Jayanta Debnath, MD

Jayanta Debnath, MD

Associate Professor, Department of Pathology, UCSF


Phone: (415) 476-1780 (voice)
Box 0511, UCSF
San Francisco, CA 94143-0511

View on UCSF Profiles

Additional Websites


Georgia Institute of Technology, Atlanta, Georgia, 1988-1992, Bachelor of Science in Chemistry, Highest Honors
Harvard Medical School, Boston, Massachusetts, 1992-1998, Doctor of Medicine, magna cum laude
National Cancer Institute, Bethesda, MD, NIH-HHMI Scholar, 1995-1997, Biochemistry
Resident, Anatomic Pathology, Department of Pathology, Brigham and Women's Hospital, 1998-2000
Clinical Fellow, Department of Pathology, Brigham and Women's Hospital, 2000-2003
Postdoctoral Fellow, Department of Cell Biology, Harvard Medical School, 2000-2005

Professional Experience

  • 2003-2005
    Instructor, Department of Cell Biology, Harvard Medical School.
  • 2005-2011
    Assistant Professor, Department of Pathology, University of California San Francisco.
  • 2011-present
    Associate Professor (with tenure), UCSF Department of Pathology.

Honors & Awards

  • 1992
    Phi Kappa Phi Scholarship Cup (Valedictorian, Georgia Institute of Technology
  • 1995-1997
    Howard Hughes Medical Institute-National Institutes of Health Research Scholar
  • 1997-1998
    Howard Hughes Medical Institute Research Award For Continuing Medical Studies
  • 1998
    Soma Weiss Medical Student Research Day Speaker Award, Harvard Medical School
  • 1998
    Honors in a Special Field, magna cum laude, Harvard Medical School
  • 2000-2003
    Howard Hughes Medical Institute Postdoctoral Fellowship For Physicians
  • 2003
    AACR Scholar-In-Training Award
  • 2006-2009
    Charles Culpeper Scholarship in the Medical Sciences, Partnership For Cures
  • 2006-2009
    AACR Genentech BioOncology Career Development Award
  • 2006-2011
    Howard Hughes Medical Institute Early Career Award for Physician Scientists
  • 2006
    Stewart Family Trust Award UCSF Cancer Center
  • 2009
    Aspen Cancer Conference Fellow
  • 2011-2016
    DOD Breast Cancer Era of Hope Scholar Award
  • 2013
    Elected Member, American Society of Clinical Investigation
  • 2013-2014
    Samuel Waxman Cancer Research Foundation (SWCRF) Award

Selected Publications

  1. Mar FA, Debnath J, Stohr BA. Autophagy-Independent Senescence and Genome Instability Driven by Targeted Telomere Dysfunction. Autophagy. 2015 Mar 9; 0.
    View on PubMed
  2. Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G. Autophagy in malignant transformation and cancer progression. EMBO J. 2015 Feb 23.
    View on PubMed
  3. Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015 Feb 16.
    View on PubMed
  4. Murrow L, Debnath J. A nuclear option that initiates autophagy. Mol Cell. 2015 Feb 5; 57(3):393-5.
    View on PubMed
  5. Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015 Jan 13; 0.
    View on PubMed
  6. Marsh T, Debnath J. Ironing out VPS34 inhibition. Nat Cell Biol. 2015 Jan; 17(1):1-3.
    View on PubMed
  7. Haller M, Hock AK, Giampazolias E, Oberst A, Green DR, Debnath J, Ryan KM, Vousden KH, Tait SW. Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy. 2014 Dec 2; 10(12):2269-78.
    View on PubMed
  8. Kenific CM, Debnath J. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2014 Sep 30.
    View on PubMed
  9. Amaravadi R, Debnath J. Mouse models address key concerns regarding autophagy inhibition in cancer therapy. Cancer Discov. 2014 Aug; 4(8):873-5.
    View on PubMed
  10. Leidal AM, Debnath J. 'Doubling down' on the autophagy pathway to suppress tumor growth. Genes Dev. 2014 Jun 1; 28(11):1137-9.
    View on PubMed
  11. Lock R, Kenific CM, Leidal AM, Salas E, Debnath J. Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion. Cancer Discov. 2014 Apr; 4(4):466-79.
    View on PubMed
  12. Goldsmith J, Levine B, Debnath J. Autophagy and cancer metabolism. Methods Enzymol. 2014; 542:25-57.
    View on PubMed
  13. Starobinets H, Debnath J. Cancer: A suppression switch. Nature. 2013 Dec 12; 504(7479):225-6.
    View on PubMed
  14. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 8; 33(19):2441-53.
    View on PubMed
  15. Chen N, Debnath J. I?B kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy. 2013 Aug; 9(8):1214-27.
    View on PubMed
  16. Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21; 494(7437):323-7.
    View on PubMed
  17. Sosa MS, Bragado P, Debnath J, Aguirre-Ghiso JA. Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv Exp Med Biol. 2013; 734:73-89.
    View on PubMed
  18. Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene. 2013 Oct 10; 32(41):4932-40.
    View on PubMed
  19. Murrow L, Debnath J. Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol. 2013 Jan 24; 8:105-37.
    View on PubMed
  20. Chen N, Eritja N, Lock R, Debnath J. Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture. Oncogene. 2013 May 16; 32(20):2543-54.
    View on PubMed

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