Morton J. Cowan, MD

Morton J. Cowan, MD

Professor, Department of Pediatrics, UCSF

Phone: (415) 476-2188 (appts)
Box 1278, UCSF
San Francisco, CA 94143-1278

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Massachusetts Institute of Technology, Cambridge, MA, B.S., 1966, Electrical Engineering
University of Pennsylvania, Philadelphia, PA, M.D., 1970, Medicine
University of California, San Francisco, Intern/Resident, 1975-77, Pediatrics
University of California, San Francisco, Fellow, 1977-79, Immunology

Professional Experience

  • 1972-74
    Scientist, Division of Lung Diseases, National Heart and Lung Institute, Bethesda, MD
  • 1974-75
    Staff Investigator, Pulmonary Biochemistry Branch, National Heart and Lung Institute, NIH, Bethesda, MD
  • 1979-83
    Assistant Professor, Department of Pediatrics, University of California, San Francisco
  • 1984-89
    Associate Professor of Pediatrics, Director, Pediatric Bone Marrow Transplant Program, University of California, San Francisco
  • 1989-present
    Professor of Pediatrics, Director, Bone Marrow Transplant Program, UCSF

Honors & Awards

  • 1966
    Tau Beta Pi, Engineer Honor Society
  • 1968-70
    Charles Hovies Scholarship
  • 1979-82
    Pediatric Clinical Research Center Investigator Award

Selected Publications

  • Kwong P.C., O'Marcaigh A.S., Howard R., Cowan M.J., Frieden I.J. Oral and genital ulceration: A unique presentation of immunodeficiency in Athabascan-speaking Native American children with severe combined immune deficiency. Archives of Dermatology 135(8):927-31, 1999.
  • Horn B, Viele M, Mentzer W, Mogck N, DeSantes K, Cowan M.J., Autoimmune hemolytic anemia in patients with SCID after T cell-depleted BM and PBSC transplantation. Bone Marrow Transplantation, 24(9):1009-13, 1999.
  • *Tarantal A, Goldstein O, Barley F, Cowan M.J., Transplantation of human peripheral blood stem cells (PBSC) into fetal rhesus monkeys (Macaca mulatta). Transplantation 69:1818-23., 2000.
  • Moshous D, Li L, deChasseval R, Philippe N, Jabado N, Cowan MJ, Fischer A, deVillartay J-P. A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p. Human Molecular Genetics 4(9);583-588, 2000.
  • Cowan M.J., Chow S-H, Tarantal A.F. Tolerance Induction Post In Utero Stem Cell Transplantation, Ernst Schering Research Series (Holzgreve/Lessl, Eds) 33:145-171, 2000.
  • Shapiro E, Krivit W, Lockman L, Jambaqu I, Peters C, Cowan M, Harris R, Bordigoni P, Loes D, Ziegler R, Moser H, Fischer A and Aubourg P. Long-Term Beneficial Effects Of Bone Marrow Transplantation For Childhood Onset Cerebral X-Linked Adrenoleukodystrophy. Lancet (2000) 356:713-718.
  • O'Marcaigh, AS, DeSantes K, Hu D, Pabst H, Horn B, Li L, Cowan MJ. Bone Marrow Transplantation for T-B- Severe Combined Immunodeficiency Disease in Athabascan-Speaking Native Americans, Bone Marrow Transplantation, (2001) 27:703-709.
  • *Chou S-H, Chawla A, Lee T-H, Zhou Y, Busch MP, Balassanian R, Ferrell L and Cowan MJ. Increased engraftment following In Utero transplantation of MHC-mismatched bone marrow cells and CD86- dendritic cells in a fetal mouse model. Transplantation, (2001) 72(11):1768-76.
  • Denianke, K, Frieden,IJ, Cowan MJ, McCalmont, TH, Cutaneous Manifestations of Maternal Engraftment in Patients with Severe Combined Immunodeficiency: A Clinicopathologic Study. Bone Marrow Transplantation, (2001) 28:227-233.
  • Bolinger A.M., Zangwill A.B, Slattery J.T., Risler L.J., Sultan D.H., Glidden D., Norstad D., Cowan M.J. Target Dose Adjustment Of Busulfan In Pediatric Patients Undergoing Bone Marrow Transplantation, Bone Marrow Transplantation, (2001) 28:1013-1018.
  • Winston DJ, Antin JH, Wolff SN, Bierer BE, Small T, Miller KB, Linker C, Kaizer H, Lazarus HM, Petersen FB, Cowan MJ, Ho WG, Wingard JR, Schiller GJ, Territo MC, Jiao J, Petrarca MA, Tonetta SA A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation. Bone Marrow Transplantation (2001) 28: 187-196.
  • Horn B, Reiss U, Matthay K, McMillan A, and Cowan M. Veno-occlusive liver disease in children with solid tumors undergoing autologous transplantation: The high incidence of disease in patients with neuroblastoma. Bone Marrow Transplantation (2002) 29(5):409-15.
  • Reed W, Kong DZ, Lee T-H, Cowan MJ, Busch MP, Baxter-Lowe LA Non-invasive Determination of the Paternal HLA Haplotype of a Fetus Using Kinetic PCR to Type Maternal Plasma. Bone Marrow Transplantation, (2002), 29: 527-529.
  • *Li L, Moshous D, Zhou Y, Wang J, Xie G, Salido E, Hu D, de Villartay J-P, and Cowan MJ A founder mutation in Artemis causes Severe Combined Immunodeficiency Disease in Athabascan-speaking Native Americans. Journal of Immunology, 2002, 168:6323-6329.
  • Reiss U, Cowan MJ, McMillan A, Horn B. Hepatic Veno-occlusive Disease in Blood and Bone Marrow Transplantation in Children: Incidence, Risk Factors, and Outcome in a Cohort of 241 Patients. Journal of Pediatric Hematology/Oncology (2002), 24(9):746-750.
  • Li L, Zhou Y, Hu D, and Cowan MJ. Prenatal diagnosis and carrier detection for Athabascan Severe Combined Immunodeficiency Disease in families at risk using polymorphic DNA markers. Prenatal Diagnosis, (2002) 22 (9):763-8.
  • *Bhattacharyya, S, Chawla, A, Smith, K, Zhou, Y, Talib, S, and Cowan, MJ. Multilineage engraftment with minimal graft-vs-host-disease following in utero transplantation of S-59 psoralen/UVA light-treated sensitized T cells and adult T cell depleted bone marrow in fetal mice. Journal of Immunology, (2002), 169:6133-6140.
  • Machatschek J, Duda J, Matthay K, Cowan MJ, Horn B. Immune reconstitution, infectious complications and posttransplant supportive care measures after autologous blood and marrow transplantation in children. Bone Marrow Transplant. 2003; 32(7):687-93
  • Lee Ann Baxter-Lowe, Denice Kong, William Reed, Morton J Cowan and Tzong-Hae Lee. New Opportunities for HLA Typing Using Kinetic Polymerase Chain Reaction. HLA 2002 (2003) Immunobiology of the Human MHC volume 1 (Eds: J. Hansen and B. Dupont), IHWG Press, Seattle WA
  • Li L, Salido E, Zhou Y, Bhattacharyya S, Yannone SM, Dunn E, Meneses J, Feeney A, and Cowan MJ. Targeted disruption of the murine Artemis counterpart results in SCID that is partially corrected with bone marrow transplantation. Journal of Immunology, (2005); 174: 2420 - 2428.
  • Wang, J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, and SM Yannone., Artemis Deficiency Confers a DNA Double-Strand Break Repair Defect and Artemis Phosphorylation Status is Altered by DNA Damage and Cell Cycle Progression, DNA Repair, DNA Repair, (2005), May 2;4(5):556-70.
  • Bhattacharyya, S and Cowan, MJ B7.2-/- Mature Dendritic Cells Induce Tolerance to Alloantigens in Fetal Mice by Generating Regulatory CD4+CD25+ and CD4+CD25- T Cells (2005) Biology of Blood and Marrow Transplantation, (2005), Biol Blood Marrow Transplant. 2005 Sep;11(9):657-71
  • McGhee, S, Stiehm, ER, Cowan, MJ, Krogstad, P, McCabe, ERB. Two-tiered universal newborn screening strategy for severe combined immunodeficiency. Molecular Genetics and Metabolism 2005 Dec;86(4):427-30.
  • Horn, B, Baxter-Lowe, LA, Englert, L, McMillan, A, Quinn, M, DeSantes, K, Cowan, MJ. Reduced Intensity Conditioning (RIC) Using Intravenous Busufan, Fludarabine and rabbit ATG for Children with Non-Malignant Disorders and CML, Bone Marrow Transplantation, 2005 Dec 5; [Epub ahead of print]