Jason G. Cyster, PhD

Professor, Department of Microbiology and Immunology, UCSF

Jason.Cyster@ucsf.edu

Phone: (415) 502-6427 and 514-2943 (voice)
Box 0414, UCSF
San Francisco, CA 94143-0414

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Additional Websites

• Lab Website

Education

University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology

Professional Experience

• 1995-2000
  Assistant Professor, Dept. of Microbiology and Immunology, Univ. of California, San Francisco
• 2000-present
  Investigator, Howard Hughes Medical Institute
• 2000-2004
  Associate Professor, Dept. of Microbiology and Immunology, Univ. of California, San Francisco
• 2004-present
  Professor, Dept of Microbiology & Immunology, Univ. of California, San Francisco

Honors & Awards

• 1984
  The Beazely Award for secondary education in Western Australia
• 1988
  J.A. Wood Memorial prize from the University of Western Australia
• 1989-1992
  Commonwealth Overseas Studentship
• 1992-1995
  Cancer Research Institute Postdoctoral Fellowship
• 1996-2000
  Pew Scholar in the Biomedical Sciences
• 1997
  Cheryl Whitlock Memorial Prize for Postdoctoral Studies
• 1998-2003
  David and Lucile Packard Foundation Fellowship
• 2005
  AAI BD Biosciences Investigator Award

Selected Publications

1. Arnon TI, Horton RM, Grigorova IL, Cyster JG. Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature. 2013 Jan 31; 493(7434):684-8.
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2. Matloubian M, Cyster JG. Th1 cell induction in lymph nodes according to a red-blue chemokine map. Immunity. 2012 Dec 14; 37(6):954-6.
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3. Yi T, Wang X, Kelly LM, An J, Xu Y, Sailer AW, Gustafsson JA, Russell DW, Cyster JG. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012 Sep 21; 37(3):535-48.
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4. Gray EE, Friend S, Suzuki K, Phan TG, Cyster JG. Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS One. 2012; 7(6):e38258.
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5. Bannard OM, Cyster JG. Immunology. When less signaling is more. Science. 2012 Jun 1; 336(6085):1120-1.
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6. Green JA, Cyster JG. S1PR2 links germinal center confinement and growth regulation. Immunol Rev. 2012 May; 247(1):36-51.
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7. Gray EE, Cyster JG. Lymph node macrophages. J Innate Immun. 2012; 4(5-6):424-36.
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8. Cyster JG, Schwab SR. Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. Annu Rev Immunol. 2012; 30:69-94.
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9. Vinuesa CG, Cyster JG. How T cells earn the follicular rite of passage. Immunity. 2011 Nov 23; 35(5):671-80.
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10. Lambe T, Crawford G, Johnson AL, Crockford TL, Bouriez-Jones T, Smyth AM, Pham TH, Zhang Q, Freeman AF, Cyster JG, Su HC, Cornall RJ. DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol. 2011 Dec; 41(12):3423-35.
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11. Wang X, Cho B, Suzuki K, Xu Y, Green JA, An J, Cyster JG. Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J Exp Med. 2011 Nov 21; 208(12):2497-510.
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12. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903.
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13. Muppidi JR, Arnon TI, Bronevetsky Y, Veerapen N, Tanaka M, Besra GS, Cyster JG. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. J Exp Med. 2011 Sep 26; 208(10):1941-8.
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14. Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol. 2011 Sep 15; 187(6):3026-32.
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15. Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 28; 475(7357):524-7.
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16. Zhi L, Kim P, Thompson BD, Pitsillides C, Bankovich AJ, Yun SH, Lin CP, Cyster JG, Wu MX. FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus. J Immunol. 2011 Sep 1; 187(5):2244-51.
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17. Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jul; 12(7):672-80.
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18. Beltman JB, Allen CD, Cyster JG, de Boer RJ. B cells within germinal centers migrate preferentially from dark to light zone. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8755-60.
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19. Gray EE, Suzuki K, Cyster JG. Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis. J Immunol. 2011 Jun 1; 186(11):6091-5.
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20. Link A, Hardie DL, Favre S, Britschgi MR, Adams DH, Sixt M, Cyster JG, Buckley CD, Luther SA. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am J Pathol. 2011 Apr; 178(4):1662-75.
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