Jason G. Cyster, PhD


Professor, Department of Microbiology and Immunology, UCSF


Phone: (415) 502-6427 and 514-2943 (voice)
Box 0414, UCSF
San Francisco, CA 94143-0414

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Additional Websites


University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology

Professional Experience

  • 1995-2000
    Assistant Professor, Dept. of Microbiology and Immunology, University of California, San Francisco
  • 2000-present
    Investigator, Howard Hughes Medical Institute
  • 2000-2004
    Associate Professor, Dept. of Microbiology and Immunology, University of California, San Francisco
  • 2004-present
    Professor, Dept of Microbiology & Immunology, University of California, San Francisco
  • 2005–present
    Director, Biomedical Sciences Graduate Program, University of California, San Francisco
  • 2010–present
    Vice chair, Dept. of Microbiol. & Immunol., University of California, San Francisco

Honors & Awards

  • 1984
    The Beazely Award for secondary education in Western Australia
  • 1988
    J.A. Wood Memorial prize from the University of Western Australia
  • 1989-1992
    Commonwealth Overseas Studentship
  • 1992-1995
    Cancer Research Institute Postdoctoral Fellowship
  • 1996-2000
    Pew Scholar in the Biomedical Sciences
  • 1997
    Cheryl Whitlock Memorial Prize for Postdoctoral Studies
  • 1998-2003
    David and Lucile Packard Foundation Fellowship
  • 2005
    AAI BD Biosciences Investigator Award
  • 2005
    External Speaker, Harvard Medical School Annual Immunology Retreat
  • 2009
    Alexandre Goidl Memorial Lectureship, University of Maryland Baltimore
  • 2009
    Keynote Speaker, Microanatomy of Immune Responses in Health and Disease, Birmingham, UK
  • 2010
    Organizing Committee Member, International Congress of Immunology, Kobe, Japan
  • 2010
    Keynote Presentation, Antibody Biology & Engineering Gordon Research Conference, Ventura, CA
  • 2010
    14th Köhler Lecture in Immunology, University of Freiburg, Germany
  • 2010
    CRI Fredrick W. Alt Award for New Discoveries in Immunology
  • 2011
    Distinguished Lecture, AAI Annual Meeting, San Francisco
  • 2011
    Elected as an AAAS Fellow
  • 2013
    Keynote Speaker, 14th International TNF conference
  • 2013
    Keynote Speaker, FASEB Meeting on Lysophospholipids
  • 2013
    Keynote Speaker, Gordon Conference on Follicular helper T cells.

Selected Publications

  1. Beck TC, Gomes AC, Cyster JG, Pereira JP. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014 Dec 15; 211(13):2567-81.
    View on PubMed
  2. Wang X, Sumida H, Cyster JG. GPR18 is required for a normal CD8aa intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014 Nov 17; 211(12):2351-9.
    View on PubMed
  3. Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. Elife. 2014; 3.
    View on PubMed
  4. Cyster JG, Dang EV, Reboldi A, Yi T. 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol. 2014 Nov; 14(11):731-43.
    View on PubMed
  5. Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG. Loss of signalling via Ga13 in germinal centre B-cell-derived lymphoma. Nature. 2014 Sep 28.
    View on PubMed
  6. Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014 Aug 8; 345(6197):679-84.
    View on PubMed
  7. Moriyama S, Takahashi N, Green JA, Hori S, Kubo M, Cyster JG, Okada T. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014 Jun 30; 211(7):1297-305.
    View on PubMed
  8. Wang X, Rodda LB, Bannard O, Cyster JG. Integrin-Mediated Interactions between B Cells and Follicular Dendritic Cells Influence Germinal Center B Cell Fitness. J Immunol. 2014 May 15; 192(10):4601-9.
    View on PubMed
  9. Cyster JG. Blown away: the unexpected role of lymphotoxin in lymphoid organ development. J Immunol. 2014 Mar 1; 192(5):2007-9.
    View on PubMed
  10. Arnon TI, Cyster JG. Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. Curr Top Microbiol Immunol. 2014; 378:107-28.
    View on PubMed
  11. Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP. Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies. Elife. 2013; 2(0):e01020.
    View on PubMed
  12. Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity. 2013 Nov 14; 39(5):912-24.
    View on PubMed
  13. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep 3; 123(9):3728-39.
    View on PubMed
  14. Yi T, Cyster JG. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. Elife. 2013; 2:e00757.
    View on PubMed
  15. Schmidt TH, Bannard O, Gray EE, Cyster JG. CXCR4 promotes B cell egress from Peyer's patches. J Exp Med. 2013 Jun 3; 210(6):1099-107.
    View on PubMed
  16. Gray EE, Ramírez-Valle F, Xu Y, Wu S, Wu Z, Karjalainen KE, Cyster JG. Deficiency in IL-17-committed V?4(+) ?d T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis. Nat Immunol. 2013 Jun; 14(6):584-92.
    View on PubMed
  17. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 6; 121(23):4740-8.
    View on PubMed
  18. Arnon TI, Horton RM, Grigorova IL, Cyster JG. Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature. 2013 Jan 31; 493(7434):684-8.
    View on PubMed
  19. Matloubian M, Cyster JG. Th1 cell induction in lymph nodes according to a red-blue chemokine map. Immunity. 2012 Dec 14; 37(6):954-6.
    View on PubMed
  20. Yi T, Wang X, Kelly LM, An J, Xu Y, Sailer AW, Gustafsson JA, Russell DW, Cyster JG. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012 Sep 21; 37(3):535-48.
    View on PubMed

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