University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Ivan El-Sayed, MD

Ivan El-Sayed, MD

Professor, Department of Otolaryngology - Head and Neck Surgery, UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

Ivan H. El-Sayed, MD, is Professor of Clinical Otolaryngology and the Director of the Otolaryngology Minimally Invasive Skill Base Surgery program and center in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. As of 2015, he has been elected to the North American Skull Base Society Directors Board, and he is recently named the Vice Chair of the American Academy of Otolaryngology Head and Neck Surgery Skull Base Committee. He has also been the Co-Course Director for Stryker-UCSF Resident Skull Base Approaches Course since 2009. Dr. El-Sayed completed his medical degree and internship from Boston University School of Medicine in Massachusetts. He completed his otolaryngology residency from Boston University, followed by a head and neck surgical oncology fellowship from UCSF. He lectures nationally and internationally on various topics related to head and neck oncology.

Dr. El-Sayed’s clinical focus is skull base surgery and he has developed the minimally invasive program into a nationally recognized program along with his neurosurgical colleagues. The program and center offers a unique capability of providing both endoscopic and open approaches to tailor the approach to the lesion. He has a broad surgical experience having performed over 500 surgical procedures on tumors of the nasal cavity/paranasal sinuses, infratemporal fossa, skull base and pituitary glands in over a decade of experience. He is also interested in the outcomes of research and clinical innovations through novel approach development. His research program goal is to develop 1) novel endoscopic surgical approaches and 2) nanotechnologies as multifunctional theranostic devices for the detection, destruction, and monitoring of oral cancer.

Education

Brown University, Providence, Rhode Island, Sc. B, 1992, Neuroscience
Boston University Medical School, Boston, MA, M.D., 1992-1996, Medicine
Boston University Medical Ctr, Boston, MA, 1996-2001, Otolaryngology-HNS
University of California, San Francisco, Postdoctoral, 2002-2003, Head and Neck Oncology-Fellowship


Professional Experience

  • 1996-1997
    Intern, Boston University Medical Center, Worcester, MA
  • 1997-2001
    Resident in Otolaryngology, Boston Univeristy Medical Center, Worcester, MA
  • 2001-2002
    Staff Physician, Fallon Clinic Department of Otolaryngology
  • 2002-2003
    Fellow, Department of Otolaryngology, University of California, San Francisco
  • 2002-2003
    Clinical Instructor, Department of Otolaryngology, UCSF
  • 2004-2009
    Assistant Professor, Department of Otolaryngology, UCSF
  • 2009-present
    Associate Professor, Department of Otolaryngology, UCSF

Honors & Awards

  • 1995
    Member, Alpha Omega Alpha Honor Society
  • 1998
    First Place: Ethics of Cochlear Implantation in Young Children, New England Otolaryngology Society
  • 2002
    U.S. Patent: Spectroscopic Diagnostics for Bacteria in Biologic Samples. Ivan El-Sayed, MD and Mostafa El-Sayed, PhD
  • 2002-2012
    Board Certified by the American Board of Otolaryngology
  • 2003
    THANKS Star Award, UCSF Medical Center
  • 2005
    "Quality Award" UCSF Medical Center Quality Improvement Office. For: Altered Airway PI Project. Member of the committee which developed this form.
  • 2007
    U.S. Patent: GTRC 3424 U.S.S.N. 11/913,915 "Shape Tunable Plasmonic Nanoparticles" Mostafa A. El-Sayed and Ivan Homer El-Sayed (Provisional Patent Filed 2005)
  • 2007
    "Hot Paper", American Chemical Society Publications, first author. [As defined by the ACS: "Hot Papers are articles published within the last two years receiving the most citations over the most recent two-month period. In a typical two-month period, Essential Science Indicators recognizes more than 200 total Hot Papers in chemistry.] For Article: Surface Plasmon Resonance Scattering and Absorption of anti-EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics: Applications in Oral Cancer. Nano Lett. 2005.
  • 2007
    Outstanding Productive Physician and Surgeon, Certificate of Accomplishment, Department of Otolaryngology, UCSF
  • 2007
    "Most Accessed Article" for the 3rd quarter of 2007, American Chemical Society Publications. For article: "Gold Nanorods for Nuclear Targeting. BioconjugChemistry 2007.
  • 2008
    "Most Accessed Article" for first quarter 2008, American Chemical Society Publications: For article: Calculated Absorption and Scattering Properties of Gold Nanoparticles of Different Size, Shape, and Composition: Applications in Biological Imaging and Biomedicine. J. Phys. Chem. B.; (Article); 2006
  • 2008
    "Editor Selected Papers in Imaging"- Bioconjugate Chemistry- For Article: Peptide-Conjugated Gold Nanorods for Nuclear Targeting. Bioconjug Chem. 2007 Sep-Oct;18(5):1490-7. Epub 2007 Jul 13.
  • 2008
    #1 ranked article in citations in the field of Chemistry for 2007. Described by ScienceWatch. For article: 14. Huang X, El-Sayed IH, Qian W, El-Sayed MA. Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods. J Am Chem Soc. 2006 Feb 15;128(6):2115-2120.
  • 2008
    "Hot Paper", American Chemical Society Publications. For article: Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods, J Am Chem Soc 2006.
  • 2008
    "Most Cited Author"- First author- recognized as one of the top 20 cited papers in Cancer Letters toward the calculation of the 2007 impact factor. Cancer Letters. 2006 Jul 28;239(1):129-35.

Selected Publications

  1. Li W, Chae R, Rubio RR, Benet A, Meybodi AT, Feng X, Huang G, El-Sayed IH. Characterization of Anatomical Landmarks for Exposing the Internal Carotid Artery in the Infratemporal Fossa through an Endoscopic Transmasticator Approach: A Morphometric Cadaveric Study. World Neurosurg. 2019 Jul 31.
    View on PubMed
  2. Wang EW, Zanation AM, Gardner PA, Schwartz TH, Eloy JA, Adappa ND, Bettag M, Bleier BS, Cappabianca P, Carrau RL, Casiano RR, Cavallo LM, Ebert CS, El-Sayed IH, Evans JJ, Fernandez-Miranda JC, Folbe AJ, Froelich S, Gentili F, Harvey RJ, Hwang PH, Jane JA, Kelly DF, Kennedy D, Knosp E, Lal D, Lee JYK, Liu JK, Lund VJ, Palmer JN, Prevedello DM, Schlosser RJ, Sindwani R, Solares CA, Tabaee A, Teo C, Thirumala PD, Thorp BD, de Arnaldo Silva Vellutini E, Witterick I, Woodworth BA, Wormald PJ, Snyderman CH. ICAR: endoscopic skull-base surgery. Int Forum Allergy Rhinol. 2019 Jul; 9(S3):S145-S365.
    View on PubMed
  3. Ali MRK, Farghali HAM, Wu Y, El-Sayed I, Osman AH, Selim SA, El-Sayed MA. Gold Nanorod-Assisted Photothermal Therapy Decreases Bleeding during Breast Cancer Surgery in Dogs and Cats. Cancers (Basel). 2019 Jun 19; 11(6).
    View on PubMed
  4. Rubio RR, Bonaventura RD, Kournoutas I, Barakat D, Vigo V, El-Sayed I, Abla AA. Stereoscopy in Surgical Neuroanatomy: Past, Present, and Future. Oper Neurosurg (Hagerstown). 2019 Jun 19.
    View on PubMed
  5. Kournoutas I, Vigo V, Chae R, Wang M, Gurrola J, Abla AA, El-Sayed I, Rubio RR. Acquisition of Volumetric Models of Skull Base Anatomy Using Endoscopic Endonasal Approaches: 3D Scanning of Deep Corridors Via Photogrammetry. World Neurosurg. 2019 Jun 07.
    View on PubMed
  6. Wang M, Chae R, Vigo V, Winkler E, McDermott MW, El-Sayed IH, Abla AA, Rubio RR. Comparative Analysis of the Subtonsillar, Far-Lateral, Extreme-Lateral, and Endoscopic Far-Medial Approaches to the Lower Clivus: An Anatomical Cadaver Study. World Neurosurg. 2019 Apr 11.
    View on PubMed
  7. Xu MJ, Plonowska KA, Gurman ZR, Humphrey AK, Ha PK, Wang SJ, El-Sayed IH, Heaton CM, George JR, Yom SS, Algazi AP, Ryan WR. Treatment modality impact on quality of life for human papillomavirus-associated oropharynx cancer. Laryngoscope. 2019 Mar 27.
    View on PubMed
  8. Rubio RR, Shehata J, Kournoutas I, Chae R, Vigo V, Wang M, El-Sayed I, Abla AA. Construction of Neuroanatomical Volumetric Models Using 3D Scanning Techniques: Technical Note and Applications. World Neurosurg. 2019 Mar 18.
    View on PubMed
  9. Miracle AC, El-Sayed IH, Glastonbury CM. Diffusion weighted imaging of esthesioneuroblastoma: Differentiation from other sinonasal masses. Head Neck. 2019 May; 41(5):1161-1164.
    View on PubMed
  10. Kim S, Dillon WP, Hope TA, El-Sayed IH, van Zante A, Wu K, Masharani U. Ectopic thyroid-stimulating hormone-secreting pituitary adenoma of the nasopharynx diagnosed by 68Ga-DOTA-TATE PET/CT. World Neurosurg. 2019 Feb 21.
    View on PubMed
  11. Chan JW, Yeh I, El-Sayed IH, Algazi AP, Glastonbury CM, Ha PK, Yom SS, van Zante A. Ultraviolet light-related DNA damage mutation signature distinguishes cutaneous from mucosal or other origin for head and neck squamous cell carcinoma of unknown primary site. Head Neck. 2019 Jan 11.
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  12. Dones F, Kournoutas I, Vigo V, Di Bonaventura R, Raygor K, El-Sayed IH, Abla AA, Rubio RR. A Combined Extradural-Intradural Technique for an En Bloc Anterior Petrosectomy: A Cadaveric Feasibility Study. World Neurosurg. 2019 Jan 09.
    View on PubMed
  13. Wu TJ, Ha PK, El-Sayed IH, George JR, Heaton CM, Ryan WR, Russell MD. Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease. Head Neck. 2019 Mar; 41(3):715-721.
    View on PubMed
  14. Plonowska KA, Strohl MP, Wang SJ, Ha PK, George JR, Heaton CM, El-Sayed IH, Mallen-St Clair J, Ryan WR. Human Papillomavirus-Associated Oropharyngeal Cancer: Patterns of Nodal Disease. Otolaryngol Head Neck Surg. 2019 Mar; 160(3):502-509.
    View on PubMed
  15. Wei L, Burke J, Benet A, Aghi M, Gurrola J, El-Sayed I. Endoscope Image Capture System with Mirrorless Camera. J Neurol Surg B Skull Base. 2019 Feb; 80(1):79-81.
    View on PubMed
  16. Byrd JK, Clair JM, El-Sayed I. AHNS Series: Do you know your guidelines? Principles for treatment of cancer of the paranasal sinuses: A review of the National Comprehensive Cancer Network guidelines. Head Neck. 2018 Sep; 40(9):1889-1896.
    View on PubMed
  17. Formeister EJ, Sean Alemi A, El-Sayed I, George JR, Ha P, Daniel Knott P, Ryan WR, Seth R, Tamplen ML, Heaton CM. Shorter interval between radiation therapy and salvage laryngopharyngeal surgery increases complication rates following microvascular free tissue transfer. Am J Otolaryngol. 2018 Sep - Oct; 39(5):548-552.
    View on PubMed
  18. Xu MJ, Wu TJ, van Zante A, El-Sayed IH, Algazi AP, Ryan WR, Ha PK, Yom SS. Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma. J Otolaryngol Head Neck Surg. 2018 Apr 25; 47(1):28.
    View on PubMed
  19. Xu MJ, Lazar AA, Garsa AA, Arron ST, Ryan WR, El-Sayed IH, George JR, Algazi AP, Heaton CM, Ha PK, Yom SS. Major prognostic factors for recurrence and survival independent of the American Joint Committee on Cancer eighth edition staging system in patients with cutaneous squamous cell carcinoma treated with multimodality therapy. Head Neck. 2018 07; 40(7):1406-1414.
    View on PubMed
  20. Yu Y, El-Sayed IH, McDermott MW, Theodosopoulos PV, van Zante A, Kased N, Glastonbury CM, Garsa AA, Yom SS. Dural recurrence among esthesioneuroblastoma patients presenting with intracranial extension. Laryngoscope. 2018 10; 128(10):2226-2233.
    View on PubMed

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