. J Invest Dermatol. 2019 06; 139(6):1264-1273.
    View on PubMed
  6. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 10 23; 25(4):871-883.
    View on PubMed
  7. Cho RJ, Alexandrov LB, den Breems NY, Atanasova VS, Farshchian M, Purdom E, Nguyen TN, Coarfa C, Rajapakshe K, Prisco M, Sahu J, Tassone P, Greenawalt EJ, Collisson EA, Wu W, Yao H, Su X, Guttmann-Gruber C, Hofbauer JP, Hashmi R, Fuentes I, Benz SC, Golovato J, Ehli EA, Davis CM, Davies GE, Covington KR, Murrell DF, Salas-Alanis JC, Palisson F, Bruckner AL, Robinson W, Has C, Bruckner-Tuderman L, Titeux M, Jonkman MF, Rashidghamat E, Lwin SM, Mellerio JE, McGrath JA, Bauer JW, Hovnanian A, Tsai KY, South AP. APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa. Sci Transl Med. 2018 08 22; 10(455).
    View on PubMed
  8. North JP, Golovato J, Vaske CJ, Sanborn JZ, Nguyen A, Wu W, Goode B, Stevers M, McMullen K, Perez White BE, Collisson EA, Bloomer M, Solomon DA, Benz SC, Cho RJ. Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. Nat Commun. 2018 05 14; 9(1):1894.
    View on PubMed
  9. Cheng JB, Cho RJ. Emergence and Evolution of Mutational Hotspots in Sun-Damaged Skin. J Invest Dermatol. 2018 01; 138(1):16-17.
    View on PubMed
  10. Fong K, Bailey CV, Tuttle P, Cunningham B, McGrath JA, Cho RJ. Questioning the Clinical Utility of Exome Sequencing in Developing Countries. Pediatr Dermatol. 2017 Jan; 34(1):e32-e34.
    View on PubMed
  11. Cho RJ, Collisson EA. Election 2016: Voting on Variants. Cancer Discov. 2016 07; 6(7):694-6.
    View on PubMed
  12. Schulman JM, Oh DH, Sanborn JZ, Pincus L, McCalmont TH, Cho RJ. Multiple Hereditary Infundibulocystic Basal Cell Carcinoma Syndrome Associated With a Germline SUFU Mutation. JAMA Dermatol. 2016 Mar; 152(3):323-7.
    View on PubMed
  13. Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct; 47(10):1194-9.
    View on PubMed
  14. Sanborn JZ, Chung J, Purdom E, Wang NJ, Kakavand H, Wilmott JS, Butler T, Thompson JF, Mann GJ, Haydu LE, Saw RP, Busam KJ, Lo RS, Collisson EA, Hur JS, Spellman PT, Cleaver JE, Gray JW, Huh N, Murali R, Scolyer RA, Bastian BC, Cho RJ. Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10995-1000.
    View on PubMed
  15. Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, Van't Veer LJ, Spellman PT, Gray JW. Erratum to: Modeling precision treatment of breast cancer. Genome Biol. 2015 May 12; 16:95.
    View on PubMed
  16. Zheng CL, Wang NJ, Chung J, Moslehi H, Sanborn JZ, Hur JS, Collisson EA, Vemula SS, Naujokas A, Chiotti KE, Cheng JB, Fassihi H, Blumberg AJ, Bailey CV, Fudem GM, Mihm FG, Cunningham BB, Neuhaus IM, Liao W, Oh DH, Cleaver JE, LeBoit PE, Costello JF, Lehmann AR, Gray JW, Spellman PT, Arron ST, Huh N, Purdom E, Cho RJ. Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. Cell Rep. 2014 Nov 20; 9(4):1228-34.
    View on PubMed
  17. Dimon MT, Wood HM, Rabbitts PH, Liao W, Cho RJ, Arron ST. No evidence for integrated viral DNA in the genome sequence of cutaneous squamous cell carcinoma. J Invest Dermatol. 2014 Jul; 134(7):2055-2057.
    View on PubMed
  18. Purdom E, Ho C, Grasso CS, Quist MJ, Cho RJ, Spellman P. Methods and challenges in timing chromosomal abnormalities within cancer samples. Bioinformatics. 2013 Dec 15; 29(24):3113-20.
    View on PubMed
  19. Kluk MJ, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC. Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One. 2013; 8(6):e67306.
    View on PubMed
  20. Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, van't Veer LJ, Spellman PT, Gray JW. Modeling precision treatment of breast cancer. Genome Biol. 2013; 14(10):R110.
    View on PubMed

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