University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Shaun R. Coughlin, MD, PhD

Shaun R. Coughlin, MD, PhD

Director, Cardiovascular Research Institute, UCSF
Distinguished Professorship in Cardiovascular Biology and Medicine, UCSF

Cancer Center Program Memberships

Affiliate Member

Education

Massachusetts Institute of Technology, Boston, MA, S.B., S.B., 1976, Biology, Physics
Massachusetts Institute of Technology, Boston, MA, S.M., 1976, Biochemistry
Massachusetts Institute of Technology, Boston, MA, Ph.D., 1981, Neur. and Endo. Reg.
Harvard Medical School, Boston, MA, M.D., 1982, Medicine


Professional Experience

  • 1982-1984
    Intern and Resident, Medical Services, Massachusetts General Hospital
  • 1984-1985
    Assistant Research Cardiologist, Cardiovascular Research Inst., UCSF
  • 1985-1986
    Clinical Fellow in Cardiology, University of California, San Francisco
  • 1986-1991
    Assistant Professor of Medicine and Associate Staff, Cardiovascular Research Intitute, UCSF
  • 1991-1996
    Associate Professor of Medicine and Senior Staff, Cardiovascular Research Institute, UCSF
  • 1992-present
    Member, Graduate Program in Biological Sciences and Program in Biomedical Sciences, UCSF
  • 1995-present
    Director, Daiichi Research Center, UCSF
  • 1996-present
    Professor of Medicine, UCSF
  • 1997-present
    Professor of Cellular and Molecular Pharmacology, UCSF
  • 1997-present
    Director, Cardiovascular Research Institute, UCSF

Honors & Awards

  • Established Investigator, AHA; Ted Zimmerman Lecture, ASH, 1991
  • 1992
    ASCI
  • 1994
    Syntex Prize in Receptor Pharmacology
  • 1997
    AAP; Owren Lecture, Oslo; AHA Sol Sherry Lecture
  • 1998
    Outstanding Investigator Award, AFMR
  • 2000
    Hoeg Award, AHA
  • 2000
    Fellow, American Academy of Arts and Sciences
  • 2000
    Russel Ross Lecture, AHA
  • 2002
    Pasarow Foundation Award for Cardiovascular Research
  • 2003
    Basic Science Prize, AHA
  • 2004
    14th Bristol-Meyers Squibb Award for Distinguished Achievement in Cardiovascular Research
  • 2004
    Member, National Academy of Sciences

Selected Publications

  1. Zhang Q, Zheng YW, Coughlin SR, Shu X. A rapid fluorogenic GPCR-ß-arrestin interaction assay. Protein Sci. 2018 Apr; 27(4):874-879.
    View on PubMed
  2. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 Jan 18; 69(2):347.
    View on PubMed
  3. Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 Jan 16; 11(513).
    View on PubMed
  4. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. Structure. 2018 Feb 06; 26(2):187-198.e4.
    View on PubMed
  5. Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, Clay H, Hsiao CD, Coughlin SR. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. J Cell Biol. 2018 Mar 05; 217(3):1097-1112.
    View on PubMed
  6. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 Jan 18; 69(2):334-346.e4.
    View on PubMed
  7. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109.
    View on PubMed
  8. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26.
    View on PubMed
  9. David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis. Sci Transl Med. 2016 08 24; 8(353):353ra112.
    View on PubMed
  10. To TL, Schepis A, Ruiz-González R, Zhang Q, Yu D, Dong Z, Coughlin SR, Shu X. Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo. Cell Chem Biol. 2016 Jul 21; 23(7):875-82.
    View on PubMed
  11. Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR. Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Dev Biol. 2016 10 01; 418(1):157-165.
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  12. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303.
    View on PubMed
  13. Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampé R, Kobilka BK, Müller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015 Nov 12; 6:8857.
    View on PubMed
  14. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406.
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  15. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015 Oct 01; 6:8448.
    View on PubMed
  16. Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22; 126(17):2047-58.
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  17. Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods. 2015 Sep; 12(9):845-851.
    View on PubMed
  18. Wilsbacher LD, Coughlin SR. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. J Vis Exp. 2015 Mar 26; (97).
    View on PubMed
  19. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93.
    View on PubMed
  20. Clay H, Coughlin SR. Mechanical vessel injury in zebrafish embryos. J Vis Exp. 2015 Feb 17; (96):e52460.
    View on PubMed

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