University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jason G. Cyster, PhD

Jason G. Cyster, PhD

Professor, Department of Microbiology and Immunology, UCSF

Cancer Center Program Memberships

Cancer Immunology

Research Summary

I have 20 years experience managing an NIH- and HHMI-funded immunology research laboratory. My research has involved defining the intercellular communications acting between immune cells to support adaptive immune responses. My group uses immunological, genetic, cell biological, and advanced imaging techniques to study these processes. Although many of our studies are performed using the mouse as a model, in several cases we have translated their work to humans, such as our recent identification of a novel gene pathway that is disrupted in germinal center B cell-type diffuse large B cell lymphoma (GCB-DLBCL).

I have been a research mentor for a large number graduate students, postdoctoral fellows, and clinical fellows. Many of my early trainees, including three past graduate students and fourteen postdoctoral fellows, are now Assistant or Associate Professors, and a number of both types of trainees hold scientist positions in the biotech sector. I have had a long-standing commitment to education with my involvement in teaching in immunology and cell biology courses in the graduate and professional schools at UCSF, and I give several teaching lectures for other professional organizations each year. As Director of the BMS graduate program from 2005-2014, I have had a leadership role in promoting graduate education at UCSF and beyond.

Education

University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology


Professional Experience

  • 1995-2000
    Assistant Professor, Dept. of Microbiology and Immunology, University of California, San Francisco
  • 2000-present
    Investigator, Howard Hughes Medical Institute
  • 2000-2004
    Associate Professor, Dept. of Microbiology and Immunology, University of California, San Francisco
  • 2004-present
    Professor, Dept of Microbiology & Immunology, University of California, San Francisco
  • 2005–present
    Director, Biomedical Sciences Graduate Program, University of California, San Francisco
  • 2010–present
    Vice chair, Dept. of Microbiol. & Immunol., University of California, San Francisco

Honors & Awards

  • 1984
    The Beazely Award for secondary education in Western Australia
  • 1988
    J.A. Wood Memorial prize from the University of Western Australia
  • 1989-1992
    Commonwealth Overseas Studentship
  • 1992-1995
    Cancer Research Institute Postdoctoral Fellowship
  • 1996-2000
    Pew Scholar in the Biomedical Sciences
  • 1997
    Cheryl Whitlock Memorial Prize for Postdoctoral Studies
  • 1998-2003
    David and Lucile Packard Foundation Fellowship
  • 2005
    AAI BD Biosciences Investigator Award
  • 2005
    External Speaker, Harvard Medical School Annual Immunology Retreat
  • 2009
    Alexandre Goidl Memorial Lectureship, University of Maryland Baltimore
  • 2009
    Keynote Speaker, Microanatomy of Immune Responses in Health and Disease, Birmingham, UK
  • 2010
    Organizing Committee Member, International Congress of Immunology, Kobe, Japan
  • 2010
    Keynote Presentation, Antibody Biology & Engineering Gordon Research Conference, Ventura, CA
  • 2010
    14th Köhler Lecture in Immunology, University of Freiburg, Germany
  • 2010
    CRI Fredrick W. Alt Award for New Discoveries in Immunology
  • 2011
    Distinguished Lecture, AAI Annual Meeting, San Francisco
  • 2011
    Elected as an AAAS Fellow
  • 2013
    Keynote Speaker, 14th International TNF conference
  • 2013
    Keynote Speaker, FASEB Meeting on Lysophospholipids
  • 2013
    Keynote Speaker, Gordon Conference on Follicular helper T cells.
  • 2018
    Elected, American Academy of Arts and Sciences

Selected Publications

  1. Dang EV, Cyster JG. Loss of sterol metabolic homeostasis triggers inflammasomes?-?how and why. Curr Opin Immunol. 2018 Aug 29; 56:1-9.
    View on PubMed
  2. Wu J, Wu H, An J, Ballantyne CM, Cyster JG. Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci U S A. 2018 Jun 11.
    View on PubMed
  3. Rodda LB, Lu E, Bennett ML, Sokol CL, Wang X, Luther SA, Barres BA, Luster AD, Ye CJ, Cyster JG. Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity. Immunity. 2018 May 15; 48(5):1014-1028.e6.
    View on PubMed
  4. Sumida H, Cyster JG. G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment. Front Immunol. 2018; 9:660.
    View on PubMed
  5. Barnes MJ, Cyster JG. Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Gas proteins. Immunol Cell Biol. 2018 Feb 19.
    View on PubMed
  6. Kara EE, Bastow CR, McKenzie DR, Gregor CE, Fenix KA, Babb R, Norton TS, Zotos D, Rodda LB, Hermes JR, Bourne K, Gilchrist DS, Nibbs RJ, Alsharifi M, Vinuesa CG, Tarlinton DM, Brink R, Hill GR, Cyster JG, Comerford I, McColl SR. Atypical chemokine receptor 4 shapes activated B cell fate. J Exp Med. 2018 Mar 05; 215(3):801-813.
    View on PubMed
  7. Sumida H, Lu E, Chen H, Yang Q, Mackie K, Cyster JG. GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage. Sci Immunol. 2017 Dec 08; 2(18).
    View on PubMed
  8. Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA. Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells. Cell Rep. 2017 Nov 28; 21(9):2500-2514.
    View on PubMed
  9. Dang EV, McDonald JG, Russell DW, Cyster JG. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017 Nov 16; 171(5):1057-1071.e11.
    View on PubMed
  10. Lu E, Dang EV, McDonald JG, Cyster JG. Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen. Sci Immunol. 2017 Apr 07; 2(10).
    View on PubMed
  11. Laidlaw BJ, Schmidt TH, Green JA, Allen CD, Okada T, Cyster JG. The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J Exp Med. 2017 Mar 06; 214(3):639-649.
    View on PubMed
  12. Bannard O, Cyster JG. Germinal centers: programmed for affinity maturation and antibody diversification. Curr Opin Immunol. 2017 Apr; 45:21-30.
    View on PubMed
  13. Laidlaw BJ, Cyster JG. Interfer'n with antibody responses. Sci Immunol. 2016 Oct 21; 1(4).
    View on PubMed
  14. Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9816-21.
    View on PubMed
  15. Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. 2016 08 03; 5.
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  16. Han BY, Foo CS, Wu S, Cyster JG. The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays. Genes Dev. 2016 07 01; 30(13):1509-14.
    View on PubMed
  17. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822.
    View on PubMed
  18. Bannard O, McGowan SJ, Ersching J, Ishido S, Victora GD, Shin JS, Cyster JG. Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. J Exp Med. 2016 05 30; 213(6):993-1009.
    View on PubMed
  19. Li J, Lu E, Yi T, Cyster JG. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016 May 05; 533(7601):110-4.
    View on PubMed
  20. Reboldi A, Cyster JG. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016 May; 271(1):230-45.
    View on PubMed

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