Shaun R. Coughlin, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Shaun R. Coughlin, MD, PhD

Director, Cardiovascular Research Institute, UCSF
Distinguished Professorship in Cardiovascular Biology and Medicine, UCSF

shaun.coughlin@ucsf.edu

Phone: (415) 502-8667
Box 3122, UCSF
San Francisco, CA 94158-3122

UCSF Profiles

Cancer Center Membership

Associate Member » Hematopoietic Malignancies

Education

Massachusetts Institute of Technology, Boston, MA, S.B., S.B., 1976, Biology, Physics
Massachusetts Institute of Technology, Boston, MA, S.M., 1976, Biochemistry
Massachusetts Institute of Technology, Boston, MA, Ph.D., 1981, Neur. and Endo. Reg.
Harvard Medical School, Boston, MA, M.D., 1982, Medicine


Professional Experience

  • 1982-1984
    Intern and Resident, Medical Services, Massachusetts General Hospital
  • 1984-1985
    Assistant Research Cardiologist, Cardiovascular Research Inst., UCSF
  • 1985-1986
    Clinical Fellow in Cardiology, University of California, San Francisco
  • 1986-1991
    Assistant Professor of Medicine and Associate Staff, Cardiovascular Research Intitute, UCSF
  • 1991-1996
    Associate Professor of Medicine and Senior Staff, Cardiovascular Research Institute, UCSF
  • 1992-present
    Member, Graduate Program in Biological Sciences and Program in Biomedical Sciences, UCSF
  • 1995-present
    Director, Daiichi Research Center, UCSF
  • 1996-present
    Professor of Medicine, UCSF
  • 1997-present
    Professor of Cellular and Molecular Pharmacology, UCSF
  • 1997-present
    Director, Cardiovascular Research Institute, UCSF

Honors & Awards

  • Established Investigator, AHA; Ted Zimmerman Lecture, ASH, 1991
  • 1992
    ASCI
  • 1994
    Syntex Prize in Receptor Pharmacology
  • 1997
    AAP; Owren Lecture, Oslo; AHA Sol Sherry Lecture
  • 1998
    Outstanding Investigator Award, AFMR
  • 2000
    Hoeg Award, AHA
  • 2000
    Fellow, American Academy of Arts and Sciences
  • 2000
    Russel Ross Lecture, AHA
  • 2002
    Pasarow Foundation Award for Cardiovascular Research
  • 2003
    Basic Science Prize, AHA
  • 2004
    14th Bristol-Meyers Squibb Award for Distinguished Achievement in Cardiovascular Research
  • 2004
    Member, National Academy of Sciences

Selected Publications

  1. To TL, Schepis A, Ruiz-González R, Zhang Q, Yu D, Dong Z, Coughlin SR, Shu X. Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo. Cell Chem Biol. 2016 Jul 21; 23(7):875-82.
    View on PubMed
  2. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016; 7:11303.
    View on PubMed
  3. Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampé R, Kobilka BK, Müller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015; 6:8857.
    View on PubMed
  4. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015; 4.
    View on PubMed
  5. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015; 6:8448.
    View on PubMed
  6. Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22; 126(17):2047-58.
    View on PubMed
  7. Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods. 2015 Sep; 12(9):845-51.
    View on PubMed
  8. Wilsbacher LD, Coughlin SR. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. J Vis Exp. 2015; (97).
    View on PubMed
  9. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 3; 112(9):2888-93.
    View on PubMed
  10. Clay H, Coughlin SR. Mechanical vessel injury in zebrafish embryos. J Vis Exp. 2015; (96):e52460.
    View on PubMed
  11. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8.
    View on PubMed
  12. Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2563-9.
    View on PubMed
  13. Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. The imperative to invest in science has never been greater. J Clin Invest. 2014 Sep; 124(9):3680-1.
    View on PubMed
  14. Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3; 502(7469):105-9.
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  15. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83.
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  16. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20; 492(7429):387-92.
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  17. Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin SR, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan; 123(1):206-14.
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  18. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22.
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  19. Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y. Wnt/ß-catenin signaling is differentially regulated by Ga proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20101-6.
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  20. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903.
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