University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Christopher C. Dvorak, MD

Christopher C. Dvorak, MD

Associate Professor of Clinical Pediatrics, Division of Pediatric Blood and Marrow Transplantation, UCSF Benioff Children’s Hospital

Cancer Center Program Memberships

Pediatric Malignancies | Cancer Immunology

Research Summary

My primary research focus is the supportive care aspects of pediatric HCT, with a goal of decreasing treatment-related morbidity and mortality, especially infections. I am the Chair of the international Pediatric Blood and Marrow Transplant Consortium’s (PBMTC) Supportive Care Strategy Group, where I lead individuals in the design of pilot multi-center trials in this field. These trials serve as the basis for the design of larger phase III trials in the COG.

In the COG, I serve on the Stem Cell Transplant and (as Vice-Chair) on the Cancer Control & Supportive Care Steering Committees, helping to oversee the design of trials in this field. Furthermore, I am the principal investigator on the Children’s Oncology Group (COG) protocol ACCL1131: An Open-Label Phase III Trial of Caspofungin vs. Azole Prophylaxis for Patients at High-Risk for Invasive Fungal Infections Undergoing Allogeneic HCT. I am also the vice-chair for COG ACCL1034: Impact of Cleaning with Chlorhexidine Gluconate on Reducing Central Line Associate Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms.

I also serve as a member of the protocol design committee for two other Supportive Care trials, including ACCL0934: A Randomized Controlled Trial of Levofloxacin to Prevent Bacteremia in Children Being Treated for Acute Leukemia or Undergoing Hematopoietic Stem Cell Transplantation and ACCL0933: A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML). Finally, I am the principal investigator on another COG trial, ASCT1221: A Randomized Phase II Study Comparing Two Different Conditioning Regimens Prior to Allogeneic Hematopoietic Cell Transplantation for Children with JMML.

Education

University of California at San Diego, BS, 1994, Molecular Biology
Vanderbilt University School of Medicine, MD, 1998, Medicine
Stanford University School of Medicine, Intern, 1999, Pediatrics
Stanford University School of Medicine, Resident, 2001, Pediatrics
Stanford University School of Medicine, Fellow, 2005, Hematology/Oncology


Professional Experience

  • 2001-2002
    Staff Physician, Pediatric and Neonatal Intensive Care Units, Stanford University
  • 2002-2004
    Staff Physician, Neonatal Intensive Care Unit, Santa Clara Valley Medical Center
  • 2005-2007
    Clinical Instructor, Division of Pediatric Stem Cell Transplantation, Stanford University
  • 2007-present
    Assistant Professor of Clinical Pediatrics, Division of Pediatric Blood and Marrow Transplantation, UCSF Benioff Children’s Hospital
  • 2013-present
    Associate Professor of Clinical Pediatrics, Division of Pediatric Blood and Marrow Transplantation, UCSF Benioff Children’s Hospital

Honors & Awards

  • 1990-1994
    Regents Scholar, University of California at San Diego
  • 2002-2005
    Arline & Pete Harman Pediatric Fellow, Lucile Packard Foundation for Children's Health
  • 2011
    Pediatric Faculty Leadership Award, UCSF Fellow's College

Selected Publications

  1. Zinter MS, Melton A, Sabnis AJ, Dvorak CC, Elicker BM, Nawaytou HM, Kameny RJ, Fineman JR. Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale. Leuk Lymphoma. 2017 Sep 28; 1-4.
    View on PubMed
  2. Ovchinsky N, Frazier W, Auletta JJ, Dvorak CC, Ardura M, Song E, McArthur J, Jeyapalan A, Tamburro R, Mahadeo KM, Traube C, Duncan CN, Bajwa RPS. Consensus Report by PALISI and PBMTC Joint Working Committees, Supportive Care Guidelines for Management of VOD in Children and Adolescents; Part 3: Focus on Cardio-Respiratory Dysfunction, Infections, Liver Dysfunction and Delirium. Biol Blood Marrow Transplant. 2017 Sep 01.
    View on PubMed
  3. Mahadeo KM, McArthur J, Adams RH, Radhi M, Angelo J, Jeyapalan A, Nicol K, Su L, Rabi H, Auletta JJ, Pai V, Duncan CN, Tamburro R, Dvorak CC, Bajwa RPS. Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2-Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues. Biol Blood Marrow Transplant. 2017 Aug 17.
    View on PubMed
  4. Wattier RL, Levy ER, Sabnis AJ, Dvorak CC, Auerbach AD. Reducing Second Gram-Negative Antibiotic Therapy on Pediatric Oncology and Hematopoietic Stem Cell Transplantation Services. Infect Control Hosp Epidemiol. 2017 Sep; 38(9):1039-1047.
    View on PubMed
  5. Cowan MJ, Dvorak CC, Long-Boyle J. Opening Marrow Niches in Patients Undergoing Autologous Hematopoietic Stem Cell Gene Therapy. Hematol Oncol Clin North Am. 2017 Oct; 31(5):809-822.
    View on PubMed
  6. Bajwa RPS, Mahadeo KM, Taragin BH, Dvorak CC, McArthur J, Jeyapalan A, Duncan CN, Tamburro R, Gehred A, Lehmann L, Richardson P, Auletta JJ, Woolfrey AE. Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment. Biol Blood Marrow Transplant. 2017 Jul 25.
    View on PubMed
  7. Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL. Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients. Am J Respir Crit Care Med. 2017 Jul 07.
    View on PubMed
  8. Ivaturi V, Dvorak CC, Chan D, Liu T, Cowan MJ, Wahlstrom J, Stricherz M, Jennissen C, Orchard PJ, Tolar J, Pai SY, Huang L, Aweeka F, Long-Boyle J. Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients. Biol Blood Marrow Transplant. 2017 Oct; 23(10):1701-1713.
    View on PubMed
  9. Cao Z, Villa KF, Lipkin CB, Robinson SB, Nejadnik B, Dvorak CC. Burden of illness associated with sinusoidal obstruction syndrome/veno-occlusive disease in patients with hematopoietic stem cell transplantation. J Med Econ. 2017 Aug; 20(8):871-883.
    View on PubMed
  10. Zinter MS, Barrows BD, Ursell PC, Kowalek K, Kalantar K, Cambronero N, DeRisi JL, Oishi P, Dvorak CC. Extracorporeal life support survival in a pediatric hematopoietic cellular transplant recipient with presumed GvHD-related fulminant myocarditis. Bone Marrow Transplant. 2017 Sep; 52(9):1330-1333.
    View on PubMed
  11. Esbenshade AJ, Zhao Z, Aftandilian C, Saab R, Wattier RL, Beauchemin M, Miller TP, Wilkes JJ, Kelly MJ, Fernbach A, Jeng M, Schwartz CL, Dvorak CC, Shyr Y, Moons KGM, Sulis ML, Friedman DL. Multisite external validation of a risk prediction model for the diagnosis of blood stream infections in febrile pediatric oncology patients without severe neutropenia. Cancer. 2017 Oct 01; 123(19):3781-3790.
    View on PubMed
  12. Dvorak CC, Patel K, Puck JM, Wahlstrom J, Dorsey MJ, Adams R, Facchino J, Cowan MJ. Unconditioned unrelated donor bone marrow transplantation for IL7Ra- and Artemis-deficient SCID. Bone Marrow Transplant. 2017 Jul; 52(7):1036-1038.
    View on PubMed
  13. Liou A, Wahlstrom JT, Dvorak CC, Horn BN. Safety of pre-emptive donor lymphocyte infusions (DLI) based on mixed chimerism (MC) in peripheral blood or bone marrow subsets in children undergoing hematopoietic stem cell transplant (HSCT) for hematologic malignancies. Bone Marrow Transplant. 2017 Jul; 52(7):1057-1059.
    View on PubMed
  14. Theiler M, Oza VS, Mathes EF, Dvorak CC, McCalmont TH, Yeh I, Sidbury R, Cordoro KM. Eosinophilic Pustular Folliculitis in Children after Stem Cell Transplantation: An Eruption Distinct from Graft-Versus-Host Disease. Pediatr Dermatol. 2017 May; 34(3):326-330.
    View on PubMed
  15. Horn B, Wahlstrom JT, Melton A, Liou A, Ouachee-Chardin M, Sunkersett G, Willert J, Hwang J, Expose-Spencer J, Cowan MC, Facchino J, Dvorak CC. Early mixed chimerism-based preemptive immunotherapy in children undergoing allogeneic hematopoietic stem cell transplantation for acute leukemia. Pediatr Blood Cancer. 2017 Aug; 64(8).
    View on PubMed
  16. Satwani P, Freedman JL, Chaudhury S, Jin Z, Levinson A, Foca MD, Krajewski J, Sahdev I, Talekar MK, Gardenswartz A, Silverman J, Hayes M, Dvorak CC. A Multicenter Study of Bacterial Blood Stream Infections in Pediatric Allogeneic Hematopoietic Cell Transplantation Recipients: The Role of Acute Gastrointestinal Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017 Apr; 23(4):642-647.
    View on PubMed
  17. Maziarz RT, Brazauskas R, Chen M, McLeod AA, Martino R, Wingard JR, Aljurf M, Battiwalla M, Dvorak CC, Geroge B, Guinan EC, Hale GA, Lazarus HM, Lee JW, Liesveld JL, Ramanathan M, Reddy V, Savani BN, Smith FO, Strasfeld L, Taplitz RA, Ustun C, Boeckh MJ, Gea-Banacloche J, Lindemans CA, Auletta JJ, Riches ML. Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study. Bone Marrow Transplant. 2017 Feb; 52(2):270-278.
    View on PubMed
  18. Dvorak CC. Musical chairs: in utero HCT via mobilization. Blood. 2016 Nov 17; 128(20):2378-2380.
    View on PubMed
  19. Nademi Z, Slatter MA, Dvorak CC, Neven B, Fischer A, Suarez F, Booth C, Rao K, Laberko A, Rodina J, Bertrand Y, Koltan S, Debski R, Flood T, Abinun M, Gennery AR, Hambleton S, Ehl S, Cant AJ. Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome. J Allergy Clin Immunol. 2017 Mar; 139(3):1046-1049.
    View on PubMed
  20. Bartelink IH, Lalmohamed A, van Reij EM, Dvorak CC, Savic RM, Zwaveling J, Bredius RG, Egberts AC, Bierings M, Kletzel M, Shaw PJ, Nath CE, Hempel G, Ansari M, Krajinovic M, Théorêt Y, Duval M, Keizer RJ, Bittencourt H, Hassan M, Güngör T, Wynn RF, Veys P, Cuvelier GD, Marktel S, Chiesa R, Cowan MJ, Slatter MA, Stricherz MK, Jennissen C, Long-Boyle JR, Boelens JJ. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. Lancet Haematol. 2016 Nov; 3(11):e526-e536.
    View on PubMed

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