Jason G. Cyster, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Jason G. Cyster, PhD

Professor, Department of Microbiology and Immunology, UCSF

Jason.Cyster@ucsf.edu

Phone: (415) 502-6427 and 514-2943 (voice)
Box 0414, UCSF
San Francisco, CA 94143-0414

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Research Summary

I have 20 years experience managing an NIH- and HHMI-funded immunology research laboratory. My research has involved defining the intercellular communications acting between immune cells to support adaptive immune responses. My group uses immunological, genetic, cell biological, and advanced imaging techniques to study these processes. Although many of our studies are performed using the mouse as a model, in several cases we have translated their work to humans, such as our recent identification of a novel gene pathway that is disrupted in germinal center B cell-type diffuse large B cell lymphoma (GCB-DLBCL).

I have been a research mentor for a large number graduate students, postdoctoral fellows, and clinical fellows. Many of my early trainees, including three past graduate students and fourteen postdoctoral fellows, are now Assistant or Associate Professors, and a number of both types of trainees hold scientist positions in the biotech sector. I have had a long-standing commitment to education with my involvement in teaching in immunology and cell biology courses in the graduate and professional schools at UCSF, and I give several teaching lectures for other professional organizations each year. As Director of the BMS graduate program from 2005-2014, I have had a leadership role in promoting graduate education at UCSF and beyond.

Education

University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology


Professional Experience

  • 1995-2000
    Assistant Professor, Dept. of Microbiology and Immunology, University of California, San Francisco
  • 2000-present
    Investigator, Howard Hughes Medical Institute
  • 2000-2004
    Associate Professor, Dept. of Microbiology and Immunology, University of California, San Francisco
  • 2004-present
    Professor, Dept of Microbiology & Immunology, University of California, San Francisco
  • 2005–present
    Director, Biomedical Sciences Graduate Program, University of California, San Francisco
  • 2010–present
    Vice chair, Dept. of Microbiol. & Immunol., University of California, San Francisco

Honors & Awards

  • 1984
    The Beazely Award for secondary education in Western Australia
  • 1988
    J.A. Wood Memorial prize from the University of Western Australia
  • 1989-1992
    Commonwealth Overseas Studentship
  • 1992-1995
    Cancer Research Institute Postdoctoral Fellowship
  • 1996-2000
    Pew Scholar in the Biomedical Sciences
  • 1997
    Cheryl Whitlock Memorial Prize for Postdoctoral Studies
  • 1998-2003
    David and Lucile Packard Foundation Fellowship
  • 2005
    AAI BD Biosciences Investigator Award
  • 2005
    External Speaker, Harvard Medical School Annual Immunology Retreat
  • 2009
    Alexandre Goidl Memorial Lectureship, University of Maryland Baltimore
  • 2009
    Keynote Speaker, Microanatomy of Immune Responses in Health and Disease, Birmingham, UK
  • 2010
    Organizing Committee Member, International Congress of Immunology, Kobe, Japan
  • 2010
    Keynote Presentation, Antibody Biology & Engineering Gordon Research Conference, Ventura, CA
  • 2010
    14th Köhler Lecture in Immunology, University of Freiburg, Germany
  • 2010
    CRI Fredrick W. Alt Award for New Discoveries in Immunology
  • 2011
    Distinguished Lecture, AAI Annual Meeting, San Francisco
  • 2011
    Elected as an AAAS Fellow
  • 2013
    Keynote Speaker, 14th International TNF conference
  • 2013
    Keynote Speaker, FASEB Meeting on Lysophospholipids
  • 2013
    Keynote Speaker, Gordon Conference on Follicular helper T cells.

Selected Publications

  1. Han BY, Foo CS, Wu S, Cyster JG. The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays. Genes Dev. 2016 Jul 1; 30(13):1509-14.
    View on PubMed
  2. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822.
    View on PubMed
  3. Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG. Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. J Exp Med. 2016 May 30; 213(6):993-1009.
    View on PubMed
  4. Li J, Lu E, Yi T, Cyster JG. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016 May 5; 533(7601):110-4.
    View on PubMed
  5. Reboldi A, Cyster JG. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016 May; 271(1):230-45.
    View on PubMed
  6. Cyster JG. Germinal Centers: Gaining Strength from the Dark Side. Immunity. 2015 Dec 15; 43(6):1026-8.
    View on PubMed
  7. Muppidi JR, Lu E, Cyster JG. The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. J Exp Med. 2015 Dec 14; 212(13):2213-22.
    View on PubMed
  8. Rodda LB, Bannard O, Ludewig B, Nagasawa T, Cyster JG. Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol. 2015 Nov 15; 195(10):4781-91.
    View on PubMed
  9. Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015 Oct 20; 43(4):764-75.
    View on PubMed
  10. Cyster JG. Getting close to the action elicits better memories. J Exp Med. 2015 Sep 21; 212(10):1484.
    View on PubMed
  11. Barnes MJ, Li CM, Xu Y, An J, Huang Y, Cyster JG. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med. 2015 Jun 29; 212(7):1011-20.
    View on PubMed
  12. Ramírez-Valle F, Gray EE, Cyster JG. Inflammation induces dermal V?4+ ?dT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):8046-51.
    View on PubMed
  13. Beck TC, Gomes AC, Cyster JG, Pereira JP. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med. 2014 Dec 15; 211(13):2567-81.
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  14. Wang X, Sumida H, Cyster JG. GPR18 is required for a normal CD8aa intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014 Nov 17; 211(12):2351-9.
    View on PubMed
  15. Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG. Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment. Elife. 2014; 3.
    View on PubMed
  16. Cyster JG, Dang EV, Reboldi A, Yi T. 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol. 2014 Nov; 14(11):731-43.
    View on PubMed
  17. Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG. Loss of signalling via Ga13 in germinal centre B-cell-derived lymphoma. Nature. 2014 Dec 11; 516(7530):254-8.
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  18. Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014 Aug 8; 345(6197):679-84.
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  19. Moriyama S, Takahashi N, Green JA, Hori S, Kubo M, Cyster JG, Okada T. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J Exp Med. 2014 Jun 30; 211(7):1297-305.
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  20. Wang X, Rodda LB, Bannard O, Cyster JG. Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. J Immunol. 2014 May 15; 192(10):4601-9.
    View on PubMed

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